본문 바로가기
KERD
논문KCI 등재

항우울제의 부작용과 대처 방안(1)-성기능 장애를 중심으로

Antidepressant - induced adverse effects And Management strategy- focused on sexual dysfunction

이수진|김정기
대한생물정신의학회 (The Korean Society Of Biological Psychiatry)|2006.11|생물정신의학 (Journal of Korean Society of Biological Psychiatry)|제13권 제4호|pp. 248-255

2

조회

0

다운로드

0

인용

0

참고문헌

주제분류정신과학

초록

Abstract

Sexual dysfunction is a relatively common adverse effect in the use of antidepressants. The sexual side effects may result in a lack of compliance with the prescribed antidepressants. The author reviewed the prevalence and updated treatment for the antidepressant-induced adverse effects focusing on sexual dysfunction.The incidence of sexual dysfunction is reported to exceed more than 50% especially with SSRIs. In order to obtain a quantified baseline and as an ongoing evaluation tool, clinicians may use some of the established questionnaires and validated instruments such as the Arizona Sexual Experience scale and Changes in Sexual Functioning Questionnaire.Clinicians should be aware that delayed ejaculation and orgasm, symptoms most frequently associated with antidepressants, are not usually associated with depression itself.Although many antidotes have been proposed, few have been subjected to double-blind trials. Some evidences have suggested that bupropion and buspiron may be the effective antidotes for SSRI induced sexual dysfunction.Additional trials will be requied to define what role, if any, bupropion and buspiron might have in the treatment of SSRI-induced sexual side effects.The available evidence is rather limited, with only small number of trials assessing each strategy. While further randomized data is awaited, for men with antidepressant induced erectile dysfunction, the addition of sidenafil or tadalafil may appear to be an effective strategy.This study was supported by a grant of the Korean Health 21 R & D Project, Ministry of health and Welfare, republic of Korea. (A050047)

참고문헌 (51)

  1. Bahk WM,, "Long-Tenn Tolerability of New Antidepressants Focusing on Bupropion SR", 16(1), pp.16~24 (2005)
  2. Judd LL, "A prospective 12-year study of subsyndromal and syndromal depressive symptomatology in unipolar depressive disorders", 55, pp.694~701 (1998)
  3. Kupfer DJ, "Long-term treatment of depression", pp.52 28~34
  4. John R Geddes, "Relapse prevention with antidepressant drug treatment in depressive disorders:a systematic review", 361, pp.653~661 (2003)
  5. Khan A, "Mallinckrodtc: placebo response and antidepressant clinical trial outcome", 191, pp.211~218 (2003)
  6. Adam Keller Ashton, "Antidepressant-related adverse effects impacing treatment compliance: Results of a patient survey", 66, pp.96~106 (2005)
  7. James N, "SSRI Antidepressant Medications : Adverse Effects and Tolerability Primary Care Companion"
  8. Balon R, "Sexual dysfunction during antidepressant treatment", 54, pp.209~212
  9. Lee S, "Antidepressant-induced sexual dysfunction : Focused on Serotonin-specific Reuptake inhibitors", 5(2), pp.167~177
  10. Rothschild AJ, "Selective serotonin reuptake inhibitor induced sexual dysfunction : efficacy of a drug holiday", 152(10), pp.1514~1516 (1995)
  11. Kennedy SH, "Eisfeld BS sexual dysfunction before antidepressant therapy in major depression", 56, pp.201~208 (1999)
  12. Lawrence AL, "Sex and serotonin reuptake inhibitor antidepressants", 29, pp.571~579 (1999)
  13. Arch Gen Psychiatry, "Nofzinger EA Thase ME Reynolds CF et al Sexual function in depressed men assessment by self-report behavioural and nocturnal penile tumescence measures before and after treatment with cognitive behavioral therapy", pp.24~30 (1993)
  14. Motejo-Gonzalez AL,, "SSRI induced sexual dysfunction : Fluoxetine, paroxetine, sertraline and fluvoxamine in a prospective, multicenter, and descriptive clinical study of 344 patients", 23(3), pp.176~194 (1997)
  15. Valerie S.L, "Estimating the prevalence and impact of antidepressant-induced Sexual Dysfunction in 2 European Countries : A Cross-Sectional Patient Survey", 67, pp.204~210 (2006)
  16. Cho SI, "A Survey of Sexual Dysfunction by Antidepressants", 11(1), pp.44~51 (2003)
  17. Gitlin MJ, "Psychotropic medications and their effects on sexual function: diagnosis, biology and treatment approaches", 55, pp.406~413
  18. Arch Gen Psychiatry 1989, "Segraves T Effects of psychotropic drugs on human erection and ejaculation", pp.275~284
  19. "Birtan D Hull EM Pharmacological analysis of male rat sexual behavior", pp.365~389
  20. Sussman N,, "Rethinking side effects of the selective serotonin reuptake inhibitor: Sexual dysfunction and weight gain", 28, pp.89~97 (1998)
  21. "Kaplan & Sadock`s Synopsis of Psychiatry"
  22. "A Physiologic mediator of penile erection" (1992), Burnett AL Lowenstein CJ Bredt DS et al
  23. Raifer J Anderson WJ Bush PA, "Nitric oxide as a mediator of relaxation of the corpus cavenosum in response to noradrenergic", (ncholinergic neurotransmission), pp.90~94
  24. Boolell M,, "Sidenafil: A novel effective oral therapy for male erectile disorder", 78, pp.257~261 (1996)
  25. Goldstein I, "et al Oral sildenafil in the treatment of erectile dysfunction", pp.1397~140423
  26. Sullivan G, "Sexual side effects of antipsychotic medication: evaluation and intervention", 41, pp.1238~1241 (1998)
  27. Bonierbale M, "The ELIXIR study : evaluation of sexual dysfunction in 4557 depressed patients in France", 19, pp.114~124 (2003)
  28. Ashton AK, "Accommodation to serotonin reuptake inhibitor-induced sexual dysfunction", 24, pp.191~192 (1998)
  29. John Zajecka, "Strategies for the treatment of antidepressant-related sexual dysfunction", 62 (2001)
  30. Hirschfeld, "RMA Management of Sexual side effects of antidepressant therapy", 60, pp.27~30 (1996)
  31. Clayton AH, "A placebo-controlled trial of bupropion SR as an antidote fer selective serotonin reuptake inhibitor-induced sexual dysfunction", 65, pp.62~67 (2004)
  32. Masand PS, "Sustained-release bupropion for selective serotonin reuptake inhibitor-induced sexual dysfunction randomised, double-blind, placebo-controlled, parallel study", 158, pp.805~807 (2001)
  33. DeBattista C, "A placebo controlled, double blinded study of bupropion SR in the treatment of SSRI induced sexual dysfunction", 66, pp.844~ (2005)
  34. Choi JH Jae YM, "A Study on the Changes of Sexual Dysfunction after Substitution of a Serotonin Reuptake Inhibitor(SRI) with Bupropion Sustained Release in Major Depressive Disorder Patients With SRI-induced Sexual Dysfunction", 11(1), pp.62~68 (2005)
  35. Nurnberg HG, "Efficacy of sildenafil citrate for the treatment of erectile dysfunction in men taking serotonin reuptake inhibitors", 158, pp.1926~1928 (2001)
  36. Nurnberg HG, "Treatment of antidepressant-associated sexual dysfunction with sildenafil", 289, pp.56~64 (2003)
  37. Fava M, "Efficacy and safety of sildenafil in men with serotonergic antidepressants-associated erectile dysfunction results from a randomized, double-blind, placebo-controlled trial", 67, pp.240~246 (2006)
  38. Carson CC, "The efficacy and safety of tadalafil:an update", 93, pp.1276~1281 (2004)
  39. Michelson D, "ME Mirtazapine, yohimbine or olanzapine augmentation therapy for serotonin female sexual dysfunction: a randomised, placebo controlled trial", 36, pp.147~152 (2002)
  40. Kang BJ, "A placebo-controlled, double blind trial of Ginkgo biloba for antidepressant-induced sexual dysfunction", 12, pp.279~284 (2002)
  41. Meston CM, "Validated instruments for assessing female sexual function", 28(1), pp.155~164 (2002)
  42. Landen M, "A randomized, double-blind, placebo-controlled trial of buspirone in combination with an SSRI in patients with treatment-refractory depression", 59, pp.664~668 (1998)
  43. Landen M, "Effect of buspirone on sexual dysfunction in depressed patients treated with selective serotonin reuptake inhibitors", 19, pp.268~271 (1999)
  44. Michdson D, "Female sexual dysfunction associated with antidepressant administration:A random placebo-controlled study of pharmacologic intervention", 157, pp.239~243 (2000)
  45. Jespersen S, "A pilot randomized,double-blind,placebo-controlled study of granisetron in the treatment of sexual dysfunction in women associwith antidepressant use", 19, pp.161~164 (2004)
  46. Nelson EB, "A placebo-controlled,crossover trial of granisetron in SRI-induced sexual dysfunction", 62, pp.469~473 (2001)
  47. Lisa Rudkin, "Strategies for managing sexual dysfunction induced by antidepressant medication" (2004)
  48. Colman CC, "A placebo-controlled comparison of the effects on sexual functioning of bupropin sustained release and fluoxetine", 23, pp.1040~1058 (2001)
  49. Colman CC, "Sexual dysfunction associated with the treatment of depression:a placebo-controlled comparison of buspiron sustained release and sertraline treatment", 11, pp.205~215 (1999)
  50. Clayton AH, "Bupropion extended release compared with escitalopram:effects on sexual functioning in 2 randomized,double-blind,placebo-controlled studies", 67, pp.736~746 (2006)
  51. Gelenberg AJ, "Mirtazapine substitution in SSRI-induced sexual dysfunction", 61, pp.356~360 (2000)

관련 논문AI추천

Selective Serotonin Reuptake Inhibitor 치료에 의한 성부작용에 관한 연구김승현, 김정웅, 조숙행대한신경정신의학회 · 신경정신의학2001 · 제40권 제4호새로운 항우울제들의 약물 상호작용이광헌대한생물치료정신의학회 · 생물치료정신의학2000 · 제6권 제1호Tianeptine, SSRIs, Moclobemide가 성기능에 미치는 영향강병조, 권도훈대한생물치료정신의학회 · 생물치료정신의학2000 · 제6권 제1호비정형 우울증의 약물치료윤진상대한생물치료정신의학회 · 생물치료정신의학1997 · 제3권 제1호기분부전증과 비전형우울증의 약물치료오강섭, 임세원대한생물정신의학회 · 생물정신의학2007 · 제14권 제1호Antidepressant-Induced Sexual Dysfunction among Newer Antidepressants in a Naturalistic Setting권용실, 이경욱, 이영민, 이정태, 이해국, 전태연, Ji-Min Nam대한신경정신의학회 · PSYCHIATRY INVESTIGATION2010 · 제7권 제1호

이 간행물의 다른 논문 (10건)

한국형 우울증 표준 진료지침 개발 및 적용연구 (II)김수영, 강이헌, 이민수pp. 219-225한국에서 우울증의 특징과 비약물학적 치료노성원, 박용천pp. 226-233정신병적 우울증의 치료 전략정한용, 이소영pp. 234-239항우울제와 자살이병철, 함병주pp. 240-247한국인 남자에서 Synapsin III 유전자의 D22S280 표지자와 정신분열병의 연합연구박용범, 이석진, 양병환, 유장근, 신윤식, 이유상, 이승연, 홍경수, 박종원pp. 256-262
원문 보기