본문 바로가기
KERD
논문KCI 등재

Human Milk Oligosaccharides as a Missing Piece in Combating Nutritional Issues during Exclusive Breastfeeding

2

조회

0

다운로드

0

인용

0

참고문헌

키워드

주제분류소아과학

초록

Extensive studies have shown that breast milk is the best source of nutrition for infants, especially during the first six months, because it fulfills almost all of their nutritional needs. Among the many functional building blocks in breast milk, human milk oligosaccharides (HMOs) have been receiving more attention recently. Furthermore, it is the third most common group of compounds in human milk, and studies have demonstrated the health benefits it provides for infants, including improved nutritional status. HMOs were previously known as the ‘bifidus factor’ due to their ‘bifidogenic’ or prebiotic effects, which enabled the nourishment of the gastrointestinal microbiota. Healthy gastrointestinal microbiota are intestinal health substrates that increase nutrient absorption and reduce the incidence of diarrhea. In addition, HMOs, directly and indirectly, protect infants against infections and strengthen their immune system, leading to a positive energy balance and promoting normal growth. Non-modifiable factors, such as genetics, and modifiable factors (e.g., maternal health, diet, nutritional status, environment) can influence the HMO profile. This review provides an overview of the current understanding of how HMOs can contribute to the prevention and treatment of nutritional issues during exclusive breastfeeding.

Abstract

Extensive studies have shown that breast milk is the best source of nutrition for infants, especially during the first six months, because it fulfills almost all of their nutritional needs. Among the many functional building blocks in breast milk, human milk oligosaccharides (HMOs) have been receiving more attention recently. Furthermore, it is the third most common group of compounds in human milk, and studies have demonstrated the health benefits it provides for infants, including improved nutritional status. HMOs were previously known as the ‘bifidus factor’ due to their ‘bifidogenic’ or prebiotic effects, which enabled the nourishment of the gastrointestinal microbiota. Healthy gastrointestinal microbiota are intestinal health substrates that increase nutrient absorption and reduce the incidence of diarrhea. In addition, HMOs, directly and indirectly, protect infants against infections and strengthen their immune system, leading to a positive energy balance and promoting normal growth. Non-modifiable factors, such as genetics, and modifiable factors (e.g., maternal health, diet, nutritional status, environment) can influence the HMO profile. This review provides an overview of the current understanding of how HMOs can contribute to the prevention and treatment of nutritional issues during exclusive breastfeeding.

참고문헌 (50)

  1. Section on Breastfeeding, "Breastfeeding and the use of human milk", Pediatrics, 129, pp.e827~e841 (2012)
  2. Victora CG, "Breastfeeding in the 21st century: epidemiology, mechanisms, and lifelong effect", Lancet, 387, pp.475~490 (2016)
  3. "Global Breastfeeding Scorecard, 2017. Tracking progress for breastfeeding policies and programmes" (2017)[URL]
  4. Bode L, "Human milk oligosaccharides : every baby needs a sugar mama", Glycobiology, 22, pp.1147~1162 (2012)
  5. Urashima T, "The predominance of type I oligosaccharides is a feature specific to human breast milk", Adv Nutr, 3, pp.473S~482S (2012)
  6. Lane JA, "The food glycome : a source of protection against pathogen colonization in the gastrointestinal tract", Int J Food Microbiol, 142, pp.1~13 (2010)
  7. Bode L, "The functional biology of human milk oligosaccharides", Early Hum Dev, 91, pp.619~622 (2015)
  8. Pekmez CT, "Gut microbiota alterations and dietary modulation in childhood malnutrition-the role of short chain fatty acids", Clin Nutr, 38, pp.615~630 (2019)
  9. Gough EK, "Linear growth faltering in infants is associated with Acidaminococcus sp. and community-level changes in the gut microbiota", Microbiome, 3, pp.24~ (2015)
  10. Lewis ZT, "Maternal fucosyltransferase 2 status affects the gut bifidobacterial communities of breastfed infants", Microbiome, 3, pp.13~ (2015)
  11. McGuire MK, "What's normal? Oligosaccharide concentrations and profiles in milk produced by healthy women vary geographically", Am J Clin Nutr, 105, pp.1086~1100 (2017)
  12. Azad MB, "Human milk oligosaccharide concentrations are associated with multiple fixed and modifiable maternal characteristics, environmental factors, and feeding practices", J Nutr, 148, pp.1733~1742 (2018)
  13. Wu S, "Development of an annotated library of neutral human milk oligosaccharides", J Proteome Res, 9, pp.4138~4151 (2010)
  14. Jovanović M, "MALDI Q-TOF CID MS for diagnostic ion screening of human milk oligosaccharide samples", Int J Mol Sci, 15, pp.6527~6543 (2014)
  15. Morrow AL, "Gastroenterology and nutrition: neonatology questions and controversies", pp.43~58 (2019), Elsevier
  16. Bode L, "Structure-function relationships of human milk oligosaccharides", Adv Nutr, 3, pp.383S~391S (2012)
  17. Totten SM, "Comprehensive profiles of human milk oligosaccharides yield highly sensitive and specific markers for determining secretor status in lactating mothers", J Proteome Res, 11, pp.6124~6133 (2012)
  18. Bering SB, "Human milk oligosaccharides to prevent gut dysfunction and necrotizing enterocolitis in preterm neonates", Nutrients, 10, pp.1461~ (2018)
  19. Meyer KM, "Maternal diet structures the breast milk microbiome in association with human milk oligosaccharides and gut-associated bacteria", Am J Obstet Gynecol, 216(1 Suppl), pp.S15~ (2017)
  20. Bode L, "Human milk oligosaccharides: prebiotics and beyond", Nutr Rev, 67(Suppl 2), pp.S183~S191 (2009)
  21. Garrido D, "Consumption of human milk glycoconjugates by infant-associated bifidobacteria: mechanisms and implications", Microbiology (Reading), 159(Pt 4), pp.649~664 (2013)
  22. Le Doare K, "Mother's milk : a purposeful contribution to the development of the infant microbiota and immunity", Front Immunol, 9, pp.361~ (2018)
  23. Robertson RC, "The human microbiome and child growth-first 1000 days and beyond", Trends Microbiol, 27, pp.131~147 (2019)
  24. Wang M, "Fecal microbiota composition of breast-fed infants is correlated with human milk oligosaccharides consumed", J Pediatr Gastroenterol Nutr, 60, pp.825~833 (2015)
  25. Sanidad KZ, "Neonatal gut microbiome and immunity", Curr Opin Microbiol, 56, pp.30~37 (2020)
  26. Schmidt WP, "Estimating the effect of recurrent infectious diseases on nutritional status: sampling frequency, sample-size, and bias", J Health Popul Nutr, 29, pp.317~326 (2011)
  27. Austin S, "Temporal change of the content of 10 oligosaccharides in the milk of Chinese urban mothers", Nutrients, 8, pp.346~ (2016)
  28. Kuntz S, "Oligosaccharides from human milk influence growth-related characteristics of intestinally transformed and non-transformed intestinal cells", Br J Nutr, 99, pp.462~471 (2008)
  29. Davis EC, "The role of early life nutrition in the establishment of gastrointestinal microbial composition and function", Gut Microbes, 8, pp.143~171 (2017)
  30. Doherty AM, "Human milk oligosaccharides and associations with immune-mediated disease and infection in childhood : a systematic review", Front Pediatr, 6, pp.91~ (2018)
  31. Zevgiti S, "Sialic acid and sialyl-lactose glyco-conjugates: design, synthesis and binding assays to lectins and swine influenza H1N1 virus", J Pept Sci, 18, pp.52~58 (2012)
  32. Duska-McEwen G, "Human milk oligosaccharides enhance innate immunity to respiratory syncytial virus and influenza in vitro", Food Nutr Sci, 5, pp.1387~1398 (2014)
  33. Stepans MB, "Early consumption of human milk oligosaccharides is inversely related to subsequent risk of respiratory and enteric disease in infants", Breastfeed Med, 1, pp.207~215 (2006)
  34. Heacock HJ, "Influence of breast versus formula milk on physiological gastroesophageal reflux in healthy, newborn infants", J Pediatr Gastroenterol Nutr, 14, pp.41~46 (1992)
  35. Eiwegger T, "Prebiotic oligosaccharides : in vitro evidence for gastrointestinal epithelial transfer and immunomodulatory properties", Pediatr Allergy Immunol, 21, pp.1179~1188 (2010)
  36. Prendergast AJ, "Interactions between intestinal pathogens, enteropathy and malnutrition in developing countries", Curr Opin Infect Dis, 29, pp.229~236 (2016)
  37. Zenhom M, "Prebiotic oligosaccharides reduce proinflammatory cytokines in intestinal Caco-2 cells via activation of PPARγ and peptidoglycan recognition protein 3", J Nutr, 141, pp.971~977 (2011)
  38. He Y, "The human milk oligosaccharide 2′-fucosyllactose modulates CD14 expression in human enterocytes, thereby attenuating LPS-induced inflammation", Gut, 65, pp.33~46 (2016)
  39. Goehring KC, "infants fed a formula containing 2′-fucosyllactose have lower inflammatory cytokines in a randomized controlled trial", J Nutr, 146, pp.2559~2566 (2016)
  40. Atochina O, "The immunomodulatory glycan LNFPIII initiates alternative activation of murine macrophages in vivo", Immunology, 125, pp.111~121 (2008)
  41. Atochina O, "LNFPIII", LeX-stimulated macrophages activate natural killer cells via CD40-CD40L interaction, 2005, pp.12, 1041~1049
  42. Sprenger N, "FUT2-dependent breast milk oligosaccharides and allergy at 2 and 5 years of age in infants with high hereditary allergy risk", Eur J Nutr, 56, pp.1293~1301 (2017)
  43. Badriul Hegar, "The Role of Two Human Milk Oligosaccharides, 2′-Fucosyllactose and Lacto-N-Neotetraose, in Infant Nutrition", Pediatric Gastroenterology, Hepatology & Nutrition, 22(4), pp.330~340 (2019), 대한소아소화기영양학회[DOI]
  44. Gabrielli O, "Preterm milk oligosaccharides during the first month of lactation", Pediatrics, 128, pp.e1520~e1531 (2011)
  45. Newburg DS, "Innate protection conferred by fucosylated oligosaccharides of human milk against diarrhea in breastfed infants", Glycobiology, 14, pp.253~263 (2004)
  46. Underwood MA, "Bifidobacterium longum subspecies infantis : champion colonizer of the infant gut", Pediatr Res, 77, pp.229~235 (2015)
  47. Davis JC, "Growth and morbidity of Gambian infants are influenced by maternal milk oligosaccharides and infant gut microbiota", Sci Rep, 7, pp.40466~ (2017)
  48. Larsson MW, "Human milk oligosaccharide composition is associated with excessive weight gain during exclusive breastfeeding-an explorative study", Front Pediatr, 7, pp.297~ (2019)
  49. Charbonneau MR, "Sialylated milk oligosaccharides promote microbiota-dependent growth in models of infant undernutrition", Cell, 164, pp.859~871 (2016)
  50. Alderete TL, "Associations between human milk oligosaccharides and infant body composition in the first 6 mo of life", Am J Clin Nutr, 102, pp.1381~1388 (2015)

관련 논문AI추천

The Role of Two Human Milk Oligosaccharides, 2′-Fucosyllactose and Lacto-N-Neotetraose, in Infant NutritionAhmad Suryawan, Alpha Fardah Atthiyah, Ariani Dewi Widodo, Badriul Hegar, Christy Manoppo, Muzal Kadim, Ninung Rose Diana, Ray Wagiu Basrowi, Reza Gunadi Ranuh, Subianto Marto Sudarmo, Supriatmo, Yulianti Wibowo, Yvan Vandenplas, Zakiudin Munasir대한소아소화기영양학회 · Pediatric Gastroenterology, Hepatology & Nutrition2019 · 제22권 제4호Human milk oligosaccharides: the novel modulator of intestinal microbiota김재한, Kyunghun Jeong, Vi Nguyen생화학분자생물학회 · BMB Reports2012 · 제45권 제8호모유 올리고당과 분유첨가 Prebiotic 올리고당의 관한 고찰정장호한국미생물·생명공학회 · 한국미생물·생명공학회지2010 · 제38권 제1호Prebiotics in the Infant Microbiome: The Past, Present, and FutureAmer Azaz, David Rawat, Jihad Al Mistarihi, Mohamad Miqdady대한소아소화기영양학회 · Pediatric Gastroenterology, Hepatology & Nutrition2020 · 제23권 제1호Human Milk Oligosaccharide Profiles and the Secretor and Lewis Gene Status of Indonesian Lactating MothersAdi Hidayat, Asmarinah, Badriul Hegar, Diana Sunardi, Nanis Sacharina Marzuki, Verawati Sudarma, Zakiudin Munasir대한소아소화기영양학회 · Pediatric Gastroenterology, Hepatology & Nutrition2023 · 제26권 제5호Gastrointestinal Health and Immunity of Milk Formula Supplemented with a Prebiotic Mixture of Short- Chain Galacto-oligosaccharides and Long-Chain Fructo-Oligosaccharides (9:1) in Healthy Infants and Toddlers: A Systematic Review with Meta-AnalysisAndy Darma, Charisma Dilantika, Juandy Jo, Melissa Stephanie Kartjito, Muzal Kadim, Ray Wagiu Basrowi, Veli Sungono대한소아소화기영양학회 · Pediatric Gastroenterology, Hepatology & Nutrition2025 · 제28권 제1호

이 간행물의 다른 논문 (7건)