Epidemiologic Changes in Over 10 Years of Community-Acquired Bacterial Enteritis in Children
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Purpose: Community-acquired bacterial enteritis (CABE) is a common problem in developed countries. It is important to understand the epidemiologic changes in bacterial pathogens for prevention and treatment. Therefore, we studied the epidemiologic changes in CABE in Korean children. Methods: A total of 197 hospitalized pediatric patients aged <19 years that presented with dysentery symptoms and showed positive polymerase chain reaction results for bacterial species in stool samples, were enrolled in this study for 10 years (June 2010 to June 2020). We classified patients in phase I (06, 2010–06, 2015) and phase II (07, 2015–06, 2020) and analyzed their epidemiologic and clinical characteristics. Results: The most common pathogens were Campylobacter species (42.6%) and Salmonella species were the second most common pathogens (23.9%). The abundance of pathogens decreased in the following order: Clostridium difficile (9.6%), Shigella (5.6%), and Clostridium perfringens (5.6%). Escherichia coli O157:H7 was found to be the rarest pathogen (2.0%). Campylobacter species showed an increase in the infection rate from 32.1% in phase I to 49.6% in phase II (p=0.0011). Shigella species showed a decline in the infection rate in phase I from 14.1% to 0.0% in phase II (p<0.001). C. difficile and C. perfringens showed an increase in infection rate in phase II compared to phase I, but the difference was not statistically significant. Conclusion: The infection rate of Campylobacter species in CABE has been rising more recently, reaching almost 50%. This study may help establish policies for prevention and treatment of CABE in Korean children.
Abstract
Purpose: Community-acquired bacterial enteritis (CABE) is a common problem in developed countries. It is important to understand the epidemiologic changes in bacterial pathogens for prevention and treatment. Therefore, we studied the epidemiologic changes in CABE in Korean children. Methods: A total of 197 hospitalized pediatric patients aged <19 years that presented with dysentery symptoms and showed positive polymerase chain reaction results for bacterial species in stool samples, were enrolled in this study for 10 years (June 2010 to June 2020). We classified patients in phase I (06, 2010–06, 2015) and phase II (07, 2015–06, 2020) and analyzed their epidemiologic and clinical characteristics. Results: The most common pathogens were Campylobacter species (42.6%) and Salmonella species were the second most common pathogens (23.9%). The abundance of pathogens decreased in the following order: Clostridium difficile (9.6%), Shigella (5.6%), and Clostridium perfringens (5.6%). Escherichia coli O157:H7 was found to be the rarest pathogen (2.0%). Campylobacter species showed an increase in the infection rate from 32.1% in phase I to 49.6% in phase II (p=0.0011). Shigella species showed a decline in the infection rate in phase I from 14.1% to 0.0% in phase II (p<0.001). C. difficile and C. perfringens showed an increase in infection rate in phase II compared to phase I, but the difference was not statistically significant. Conclusion: The infection rate of Campylobacter species in CABE has been rising more recently, reaching almost 50%. This study may help establish policies for prevention and treatment of CABE in Korean children.
참고문헌 (31)
- Mokomane M, "The global problem of childhood diarrhoeal diseases : emerging strategies in prevention and management", Ther Adv Infect Dis, 5, pp.29~43 (2018)
- Yousry A. Hawash, "High Frequency of Enteric Protozoan, Viral, and Bacterial Potential Pathogens in Community-Acquired Acute Diarrheal Episodes: Evidence Based on Results of Luminex Gastrointestinal Pathogen Panel Assay", Parasites, Hosts and Diseases, 55(5), pp.513~521 (2017), 대한기생충학ㆍ열대의학회
- Faour-Klingbeil D, "Prevention and control of foodborne diseases in Middle-East North African countries : review of national control systems", Int J Environ Res Public Health, 17, pp.70~ (2019)
- Pedersen SK, "Proficiency of WHO Global Foodborne Infections Network External Quality Assurance System participants in identification and susceptibility testing of thermotolerant Campylobacter spp. from 2003 to 2012", J Clin Microbiol, 56, pp.e01066~18 (2018)
- Lake IR, "Climate change, foodborne pathogens and illness in higher-income countries", Curr Environ Health Rep, 5, pp.187~196 (2018)
- Sire JM, "Community-acquired infectious diarrhoea in children under 5 years of age in Dakar, Senegal", Paediatr Int Child Health, 33, pp.139~144 (2013)
- Tian L, "Characteristics of bacterial pathogens associated with acute diarrhea in children under 5 years of age : a hospital-based cross-sectional study", BMC Infect Dis, 16, pp.253~ (2016)
- Tack DM, "Preliminary incidence and trends of infections with pathogens transmitted commonly through food - Foodborne Diseases Active Surveillance Network, 10 U.S. sites, 2016-2019", MMWR Morb Mortal Wkly Rep, 69, pp.509~514 (2020)
- Kutsuna S, "Spectrum of enteropathogens in cases of traveler’s diarrhea that were detected using the FilmArray GI panel : new epidemiology in Japan", J Infect Chemother, 27, pp.49~54 (2021)
- Wang M, "Salmonella virulence and immune escape", Microorganisms, 8, pp.407~ (2020)
- Beier RC, "Editorial for the special issue : foodborne pathogen distribution, ecology, inactivation, and methods of differentiation", Microorganisms, 7, pp.701~ (2019)
- Abdoli A, "Commentary: estimates of global, regional, and national morbidity, mortality, and aetiologies of diarrhoeal diseases: a systematic analysis for the Global Burden of Disease Study 2015", Front Med(Lausanne), 5, pp.11~ (2018)
- Marder Mph EP, "Preliminary incidence and trends of infections with pathogens transmitted commonly through food - Foodborne Diseases Active Surveillance Network, 10 U.S. sites, 2006-2017", MMWR Morb Mortal Wkly Rep, 67, pp.324~328 (2018)
- Pai Hyunjoo, "History and Epidemiology of Bacillary Dysentery in Korea: from Korean War to 2017", Infection and Chemotherapy, 52(1), pp.123~131 (2020), 대한감염학회[DOI]
- Kuhn KG, "Campylobacter infections expected to increase due to climate change in Northern Europe", Sci Rep, 10, pp.13874~ (2020)
- Schmutz C, "Inverse trends of Campylobacter and Salmonella in Swiss surveillance data, 1988-2013", Euro Surveill, 21, pp.30130~ (2016)
- Gu B, "Comparison of the prevalence and changing resistance to nalidixic acid and ciprofloxacin of Shigella between Europe-America and Asia-Africa from 1998 to 2009", Int J Antimicrob Agents, 40, pp.9~17 (2012)
- De Roo AC, "Clostridium difficile infection : an epidemiology update", Clin Colon Rectal Surg, 33, pp.49~57 (2020)
- Hafiz RA, "The risk of community-acquired enteric infection in proton pump inhibitor therapy : systematic review and meta-analysis", Ann Pharmacother, 52, pp.613~622 (2018)
- 손강주, "국민건강보험 청구 자료를 이용한 국내 의료기관 Clostridioides difficile 감염 추이 분석", Annals of Clinical Microbiology, 23(4), pp.1~9 (2020), 대한임상미생물학회[DOI]
- 정희라, "소아 Clostridioides difficile 감염의 발생률 및 임상양상", Pediatric Infection and Vaccine, 27(3), pp.158~170 (2020), 대한소아감염학회[DOI]
- Mora ZV, "Clostridium perfringens as foodborne pathogen in broiler production: pathophysiology and potential strategies for controlling necrotic enteritis", Animals(Basel), 10, pp.1718~ (2020)
- Nielsen HL, "Risk of inflammatory bowel disease after Campylobacter jejuni and Campylobacter concisus infection : a population-based cohort study", Scand J Gastroenterol, 54, pp.265~272 (2019)
- Kalischuk LD, "A role for Campylobacter jejuni-induced enteritis in inflammatory bowel disease?", Am J Physiol Gastrointest Liver Physiol, 298, pp.1~9 (2010)[DOI]
- Bronowski C, "Role of environmental survival in transmission of Campylobacter jejuni", FEMS Microbiol Lett, 356, pp.8~19 (2014)
- Trompette M, "Increased incidence of Campylobacter enteritis and their quinolone resistance between 2010 and 2015 : results of a French national observatory conducted in 21 general hospitals(CHG)", Clin Res Hepatol Gastroenterol, 43, pp.338~345 (2019)
- 장원태, "Campylobacter Enteritis: Clinical Features and Laboratory Findings in Children Treated at a Single Hospital", Pediatric Infection and Vaccine, 26(1), pp.22~31 (2019), 대한소아감염학회[DOI]
- Chen J, "Chinese clinical practice guidelines for acute infectious diarrhea in children", World J Pediatr, 14, pp.429~436 (2018)
- Dahiya S, "Current antibiotic use in the treatment of enteric fever in children", Indian J Med Res, 149, pp.263~269 (2019)
- Peretz A, "Correlation between fecal calprotectin levels, disease severity and the hypervirulent ribotype 027 strain in patients with Clostridium difficile infection", BMC Infect Dis, 16, pp.309~ (2016)
- Casanovas-Moreno-Torres I, "Potential clinical use of azithromycin against gastroenteritis-causing pathogens other than Campylobacter", New Microbiol, 43, pp.198~200 (2020)
