The Gastroesophageal Reflux Disease Questionnaire in Adolescents: What Is the Best Cutoff Score?
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Background: A self-assessment questionnaire, the GERD-Questionnaire (GERD-Q) was used to determine the prevalence of GERD in adolescents, describe the related factors, and determine the impact on quality of life (QoL). Methods: The incidence of GERD was evaluated using the GERD-Q in adolescents aged 12–18 years. The Pediatric Gastroesophageal Reflux Disease Symptom Questionnaire and Quality of Life Questionnaire (PGSQ-A) for adolescents were additionally administered. Some factors considered related to GERD were also evaluated. Results: The 520 adolescents were included. The prevalence of suspected GERD, according to a GERD-Q cutoff score of ≥7 was 32.9%, and those drinking soda were 1.7 times more likely to have GERD (95% confidence interval, 1.3–2.2; p <0.001). However, soda consumption was not a risk factor for development of GERD symptoms. Applying a cutoff score of ≥8, only 10.9% of the participants had a positive GERD score, but the association with soda consumption persisted. The median PGSQ-A score in subjects suspected of GERD was 8 (range 0–37) on weekends and 1 (range 0–17) during weekdays ( p <0.001) compared to those not suspected of GERD, with a median of 2 (range 0–27) during weekends and 0 (range 0–10) during weekdays. Heartburn, regurgitation, and extraesophageal symptoms correlated significantly with QoL ( p <0.001). Conclusion: The prevalence of suspected GERD in adolescents was 32.9% or 10.9%, depending on the cutoff score used. There was a statistically significant difference in PGSQ-A scores between the subjects suspected or not of GERD, indicating an impaired QoL.
Abstract
Background: A self-assessment questionnaire, the GERD-Questionnaire (GERD-Q) was used to determine the prevalence of GERD in adolescents, describe the related factors, and determine the impact on quality of life (QoL). Methods: The incidence of GERD was evaluated using the GERD-Q in adolescents aged 12–18 years. The Pediatric Gastroesophageal Reflux Disease Symptom Questionnaire and Quality of Life Questionnaire (PGSQ-A) for adolescents were additionally administered. Some factors considered related to GERD were also evaluated. Results: The 520 adolescents were included. The prevalence of suspected GERD, according to a GERD-Q cutoff score of ≥7 was 32.9%, and those drinking soda were 1.7 times more likely to have GERD (95% confidence interval, 1.3–2.2; p <0.001). However, soda consumption was not a risk factor for development of GERD symptoms. Applying a cutoff score of ≥8, only 10.9% of the participants had a positive GERD score, but the association with soda consumption persisted. The median PGSQ-A score in subjects suspected of GERD was 8 (range 0–37) on weekends and 1 (range 0–17) during weekdays ( p <0.001) compared to those not suspected of GERD, with a median of 2 (range 0–27) during weekends and 0 (range 0–10) during weekdays. Heartburn, regurgitation, and extraesophageal symptoms correlated significantly with QoL ( p <0.001). Conclusion: The prevalence of suspected GERD in adolescents was 32.9% or 10.9%, depending on the cutoff score used. There was a statistically significant difference in PGSQ-A scores between the subjects suspected or not of GERD, indicating an impaired QoL.
참고문헌 (30)
- Nelson SP, "Prevalence of symptoms of gastroesophageal reflux during childhood : a pediatric practice-based survey", Arch Pediatr Adolesc Med, 154, pp.150~154 (2000)
- El-Serag HB, "Systematic review : update of gastro-oesophageal reflux disease", Gut, 63, pp.871~880 (2014)
- Hegar B, "Evaluation and management of the pediatric patients with suspected gastroesophageal reflux disease", Indones J Gastroenterol Hepatol Dig Endosc, 12, pp.171~178 (2011)
- Hegar B, "Esofagitis refluks pada anak", Sari Pediatri, 8, pp.43~52 (2006)
- Vandenplas Y, "Pediatric gastroesophageal reflux clinical practice guidelines : joint recommendations of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition(NASPGHAN)and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition(ESPGHAN)", J Pediatr Gastroenterol Nutr, 49, pp.498~547 (2009)
- Jones R, "Development of the GerdQ, a tool for the diagnosis and management of gastro-oesophageal reflux disease in primary care", Aliment Pharmacol Ther, 30, pp.1030~1038 (2009)
- Chiu JY, "Correlation between gastroesophageal reflux disease questionnaire and erosive esophagitis in school-aged children receiving endoscopy", Pediatr Neonatol, 55, pp.439~443 (2014)
- Irvine EJ, "Quality of life assessment in gastro-oesophageal reflux disease", Gut, 53(Suppl 4), pp.iv35~39 (2004)
- Kleinman L, "Development and psychometric evaluation of 2 age-stratified versions of the Pediatric GERD Symptom and Quality of Life Questionnaire", J Pediatr Gastroenterol Nutr, 52, pp.514~522 (2011)
- Jonasson C, "Validation of the GerdQ questionnaire for the diagnosis of gastro-oesophageal reflux disease", Aliment Pharmacol Ther, 37, pp.564~572 (2013)
- Syam AF, "Prevalence and risk factors of GERD in Indonesian population-an internet-based study", Adv Sci Lett, 23, pp.6734~6738 (2017)
- Okimoto E, "Prevalence of gastroesophageal reflux disease in children, adults, and elderly in the same community", J Gastroenterol Hepatol, 30, pp.1140~1146 (2015)
- Martigne L, "Prevalence and management of gastroesophageal reflux disease in children and adolescents : a nationwide cross-sectional observational study", Eur J Pediatr, 171, pp.1767~1773 (2012)
- Borrelli O, "Role of gastroesophageal reflux in children with unexplained chronic cough", J Pediatr Gastroenterol Nutr, 53, pp.287~292 (2011)
- Madanick RD, "Management of GERD-related chronic cough", Gastroenterol Hepatol(N Y), 9, pp.311~313 (2013)
- Phipps CD, "Gastroesophageal reflux contributing to chronic sinus disease in children : a prospective analysis", Arch Otolaryngol Head Neck Surg, 126, pp.831~836 (2000)
- Hanna BC, "Gastroesophageal reflux and chronic rhinosinusitis", Curr Opin Otolaryngol Head Neck Surg, 20, pp.15~18 (2012)
- Sone M, "Otitis media in adults as a symptom of gastroesophageal reflux", Otolaryngol Head Neck Surg, 136, pp.19~22 (2007)
- Turk H, "Effect of proton pump inhibition on acid, weakly acid and weakly alkaline gastro-esophageal reflux in children", World J Pediatr, 9, pp.36~41 (2013)
- Thakkar K, "Gastroesophageal reflux and asthma in children : a systematic review", Pediatrics, 125, pp.e925~30 (2010)
- McCallister JW, "The relationship between gastroesophageal reflux and asthma : an update", Ther Adv Respir Dis, 5, pp.143~150 (2011)
- Blondeau K, "The relationship between gastroesophageal reflux and cough in children with chronic unexplained cough using combined impedance-pH-manometry recordings", Pediatr Pulmonol, 46, pp.286~294 (2011)
- Johnson T, "Systematic review : the effects of carbonated beverages on gastro-oesophageal reflux disease", Aliment Pharmacol Ther, 31, pp.607~614 (2010)
- Kohata Y, "Long-term benefits of smoking cessation on gastroesophageal reflux disease and health-related quality of life", PLoS One, 11, pp.e0147860~ (2016)
- Chang CH, "Alcohol and tea consumption are associated with asymptomatic erosive esophagitis in Taiwanese men", PLoS One, 12, pp.e0173230~ (2017)
- Acierno SP, "Development of a quality of life instrument for pediatric gastroesophageal reflux disease : qualitative interviews", J Pediatr Gastroenterol Nutr, 50, pp.486~492 (2010)
- Gisbert JP, "Impact of gastroesophageal reflux disease on patients' daily lives : a European observational study in the primary care setting", Health Qual Life Outcomes, 7, pp.60~ (2009)
- Gong EJ, "Quality of life, patient satisfaction, and disease burden in patients with gastroesophageal reflux disease with or without laryngopharyngeal reflux symptoms", J Gastroenterol Hepatol, 32, pp.1336~1340 (2017)
- Pao M, "Anxiety in medically ill children", adolescents, 2011, pp.28, 40~49
- Thapar A, "Depression in adolescence", Lancet, 379, pp.1056~1067 (2012)