본문 바로가기
KERD
논문KCI 등재

일회 Donepezil 투약이 알쯔하이머병 환자에 미치는 영향 및 반응군 예측 인자로서의 가능성

Whether Alzheimer’s Disease is Responsive to a Single Oral Dose of Donepezil and this Response is Predictive Factor in Alzheimer’s Disease

2

조회

0

다운로드

0

인용

0

참고문헌

주제분류정신과학

초록

objectives:Though a proportion of Alzheimer’s disease(AD) patients treated with donepezil have shown positive response on cognition, but the responders’ characteristics are still uncertain. This study attempts to identify whether a single oral dose of donepezil(5mg) can change cognition and the relationship between single dose responder items and long-term responder are examined. Methods:Twenty-three AD patients for single donepezil challenge study group and eleven AD patients for controls were participated in the study. Seven days after baseline study for neuropsychological test and EEG,same studies were rechecked after donepezil medication in study group. In donepezil study groups, 12 weeks after donepezil medication, neuropsychological test and EEG were rechecked. Results:After single donepezil challenge, forward digit span, Rey-Osterrieth Complex Figure Test copy, SVLT delayed recall were significantly improved, and beta spectra power in anterior, theta spectra power in posterior field were significantly decreased. According to linear regression analysis, forward digit span after single donepezil challenge was significantly positive correlated with long-term responders. Conclusions:This study suggests that single donepezil medication can significantly change cognitive functions and EEG in AD patients. Among these responsive items, forward digit span was significantly correlated with long-term responder.

Abstract

objectives:Though a proportion of Alzheimer’s disease(AD) patients treated with donepezil have shown positive response on cognition, but the responders’ characteristics are still uncertain. This study attempts to identify whether a single oral dose of donepezil(5mg) can change cognition and the relationship between single dose responder items and long-term responder are examined. Methods:Twenty-three AD patients for single donepezil challenge study group and eleven AD patients for controls were participated in the study. Seven days after baseline study for neuropsychological test and EEG,same studies were rechecked after donepezil medication in study group. In donepezil study groups, 12 weeks after donepezil medication, neuropsychological test and EEG were rechecked. Results:After single donepezil challenge, forward digit span, Rey-Osterrieth Complex Figure Test copy, SVLT delayed recall were significantly improved, and beta spectra power in anterior, theta spectra power in posterior field were significantly decreased. According to linear regression analysis, forward digit span after single donepezil challenge was significantly positive correlated with long-term responders. Conclusions:This study suggests that single donepezil medication can significantly change cognitive functions and EEG in AD patients. Among these responsive items, forward digit span was significantly correlated with long-term responder.

참고문헌 (37)

  1. Whitehouse PJ, "Alzheimer’s disease and senile dementia: loss of neurons in the basal forebrain", Science, 215, pp.1237~1239 (1982)
  2. Whitehouse PJ, "Alzheimer’s disease: evidence for selective loss of cholinergic neurons in the nucleus basalis", Ann Neurol, 10, pp.122~126 (1981)
  3. Giacobini E, "Pharmacotherapy of Alzheimer disease: new drugs and novel strategies", Prog Brain Res, 98, pp.447~454 (1993)
  4. Davis RE, "Cholinergic therapies for Alzheimer’s disease", Arzneimittelforschung Drug Res, 45, pp.425~431 (1995)
  5. Rogers SL, "Donepezil Improves Cognition and Global Function in Alzheimer Disease: A 15-Week, Double-blind, Placebo-Controlled Study", Arch Int Med, 158, pp.1021~1031 (1998)
  6. Rogers SL, "A 24-week, double-blind, placebo-controlled trial of donepezil in patients with Alzheimer’s disease", Neurology, 50, pp.136~145 (1998)
  7. Cummings JL, "Use of cholinesterase inhibitors in clinical practice: evidence-based recommendations", Am J Geriatr Psychiatry, 11, pp.131~145 (2003)
  8. Schneider LS, "Delay in nursing home placement with donepezil", J Am Geriatr Soc, 52, pp.1024~1026 (2004)
  9. Kwak YT, "Changes of Quantitative EEG after Donepezil Treatment in Alzheimer’s Disease", J Korean Neurol Assoc, 19, pp.245~250 (2001)
  10. Giacobini E, "Cholinesterase inhibitor therapy stabilizes symptoms of Alzheimer’s disease", Alzheimer Dis Assoc Disord, 14, pp.3~10 (2000)
  11. Wilcock GK, "The treatment of Alzheimer’s disease with anticholinesterase drugs", Alzheimer Rev, 4, pp.73~77 (1993)
  12. Byrne EJ, "Tetrahydroaminoacridine and Alzheimer’s disease", BMJ, 308, pp.368~369 (1994)
  13. Winkler MA, "Tacrine for Alzheimer’s disease- Which patient, what dose", JAMA, 271, pp.1023~1024 (1994)
  14. Schneider LS, "Do blood pressure and age predict response to tacrine(THA) in Alzheimer’s disease? A preliminary report", Psychopharmacol Bull, 27, pp.309~314 (1991)
  15. Kanetaka H, "Prediction of response to donepezil in Alzheimer’s disease: combined MRI analysis of the substantia innominata and SPECT measurement of cerebral perfusion", Nucl Med Commun, 29, pp.568~573 (2008)
  16. Hanyu H, "Regional cerebral blood flow patterns and response to donepezil treatment in patients with Alzheimer’s disease", Dement Geriatr Cogn Disord, 15, pp.177~182 (2003)
  17. Riekkinen Jr P, "Frontal dysfunction blocks the therapeutic effect of THA on attention in Alzheimer’s disease", Neuroreport, 8, pp.1845~1849 (1997)
  18. Sahakian BJ, "Further analysis of the cognitive effects of tetrahydroaminoacridine(THA) in Alzheimer’s disease: assessment of attentional and mnemonic function using CANTAB", Psychopharmacology, 110, pp.395~401 (1993)
  19. Alhainen K, "Discrimination of tetrahydroaminoacridine responders by a single dose pharmaco- EEG in patients with Alzheimer’s disease", Neurosci Lett, 127, pp.113~116 (1991)
  20. Pietrzak RH, "Methodological improvements in quantifying cognitive change in clinical trials: an example with single-dose administration of donepezil", J Nutr Health Aging, 13, pp.268~273 (2009)
  21. McKhann G, "Clinical diagnosis of Alzheimer’s disease: report of the NINCDS-ADRDA Work Group under Auspices of Department of Health and Human Services Task Force on Alzheimer’s Disease", Neurology, 34, pp.939~944 (1984)
  22. Kang Y, "A validity study on the Korean Mini-Mental State Examination(K-MMSE) in dementia patients", J Korean Neurol Assoc, 15, pp.300~308 (1997)
  23. Hughes CP, "A new clinical scale for the staging of dementia", Br J Psychiatry, 140, pp.566~572 (1982)
  24. Kang Y, "Samsung Neuropsychological Screening Battery. In: Current research in dementia", The Korean Dementia Association, pp.99~107 (1998)
  25. Bendat JS, "Random Data Analysis and Measurement Procedures. 2nd ed", pp.121~132 (1986), Wiley Interscience Press
  26. Jann MW, "Clinical pharmacokinetics and pharmacodynamics of cholinesterase inhibitors", Clin Pharmacokinet, 41, pp.719~739 (2002)
  27. 곽용태, "알쯔하이머병과 소혈관성 치매에서 Donepezil 복용 후 K-MMSE의 변화와 의미 있는 K-MMSE 변화를 보이는 알쯔하이머병 환자의 특징", 생물정신의학, 12(2), pp.17~28 (2005), 대한생물정신의학회
  28. Doraiswamy PM, "The Alzheimer’s Disease Assessment Scale: evaluation of psychometric properties and patterns of cognitive decline in multicenter clinical trials of mild to moderate Alzheimer’s disease", Alzheimer Dis Assoc Disord, 15, pp.174~183 (2001)
  29. Farlow M, "A controlled trial of tacrine in Alzheimer’s disease", JAMA, 268, pp.2523~2529 (1992)
  30. Jahanshahi M, "A preliminary investigation of the running digit span as a test of working memory", Behav Neurol, 20, pp.17~25 (2008)
  31. Callaway E, "Cholinergic activity and constraints on information processing", Biol Psychol, 33, pp.1~22 (1992)
  32. Sunderland T, "Newhouse PA. Differential responsivity of mood, behavior, and cognition to cholinergic agents in elderly neuropsychiatric populations", Brain Res, 472, pp.371~389 (1988)
  33. Snyder PJ, "Reversal of scopolamine-induced deficits with a single dose of donepezil, an acetylcholinesterase inhibitor", Alzheimers Dement, 1, pp.126~135 (2005)
  34. Almkvist O, "Responder characteristics to a single oral dose of cholinesterase inhibitor: a doubleblind placebo-controlled study with tacrine in Alzheimer patients", Dement Geriatr Cogn Disord, 12, pp.22~32 (2001)
  35. McLendon BM, "Defining meaningful change in Alzheimer’s disease trials: the donepezil experience", J Geriatr Psychiatry Neurol, 12, pp.39~48 (1999)
  36. Eagger SA, "Serum levels of tacrine in relation to clinical response in Alzheimer’s disease", Int J Geriatr Psychiatry, 7, pp.115~119 (1992)
  37. Pomara N, "Pretreatment postural blood pressure drop as possible predictor of response to the cholinesterase inhibitor Velnacrine(HP 029) in Alzheimer’s disease", Psychopharmacol Bull, 27, pp.301~307 (1991)

관련 논문AI추천

Single Photon Emission Computerized Tomography and Neuropsychological Tests That Predict a Good Response to Donepezil Therapy for Alzheimer’s Disease강경욱, 김동은, 김병채, 김자혜, 김태훈, 박경원, 송호천, 정광우, 정아리, 최승민, 하정민, Mony J. de Leon대한치매학회 · Dementia and Neurocognitive Disorders(대한치매학회지)2015 · 제14권 제3호알츠하이머병 치매 환자에서 도네페질(Donepezil)에 대한 최초 투약군과 전환군 간의 임상적 효용 비교 평가: 12개월 추적관찰 연구강효신, 김도관, 김혜란, 문유진, 안인숙, 윤지혜, 이영민, 정재원, 황태영대한노인정신의학회 · 노인정신의학2010 · 제14권 제2호순수 알츠하이머병 치매 환자군과 혼합성 치매 환자군에서 12개월간의 도네페질(Donepezil) 투여에 따른 치료 성적의 비교 평가강효신, 김도관, 김혜란, 문유진, 안인숙, 윤지혜, 이영민, 정재원, 황태영대한노인정신의학회 · 노인정신의학2010 · 제14권 제1호알츠하이머병에서 아세틸콜린에스테라제 억제제에 대한 치료 반응과 관련된 요인김정란, 이미지, 한송이대한생물치료정신의학회 · 생물치료정신의학2015 · 제21권 제2호The Effect of Choline Acetyltransferase Genotype on Donepezil Treatment Response in Patients with Alzheimer’s Disease김기웅, 김도훈, 김문두, 김봉조, 김영훈, 김정란, 문석우, 우종인, 유승호, 윤종철, 이강욱, 이동영, 이정희, 이창욱, 이혜국, 장성만, 주진형, Nam-Jin Lee대한정신약물학회 · Clinical Psychopharmacology and Neuroscience2015 · 제13권 제2호알쯔하이머병과 소혈관성 치매에서 Donepezil 복용 후 K-MMSE의 변화와 의미 있는 K-MMSE 변화를 보이는 알쯔하이머병 환자의 특징김준, 곽용태, 이유상, 한일우대한생물정신의학회 · 생물정신의학2005 · 제12권 제2호

이 간행물의 다른 논문 (4건)