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페니실린으로 완치한 버섯 중독에 의한 소아 급성 간부전 1예

A Case of Hyperacute Liver Failure from Mushroom Intoxication in a Child Treated with Penicillin

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주제분류소아과학

초록

Hyperacute liver failure from mushroom intoxication in children is rare and has a low survival rate. We report a case of hyperacute liver failure from mushroom intoxication in a 29-month-old boy. The patient ingested a mushroom about three days prior to presentation. He was admitted to the hospital with vomiting, abdominal pain, seizures, and hematemesis. During the hospitalization the patient developed hepatic encephalopathy (stage IV-a), and a coagulopathy. He recovered fully with specific medication, Penicillin GK and N-acetylcysteine.

Abstract

Hyperacute liver failure from mushroom intoxication in children is rare and has a low survival rate. We report a case of hyperacute liver failure from mushroom intoxication in a 29-month-old boy. The patient ingested a mushroom about three days prior to presentation. He was admitted to the hospital with vomiting, abdominal pain, seizures, and hematemesis. During the hospitalization the patient developed hepatic encephalopathy (stage IV-a), and a coagulopathy. He recovered fully with specific medication, Penicillin GK and N-acetylcysteine.

참고문헌 (11)

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  4. Squires RH Jr, "Alonso E, Sokol RJ, Narkewicz MR, et al. Acute liver failure in children; the first 348 patients in the pediatric acute liver failure study group", J Pediatr, 148, pp.652~658 (2006)
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  7. Letschert K, "Molecular characterization and inhibition of Amanitin uptake into human hepatocytes", Toxicological Sciences, 91, pp.140~149 (2006)
  8. Ritter C, "Protective effect of N-acetylcysteine and deferoxamine on carbon tetrachloride-induced acute hepatic failure in rats", Crit Care Med, 32, pp.2079~2084 (2004)
  9. San-Miguel B, "N-acetyl-cysteine protects liver from apoptotic death in an animal model of fulminant hepatic failure", Apoptosis, 11, pp.1945~1957 (2006)
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  11. Harrison P, "Evidence of increased guanylate cyclase activation by acetylcysteine in fulminant hepatic failure", Hepatol, 23, pp.1067~1072 (1996)

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