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남성 알코올 의존 환자들에서 금주 치료 후의 혈청 지질 농도 변화

Serum Lipid Profiles after Abstinence in Korean Male Patients With Alcohol Dependence

박웅섭|이승호
대한생물정신의학회 (The Korean Society Of Biological Psychiatry)|2008.02|생물정신의학 (Journal of Korean Society of Biological Psychiatry)|제15권 제1호|pp. 23-28

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키워드

알코올 의존 금주 혈청 지질 심혈관계 위험도.Alcohol dependence Abstinence Lipid profile Cardiovascular risk.
주제분류정신과학

초록

목적: 만성 알코올 환자의 정신과적 치료에 있어 금주는 가장 기본적이고 필수적인 요소이다. 여러 연구들은 알코올 섭취량과 심혈관계 위험도 사이에 ‘J’자형 또는 ‘U’자형의 관계를 보고하고 있다. 따라서 금주 치료가 심혈관계 위험도를 감소시킬 것으로 예상되나, 심혈관계 위험도와 밀접한 관련을 맺고 있는 혈청 지질에 대한 연구들은 다소 상반된 결과를 보고하고 있다. 본 연구는 만성 알코올 환자에서 단기간의 금주가 혈청 지질에 어떠한 영향을 미치는지 알아보는 것이다.

Abstract

Objectives: The treatment of alohol dependence requires maintaining abstinence. However, some previous studies have suggested that the abstinence may increase the cardiovascular risk in patients with alcohol dependence. The aim of the present study was to examine the effect of alcohol abstinence on lipid profile in Korean male patients with alcohol dependence.Methods: Twenty-eight male patients with alcohol dependence were recruited from a psychiatric unit located at Gangneung Dongin Hospital. Lipid profiles of the patients were compared before and after a month of alcohol abstinence. Results: After abstinence of 1 month, high-density lipoprotein (HDL) cholesterol and triglyceride (TG) level was significantly decreased(p=0.000; p=0.0086, respectively). Low-density lipoprotein (LDL) cholesterol level showed a tendency to increase(p=0.066). Total cholesterol level also showed a tendency to decrease(p=0.074).Conclusion: These results show that acute abstinence treatment might paradoxically aggravate dyslipidemia in patients with alcohol dependence. Thus, this study shows that more concern associated with cardiovascular risk is needed during short-term abstinence period.

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