Birth Weight and the Development of Functional Gastrointestinal Disorders in Infants
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Purpose: To assess the association between birth weight and the development of functional gastrointestinal disorders (FGIDs) in the first year of life. Methods: This is a secondary analysis of a prospective cohort multicenter study including neonates, consecutively enrolled at birth, and followed up for one year. At birth all infants were classified by birth weight as extremely low (ELBW), very low, or low when <1,000, <1,500, and <2,500 g, respectively, and by birth weight for gestational age as appropriate (AGA, weight in the 10–90th percentile), small (SGA, weight <10th percentile), and large (LGA, weight >90th percentile) for gestational age. FGIDs were classified according to the Rome III criteria and assessed at 1, 3, 6, and 12 months of life. Results: Among 1,152 newborns enrolled, 934 (81.1%) completed the study: 302 (32.3%) were preterm, 35 (3.7%) were ELBW, 104 (11.1%) were SGA, 782 (83.7%) were AGA, and 48 (5.1%) were LGA infants. Overall, throughout the first year of life, 718 (76.9%) reported at least one FGID. The proportion of infants presenting with at least one FGID was significantly higher in ELBW (97%) compared to LBW (74%) (p=0.01) and in LGA (85.4%) and SGA (85.6%) compared to AGA (75.2%) (p=0.0001). On multivariate analysis, SGA was significantly associated with infantile colic. Conclusion: We observed an increased risk of FGIDs in ELBW, SGA, and LGA neonates. Our results suggest that prenatal factors determining birth weight may influence the development of FGIDs in infants. Understanding the role of all potential risk factors may provide new insights and targeted approaches for FGIDs.
Abstract
Purpose: To assess the association between birth weight and the development of functional gastrointestinal disorders (FGIDs) in the first year of life. Methods: This is a secondary analysis of a prospective cohort multicenter study including neonates, consecutively enrolled at birth, and followed up for one year. At birth all infants were classified by birth weight as extremely low (ELBW), very low, or low when <1,000, <1,500, and <2,500 g, respectively, and by birth weight for gestational age as appropriate (AGA, weight in the 10–90th percentile), small (SGA, weight <10th percentile), and large (LGA, weight >90th percentile) for gestational age. FGIDs were classified according to the Rome III criteria and assessed at 1, 3, 6, and 12 months of life. Results: Among 1,152 newborns enrolled, 934 (81.1%) completed the study: 302 (32.3%) were preterm, 35 (3.7%) were ELBW, 104 (11.1%) were SGA, 782 (83.7%) were AGA, and 48 (5.1%) were LGA infants. Overall, throughout the first year of life, 718 (76.9%) reported at least one FGID. The proportion of infants presenting with at least one FGID was significantly higher in ELBW (97%) compared to LBW (74%) (p=0.01) and in LGA (85.4%) and SGA (85.6%) compared to AGA (75.2%) (p=0.0001). On multivariate analysis, SGA was significantly associated with infantile colic. Conclusion: We observed an increased risk of FGIDs in ELBW, SGA, and LGA neonates. Our results suggest that prenatal factors determining birth weight may influence the development of FGIDs in infants. Understanding the role of all potential risk factors may provide new insights and targeted approaches for FGIDs.
참고문헌 (43)
- Baldassarre ME, "Non-communicable chronic diseases : the role of neonatal characteristics", Iran J Pediatr, 27, pp.e9322~ (2017)
- Salvatore S, "Neonatal antibiotics and prematurity are associated with an increased risk of functional gastrointestinal disorders in the first year of life", J Pediatr, 212, pp.44~51 (2019)
- Søndergaard C, "Fetal growth and infantile colic", Arch Dis Child Fetal Neonatal Ed, 83, pp.F44~7 (2000)
- Yvan Vandenplas, "Functional Gastrointestinal Disorders in Infancy: Impact on the Health of the Infant and Family", Pediatric Gastroenterology, Hepatology & Nutrition, 22(3), pp.207~216 (2019), 대한소아소화기영양학회[DOI]
- Mahon J, "The costs of functional gastrointestinal disorders and related signs and symptoms in infants : a systematic literature review and cost calculation for England", BMJ Open, 7, pp.e015594~ (2017)
- Indrio F, "Infantile colic, regurgitation, and constipation : an early traumatic insult in the development of functional gastrointestinal disorders in children", Eur J Pediatr, 174, pp.841~842 (2015)
- Savino F, "A prospective 10-year study on children who had severe infantile colic", Acta Paediatr Suppl, 94, pp.129~132 (2005)
- Indrio F, "Prevention of functional gastrointestinal disorders in neonates: clinical and socioeconomic impact", Benef Microbes, 6, pp.195~198 (2015)
- Baldassarre ME, "Administration of a multi-strain probiotic product to women in the perinatal period differentially affects the breast milk cytokine profile and may have beneficial effects on neonatal gastrointestinal functional symptoms. A randomized clinical trial", Nutrients, 8, pp.677~ (2016)
- Baldassarre ME, "Rationale of probiotic supplementation during pregnancy and neonatal period", Nutrients, 10, pp.1693~ (2018)
- Baldassarre ME, "Dysbiosis and prematurity : is there a role for probiotics", Nutrients, 11, pp.1273~ (2019)
- Bertino E, "Neonatal anthropometric charts : the Italian neonatal study compared with other European studies", J Pediatr Gastroenterol Nutr, 51, pp.353~361 (2010)
- Hyman PE, "Childhood functional gastrointestinal disorders : neonate", toddler, 2006, pp.130, 1519~1526
- Patel RM, "Short-and long-term outcomes for extremely preterm infants", Am J Perinatol, 33, pp.318~328 (2016)
- Mårild K, "Pregnancy outcome and risk of celiac disease in offspring : a nationwide case-control study", Gastroenterology, 142, pp.39~45 (2012)
- Salvatore S, "Prevalence of undiagnosed celiac disease in the parents of preterm and", or small for gestational age infants, 2007, pp.102, 168~173
- Steiner N, "Small for gestational age as an independent risk factor for long-term pediatric gastrointestinal morbidity of the offspring", J Matern Fetal Neonatal Med, 32, pp.1407~1411 (2019)
- Mezoff EA, "The winding road to understanding the neonatal origins of inflammatory gastrointestinal disorders", J Pediatr Gastroenterol Nutr, 57, pp.543~549 (2013)
- Iacono G, "Gastrointestinal symptoms in infancy : a population-based prospective study", Dig Liver Dis, 37, pp.432~438 (2005)
- Milidou I, "Gestational age, small for gestational age, and infantile colic", Paediatr Perinat Epidemiol, 28, pp.138~145 (2014)
- Das UG, "Abnormal fetal growth : intrauterine growth retardation, small for gestational age, large for gestational age", Pediatr Clin North Am, 51, pp.639~654 (2004)
- Barker DJ, "Adult consequences of fetal growth restriction", Clin Obstet Gynecol, 49, pp.270~283 (2006)
- Ciccone MM, "Aorta structural alterations in term neonates : the role of birth and maternal characteristics", BioMed Res Int, 2013, pp.459168~ (2013)
- Rhoads JM, "Infant colic represents gut inflammation and dysbiosis", J Pediatr, 203, pp.55~61 (2018)
- Shamir R, "Infant crying, colic, and gastrointestinal discomfort in early childhood: a review of the evidence and most plausible mechanisms", J Pediatr Gastroenterol Nutr, 57(Suppl 1), pp.S1~45 (2013)
- Melville JM, "The immune consequences of preterm birth", Front Neurosci, 7, pp.79~ (2013)
- Chatrath R, "Immune status of full-term small-for-gestational age neonates in India", J Trop Pediatr, 43, pp.345~348 (1997)
- Steinborn A, "Small for gestational age(SGA)neonates show reduced suppressive activity of their regulatory T cells", Clin Immunol, 134, pp.188~197 (2010)
- Rathore DK, "Underweight full-term Indian neonates show differences in umbilical cord blood leukocyte phenotype : a cross-sectional study", PLoS One, 10, pp.e0123589~ (2015)
- Prentice S, "They are what you eat : can nutritional factors during gestation and early infancy modulate the neonatal immune response", Front Immunol, 8, pp.1641~ (2017)
- Di Mauro A, "Gastrointestinal function development and microbiota", Ital J Pediatr, 39, pp.15~ (2013)
- Indrio F, "Microbiota in healthy term infant", Early Hum Dev, 89, pp.S15~7 (2013)
- Indrio F, "Gut motility alterations in neonates and young infants : relation to colic", J Pediatr Gastroenterol Nutr, 57, pp.S9~11 (2013)
- Saps M, "Post-infectious functional gastrointestinal disorders in children", J Pediatr, 152, pp.812~816 (2008)
- Baldassarre ME, "Effectiveness and safety of a probiotic-mixture for the treatment of infantile colic : a double-blind, randomized, placebocontrolled clinical trial with fecal real-time PCR and NMR-based metabolomics analysis", Nutrients, 10, pp.195~ (2018)
- Indrio F, "Microbiota involvement in the gut-brain axis", J Pediatr Gastroenterol Nutr, 57, pp.S11~5 (2013)
- Grunau R, "Early pain in preterm infants. A model of long-term effects", Clin Perinatol, 29, pp.373~394 (2002)
- Shenassa ED, "Maternal smoking and infantile gastrointestinal dysregulation : the case of colic", Pediatrics, 114, pp.e497~505 (2004)
- Salvatore S, "Review shows that parental reassurance and nutritional advice help to optimise the management of functional gastrointestinal disorders in infants", Acta Paediatr, 107, pp.1512~1520 (2018)
- Pensabene L, "Cow's milk protein allergy in infancy : a risk factor for functional gastrointestinal disorders in children", Nutrients, 10, pp.1716~ (2018)
- Levy RL, "Exploring the intergenerational transmission of illness behavior : from observations to experimental intervention", Ann Behav Med, 41, pp.174~182 (2011)
- Laforgia N, "The role of oxidative stress in the pathomechanism of congenital malformations", Oxid Med Cell Longev, 2018, pp.7404082~ (2018)
- Langer O, "Fetal macrosomia : etiologic factors", Clin Obstet Gynecol, 43, pp.283~297 (2000)