Efficacy of the Probiotic Probiotical Confirmed in Acute Gastroenteritis
0
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Purpose: Some probiotic strains reduce the duration of acute diarrhea. Because of strain and product specificity, each product needs to be supported by clinical data. This study aimed to test the efficacy of the synbiotic food supplement Probiotical (Streptococcus thermophilus, Lactobacillus rhamnosus, Lactobacillus acidophilus, Bifidobacterium lactis, Bifidobacterium infantis, fructo-oligosaccharides) in children with acute gastroenteritis of likely infectious origin. The primary endpoint was the number of children with normal stool consistency during the treatment duration. Methods: A total of 46 children (aged 3.6 months to 12 years) with acute gastroenteritis that started less than 48 hours prior to their visit at a hospital-based emergency department were included in this prospective, randomized, placebo-controlled trial. All children were treated with oral rehydration solution and placebo (n=20) or the test product (n=26). Results: Significantly more children had a normal stool consistency on days 1 and 2 in the probiotic group: 5 children (20%) on day 1 in the probiotic group compared with none in the placebo group (p=0.046). On day 2, 11 children in the probiotic group (46%) and 3 (16%) in the placebo group (p=0.024) had a normal stool consistency. The mean duration of diarrhea was shorter in the probiotic group compared with that in the placebo group (3.04±1.36 vs. 4.20±1.34 days) (p=0.018). Conclusion: The test product was shown to normalize stool consistency significantly more rapidly than the placebo. These data confirm the findings from a previous study in a larger group of children performed in a primary healthcare setting.
Abstract
Purpose: Some probiotic strains reduce the duration of acute diarrhea. Because of strain and product specificity, each product needs to be supported by clinical data. This study aimed to test the efficacy of the synbiotic food supplement Probiotical (Streptococcus thermophilus, Lactobacillus rhamnosus, Lactobacillus acidophilus, Bifidobacterium lactis, Bifidobacterium infantis, fructo-oligosaccharides) in children with acute gastroenteritis of likely infectious origin. The primary endpoint was the number of children with normal stool consistency during the treatment duration. Methods: A total of 46 children (aged 3.6 months to 12 years) with acute gastroenteritis that started less than 48 hours prior to their visit at a hospital-based emergency department were included in this prospective, randomized, placebo-controlled trial. All children were treated with oral rehydration solution and placebo (n=20) or the test product (n=26). Results: Significantly more children had a normal stool consistency on days 1 and 2 in the probiotic group: 5 children (20%) on day 1 in the probiotic group compared with none in the placebo group (p=0.046). On day 2, 11 children in the probiotic group (46%) and 3 (16%) in the placebo group (p=0.024) had a normal stool consistency. The mean duration of diarrhea was shorter in the probiotic group compared with that in the placebo group (3.04±1.36 vs. 4.20±1.34 days) (p=0.018). Conclusion: The test product was shown to normalize stool consistency significantly more rapidly than the placebo. These data confirm the findings from a previous study in a larger group of children performed in a primary healthcare setting.
참고문헌 (25)
- Singh M, "Predictors of mortality in children admitted to the pediatric intensive care unit with acute gastroenteritis with severe dehydration", Indian J Pediatr, 86, pp.1142~1145 (2019)
- Lewis SJ, "Stool form scale as a useful guide to intestinal transit time", Scand J Gastroenterol, 32, pp.920~924 (1997)
- Sazawal S, "Efficacy of probiotics in prevention of acute diarrhoea : a meta-analysis of masked, randomised, placebo-controlled trials", Lancet Infect Dis, 6, pp.374~382 (2006)
- Plaza-Diaz J, "Mechanisms of action of probiotics", Adv Nutr, 10(suppl_1), pp.S49~66 (2019)
- Guarino A, "Universal recommendations for the management of acute diarrhea in nonmalnourished children", J Pediatr Gastroenterol Nutr, 67, pp.586~593 (2018)
- Allen SJ, "Probiotics for treating acute infectious diarrhoea", Cochrane Database Syst Rev, 2010, pp.CD003048~ (2010)
- Friedman JN, "Development of a clinical dehydration scale for use in children between 1 and 36 months of age", J Pediatr, 145, pp.201~207 (2004)
- Guarino A, "European Society for Pediatric Gastroenterology, Hepatology, and Nutrition", European Society for Pediatric Infectious Diseases evidence-based guidelines for the management of acute gastroenteritis in children in Europe : update 2014, 2014, pp.59, 132~152
- Thomas DW, "Probiotics and prebiotics in pediatrics", Pediatrics, 126, pp.1217~1231 (2010)
- Vandenplas Y, "Saccharomyces boulardii in childhood", Eur J Pediatr, 168, pp.253~265 (2009)
- Applegate JA, "Systematic review of probiotics for the treatment of community-acquired acute diarrhea in children", BMC Public Health, 13(Suppl 3), pp.S16~ (2013)
- Chapman CM, "Health benefits of probiotics : are mixtures more effective than single strains", Eur J Nutr, 50, pp.1~17 (2011)
- Juntunen M, "Adherence of probiotic bacteria to human intestinal mucus in healthy infants and during rotavirus infection", Clin Diagn Lab Immunol, 8, pp.293~296 (2001)
- Grandy G, "Probiotics in the treatment of acute rotavirus diarrhoea. A randomized, double-blind, controlled trial using two different probiotic preparations in Bolivian children", BMC Infect Dis, 10, pp.253~ (2010)
- Shornikova AV, "Bacteriotherapy with Lactobacillus reuteri in rotavirus gastroenteritis", Pediatr Infect Dis J, 16, pp.1103~1107 (1997)
- Kale-Pradhan PB, "Role of Lactobacillus in the prevention of antibiotic-associated diarrhea : a meta-analysis", Pharmacotherapy, 30, pp.119~126 (2010)
- Vandenplas Y, "Randomised clinical trial: the synbiotic food supplement Probiotical vs. placebo for acute gastroenteritis in children", Aliment Pharmacol Ther, 34, pp.862~867 (2011)
- Canani RB, "Probiotics for treatment of acute diarrhoea in children : randomised clinical trial of five different preparations", BMJ, 335, pp.340~ (2007)
- Schnadower D, "Lactobacillus rhamnosus GG versus placebo for acute gastroenteritis in children", N Engl J Med, 379, pp.2002~2014 (2018)
- Freedman SB, "Multicenter trial of a combination probiotic for children with gastroenteritis", N Engl J Med, 379, pp.2015~2026 (2018)
- Saavedra JM, "Feeding of Bifidobacterium bifidum and Streptococcus thermophilus to infants in hospital for prevention of diarrhoea and shedding of rotavirus", Lancet, 344, pp.1046~1049 (1994)
- García-Menor E, "A multicenter, prospective, randomized controlled trial to evaluate the additional benefit of a multistrain synbiotic(Prodefen®)in the clinical management of acute viral diarrhea in children", Glob Pediatr Health, 3, pp.2333794~ (2016)
- Hoekstra JH, "Oral rehydration solution containing a mixture of non-digestible carbohydrates in the treatment of acute diarrhea : a multicenter randomized placebo controlled study on behalf of the ESPGHAN working group on intestinal infections", J Pediatr Gastroenterol Nutr, 39, pp.239~245 (2004)
- Passariello A, "Efficacy of a new hypotonic oral rehydration solution containing zinc and prebiotics in the treatment of childhood acute diarrhea : a randomized controlled trial", J Pediatr, 158, pp.288~292 (2011)
- Szajewska H, "Saccharomyces boulardii for treating acute gastroenteritis in children : updated meta-analysis of randomized controlled trials", Aliment Pharmacol Ther, 30, pp.960~961 (2009)