정신분열병 입원 환자에서의 대사 증후군 유병률 연구
The Prevalence of Metabolic Syndrome Among Inpatients with Schizophrenia
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objectives：Metabolic syndrome(MS) is a prevalent disorder in psychiatric patients, yet limited data exist on its prevalence and risk factors in Korean patients with schizophrenia. Methods：This study was conducted from September 2008 to January 2009 and included 970 inpatients with schizophrenia from two mental hospitals in Yong-in city. Assessment of MS was performed based on American Heart Association criteria using modified abdominal obesity threshold of 90cm for men, 85cm for women. Comparative analysis was performed using age- and gender matched sample from KHANES III. For evaluating risk factors, analysis included 766 inpatients taking consistent medications at least for 30 days. Results：MS prevalence was 26.2%, being higher in women(p < 0.001). Compared to general population,prevalence of inpatients was significantly high in female(p = 0.023), low in male(p < 0.001) and overall patients(p = 0.030). As to each metabolic parameters, abdominal obesity was more prevalent in patients(p <0.001), but others are equally or more prevalent in general population. After multivariate analysis, female gender and old age remained as risk factors of MS. Conclusions：The prevalence of MS of inpatients with schizophrenia was 26.2% and significantly low compared to general population. Female gender and old age were risk factors of MS.
Abstract
objectives：Metabolic syndrome(MS) is a prevalent disorder in psychiatric patients, yet limited data exist on its prevalence and risk factors in Korean patients with schizophrenia. Methods：This study was conducted from September 2008 to January 2009 and included 970 inpatients with schizophrenia from two mental hospitals in Yong-in city. Assessment of MS was performed based on American Heart Association criteria using modified abdominal obesity threshold of 90cm for men, 85cm for women. Comparative analysis was performed using age- and gender matched sample from KHANES III. For evaluating risk factors, analysis included 766 inpatients taking consistent medications at least for 30 days. Results：MS prevalence was 26.2%, being higher in women(p < 0.001). Compared to general population,prevalence of inpatients was significantly high in female(p = 0.023), low in male(p < 0.001) and overall patients(p = 0.030). As to each metabolic parameters, abdominal obesity was more prevalent in patients(p <0.001), but others are equally or more prevalent in general population. After multivariate analysis, female gender and old age remained as risk factors of MS. Conclusions：The prevalence of MS of inpatients with schizophrenia was 26.2% and significantly low compared to general population. Female gender and old age were risk factors of MS.
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