Clinical and Endoscopic Findings in Children with Peptic Ulcer in Terms of Helicobacter pylori in Incheon
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Purpose: Interest in peptic ulcer in children has been relatively low because the disease is rarer in children than in adults and there were restrictions in the application of endoscopy to children, but the recent development of pediatric endoscopy is activating research on pediatric peptic ulcer. Thus, this study compared the H. pylori infection rate and clinical and endoscopic findings among pediatric patients diagnosed with peptic ulcer. Methods: We analyzed retrospectively 58 pediatric patients for whom whether to be infected with H. pylori was confirmed selected out of pediatric patients diagnosed with gastric ulcer or duodenal ulcer through upper gastrointestinal endoscopy at the Department of Pediatrics of Gachon University Gil Hospital during the period from January 2002 to December 2007. A case was considered H. pylori positive if H. pylori was detected in the Giemsa stain of tissue or the results of UBT (urea breath test) and CLO (rapid urease test) were both positive. Results: Of the pediatric patients, 37 were infected with H. pylori and 21 were not. The H. pylori infection rate increased with aging and the result was statistically significant (p＜0.05). However, H. pylori infection was not in a statistically significant correlation with sex, chief complaint, and gastroduodenal ulcer (p＞0.05). Conclusion: H. pylori infection increased with aging, but was not significantly correlated with gastroduodenal ulcer. Further research may need to examine prospectively the relation between H. pylori and gastroduodenal ulcer in the Incheon area.
Abstract
Purpose: Interest in peptic ulcer in children has been relatively low because the disease is rarer in children than in adults and there were restrictions in the application of endoscopy to children, but the recent development of pediatric endoscopy is activating research on pediatric peptic ulcer. Thus, this study compared the H. pylori infection rate and clinical and endoscopic findings among pediatric patients diagnosed with peptic ulcer. Methods: We analyzed retrospectively 58 pediatric patients for whom whether to be infected with H. pylori was confirmed selected out of pediatric patients diagnosed with gastric ulcer or duodenal ulcer through upper gastrointestinal endoscopy at the Department of Pediatrics of Gachon University Gil Hospital during the period from January 2002 to December 2007. A case was considered H. pylori positive if H. pylori was detected in the Giemsa stain of tissue or the results of UBT (urea breath test) and CLO (rapid urease test) were both positive. Results: Of the pediatric patients, 37 were infected with H. pylori and 21 were not. The H. pylori infection rate increased with aging and the result was statistically significant (p＜0.05). However, H. pylori infection was not in a statistically significant correlation with sex, chief complaint, and gastroduodenal ulcer (p＞0.05). Conclusion: H. pylori infection increased with aging, but was not significantly correlated with gastroduodenal ulcer. Further research may need to examine prospectively the relation between H. pylori and gastroduodenal ulcer in the Incheon area.
참고문헌 (28)
- Lee A, "Gastric bacteria other than Helicobacter pylori", Gasttoenterol Clin North Am, 22, pp.21~42 (1993)
- Marshall BJ, "Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration", Lancet, 1, pp.1311~1315 (1984)
- Douglas OF, "Histological predictors of active Helicobacter pylori infection", Dig Dis Sci, 41, pp.937~943 (1996)
- Sarker SA, "Causal relationship of Helicobacter pylori with iron‐deficiency anemia or failure of iron supplementation in children", Gastroenterology, 135, pp.1534~1542 (2008)
- Hill ID, "Transient protein losing enteropathy associated with acute gastritis and Campylobacter pylori", Arch Dis Child, 62, pp.1215~1219 (1987)
- Kato S, "What is new related to Helicobacter pylori infection in children and teen‐agers?", Arch Pediatr Adolesc Med, 159, pp.415~421 (2005)
- Sullivan PB, "Helicobacter pylori in Gambian children with chronic diarrhea and malnutrition", Arch Dis Child, 65, pp.189~191 (1990)
- 이경신, "소아 Helicobacter pylori 감염의 상부 위장관 내시경 소견 및 치료 효과", Pediatric Gastroenterology, Hepatology & Nutrition, 8(1), pp.12~20 (2005), 대한소아소화기영양학회
- Seo JK, "Recurrent abdominal pain in children", J Korean Med Assoc, 42, pp.859~867 (1999)
- Valle J, "Long‐term course and consequences of Helicobacter pylori gastritis. Results of a 32-year follow-up study", Scand J Gastroenterol, 31, pp.546~550 (1996)
- Wedd PM, "Relation between infection with Helicobacter pylori and living condition in childhood: evidence for person to person transmission in early life", BMJ, 308, pp.750~753 (1994)
- Jung MK, "Relation between Helicobacter pylori infection and socioeconomic status in Korean adolescents", Korean J Pediatr Gastroenterol Nutr, 3, pp.17~22 (2000)
- Megraud F, "Helicobacter pylori and duodenal ulcer: Evidence suggesting causation", Dig Dis Sci, 37, pp.769~772 (1992)
- 한지환, "가와사끼병 급성기 치료의 최신 지견", Korean Journal of Pediatrics, 51(5), pp.457~461 (2008), 대한소아과학회
- Barthel JS, "Diagnosis of Campylobacter pylori infections: The “gold standard” and the alternatives", Rev Infect Dis, 12, pp.107~114 (1990)
- Brown KE, "Diagnosis of Helicobacter pylori infection", Gastroenterol Clin Nor Am, 22, pp.105~115 (1993)
- Egbaria R, "Peptic ulcers and erosions are common in Israel children undergoing upper endoscopy", Helicobacter, 13, pp.62~68 (2008)
- Bittencourt PF, "Gastroduodenal peptic ulcer and Helicobacter pylori infection in children and adolescents", J Pediatr, 82, pp.325~334 (2006)
- 김용주, "급성 복통을 호소하는 환아에서 위장관 점막병변에 관한 연구", Pediatric Gastroenterology, Hepatology & Nutrition, 9(2), pp.176~182 (2006), 대한소아소화기영양학회
- Lee SL, "A clinical study on peptic ulcer in childhood", J Korean Pediatr Soc, 32, pp.198~205 (1989)
- Park IS, "Peptic ulcer disease in infants and children", J Korean Pediatr Soc, 38, pp.339~346 (1995)
- Choe YH, "The eradication of Helicobacter pylori in the duodenal ulcer in children and the duodenal recurrence", Korean J Pediatr Gastroenterol Nutr, 1, pp.30~36 (1998)
- Drumm B, "Intrafamilial clustering of Helicobacter pylori infection", N Engl J Med, 322, pp.359~363 (1990)
- Hassel E, "Unique features of Helicobacter pylori disease in children", Dig Dis Sci, 36, pp.417~423 (1991)
- Drumm B, "Campylobacter pylori-associated primary gastritis in children", Pediatrics, 80, pp.192~195 (1987)
- Kilbridge PM, "Campylobacter pylori-associated gastritis and peptic ulcer disease in children", Am J Dis Child, 142, pp.1149~1152 (1988)
- Aeri M, "Positive association between Helicobacter pylori and gastroesophageal reflux disease in children", J Pediatr Gastroenterol Nutr, 49, pp.283~288 (2009)
- Kim HJ, "Clinical and endoscopic findings in children with duodenal ulcer due to Helicobacter pylori infection", J Korean Pediatr Soc, 42, pp.69~76 (1999)