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단기 호르몬 병합 치료가 폐경 후 우울증 환자의 인지 기능에 미치는 영향

The Effect of Hormone Replacement Therapy for Cognitive Function of Postmenopausal Depression

이문수|김승현|고영훈|조숙행|정인과|이상훈
대한생물정신의학회 (The Korean Society Of Biological Psychiatry)|2005.11|생물정신의학 (Journal of Korean Society of Biological Psychiatry)|제12권 제2호|pp. 109-116

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참고문헌

키워드

폐경기·우울증·인지기능·호르몬대체요법.Menopausal·Depression·Cognitive function·Hormone replacement therapy.
주제분류정신과학

초록

Abstract

purpose：We investigated the effect of menopausal duration on cognitive function using adjunctive hormone replacement therapy(HRT) in postmenopausal women with depression. Method：Twelve postmenopausal women with depressive disorder were enrolled. Six patients having menopausal duration of less than 3 years was assigned to the short duration group and six patients of more than 3 years to the long duration group. Each patient was treated with conjugated equine estrogen(1.25mg) plus medroxyprogesterone(5mg) for 8 weeks. Cognitive performance was measured by the Verbal Memory Test, Visual Memory Test, Trail Making Test, Digit Symbol Test, and Attention Shift Test. The Beck Depression Inventory was used for evaluation of depressed mood. The reproductive hormone levels were also measured. Results：The long duration group showed the lower performance only in Trail Making Test B compared with the short duration group at baseline. After 8 weeks, the long duration group performed significantly better in the Trail Making Test B compared with the short duration group. The differences in change of depressive mood and gonadal hormone level between two groups were not significant. Conclusion：Menopausal duration before HRT may influence the effect of estrogen on cognition in some cognitive domains. This might be related with estrogen receptor hypersensitivity which induced by the longer estrogen deficiency.

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