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조현병 환자에서의 Mismatch Negativity와 기능 상태의 연관성 연구

Association between Mismatch Negativity and Functional Status in Patients with Schizophrenia

이민희|권준수|이수지|김성년|김민아
대한조현병학회 (Korean Academy of Schizophrenia)|2013.10|대한조현병학회지 (Korean Journal of Schizophrenia Research)|제16권 제2호|pp. 98-106

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키워드

조현병Schizophrenia사건관련전위인지 기능Cognitive function심리사회적 기능Mismatch negativityEvent related potentialFunctional status.
주제분류정신과학

초록

본 연구는 MMN과 조현병 환자의 기능 상태를 포함한 임상 지표들 사이의 연관성을 밝히고자 하였다. 26명의 조현병 환자와 48명의 정상 대조군에서 수동적 oddball task를 수행하는 동안 뇌파를 측정하여 MMN을 평가하였고, MMN 진폭의 집단간 차이와 함께 신경인지기능검사를 포함한 임상 평가 결과, GAF 점수와의 상관관계를 분석하였다. 그 결과 정상 대조군에 비하여 조현병 환자군에서 Fz, FCz, Cz, CPz, Pz, POz의 뇌파 측정 부위에서 MMN의 진폭이 유의하게 감소하였음을 발견하였다. 피어슨 상관분석 결과 조현병 환자군에서단축형 한국판 성인 지능 검사의 소검사들과 MMN 진폭이 통계적으로 유의한 상관 관계를 보였다. 또한, MMN 진폭은 Fz, Cz, CPz에서 GAF 점수와 관련이 있었다. 본 연구는 조현병환자들에서 MMN 진폭의 감소가 인지 기능 및 심리사회적 기능의 손상과 관련이 있음을 밝힘으로써, MMN이 환자들의 기능 상태를 평가하고 치료 반응 및 예후에 대한 정보를 얻는 데중요한 역할을 할 수 있음을 제시하였다.

Abstract

Objectives : It has been constantly reported that mismatch negativity (MMN) is impaired in patients with schizophrenia. However, the mechanism which relates impaired MMN and schizophrenia is not clear yet. The aim of this study is to investigate the association between MMN and clinical variables including functional status in patients with schizophrenia. Methods : The present study assessed MMN using passive auditory oddball task in 26 patients with schizophrenia and 48 healthy controls. Repeated measures Analysis of Variance with age as a covariate was carried out for comparing peak amplitude and latency of MMN at 8 central line electrodes (FPz, Fz, FCz, Cz, CPz, Pz, POz, Oz) across groups. Pearson’s correlation was performed to reveal the relationship between MMN and clinical variables including neurocognitive test results and the Global Assessment of Functioning score. Results : MMN amplitude was significantly reduced in patients with schizophrenia compared with healthy controls. Pearson’s correlation showed that subsets of short form of Korean Wechsler Adult Intelligence Scale scores and GAF scores were associated with MMN amplitude in patients with schizophrenia. Conclusion : These findings suggest that MMN amplitude is associated with current functional status including cognitive function in patients with schizophrenia.

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