정신질환의 가족력에 따른 정신증에 대한 임상적 고위험군의 뇌 휴지기 기능적 연결성의 차이에 대한 예비적 연구
Pilot Study on Resting-State Functional Connectivity under the Effects of Familial Loading in People at Ultra-High Risk for Psychosis
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Objectives : People at ultra-high risk for psychosis have heterogenous character and different long-term outcomes. We divided ultra-high risk subjects into two subgroups by presence of familial history and tried to find different pattern of functional connectivity of the default mode network (DMN) between the two groups in order to examine the effects familial loading. Methods : Eleven subjects at clinical-high risk (CHR) group with familial history of psychiatric illness and nineteen subjects of CHR group without familial history were recruited. All the subjects were scanned using resting-state functional magnetic resonance imaging. A posterior cingulate cortex was the seed region of the analysis, and the DMN of the both high risk group were analyzed with voxel-wise two sample T test. Results : The CHR group with familial history showed greater functional connectivity in the precuneus area in contrast with the other high risk subjects (peak-level t=5.49, p<0.001). There were no significant differences in total score on the Positive and Negative Syndrome Scale and Scales of Psychosis-risk Syndrome between the two groups. Conclusion : The study suggests that the abnormalities of functional connectivity between precuneus and posterior cingulate area may be associated with the genetic vulnerability of high risk trait.
Abstract
Objectives : People at ultra-high risk for psychosis have heterogenous character and different long-term outcomes. We divided ultra-high risk subjects into two subgroups by presence of familial history and tried to find different pattern of functional connectivity of the default mode network (DMN) between the two groups in order to examine the effects familial loading. Methods : Eleven subjects at clinical-high risk (CHR) group with familial history of psychiatric illness and nineteen subjects of CHR group without familial history were recruited. All the subjects were scanned using resting-state functional magnetic resonance imaging. A posterior cingulate cortex was the seed region of the analysis, and the DMN of the both high risk group were analyzed with voxel-wise two sample T test. Results : The CHR group with familial history showed greater functional connectivity in the precuneus area in contrast with the other high risk subjects (peak-level t=5.49, p<0.001). There were no significant differences in total score on the Positive and Negative Syndrome Scale and Scales of Psychosis-risk Syndrome between the two groups. Conclusion : The study suggests that the abnormalities of functional connectivity between precuneus and posterior cingulate area may be associated with the genetic vulnerability of high risk trait.
참고문헌 (73)
- clinical psychiatry. 10th ed, "Kaplan & Sadock’s synopsis of psychiatry: behavioral sciences", pp.Lippincott Williams & Wilkins, Sadock BJ
- 김의태, "국내 정신분열병 환자의 재발에 의한 의료비용 증가에 관한 연구", 대한정신약물학회지, 22(1), pp.29~33 (2011), 대한정신약물학회
- McGue M, "The analysis of schizophrenia family data", Behav Genet, 16, pp.75~87 (1986)
- Gottesman II, "A critical review of recent adoption, twin, and family studies of schizophrenia: behavioral genetics perspectives", Schizophr Bull, 2, pp.360~401 (1976)
- Eaton WW., "Epidemiology of schizophrenia", Epidemiol Rev, 7, pp.105~126 (1985)
- Gottesman II, "Confirming unexpressed genotypes for schizophrenia. Risks in the offspring of Fischer’s Danish identical and fraternal discordant twins", Arch Gen Psychiatry, 46, pp.867~872 (1989)
- Nicodemus KK, "Serious obstetric complications interact with hypoxia-regulated", vascular-expression genes to influence schizophrenia risk, 2008, pp.13, 873~877
- Gejman PV, "Genetics of schizophrenia: new findings and challenges", Annu Rev Genomics Hum Genet, 12, pp.121~144 (2011)
- McGlashan TH, "Duration of untreated psychosis in first-episode schi-zophrenia: marker or determinant of course?", Biol Psychiatry, 46, pp.899~907 (1999)
- Drake RJ, "Causes and consequences of duration of untreated psychosis in schizophrenia", Br J Psychiatry, 177, pp.511~515 (2000)
- Larsen TK, "Premorbid functioning versus duration of untreated psychosis in 1 year outcome in first-episode psychosis", Schizophr Res, 45, pp.1~9 (2000)
- Melle I, "Opjordsmoen S, et al. Reducing the duration of untreated first-episode psychosis: effects on clinical presentation", Arch Gen Psychiatry, 61, pp.143~150 (2004)
- McGorry PD, "Early intervention in psychosis: concepts, evidence and future directions", World Psychiatry, 7, pp.148~156 (2008)
- Anonymous, "International clinical practice guidelines for early psychosis", Br J Psychiatry Suppl, 48, pp.120~124 (2005)
- McGorry PD, "The “close-in” or ultra high-risk model: a safe and effective strategy for research and clinical intervention in prepsychotic mental disorder", Schizophr Bull, 29, pp.771~790 (2003)
- Keith SJ, "The diagnosis of schizophrenia: a review of onset and duration issues", Schizophr Bull, 17, pp.51~67 (1991)
- Cornblatt B, "The schizophrenia prodrome: treatment and high-risk perspectives", Schizophr Res, 54, pp.177~186 (2002)
- Yung AR, "Is pre-psychotic intervention realistic in schi-zophrenia and related disorders?", Aust N Z J Psychiatry, 31, pp.799~805 (1997)
- Yung AR, "Monitoring and care of young people at incipient risk of psychosis", Schizophr Bull, 22, pp.283~303 (1996)
- Kwon JS, "Current concept of prodrome from the experience of the Seoul Youth Clinic high risk cohort in Korea", Clinical Neuropsychiatry, 7, pp.56~62 (2010)
- Miller TJ, "Prodromal assessment with the structured interview for prodromal syndromes and the scale of prodromal symptoms: predictive validity, interrater reliability, and training to reliability", Schi-zophr Bull, 29, pp.703~715 (2003)
- Yung AR, "Psychosis prediction: 12-month follow up of a high-risk (“prodromal”) group", Schizophr Res, 60, pp.21~32 (2003)
- Woods SW, "Validity of the prodromal risk syndrome for first psychosis: findings from the North American Prodrome Longitudinal Study", Schizophr Bull, 35, pp.894~908 (2009)
- Ruhrmann S, "Prediction of psychosis in adolescents and young adults at high risk: results from the prospective European prediction of psychosis study", Arch Gen Psychiatry, 67, pp.241~251 (2010)
- Mason O, "Risk factors for transition to first episode psychosis among individuals with ‘at-risk mental states’", Schizophr Res, 71, pp.227~237 (2004)
- Cannon TD, "Prediction of psychosis in youth at high clinical risk: a multisite longitudinal study in North America", Arch Gen Psychiatry, 65, pp.28~37 (2008)
- Schlosser DA, "Recovery From an At-Risk State: Clinical and Functional Outcomes of Putatively Prodromal Youth Who Do Not Develop Psychosis" (2011), Schizophr Bull
- Simon AE, "High remission rates from an initial ultra-high risk state for psychosis", Schizophr Res, 116, pp.168~172 (2010)
- Addington J, "At clinical high risk for psychosis: outcome for nonconverters", Am J Psychiatry, 168, pp.800~805 (2011)
- Simon AE, "Ultra high-risk state for psychosis and non-transition: a systematic review", Schizophr Res, 132, pp.8~17 (2011)
- Fornito A, "Anatomic abnormalities of the anterior cingulate cortex before psychosis onset: an MRI study of ultra-high-risk individuals", Biol Psychiatry, 64, pp.758~765 (2008)
- Pantelis C, "Neuroanatomical abnormalities before and after onset of psychosis: a cross-sectional and longitudinal MRI comparison", Lancet, 361, pp.281~288 (2003)
- Fusar-Poli P, "Neurofunctional correlates of vulnerability to psychosis: a systematic review and meta-analysis", Neurosci Biobehav Rev, 31, pp.465~484 (2007)
- Shin KS, "Preattentive auditory processing in ultra-high-risk for schizophrenia with magnetoencephalography", Biol Psychiatry, 65, pp.1071~1078 (2009)
- Armando M, "Adolescents at ultra-high risk for psychosis with and without 22q11 deletion syndrome: A comparison of prodromal psychotic symptoms and general functioning", Schizophr Res, 139, pp.151~156 (2012)
- Greenwood TA, "Initial heritability analyses of endophenotypic measures for schizophrenia: the consortium on the genetics of schizophrenia", Arch Gen Psychiatry, 64, pp.1242~1250 (2007)
- Reitz C, "Endophenotypes in normal brain morphology and Alzheimer’s disease: a review", Neuroscience, 164, pp.174~190 (2009)
- Brotman MA, "Facial emotion labeling deficits in children and adolescents at risk for bipolar disorder", Am J Psychiatry, 165, pp.385~389 (2008)
- Fox MD, "Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging", Nat Rev Neurosci, 8, pp.700~711 (2007)
- Gusnard DA, "Searching for a baseline: functional imaging and the resting human brain", Nat Rev Neurosci, 2, pp.685~694 (2001)
- Fransson P, "Spontaneous low-frequency BOLD signal fluctuations: an fMRI investigation of the resting-state default mode of brain function hypothesis", Hum Brain Mapp, 26, pp.15~29 (2005)
- Shim G, "Altered resting-state connectivity in subjects at ultra-high risk for psychosis: an fMRI study", Behav Brain Funct, 6, pp.58~ (2010)
- Zhou Y, "Functional disintegration in paranoid schizophrenia using resting-state fMRI", Schizophr Res, 97, pp.194~205 (2007)
- Garrity AG, "Aberrant “default mode” functional connectivity in schizophrenia", Am J Psychiatry, 164, pp.450~457 (2007)
- Pomarol-Clotet E, "Failure to deactivate in the prefrontal cortex in schizophrenia: dysfunction of the default mode network?", Psychol Med, 38, pp.1185~1193 (2008)
- Meyer-Lindenberg AS, "Regionally specific disturbance of dorsolateral prefrontal-hippocampal functional connectivity in schizophrenia", Arch Gen Psychiatry, 62, pp.379~386 (2005)
- Camchong J, "Altered functional and anatomical connectivity in schizophrenia", Schizophr Bull, 37, pp.640~650 (2011)
- Whitfield-Gabrieli S, "Default mode network activity and connectivity in psychopathology", Annu Rev Clin Psychol, 8, pp.49~76 (2012)
- Whitfield-Gabrieli S, "Hyperactivity and hyperconnectivity of the default network in schizophrenia and in first-degree relatives of persons with schizophrenia", Proc Natl Acad Sci U S A, 106, pp.1279~1284 (2009)
- Liu H, "Schizophrenic patients and their unaffected siblings share increased resting- state connectivity in the task-negative network but not its anticorrelated task-positive network", Schizophr Bull, 38, pp.285~294 (2012)
- Ziermans TB, "Progressive structural brain changes during development of psychosis", Schizophr Bull, 38, pp.519~530 (2012)
- Glahn DC, "Genetic control over the resting brain", Proc Natl Acad Sci U S A, 107, pp.1223~1228 (2010)
- Broyd SJ, "Default-mode brain dysfunction in mental disorders: a systematic review", Neurosci Biobehav Rev, 33, pp.279~296 (2009)
- Greicius MD, "Resting-state functional connectivity in major depression: abnormally increased contributions from subgenual cingulate cortex and thalamus", Biol Psychiatry, 62, pp.429~437 (2007)
- Zhao XH, "Altered default mode network activity in patient with anxiety disorders: an fMRI study", Eur J Radiol, 63, pp.373~378 (2007)
- Chung YS, "Deficit of theory of mind in individuals at ultra-high-risk for schizophrenia", Schizophr Res, 99, pp.111~118 (2008)
- Yung AR, "Mapping the onset of psychosis: the Comprehensive Assessment of At-Risk Mental States", Aust N Z J Psychiatry, 39, pp.964~971 (2005)
- Tzourio-Mazoyer N, "Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain", NeuroImage, 15, pp.273~289 (2002)
- Bluhm RL, "Spontaneous low-frequency fluctuations in the BOLD signal in schizophrenic patients: anomalies in the default network", Schizophr Bull, 33, pp.1004~1012 (2007)
- Castellanos FX, "Cingulate-precuneus interactions: a new locus of dysfunction in adult attention-deficit", hyperactivity disorder, 2008, pp.63, 332~337
- Kjaer TW, "Reflective Self-Awareness and Conscious States: PET Evidence for a Common Midline Parietofrontal Core", Neuro Image, 17, pp.1080~1086 (2002)
- Lou HC, "Parietal cortex and representation of the mental Self", Proc Natl Acad Sci U S A, 101, pp.6827~6832 (2004)
- Fransson P, "The precuneus", posterior cingulate cortex plays a pivotal role in the default mode network: Evidence from a partial correlation network analysis, 2008, pp.42, 1178~1184
- Calhoun VD, "Exploring the psychosis functional connectome: aberrant intrinsic networks in schizophrenia and bipolar disorder", Front Psychiatry, 2, pp.75~ (2011)
- Bleuler E., "Dementia praecox or the group of schizophrenias", Vertex, 21, pp.394~400 (2010)
- Solovay MR, "Comparative studies of thought disorders. I. Mania and schizophrenia", Arch Gen Psychiatry, 44, pp.13~20 (1987)
- Kerns JG, "Cognitive impairments associated with formal thought disorder in people with schizophrenia", J Abnorm Psychol, 111, pp.211~224 (2002)
- van Os J, "Gene-environment interactions in schizophrenia: review of epidemiological findings and future directions", Schizophr Bull, 34, pp.1066~1082 (2008)
- Gottesman II, "The endophenotype concept in psychiatry: etymology and strategic intentions", Am J Psychiatry, 160, pp.636~645 (2003)
- Schulze TG, "Molecular genetic overlap in bipolar disorder, schizophrenia, and major depressive disorder", World J Biol Psychiatry (2012)
- Lichtenstein P, "Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: a population-based study", Lancet, 373, pp.234~239 (2009)
- Reig S, "Multicenter study of brain volume abnormalities in children and adolescent-onset psychosis", Schizophr Bull, 37, pp.1270~1280 (2011)
- Olvet DM, "Comparing clinical and neurocognitive features of the schizophrenia prodrome to the bipolar prodrome", Schizophr Res, 123, pp.59~63 (2010)
