정신의학에서의 약물유전학 현황
Current Pharmacogenetics in Psychiatry
0
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Pharmacogenetics is opening a new era of precision medicine in psychiatry. Drug-metabolizing enzymes are characterized by genetic polymorphisms, which render a large portion of variability in individual drug metabolism. Dose adjustment based on pharmacogenetics knowledge is a first step to translate pharmacogenetics into clinical practice. However, diverse factors including cost-effectiveness should be addressed to provide clinical recommendation. To address current challenges in pharmacogenetics testing in psychiatry, this review provides an update regarding genotyping (SNP analysis, array, and next-generation sequencing), genotype-phenotype correlations, and cost-effectiveness. The current updates on pharmacogenetics in psychiatry will provide guidance for both clinician and researchers to have a consensus in harmonizing efforts to advance the pharmacogenetics field in a part of precision medicine in psychiatry
Abstract
Pharmacogenetics is opening a new era of precision medicine in psychiatry. Drug-metabolizing enzymes are characterized by genetic polymorphisms, which render a large portion of variability in individual drug metabolism. Dose adjustment based on pharmacogenetics knowledge is a first step to translate pharmacogenetics into clinical practice. However, diverse factors including cost-effectiveness should be addressed to provide clinical recommendation. To address current challenges in pharmacogenetics testing in psychiatry, this review provides an update regarding genotyping (SNP analysis, array, and next-generation sequencing), genotype-phenotype correlations, and cost-effectiveness. The current updates on pharmacogenetics in psychiatry will provide guidance for both clinician and researchers to have a consensus in harmonizing efforts to advance the pharmacogenetics field in a part of precision medicine in psychiatry
참고문헌 (36)
- Ingelman-Sundberg M, "Polymorphic human cytochrome P450 enzymes : an opportunity for individualized drug treatment", Trends Pharmacol Sci, 20, pp.342~349 (1999)
- Gonzalez FJ, "Pharmacogenetic phenotyping and genotyping", Clin Pharmacokinet, 26, pp.59~70 (1994)
- Motulsky AG, "Drug reactions, enzymes, and biochemical genetics", J Am Med Assoc, 165, pp.835~837 (1957)
- Kalow W, "Contribution of hereditary factors to the response to drugs", Fed Proc, 24, pp.1259~1265 (1965)
- Mahgoub A, "Polymorphic hydroxylation of debrisoquine in man", Lancet, 2, pp.584~586 (1977)
- David R Nelson, "Cytochrome P450 (CYP) gene superfamily", eLS (2021), Wiley[DOI]
- Mulder H, "Prevalence of patients using drugs metabolized by cytochrome P4502D6 in different populations : a cross-sectional study", Ann Pharmacother, 41, pp.408~413 (2007)
- Sakaeda T, "Pharmacogenetics of drug transporters and its impact on the pharmacotherapy", Curr Top Med Chem, 4, pp.1385~1398 (2004)
- Stingl JC, "Genetic variability of drugmetabolizing enzymes : the dual impact on psychiatric therapy and regulation of brain function", Mol Psychiatry, 18, pp.273~287 (2013)
- Nebert DW, "From human genetics and genomics to pharmacogenetics and pharmacogenomics : past lessons, future directions", Drug Metab Rev, 40, pp.187~224 (2008)
- Ingelman-Sundberg M, "Influence of cytochrome P450 polymorphisms on drug therapies : pharmacogenetic, pharmacoepigenetic and clinical aspects", Pharmacol Ther, 116, pp.496~526 (2007)
- Baumann P, "The AGNP-TDM expert group consensus guidelines : therapeutic drug monitoring in psychiatry", Pharmacopsychiatry, 37, pp.243~265 (2004)
- Hall-Flavin DK, "Utility of integrated pharmacogenomic testing to support the treatment of major depressive disorder in a psychiatric outpatient setting", Pharmacogenet Genomics, 23, pp.535~548 (2013)
- Bousman CA, "Pharmacogenetic tests and depressive symptom remission : a metaanalysis of randomized controlled trials", Pharmacogenomics, 20, pp.37~47 (2019)
- Jukić MM, "Impact of CYP2C19 genotype on escitalopram exposure and therapeutic failure : a retrospective study based on 2, 087 patients", Am J Psychiatry, 175, pp.463~470 (2018)
- Solomon HV, "Does obtaining CYP2D6 and CYP2C19 pharmacogenetic testing predict antidepressant response or adverse drug reactions", Psychiatry Res, 271, pp.604~613 (2019)
- Jukic MM, "Effect of CYP2D6 genotype on exposure and efficacy of risperidone and aripiprazole : a retrospective, cohort study", Lancet Psychiatry, 6, pp.418~426 (2019)
- Rosenblat JD, "Does pharmacogenomic testing improve clinical outcomes for major depressive disorder? A systematic review of clinical trials and cost-effectiveness studies", J Clin Psychiatry, 78, pp.720~729 (2017)
- Peterson K, "Rapid evidence review of the comparative effectiveness, harms, and cost-effectiveness of pharmacogenomics-guided antidepressant treatment versus usual care for major depressive disorder", Psychopharmacology(Berl), 234, pp.1649~1661 (2017)
- Maciel A, "Estimating cost savings of pharmacogenetic testing for depression in real-world clinical settings", Neuropsychiatr Dis Treat, 14, pp.225~230 (2018)
- Hornberger J, "Cost-effectiveness of combinatorial pharmacogenomic testing for treatment-resistant major depressive disorder patients", Am J Manag Care, 21, pp.e357~e365 (2015)[DOI]
- Mitropoulos K, "Relevance of pharmacogenomics for developing countries in Europe", Drug Metabol Drug Interact, 26, pp.143~146 (2011)
- Roederer MW, "Pharmacogenetics and rational drug use around the world", Pharmacogenomics, 12, pp.897~905 (2011)
- Mrazek DA, "Psychiatric pharmacogenomic testing in clinical practice", Dialogues Clin Neurosci, 12, pp.69~76 (2010)
- Pratt VM, "Recommendations for clinical CYP2C19 genotyping allele selection : a report of the association for molecular pathology", J Mol Diagn, 20, pp.269~276 (2018)
- Nofziger C, "PharmVar GeneFocus : CYP2D6", Clin Pharmacol Ther, 107, pp.154~170 (2020)
- Gaedigk A, "The CYP2D6 activity score : translating genotype information into a qualitative measure of phenotype", Clin Pharmacol Ther, 83, pp.234~242 (2008)
- Lauschke VM, "Prediction of drug response and adverse drug reactions : from twin studies to next generation sequencing", Eur J Pharm Sci, 130, pp.65~77 (2019)
- Fabbri C, "A polygenic predictor of treatment-resistant depression using whole exome sequencing and genome-wide genotyping", Transl Psychiatry, 10, pp.50~ (2020)
- McGraw J, "Cytochrome P450 variations in different ethnic populations", Expert Opin Drug Metab Toxicol, 8, pp.371~382 (2012)
- Lee SY, "Sequencebased CYP2D6 genotyping in the Korean population", Ther Drug Monit, 28, pp.382~387 (2006)
- Lee SJ, "Discovery of novel functional variants and extensive evaluation of CYP2D6genetic polymorphisms in Koreans", Drug Metab Dispos, 37, pp.1464~1470 (2009)
- Park IH, "Lack of any association between functionally significant CYP2D6 polymorphisms and clinical outcomes in early breast cancer patients receiving adjuvant tamoxifen treatment", Breast Cancer Res Treat, 131, pp.455~461 (2012)
- 변지영, "CYP2D6 allele frequencies in Korean population, comparisonwith East Asian, Caucasian and African populations,and the comparison of metabolic activity of CYP2D6 genotypes", Archives of Pharmacal Research, 41(9), pp.921~930 (2018), 대한약학회
- Kirchheiner J, "Pharmacogenetics-based therapeutic recommendations--ready for clinical practice?", Nat Rev Drug Discov, 4, pp.639~647 (2005)
- Swen JJ, "Pharmacogenetics : from bench to byte--an update of guidelines", Clin Pharmacol Ther, 89, pp.662~673 (2011)
