Omega-3 Polyunsaturated Fatty Acid for Cholestasis due to BileDuct Paucity
1
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Omega (ω)-3 polyunsaturated fatty acids appear to be effective in preventing and treating parenteral nu-trition-associated liver disease, and several mechanisms were proposed for this observation. An 8-week-old male infant with cholestasis and acholic stool was diagnosed non-syndromic intrahepatic interlobular bile duct paucity by open-wedge liver biopsy. Initially he was treated with usual supportive medical therapy, including ursodeoxycholic acid. However, the clinical status and laboratory tests did not improve. Omega (ω)-3 polyunsaturated fatty acids (initially intravenous administration and oral administration later), were started and his liver function, including amino-transferase level and bilirubin levels normalized, and the ivory stool color turned green. We report the possible effec-tiveness of ω-3 polyunsaturated fatty acids as a potent choleretic agent for non-syndromic intrahepatic interlobular bile duct paucity, a very rare structural pediatric hepatic disease.
Abstract
Omega (ω)-3 polyunsaturated fatty acids appear to be effective in preventing and treating parenteral nu-trition-associated liver disease, and several mechanisms were proposed for this observation. An 8-week-old male infant with cholestasis and acholic stool was diagnosed non-syndromic intrahepatic interlobular bile duct paucity by open-wedge liver biopsy. Initially he was treated with usual supportive medical therapy, including ursodeoxycholic acid. However, the clinical status and laboratory tests did not improve. Omega (ω)-3 polyunsaturated fatty acids (initially intravenous administration and oral administration later), were started and his liver function, including amino-transferase level and bilirubin levels normalized, and the ivory stool color turned green. We report the possible effec-tiveness of ω-3 polyunsaturated fatty acids as a potent choleretic agent for non-syndromic intrahepatic interlobular bile duct paucity, a very rare structural pediatric hepatic disease.
참고문헌 (13)
- de Meijer VE, "Fish oil-based lipid emulsions prevent and reverse parenteral nutrition-associated liver disease: the Boston experience", JPEN J Parenter Enteral Nutr, 33, pp.541~547 (2009)
- Rollins MD, "Elimination of soybean lipid emulsion in parenteral nutrition and supplementation with enteral fish oil improve cholestasis in infants with short bowel syndrome", Nutr Clin Pract, 25, pp.199~204 (2010)
- Gura KM, "Safety and efficacy of a fish-oil-based fat emulsion in the treatment of parenteral nutrition-associated liver disease", Pediatrics, 121, pp.e678~e686 (2008)
- Alwayn IP, "Omega-3 fatty acid supplementation prevents hepatic steatosis in a murine model of nonalcoholic fatty liver disease", Pediatr Res, 57, pp.445~452 (2005)
- Clarke SD, "Dietary polyunsaturated fatty acid regulation of gene transcription", Annu Rev Nutr, 14, pp.83~98 (1994)
- Bagga D, "Differential effects of prostaglandin derived from omega-6 and omega-3 polyunsaturated fatty acids on COX-2 expression and IL-6 secretion", Proc Natl Acad Sci U S A, 100, pp.1751~1756 (2003)
- Calder PC, "Mechanisms of action of (n-3) fatty acids", J Nutr, 142, pp.592S~599S (2012)
- Serhan CN, "Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals", J Exp Med, 196, pp.1025~1037 (2002)
- Bérard AM, "Dietary fish oil up-regulates cholesterol 7alpha-hydroxylase mRNA in mouse liver leading to an increase in bile acid and cholesterol excretion", FEBS Lett, 559, pp.125~128 (2004)
- Ramaprasad TR, "Spray-dried milk supplemented with alpha-linolenic acid or eicosapentaenoic acid and docosahexaenoic acid decreases HMG Co A reductase activity and increases biliary secretion of lipids in rats", Steroids, 71, pp.409~415 (2006)
- Mercer DF, "Hepatic fibrosis persists and progresses despite biochemical improvement in children treated with intravenous fish oil emulsion", J Pediatr Gastroenterol Nutr, 56, pp.364~369 (2013)
- Lee S, "Reduction of hepatocellular injury after common bile duct ligation using omega-3 fatty acids", J Pediatr Surg, 43, pp.2010~2015 (2008)
- Chen CC, "Fish omega-3 fatty acids induce liver fibrosis in the treatment of bile duct-ligated rats", Dig Dis Sci, 58, pp.440~447 (2013)