Peri-Operative Liver Fibrosis and Native Liver Survival in Pediatric Patients with Biliary Atresia: A Systematic Review and Meta-Analysis
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No systematic review to date has examined histopathological parameters in relation to native liver survival in children who undergo the Kasai operation for biliary atresia (BA). A systematic review and meta-analysis is presented, comparing the frequency of native liver survival in peri-operative severe vs. non-severe liver fibrosis cases, in addition to other reported histopathology parameters. Records were sourced from MEDLINE, Embase, and CENTRAL databases. Studies followed the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines and compared native liver survival frequencies in pediatric patients with evidence of severe vs. non-severe liver fibrosis, bile duct proliferation, cholestasis, lobular inflammation, portal inflammation, and giant cell transformation on peri-operative biopsies. The primary outcome was the frequency of native liver survival. A random effects meta-analysis was used. Twenty-eight observational studies were included, 1,171 pediatric patients with BA of whom 631 survived with their native liver. Lower odds of native liver survival in the severe liver fibrosis vs. non-severe liver fibrosis groups were reported (odds ratio [OR], 0.16; 95% confidence interval [CI], 0.08–0.33; I2=46%). No difference in the odds of native liver survival in the severe bile duct destruction vs. non-severe bile duct destruction groups were reported (OR, 0.17; 95% CI, 0.00–63.63; I2=96%). Lower odds of native liver survival were documented in the severe cholestasis vs. non-severe cholestasis (OR, 0.10; 95% CI, 0.01–0.73; I2=80%) and severe lobular inflammation vs. non-severe lobular inflammation groups (OR, 0.02; 95% CI, 0.00–0.62; I2=69%). There was no difference in the odds of native liver survival in the severe portal inflammation vs. non-severe portal inflammation groups (OR, 0.03; 95% CI, 0.00–3.22; I2=86%) or between the severe giant cell transformation vs. non-severe giant cell transformation groups (OR, 0.15; 95% CI, 0.00–175.21; I2=94%). The meta-analysis loosely suggests that the presence of severe liver fibrosis, cholestasis, and lobular inflammation are associated with lower odds of native liver survival in pediatric patients after Kasai.
Abstract
No systematic review to date has examined histopathological parameters in relation to native liver survival in children who undergo the Kasai operation for biliary atresia (BA). A systematic review and meta-analysis is presented, comparing the frequency of native liver survival in peri-operative severe vs. non-severe liver fibrosis cases, in addition to other reported histopathology parameters. Records were sourced from MEDLINE, Embase, and CENTRAL databases. Studies followed the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines and compared native liver survival frequencies in pediatric patients with evidence of severe vs. non-severe liver fibrosis, bile duct proliferation, cholestasis, lobular inflammation, portal inflammation, and giant cell transformation on peri-operative biopsies. The primary outcome was the frequency of native liver survival. A random effects meta-analysis was used. Twenty-eight observational studies were included, 1,171 pediatric patients with BA of whom 631 survived with their native liver. Lower odds of native liver survival in the severe liver fibrosis vs. non-severe liver fibrosis groups were reported (odds ratio [OR], 0.16; 95% confidence interval [CI], 0.08–0.33; I2=46%). No difference in the odds of native liver survival in the severe bile duct destruction vs. non-severe bile duct destruction groups were reported (OR, 0.17; 95% CI, 0.00–63.63; I2=96%). Lower odds of native liver survival were documented in the severe cholestasis vs. non-severe cholestasis (OR, 0.10; 95% CI, 0.01–0.73; I2=80%) and severe lobular inflammation vs. non-severe lobular inflammation groups (OR, 0.02; 95% CI, 0.00–0.62; I2=69%). There was no difference in the odds of native liver survival in the severe portal inflammation vs. non-severe portal inflammation groups (OR, 0.03; 95% CI, 0.00–3.22; I2=86%) or between the severe giant cell transformation vs. non-severe giant cell transformation groups (OR, 0.15; 95% CI, 0.00–175.21; I2=94%). The meta-analysis loosely suggests that the presence of severe liver fibrosis, cholestasis, and lobular inflammation are associated with lower odds of native liver survival in pediatric patients after Kasai.
참고문헌 (80)
- Balistreri WF, "Biliary atresia: current concepts and research directions. Summary of a symposium", Hepatology, 23, pp.1682~1692 (1996)
- Schreiber RA, "Biliary atresia", J Pediatr Gastroenterol Nutr, 35(1), pp.11~16 (2002)
- Lakshminarayanan B, "Biliary atresia: a comprehensive review", J Autoimmun, 73, pp.1~9 (2016)
- Nomden M, "A higher incidence of isolated biliary atresia in rural areas : results from an epidemiological study in the Netherlands", J Pediatr Gastroenterol Nutr, 72, pp.202~209 (2021)
- Schreiber RA, "Biliary atresia : the Canadian experience", J Pediatr, 151, pp.659~665 (2007)[DOI]
- Townsend MR, "Factors associated with timing and adverse outcomes in patients with biliary atresia undergoing Kasai hepatoportoenterostomy", J Pediatr, 199, pp.237~242 (2018)[DOI]
- Nio M, "Impact of age at Kasai operation on short-and long-term outcomes of type III biliary atresia at a single institution", J Pediatr Surg, 45, pp.2361~2363 (2010)
- Qiao G, "Conditional probability of survival in patients with biliary atresia after Kasai portoenterostomy : a Chinese population-based study", J Pediatr Surg, 50, pp.1310~1315 (2015)
- Karrer FM, "Long-term results with the Kasai operation for biliary atresia", Arch Surg, 131, pp.493~496 (1996)
- Tessier MEM, "Beyond the Pediatric end-stage liver disease system : solutions for infants with biliary atresia requiring liver transplant", World J Gastroenterol, 20, pp.11062~11068 (2014)
- Schoen BT, "The Kasai portoenterostomy : when is it too late?", J Pediatr Surg, 36, pp.97~99 (2001)
- Capparelli MA, "Preoperative risk factors for the early failure of the Kasai portoenterostomy in patients with biliary atresia", Pediatr Surg Int, 37, pp.1183~1189 (2021)
- El-Araby HA, "Temporal histopathological changes in biliary atresia : a perspective for rapid fibrosis progression", Ann Hepatol, 21, pp.100263~ (2021)
- He L, "Biomarkers for the diagnosis and post-Kasai portoenterostomy prognosis of biliary atresia : a systematic review and meta-analysis", Sci Rep, 11, pp.11692~ (2021)
- Xiaojie Tang, "Matrix Metalloproteinase-7 as a Diagnostic Marker for Biliary Atresia: a Systematic Review and Meta-analysis", Indian Journal of Surgery, 84(4), pp.682~689 (2021), Springer Science and Business Media LLC[DOI]
- Yoon HM, "Diagnostic performance of sonographic features in patients with biliary atresia : a systematic review and meta-analysis", J Ultrasound Med, 36, pp.2027~2038 (2017)
- Hinojosa-Gonzalez DE, "Laparoscopic vs open portoenterostomy in biliary atresia : a systematic review and meta-analysis", Pediatr Surg Int, 37, pp.1477~1487 (2021)
- Losty P, "Biliary atresia--lessons from the Dublin experience", Ir Med J, 85, pp.144~147 (1992)
- Lin JN, "The efficacy of Kasai operation for biliary atresia : a single institutional experience", J Pediatr Surg, 27, pp.704~706 (1992)
- Wildhaber BE, "The Kasai portoenterostomy for biliary atresia : a review of a 27-year experience with 81 patients", J Pediatr Surg, 38, pp.1480~1485 (2003)
- Engelskirchen R, "Biliary atresia--a 25-year survey", Eur J Pediatr Surg, 1, pp.154~160 (1991)
- Karrer FM, "Biliary atresia registry, 1976 to 1989", J Pediatr Surg, 25, pp.1076~1080 (1990)
- Higgins JPT, "Cochrane handbook for systematic reviews of interventions" (2019), Wiley-Blackwell
- Page MJ, "The PRISMA 2020 statement : an updated guideline for reporting systematic reviews", Syst Rev, 10, pp.89~ (2021)
- Bramer WM, "A systematic approach to searching : an efficient and complete method to develop literature searches", J Med Libr Assoc, 106, pp.531~541 (2018)
- Davenport M, "The outcome of the older(> or =100 days)infant with biliary atresia", J Pediatr Surg, 39, pp.575~581 (2004)
- Okazaki T, "Long-term postsurgical outcome of biliary atresia", J Pediatr Surg, 34, pp.312~315 (1999)
- Uchida K, "Predicting factor of quality of life in long-term jaundice-free survivors after the Kasai operation", J Pediatr Surg, 39, pp.1040~1044 (2004)
- Caruso M, "Ultrasound, shear-wave elastography, and magnetic resonance imaging in native liver survivor patients with biliary atresia after Kasai portoenterostomy : correlation with medical outcome after treatment", Acta Radiol, 61, pp.1300~1308 (2020)
- Gunadi, "Histopathological findings for prediction of liver cirrhosis and survival in biliary atresia patients after Kasai procedure", Diagn Pathol, 15, pp.79~ (2020)
- Hukkinen M, "Very low bilirubin after portoenterostomy improves survival of the native liver in patients with biliary atresia by deferring liver fibrogenesis", Surgery, 165, pp.843~850 (2019)
- Ferreira AR, "Multivariate analysis of biliary flow-related factors and post-Kasai survival in biliary atresia patients", Arq Gastroenterol, 56, pp.71~78 (2019)
- Nguyen AHP, "Biliary atresia liver histopathological determinants of early post-Kasai outcome", J Pediatr Surg, 56, pp.1169~1173 (2021)
- Ramachandran P, "α-Smooth muscle actin expression predicts the outcome of Kasai portoenterostomy in biliary atresia", Saudi J Gastroenterol, 25, pp.101~105 (2019)
- Udomsinprasert W, "Hepatic glypican-3 and alpha-smooth muscle actin overexpressions reflect severity of liver fibrosis and predict outcome after successful portoenterostomy in biliary atresia", Surgery, 167, pp.560~568 (2020)
- Wu JF, "Transient elastography is useful in diagnosing biliary atresia and predicting prognosis after hepatoportoenterostomy", Hepatology, 68, pp.616~624 (2018)
- Zhou W, "The combination of conventional ultrasound and shear-wave elastography in evaluating the segmental heterogeneity of liver fibrosis in biliary atresia patients after Kasai portoenterostomy", Pediatr Surg Int, 37, pp.1099~1108 (2021)
- Shimadera S, "Predicting factors on the occurrence of cystic dilatation of intrahepatic biliary system in biliary atresia", Pediatr Surg Int, 26, pp.611~614 (2010)
- Azarow KS, "Biliary atresia : should all patients undergo a portoenterostomy?", J Pediatr Surg, 32, pp.168~172 (1997)[DOI]
- Santo K, "Segmental atrophy of explanted livers in biliary atresia : pathological data from 63 cases of failed portoenterostomy", J Pediatr Gastroenterol Nutr, 72, pp.88~94 (2021)
- Lang T, "Biliary atresia: which factors predict the success of a Kasai operation? An analysis of 36 patients", Eur J Med Res, 5, pp.110~114 (2000)
- Wells G, "The Newcastle-Ottawa Scale(NOS)for assessing the quality of nonrandomised studies in meta-analyses" (2000), Ottawa Hospital Research Institute
- Stang A, "Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses", Eur J Epidemiol, 25, pp.603~605 (2010)
- Wang J, "Recommended software", packages for meta-analysis of diagnostic accuracy, 2019, pp.4, 22~
- Meyers RL, "High-dose steroids, ursodeoxycholic acid, and chronic intravenous antibiotics improve bile flow after Kasai procedure in infants with biliary atresia", J Pediatr Surg, 38, pp.406~411 (2003)
- Oh M, "The Kasai procedure in the treatment of biliary atresia", J Pediatr Surg, 30, pp.1077~1080 (1995)
- Serinet MO, "Management of patients with biliary atresia in France : results of a decentralized policy 1986-2002", Hepatology, 44, pp.75~84 (2006)
- Shteyer E, "Outcome after portoenterostomy in biliary atresia : pivotal role of degree of liver fibrosis and intensity of stellate cell activation", J Pediatr Gastroenterol Nutr, 42, pp.93~99 (2006)
- Volpert D, "Outcome of early hepatic portoenterostomy for biliary atresia", J Pediatr Gastroenterol Nutr, 32, pp.265~269 (2001)
- Apostu RC, "Biological and histological assessment of the hepatoportoenterostomy role in biliary atresia as a stand-alone procedure or as a bridge toward liver transplantation", Medicina(Kaunas), 57, pp.16~ (2020)
- Jaramillo C, "Quantitative liver fibrosis using collagen hybridizing peptide to predict native liver survival in biliary atresia : a pilot study", J Pediatr Gastroenterol Nutr, 70, pp.87~92 (2021)
- Lemoine C, "The evolution of early liver biopsy findings in babies with jaundice may delay the diagnosis and treatment of biliary atresia", J Pediatr Surg, 55, pp.866~872 (2020)
- Patel KR, "Biliary atresia patients with successful Kasai portoenterostomy can present with features of obliterative portal venopathy", J Pediatr Gastroenterol Nutr, 71, pp.91~98 (2020)
- Suda K, "Histological significance of hepatitis-like findings in biliary atresia : an analysis of 34 Japanese cases", Pediatr Int, 61, pp.364~368 (2019)
- Ueno T, "Impact of serum autotaxin level correlating with histological findings in biliary atresia", J Pediatr Surg, 56, pp.1174~1178 (2021)
- Kobayashi H, "Connective tissue growth factor and progressive fibrosis in biliary atresia", Pediatr Surg Int, 21, pp.12~16 (2005)
- Kerola A, "Divergent expression of liver transforming growth factor superfamily cytokines after successful portoenterostomy in biliary atresia", Surgery, 165, pp.905~911 (2019)
- Lee JYJ, "The value of preoperative liver biopsy in the diagnosis of extrahepatic biliary atresia : a systematic review and meta-analysis", J Pediatr Surg, 51, pp.753~761 (2016)
- Webb NL, "Clinical significance of liver histology on outcomes in biliary atresia", J Paediatr Child Health, 53, pp.252~256 (2017)
- Pape L, "Prognostic value of computerized quantification of liver fibrosis in children with biliary atresia", Liver Transpl, 15, pp.876~882 (2009)
- Russo P, "Key histopathologic features of liver biopsies that distinguish biliary atresia from other causes of infantile cholestasis and their correlation with outcome : a multicenter study", Am J Surg Pathol, 40, pp.1601~1615 (2016)
- Hukkinen M, "Treatment policy and liver histopathology predict biliary atresia outcomes : results after national centralization and protocol biopsies", J Am Coll Surg, 226, pp.46~57 (2018)[DOI]
- Kerola A, "Molecular signature of active fibrogenesis prevails in biliary atresia after successful portoenterostomy", Surgery, 162, pp.548~556 (2017)
- Jeon TY, "Serial ultrasound findings associated with early liver transplantation after Kasai portoenterostomy in biliary atresia", Clin Radiol, 68, pp.588~594 (2013)
- Hukkinen M, "Predicting native liver injury and survival in biliary atresia", Semin Pediatr Surg, 29, pp.150943~ (2020)
- Luo Z, "Gene expression signatures associated with survival times of pediatric patients with biliary atresia identify potential therapeutic agents", Gastroenterology, 157, pp.1138~1152 (2019)[DOI]
- Duché M, "Prognostic value of portal pressure at the time of Kasai operation in patients with biliary atresia", J Pediatr Gastroenterol Nutr, 43, pp.640~645 (2006)
- Vazquez-Estevez J, "Biliary atresia : early determination of prognosis", J Pediatr Surg, 24, pp.48~50 (1989)
- Mukhopadhyay SG, "A histopathological study of liver and biliary remnants in the long-term survivors(>10 years)of cases of biliary atresia", Indian J Pathol Microbiol, 57, pp.380~385 (2014)
- Santos JL, "The extent of biliary proliferation in liver biopsies from patients with biliary atresia at portoenterostomy is associated with the postoperative prognosis", J Pediatr Surg, 44, pp.695~701 (2009)
- Kerola A, "Increased MMP-7 expression in biliary epithelium and serum underpins native liver fibrosis after successful portoenterostomy in biliary atresia", J Pathol Clin Res, 2, pp.187~198 (2016)
- Wu JF, "Quantification of serum matrix metallopeptide 7 Levels may assist in the diagnosis and predict the outcome for patients with biliary atresia", J Pediatr, 208, pp.30~37 (2019)[DOI]
- Bessho K, "Biliary atresia : will blocking inflammation tame the disease?", Annu Rev Med, 62, pp.171~185 (2011)
- Wu JF, "A high serum interleukin-12p40 level prior to Kasai surgery predict a favourable outcome in children with biliary atresia", Liver Int, 32, pp.1557~1563 (2012)
- Goda SS, "Preoperative serum IL-12p40 Is a potential predictor of Kasai portoenterostomy outcome in infants with biliary atresia", Gastroenterol Res Pract, 2017, pp.9089068~ (2017)
- Deeks JJ, "Cochrane handbook for systematic reviews of interventions version 6.2" (2021), Cochrane
- Sarkhy A, "Does adjuvant steroid therapy post-Kasai portoenterostomy improve outcome of biliary atresia? Systematic review and meta-analysis", Can J Gastroenterol, 25, pp.440~444 (2011)
- Zhang D, "Postoperative steroids after Kasai portoenterostomy for biliary atresia : a meta-analysis", Int J Surg, 12, pp.1203~1209 (2014)
- Chen Y, "Postoperative steroid therapy for biliary atresia : systematic review and meta-analysis", J Pediatr Surg, 50, pp.1590~1594 (2015)
- Lopez RN, "Early and peri-operative prognostic indicators in infants undergoing hepatic portoenterostomy for biliary atresia : a review", Curr Gastroenterol Rep, 19, pp.16~ (2017)