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Monkeypox and Its Recent OUTBREAKS; A Systemic Review

Gul Kainat|Shafiq Maheen|Rahman Khizar|Abedien Zain Ul
한국미생물·생명공학회 (The Korean Society For Microbiology And Biotechnology)|2022.12|한국미생물·생명공학회지 (Microbiology and Biotechnology Letters)|제50권 제4호|pp. 457-464|DOI 10.48022/mbl.2209.09001

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참고문헌

키워드

smallpoxzoonosisMonkeypoximmunizationMPXV
주제분류생물학

초록

A public health concern emerging from a zoonotic disease. Monkeypox is caused by the orthopoxvirus specie Monkeypox virus (MPXV). Monkeypox was identified as the most common orthopoxvirus infection in humans following the eradication of smallpox. Monkeypox has a similar clinical presentation to smallpox. The MPXV is now considered a high-threat pathogen that causes a serious public-health problem. The continuous spread of Monkeypox virus from West Africa to all other places around the world throughout 2018 to 2022, have raised concerns that MPXV could have emerged to acquire the immunological and ecological niche vacated by smallpox virus. This review highlights the current knowledge about Monkeypox evolution, infection biology, and epidemiology around the world since from 1970 to 2022, with a focus on the human, viral, and cellular factors that influence virus emergence, infection, spread, and maintenance in nature. This paper also discusses the current therapeutic options for Monkeypox treatment and control. Under the right conditions, with limited smallpox vaccination and very little orthopoxvirus immunity in some areas of the world, MPXV could become a more efficient human pathogen. Finally, the review identified knowledge gaps, particularly in terms of identifying a definitive reservoir host for monkeypox and proposes future research endeavors to address the unanswered questions.

Abstract

A public health concern emerging from a zoonotic disease. Monkeypox is caused by the orthopoxvirus specie Monkeypox virus (MPXV). Monkeypox was identified as the most common orthopoxvirus infection in humans following the eradication of smallpox. Monkeypox has a similar clinical presentation to smallpox. The MPXV is now considered a high-threat pathogen that causes a serious public-health problem. The continuous spread of Monkeypox virus from West Africa to all other places around the world throughout 2018 to 2022, have raised concerns that MPXV could have emerged to acquire the immunological and ecological niche vacated by smallpox virus. This review highlights the current knowledge about Monkeypox evolution, infection biology, and epidemiology around the world since from 1970 to 2022, with a focus on the human, viral, and cellular factors that influence virus emergence, infection, spread, and maintenance in nature. This paper also discusses the current therapeutic options for Monkeypox treatment and control. Under the right conditions, with limited smallpox vaccination and very little orthopoxvirus immunity in some areas of the world, MPXV could become a more efficient human pathogen. Finally, the review identified knowledge gaps, particularly in terms of identifying a definitive reservoir host for monkeypox and proposes future research endeavors to address the unanswered questions.

참고문헌 (69)

  1. Alakunle E, "Monkeypox virus in Nigeria : infection biology, epidemiology, and evolution", Viruses, 12, pp.1257~ (2020)
  2. Diven DG, "An overview of poxviruses", J. Am. Acad. Dermatol, 44, pp.1~6 (2001)
  3. Essbauer S, "Zoonotic poxviruses", Vet. Microb, 140, pp.229~236 (2010)
  4. "Virus Taxonomy: 2020 Release"[URL]
  5. Jezek Z, "Smallpox and its posteradication surveillance", Bull. World Health Org, 65, pp.425~ (1987)
  6. "Monkeypox"[URL]
  7. "Monkeypox Virus online"[URL]
  8. Magnus PV, "A pox-like disease in cynomolgus monkeys", Acta Pathol. Microbiol. Scandinavica, 46, pp.156~176 (1959)
  9. Ladnyj ID, "A human infection caused by monkeypox virus in Basankusu Territory, Democratic Republic of the Congo", Bull. World Health Org, 46, pp.593~ (1972)
  10. Albarnaz JD, "Modulating vaccinia virus immunomodulators to improve immunological memory", Viruses, 10, pp.101~ (2018)
  11. Kugelman JR, "Genomic variability of monkeypox virus among humans, Democratic Republic of the Congo", Emerg. Infect. Dis, 20, pp.232~ (2014)
  12. Al-Mosawi DAJ, "Human-monkey pox disease : An educational CME article", Int. J. Clin. Expl. Dermatol, 7, pp.33~43 (2022)
  13. Tiwari D, "Monkeypox-a Review", Eur. J. Mol. Clin. Med, 9, pp.2599~2611 (2022)
  14. Weaver JR, "Monkeypox virus and insights into its immunomodulatory proteins", Immunol. Rev, 225, pp.96~113 (2008)
  15. Khodakevich L, "Monkeypox virus in relation to the ecological features surrounding human settlements in Bumba zone, Zaire", Trop. Geogr. Med, 39, pp.56~63 (1987)
  16. Weinstein RA, "Reemergence of monkeypox : prevalence, diagnostics, and countermeasures", Clin. Infect. Dis, 41, pp.1765~1771 (2005)
  17. Kaler J, "Monkeypox : a comprehensive review of transmission, pathogenesis, and manifestation", Cureus, 14, pp.e26531~ (2022)
  18. Mucker EM, "Evaluation of virulence in cynomolgus macaques using a virus preparation enriched for the extracellular form of monkeypox virus", Viruses, 14, pp.1993~ (2022)
  19. Hasan S, "Monkeypox disease : An emerging public health concern in the shadow of COVID-19 pandemic : An update", Trop. Med. Infect. Dis, 7, pp.283~ (2022)
  20. Ola P, "Monkeypox deaths demand understanding of spectral theory of infectious disease pathogenesis", ~ (2022)
  21. Fenner F, "Smallpox and its eradication" (1988), World Health Organization
  22. Fenner F, "Human monkeypox and other poxvirus infections of man. Smallpox and its Eradication", pp.1287~1320 (1988), World Health Organization
  23. Kumar N, "The 2022 outbreak and the pathobiology of the monkeypox virus", J. Autoimm, 131, pp.102855~ (2022)
  24. Lansiaux E, "The virology of human monkeypox virus(hMPXV) : a brief overview", Virus Res, 322, pp.198932~ (2022)
  25. Sah R, "Monkeypox and its Possible Sexual Transmission : Where are we now with its evidence?", Pathogens, 11, pp.924~ (2022)
  26. Heli Harvala, "Evaluating the risk of transfusion and transplant‐transmitted monkeypox infections", Transfusion Medicine, 32(6), pp.460~466 (2022), Wiley[DOI]
  27. Vivancos R, "Community transmission of monkeypox in the United Kingdom, April to May 2022", Eurosurveillance, 27, pp.2200422~ (2022)
  28. Diaz JH, "The disease ecology, epidemiology, clinical manifestations, management, prevention, and control of increasing human infections with animal orthopoxviruses", Wilderness Environ. Med, 32, pp.528~536 (2021)
  29. Goyal R, "A comprehensive review on rising concern of transmission potential of monkeypox virus on healthcare system", Indo Global J. Pharm. Sci, 12, pp.265~272 (2022)
  30. Daniel Hornuss, "Transmission characteristics, replication patterns and clinical manifestations of human monkeypox virus—an in-depth analysis of four cases from Germany", Clinical Microbiology and Infection, 29(1), pp.112.e5~112.e9 (2023), Elsevier BV[DOI]
  31. Shepherd W, "The risk of reverse zoonotic transmission to pet animals during the current global monkeypox outbreak, United Kingdom, June to mid-September 2022", Eurosurveillance, 27, pp.2200758~ (2022)
  32. Riopelle JC, "Atypical and unique transmission of monkeypox virus during the 2022 outbreak : an overview of the current state of knowledge", Viruses, 14, pp.2012~ (2022)
  33. Presse C, "Monkeypox: a zoonosis and sexually transmitted infection (STI)", Press release of the French National Academy of Medicine, ~ (2022)
  34. Miura F, "Estimated incubation period for monkeypox cases confirmed in the Netherlands, May 2022", Euro Surveill, 27, pp.2200448~ (2022)
  35. Ihekweazu C, "Importance of epidemiological research of monkeypox : is incidence increasing?", Expert Rev. Anti Infect. Ther, 18, pp.389~392 (2020)
  36. Beer EM, "A systematic review of the epidemiology of human monkeypox outbreaks and implications for outbreak strategy", PLoS Negl. Trop. Dis, 13, pp.e0007791~ (2019)
  37. Fine PE, "The transmission potential of monkeypox virus in human populations", Int. J. Epidemiol, 17, pp.643~650 (1988)
  38. Cho C, "Monkeypox virus", Bacteriol. Rev. ASM, 37, pp.1~18 (1973)
  39. Kabuga AI, "A review of the monkeypox virus and a recent outbreak of skin rash disease in Nigeria", J. Med. Virol, 91, pp.533~540 (2019)
  40. Fowotade A, "Re-emergence of monkeypox in Nigeria : A cause for concern and public enlightenment", Afr. J. Clin. Exp. Microbiol, 19, pp.307~313 (2018)
  41. Bunge EM, "The changing epidemiology of human monkeypox—A potential threat? A systematic review", PLoS Negl. Trop. Dis, 16, pp.e0010141~ (2022)
  42. Durski KN, "Emergence of monkeypox—west and central Africa, 1970-2017", MMWR Morb. Mortal. Wkly Rep, 67, pp.306~310 (2018)
  43. Vaughan AM, "A large multi-country outbreak of monkeypox across 41 countries in the WHO European Region, 7March to 23 August 2022", Eurosurveillance, 27, pp.2200620~ (2022)
  44. Chakraborty C, "Evolution, epidemiology, geographical distribution, and mutational landscape of newly emerging monkeypox virus", GeroScience, 12, pp.1~17 (2022)
  45. Li H, "The evolving epidemiology of monkeypox virus", Cytokine Growth Factor Rev (2022)
  46. Vusirikala A, "Epidemiology of early monkeypox virus transmission in sexual networks of gay and bisexual men, England, 2022", Emerg. Infect. Dis, 28, pp.2082~2086 (2022)
  47. McCarthy MW, "Recent advances in the diagnosis monkeypox : implications for public health", Expert Rev. Mol. Diagn, 22, pp.739~744 (2022)
  48. Costello V, "Imported monkeypox from international traveler, Maryland, USA, 2021", Emerg. Infect. Dis, 28, pp.1002~ (2022)
  49. Adnan N, "Human monkeypox virus : An updated review", Medicine, 101, pp.e30406~ (2022)
  50. Shaheen N, "Is there a need to be worried about the new monkeypox virus outbreak? A brief review on the monkeypox outbreak", Ann. Med. Surg, 81, pp.104396~ (2022)
  51. Parvin R, "Monkeypox virus : A comprehensive review of taxonomy, evolution, epidemiology, diagnosis, prevention, and control regiments so far", Ger. J. Microbiol, 2, pp.1~15 (2022)
  52. Petersen E, "Human monkeypox : epidemiologic and clinical characteristics, diagnosis, and prevention", Infect. Dis. Clin, 33, pp.1027~1043 (2019)
  53. Altindis M, "Diagnosis of monkeypox virus-An overview", Travel Med. Infect. Dis, 50, pp.102459~ (2022)
  54. Kabuga AI, "A review of the monkeypox virus and a recent outbreak of skin rash disease in Nigeria", J. Med. Virol, 91, pp.533~540 (2019)
  55. Delaune D, "Drug development against smallpox : present and future", Antimicrob. Agents Chemother, 64, pp.e01683~19 (2020)
  56. Brown K, "Human monkeypox : current state of knowledge and implications for the future", Trop. Med. Infect. Dis, 1, pp.8~ (2016)
  57. Chinwenda VU, "Factors associated with the practice of monkey pox preventive behaviours among health workers in Yenagoa LGA, Bayelsa state, Nigeria", IOSR J. Nursing Health Sci, 8, pp.75~85 (2019)
  58. Brown K, "Human monkeypox : current state of knowledge and implications for the future", Trop. Med. Infect. Dis, 1, pp.8~ (2016)
  59. Chakraborty S, "Clinical management, antiviral drugs and immunotherapeutics for treating monkeypox. An update on current knowledge and futuristic prospects", Int. J. Surg, 105, pp.106847~ (2022)
  60. Cheema AY, "Monkeypox : a review of clinical features, diagnosis, and treatment", Cureus, 14, pp.e26756~ (2022)
  61. Gong Q, "Monkeypox virus : a reemergent threat to humans", Virol. Sin, 37, pp.477~482 (2022)
  62. Schnierle BS, "Monkeypox goes north : Ongoing worldwide monkeypox infections in humans", Viruses, 14, pp.1874~ (2022)
  63. Deshmukh P, "Monkeypox:What do we know so far? A short narrative review of literature", J. Assoc. Physicians India, 70, pp.87~90 (2022)
  64. Nasir IA, "Reminiscing the recent incidence of monkeypox in Nigeria : Its ecologicepidemiology and literature review", Port Harcourt Med. J, 12, pp.1~ (2018)
  65. Petersen E, "Monkeypox—Enhancing public health preparedness for an emerging lethal human zoonotic epidemic threat in the wake of the smallpox post-eradication era", Int. J. Infect. Dis, 78, pp.78~84 (2019)
  66. Petersen BW, "Clinical guidance for smallpox vaccine use in a postevent vaccination program", MMWR Wkly Rep. Recomm. Rep, 64, pp.1~26 (2015)
  67. Petersen BW, "Vaccinating against monkeypox in the Democratic Republic of the Congo", Antiviral Res, 162, pp.171~177 (2019)
  68. Liu Y, "The effective reproductive number of the Omicron variant of SARS-CoV-2 is several times relative to Delta", J. Travel Med, 29, pp.taac037~ (2022)
  69. Nguyen P, "Reemergence of human monkeypox and declining population immunity in the context of urbanization, Nigeria, 2017-2020", Emerg. Infect. Dis, 27, pp.1007~1014 (2021)

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