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정신분열병과 양극성장애에서 뇌파 동시성의 비교분석

The differences of EEG coherence between schizophrenia and bipolar disorder

홍경수|박종원|이용석|이유상|신재공|오홍석|곽용태|김용규
대한생물정신의학회 (The Korean Society Of Biological Psychiatry)|2005.11|생물정신의학 (Journal of Korean Society of Biological Psychiatry)|제12권 제2호|pp. 46-58

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참고문헌

키워드

뇌파·동시성·정신분열병·양극성장애EEG·Coherence·Schizophrenia·Bipolar disorder.
주제분류정신과학

초록

Abstract

bjectives：EEG coherence could imply the connectivity between two different areas of the brain, which is known to be important in the pathophysiology of bipolar I disorder(BPD I) and schizophrenia. The authors investigated EEG coherence in patients with BPD I and schizophrenia to examine the connectivity of the neural circuit. Methods：EEGs were recorded in 15 schizophrenia and 14 bipolar disorder patients, and 14 age-matched normal control subjects from 16 electrodes with linked-ear reference. Spectral parameters and coherence were calculated for the alpha bandwidth(8-13Hz) by a multi-channel autoregressive model using 20 artifactfree 2-seconds epochs and the differences were compared among three groups by two different statistical methods； F-test and Kruskal-Wallis test. Furthermore, when there were significant differences among three groups, Scheffe’s multiple comparison tests were provided and Jonckheere-Terpstra tests for the ordered alternative were given. Results：In the intra-hemispheric comparison, left frontal coherence was increased in order of control, BPD I and schizophrenia. In the inter-hemispheric comparison, 1) inter-prefrontal coherence in BPD I was signifi- Ocantly higher than in normal controls, and 2) inter-prefrontal coherence in schizophrenia was significantly lower than in controls. Conclusion：These results suggest that 1) both schizophrenia and BPD I are diseases having the abnormality of neural circuit connectivity in both frontal and prefrontal lobes, and 2) the abnormality is more severe in schizophrenia than in BPD I. Furthermore, the data support that a common pathogenetic process may reside in both schizophrenia and BPD I.

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