본문 바로가기
KERD
논문KCI 등재

급성 조증 환자에서 혈소판 BDNF 농도에 대한 예비연구

Platelet BDNF level in patients with acute bipolar manic episode: the preliminary study

1

조회

0

다운로드

0

인용

0

참고문헌

키워드

주제분류정신과학

초록

Objectives Serum and plasma BDNF levels have been shown to be decreased in patients with mood disorder such as major depressive disorder and bipolar disorder. We investigated whether platelet BDNF levels would be lower in patients with acute bipolar manic episode compared with those of normal controls. Methods BDNF levels were examined in platelet-rich plasma(PRP) and platelet-poor plasma(PPP) in 20 healthy controls and 20 hospitalized patients who were diagnosed as bipolar I disorder, most recent episode manic using a Structured Clinical Interview for DSM-IV. And severity of manic symptoms was measured using Young Mania Rating Scale(YMRS). Platelet BDNF level was calculated by subtracting PPP BDNF from PRP BDNF level, and dividing the result by the total platelet count, and it was expressed as pg/106 platelet. Results Platelet BDNF levels were significantly lower in patients with acute bipolar manic episode (4.55±3.36 pg/106 platelet) than in normal controls (6.84±2.32 pg/106 platelet)(p=0.008). However we failed to reveal the significant negative correlation between platelet BDNF levels and YMRS scores in patients with acute bipolar episode. Conclusions Our finding suggests that there is a decrease in the platelet BDNF of patients with acute bipolar manic episode.

Abstract

Objectives Serum and plasma BDNF levels have been shown to be decreased in patients with mood disorder such as major depressive disorder and bipolar disorder. We investigated whether platelet BDNF levels would be lower in patients with acute bipolar manic episode compared with those of normal controls. Methods BDNF levels were examined in platelet-rich plasma(PRP) and platelet-poor plasma(PPP) in 20 healthy controls and 20 hospitalized patients who were diagnosed as bipolar I disorder, most recent episode manic using a Structured Clinical Interview for DSM-IV. And severity of manic symptoms was measured using Young Mania Rating Scale(YMRS). Platelet BDNF level was calculated by subtracting PPP BDNF from PRP BDNF level, and dividing the result by the total platelet count, and it was expressed as pg/106 platelet. Results Platelet BDNF levels were significantly lower in patients with acute bipolar manic episode (4.55±3.36 pg/106 platelet) than in normal controls (6.84±2.32 pg/106 platelet)(p=0.008). However we failed to reveal the significant negative correlation between platelet BDNF levels and YMRS scores in patients with acute bipolar episode. Conclusions Our finding suggests that there is a decrease in the platelet BDNF of patients with acute bipolar manic episode.

참고문헌 (49)

  1. Duman RS, "Neuronal plasticity and survival in mood disorders", Biol Psychiatry, 48, pp.732~739 (2000)
  2. Lee BH, "Decreased plasma BDNF level in depressive patients", J Affect Disord, 101, pp.239~244 (2007)
  3. Shimizu E, "Alterations of serum levels of brain-derived neurotrophic factor (BDNF) in depressed patients with or without antidepressants", Biol Psychiatry, 54, pp.70~75 (2003)
  4. Brunoni AR, "A systematic review and meta-analysis of clinical studies on major depression and BDNF levels: implications for the role of neuroplasticity in depression", Int J Neuropsychopharmacol, 11, pp.1169~1180 (2008)
  5. Matrisciano F, "Changes in BDNF serum levels in patients with major depression disorder (MDD) after 6 months treatment with sertraline, escitalopram, or venlafaxine", J Psychiatr Res, 43, pp.247~254 (2009)
  6. Li B, "Strategy to develop a new drug for treatment-resistant depression--role of electroconvulsive stimuli and BDNF", Yakugaku Zasshi, 127, pp.735~742 (2007)
  7. Einat H, "Possible involvement of the ERK signaling cascade in bipolar disorder: behavioral leads from the study of mutant mice", Drug News Perspect, 16, pp.453~463 (2003)
  8. Sklar P, "Family-based association study of 76 candidate genes in bipolar disorder: BDNF is a potential risk locus. Brain-derived neutrophic factor", Mol Psychiatry, 7, pp.579~593 (2002)
  9. Neves-Pereira M, "The brain-derived neurotrophic factor gene confers susceptibility to bipolar disorder: evidence from a family-based association study", Am J Hum Genet, 71, pp.651~655 (2002)
  10. Geller B, "Linkage disequilibrium of the brain-derived neurotrophic factor Val66Met polymorphism in children with a prepubertal and early adolescent bipolar disorder phenotype", Am J Psychiatry, 161, pp.1698~1700 (2004)
  11. Skibinska M, "Association analysis of brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism in schizophrenia and bipolar affective disorder", World J Biol Psychiatry, 5, pp.215~220 (2004)
  12. Lohoff FW, "Confirmation of association between the Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) gene and bipolar I disorder", Am J Med Genet B Neuropsychiatr Genet, 139B, pp.51~53 (2005)
  13. Green EK, "Genetic variation of brain-derived neurotrophic factor (BDNF) in bipolar disorder: case-control study of over 3000 individuals from the UK", Br J Psychiatry, 188, pp.21~25 (2006)
  14. Agelo BMC, "Serum brain-derived neurotrophic factor is decreased in bipolar disorder during depressive and manic episodes", Neuroscience Letters, 398, pp.215~219 (2006)
  15. Donovan MJ, "Neurotrophin and neurotrophin receptors in vascular smooth muscle cells. Regulation of expression in response to injury", Am J Pathol, 147, pp.309~324 (1995)
  16. Kerschensteiner M, "Activated human T cells, B cells, and monocytes produce brain-derived neurotrophic factor in vitro and in inflammatory brain lesions: a neuroprotective role of inflammation?", J Exp Med, 189, pp.865~870 (1999)
  17. Nakahashi T, "Vascular endothelial cells synthesize and secrete brain-derived neurotrophic factor", FEBS Lett, 470, pp.113~117 (2000)
  18. Pardridge WM, "Transport of human recombinant brain-derived neurotrophic factor (BDNF) through the rat blood-brain barrier in vivo using vector-mediated peptide drug delivery", Pharm Res, 11, pp.738~746 (1994)
  19. Fujimura H, "Brain-derived neurotrophic factor is stored in human platelets and released by agonist stimulation", Thromb Haemost, 87, pp.728~734 (2002)
  20. Rosenfeld RD, "Purification and identification of brain-derived neurotrophic factor from human serum", Protein Expr Purif, 6, pp.465~471 (1995)
  21. Karege F, "Postnatal developmental profile of brain-derived neurotrophic factor in rat brain and platelets", Neurosci Lett, 328, pp.261~264 (2002)
  22. Kishino A, "Analysis of effects and pharmacokinetics of subcutaneously administered BDNF", Neuroreport, 12, pp.1067~1072 (2001)
  23. Pan W, "Transport of brain-derived neurotrophic factor across the blood-brain barrier", Neuropharmacology, 37, pp.1553~1561 (1998)
  24. Poduslo JF, "Permeability at the blood-brain and blood-nerve barriers of the neurotrophic factors: NGF, CNTF, NT-3, BDNF", Brain Res Mol Brain Res, 36, pp.280~286 (1996)
  25. Lommatzsch M, "The impact of age, weight and gender on BDNF levels in human platelets and plasma", Neurobiol Aging, 26, pp.115~123 (2005)
  26. Lee BH, "Reduced platelet BDNF level in patients with major depression" (2009), Prog Neuropsychopharmacol Biol Psychiatry
  27. P, version 2.0), "Structured Clinical Interview for DSM-IV Axis I Disorder, Patient Edition (SCID-I", pp.1998, First M SR
  28. Young RC, "A rating scale for mania: reliability, validity and sensitivity", Br J Psychiatry, 133, pp.429~435 (1978)
  29. Lommatzsch M, "Platelet and plasma BDNF in lower respiratory tract infections of the adult", Respir Med, 101, pp.1493~1499 (2007)
  30. Pandey GN, "Brain-derived neurotrophic factor gene expression in pediatric bipolar disorder: effects of treatment and clinical response", J Am Acad Child Adolesc Psychiatry, 47, pp.1077~1085 (2008)
  31. Tramontina JF, "Brain-derived neurotrophic factor serum levels before and after treatment for acute mania", Neurosci Lett, 452, pp.111~113 (2009)
  32. Machado-Vieira R, "Decreased plasma brain derived neurotrophic factor levels in unmedicated bipolar patients during manic episode", Biol Psychiatry, 61, pp.142~144 (2007)
  33. Monteleone P, "Decreased levels of serum brain-derived neurotrophic factor in both depressed and euthymic patients with unipolar depression and in euthymic patients with bipolar I and II disorders", Bipolar Disord, 10, pp.95~100 (2008)
  34. Gama CS, "Serum levels of brain-derived neurotrophic factor in patients with schizophrenia and bipolar disorder", Neurosci Lett, 420, pp.45~48 (2007)
  35. Tseng M, "BDNF protein levels are decreased in transformed lymphoblasts from lithium-responsive patients with bipolar disorder", J Psychiatry Neurosci, 33, pp.449~453 (2008)
  36. Lee HY, "Plasma brain-derived neurotrophic factor as a peripheral marker for the action mechanism of antidepressants", Neuropsychobiology, 57, pp.194~199 (2008)
  37. Duman RS, "A neurotrophic model for stress-related mood disorders", Biol Psychiatry, 59, pp.1116~1127 (2006)
  38. Castren E, "Role of neurotrophic factors in depression", Curr Opin Pharmacol, 7, pp.18~21 (2007)
  39. Yamamoto H, "Human Platelets Contain Brain-Derived Neurotrophic Factor", Journal of Neuroscience, 10, pp.3469~3478 (1990)
  40. Lommatzsch M, "Brain-derived neurotrophic factor in platelets and airflow limitation in asthma", Am J Respir Crit Care Med, 171, pp.115~120 (2005)
  41. Trajkovska V, "Measurements of brain-derived neurotrophic factor: methodological aspects and demographical data", Brain Res Bull, 73, pp.143~149 (2007)
  42. Deveci A, "Serum BDNF levels in suicide attempters related to psychosocial stressors: a comparative study with depression", Neuropsychobiology, 56, pp.93~97 (2007)
  43. Kim YK, "Low plasma BDNF is associated with suicidal behavior in major depression", Prog Neuropsychopharmacol Biol Psychiatry, 31, pp.78~85 (2007)
  44. Croll SD, "Expression of BDNF and trkB as a function of age and cognitive performance", Brain Res, 812, pp.200~208 (1998)
  45. Marin J, "Age-related changes in vascular responses", Exp Gerontol, 34, pp.503~512 (1999)
  46. Karege F, "Decreased serum brain-derived neurotrophic factor levels in major depressed patients", Psychiatry Res, 109, pp.143~148 (2002)
  47. Angelucci F, "Mapping the differences in the brain concentration of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in an animal model of depression", Neuroreport, 11, pp.1369~1373 (2000)
  48. Lommatzsch M, "Abundant production of brain-derived neurotrophic factor by adult visceral epithelia - Implications for paracrine and target-derived neurotrophic functions", American Journal of Pathology, 155, pp.1183~1193 (1999)
  49. Araya AV, "Evaluation of the effect of caloric restriction on serum BDNF in overweight and obese subjects: preliminary evidences", Endocrine, 33, pp.300~304 (2008)

관련 논문AI추천

치료저항성 정신분열병 환자에서 반복적 경두개자기자극술 병행치료시 혈장 BDNF 농도 변화 : 예비 연구김용구, 오소영대한생물정신의학회 · 생물정신의학2009 · 제16권 제3호자살 시도자에서 혈장 Brain-Derived Neurotrophic Factor 농도 저하김계현, 김용구, 심세훈, 양종철, 원성두, 이분희, 이헌정, 한창수대한생물정신의학회 · 생물정신의학2005 · 제12권 제2호Elevated Brain-Derived Neurotrophic Factor Levels During Depressive Mixed StatesHotaka Shinzato, Kazuhiro Kurihara, Kazuki Ota, Naoaki Otsuka, Tsuyoshi Kondo, Yoshikazu Takaesu, Yu Zamami대한신경정신의학회 · PSYCHIATRY INVESTIGATION2023 · 제20권 제11호Association of the Brain-derived Neurotrophic Factor Gene and Clinical Features of Bipolar Disorder in Korea이은, 김세주, 석정호, 전덕인, 조현상, Hye Ji Min대한정신약물학회 · Clinical Psychopharmacology and Neuroscience2012 · 제10권 제3호양극성 장애, 조증 삽화 입원 환자에서 조증 증상 경과 예측과 관련있는 임상 변인 연구김채리, 박진완, 백두현, 우성일, 이연정, 한상우, 황재욱대한생물치료정신의학회 · 생물치료정신의학2017 · 제23권 제3호Effect of Oxcarbazepine on Serum Brain Derived Neurotrophic Factor in Bipolar Mania: An Exploratory StudyBiswa Ranjan Mishra, Debadatta Mohapatra, Debasis Bisoi, Jaseem Jowhar, Rituparna Maiti, Sansita Parida대한정신약물학회 · Clinical Psychopharmacology and Neuroscience2017 · 제15권 제2호

이 간행물의 다른 논문 (6건)