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Surgery in Pediatric Crohn’s Disease: Indications, Timing and Post-Operative Management

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주제분류소아과학

초록

Pediatric onset Crohn’s disease (CD) tends to have complicated behavior (stricture or penetration) than elderly onset CD at diagnosis. Considering the longer duration of the disease in pediatric patients, the accumulative chance of surgical treatment is higher than in adult onset CD patients. Possible operative indications include perianal CD, in-testinal stricture or obstruction, abdominal abscess or fistula, intestinal hemorrhage, neoplastic changes and medi-cally untreatable inflammation. Growth retardation is an operative indication only for pediatric patients. Surgery can affect a patient’s clinical course, especially for pediatric CD patient who are growing physically and mentally, so the decision should be made by careful consideration of several factors. The complex and diverse clinical conditions hinder development of a systemized treatment algorithm. Therefore, timing of surgery in pediatric CD patients should be determined with individualized approach by an experienced and well organized multidisciplinary inflammatory bowel disease team. Best long-term outcomes will require proactive post-operative monitoring and therapeutic mod-ifications according to the conditions.

Abstract

Pediatric onset Crohn’s disease (CD) tends to have complicated behavior (stricture or penetration) than elderly onset CD at diagnosis. Considering the longer duration of the disease in pediatric patients, the accumulative chance of surgical treatment is higher than in adult onset CD patients. Possible operative indications include perianal CD, in-testinal stricture or obstruction, abdominal abscess or fistula, intestinal hemorrhage, neoplastic changes and medi-cally untreatable inflammation. Growth retardation is an operative indication only for pediatric patients. Surgery can affect a patient’s clinical course, especially for pediatric CD patient who are growing physically and mentally, so the decision should be made by careful consideration of several factors. The complex and diverse clinical conditions hinder development of a systemized treatment algorithm. Therefore, timing of surgery in pediatric CD patients should be determined with individualized approach by an experienced and well organized multidisciplinary inflammatory bowel disease team. Best long-term outcomes will require proactive post-operative monitoring and therapeutic mod-ifications according to the conditions.

참고문헌 (47)

  1. Levine A, "Pediatric modification of the Montreal classification for inflammatory bowel disease: the Paris classification", Inflamm Bowel Dis, 17, pp.1314~1321 (2011)
  2. Gower-Rousseau C, "Epidemiology of inflammatory bowel diseases: new insights from a French population-based registry (EPIMAD)", Dig Liver Dis, 45, pp.89~94 (2013)
  3. El-Asmar K, "Surgical aspects of inflammatory bowel diseases in pediatric and adolescent age groups", Int J Colorectal Dis, 31, pp.301~305 (2016)
  4. 나소영, "Biological Therapy for Inflammatory Bowel Disease in Children", Pediatric Gastroenterology, Hepatology & Nutrition, 15(1), pp.13~18 (2012), 대한소아소화기영양학회
  5. Lakatos PL, "Has there been a change in the natural history of Crohn's disease? Surgical rates and medical management in a population-based inception cohort from Western Hungary between 1977-2009", Am J Gastroenterol, 107, pp.579~588 (2012)
  6. Gupta N, "Risk factors for initial surgery in pediatric patients with Crohn's disease", Gastroenterology, 130, pp.1069~1077 (2006)
  7. Hatch QM, "Is modern medical management changing ultimate patient outcomes in inflammatory bowel disease?", J Gastrointest Surg, 20, pp.1867~1873 (2016)
  8. Kim HJ, "Clinical characteristics and long-term outcomes of paediatric Crohn's disease: a single-centre experience", J Crohns Colitis, 11, pp.157~164 (2017)
  9. Seifarth C, "Indications and specific surgical techniques in Crohn's disease", Viszeralmedizin, 31, pp.273~279 (2015)
  10. Scott N, "Timing of ileocolonic resection for symptomatic Crohn's disease--the patient's view", Gut, 35, pp.656~657 (1994)
  11. Bhakta A, "Increased incidence of surgical site infection in IBD patients", Dis Colon Rectum, 59, pp.316~322 (2016)
  12. Hansen LF, "Surgery and postoperative recurrence in children with Crohn disease", J Pediatr Gastroenterol Nutr, 60, pp.347~351 (2015)
  13. Pariente B, "Development of the Crohn's disease digestive damage score, the Lémann score", Inflamm Bowel Dis, 17, pp.1415~1422 (2011)
  14. Keljo DJ, "Course and treatment of perianal disease in children newly diagnosed with Crohn's disease", Inflamm Bowel Dis, 15, pp.383~387 (2009)
  15. Baillie CT, "Surgical strategies in paediatric inflammatory bowel disease", World J Gastroenterol, 21, pp.6101~6116 (2015)
  16. Alós R, "Timing of surgery in Crohn's disease:a key issue in the management", World J Gastroenterol, 14, pp.5532~5539 (2008)
  17. de Zoeten EF, "Diagnosis and treatment of perianal Crohn disease: NASPGHAN clinical report and consensus statement", J Pediatr Gastroenterol Nutr, 57, pp.401~412 (2013)
  18. Sandborn WJ, "AGA technical review on perianal Crohn's disease", Gastroenterology, 125, pp.1508~1530 (2003)
  19. Halme L, "Factors related to frequency, type, and outcome of anal fistulas in Crohn's disease", Dis Colon Rectum, 38, pp.55~59 (1995)
  20. Regueiro M, "Treatment of perianal fistulizing Crohn's disease with infliximab alone or as an adjunct to exam under anesthesia with seton placement", Inflamm Bowel Dis, 9, pp.98~103 (2003)
  21. Panés J, "Expanded allogeneic adipose-derived mesenchymal stem cells (Cx601) for complex perianal fistulas in Crohn's disease: a phase 3randomised, double-blind controlled trial", Lancet, 388, pp.1281~1290 (2016)
  22. Strong S, "Clinical practice guideline for the surgical management of Crohn's disease", Dis Colon Rectum, 58, pp.1021~1036 (2015)
  23. Di Nardo G, "Intralesional steroid injection after endoscopic balloon dilation in pediatric Crohn's disease with stricture: a prospective, randomized, doubleblind, controlled trial", Gastrointest Endosc, 72, pp.1201~1208 (2010)
  24. Hagel AF, "Outcome and complications of endoscopic balloon dilatations in various types of ileocaecal and colonic stenosis in patients with Crohn's disease", Surg Endosc, 28, pp.2966~2972 (2014)
  25. Michelassi F, "Primary and recurrent Crohn's disease. Experience with 1379 patients", Ann Surg, 214, pp.230~238 (1991)
  26. Pfefferkorn MD, "NASPGHAN clinical report on the evaluation and treatment of pediatric patients with internal penetrating Crohn disease: intraabdominal abscess with and without fistula", J Pediatr Gastroenterol Nutr, 57, pp.394~400 (2013)
  27. Garcia JC, "Abscesses in Crohn's disease: outcome of medical versus surgical treatment", J Clin Gastroenterol, 32, pp.409~412 (2001)
  28. Kim KJ, "Risk factors and outcome of acute severe lower gastrointestinal bleeding in Crohn's disease", Dig Liver Dis, 44, pp.723~728 (2012)
  29. Papi C, "Infliximab for severe recurrent Crohn's disease presenting with massive gastrointestinal hemorrhage", J Clin Gastroenterol, 36, pp.238~241 (2003)
  30. Podugu A, "Crohn's disease presenting as acute gastrointestinal hemorrhage", World J Gastroenterol, 22, pp.4073~4078 (2016)
  31. Vasseur F, "Nutritional status and growth in pediatric Crohn's disease: a population-based study", Am J Gastroenterol, 105, pp.1893~1900 (2010)
  32. Ruemmele FM, "Consensus guidelines of ECCO", ESPGHAN on the medical management of pediatric Crohn's disease, 2014, pp.8, 1179~1207
  33. Malik S, "Growth in children receiving contemporary disease specific therapy for Crohn's disease", Arch Dis Child, 97, pp.698~703 (2012)
  34. Singh Ranger G, "Surgery results in significant improvement in growth in children with Crohn's disease refractory to medical therapy", Pediatr Surg Int, 22, pp.347~352 (2006)
  35. Yu JX, "Surveillance of patients with inflammatory bowel disease", Best Pract Res Clin Gastroenterol, 30, pp.949~958 (2016)
  36. Farraye FA, "AGA technical review on the diagnosis and management of colorectal neoplasia in inflammatory bowel disease", Gastroenterology, 138, pp.746~774 (2010)
  37. Colombel JF, "Infliximab, azathioprine, or combination therapy for Crohn's disease", N Engl J Med, 362, pp.1383~1395 (2010)
  38. Hyams JS, "Safety and efficacy of adalimumab for moderate to severe Crohn's disease in children", Gastroenterology, 143, pp.365~374.e2 (2012)
  39. Buisson A, "Review article: the natural history of postoperative Crohn's disease recurrence", Aliment Pharmacol Ther, 35, pp.625~633 (2012)
  40. Rutgeerts P, "Predictability of the postoperative course of Crohn's disease", Gastroenterology, 99, pp.956~963 (1990)
  41. Hashash JG, "The evolving management of postoperative Crohn's disease", Expert Rev Gastroenterol Hepatol, 6, pp.637~648 (2012)
  42. Regueiro M, "Management and prevention of postoperative Crohn's disease", Inflamm Bowel Dis, 15, pp.1583~1590 (2009)
  43. Domènech E, "Optimizing post-operative Crohn's disease treatment", Ann Gastroenterol, 27, pp.313~319 (2014)
  44. Danese S, "New therapies for inflammatory bowel disease:from the bench to the bedside", Gut, 61, pp.918~932 (2012)
  45. Peyrin-Biroulet L, "Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE): determining therapeutic goals for treat-to-target", Am J Gastroenterol, 110, pp.1324~1338 (2015)
  46. de Groof EJ, "Single-port surgery in inflammatory bowel disease: a review of current evidence", World J Surg, 40, pp.2276~2282 (2016)
  47. Smith NP, "BAPS UK inflammatory bowel disease surgical practice survey", J Pediatr Surg, 42, pp.296~299 (2007)

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