‘2019 한국형 조현병 약물치료 지침서’에 따른 조현병에서 동반증상 및 부작용의 치료
Korean Treatment Guideline on Pharmacotherapy of Co-existing Symptoms and Antipsychotics-related Side Effects in Patients with Schizophrenia
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초록
Objectives: The current study covers a secondary revision of the guidelines for the pharmacotherapy of schizophrenia issued by the Korean Medication Algorithm for Schizophrenia (KMAP-SCZ) 2001, specifically for co-existing symptoms and antipsychotics-related side-effects in schizophrenia patients. Methods: An expert consensus regarding the strategies of pharmacotherapy for positive symptoms of schizophrenia, co-existing symptoms of schizophrenia, and side-effect of antipsychotics in patients with schizophrenia was retrieved by responses obtained using a 30-item questionnaire. Results: For the co-existing symptoms, agitation could be treated with oral or intramuscular injection of benzodiazepine or antipsychotics; depressive symptoms with atypical antipsychotics and adjunctive use of antidepressant; obsessive-compulsive symptoms with selective serotonin reuptake inhibitors and antipsychotics other than clozapine and olanzapine; negative symptoms with atypical antipsychotics or antidepressants; higher risk of suicide with clozapine; comorbid substance abuse with use of naltrexone or bupropion/varenicline, respectively. For the antipsychotics-related side effects, anticholinergics (extrapyramidal symptom), propranolol and benzodiazepine (akathisia), topiramate or metformin (weight gain), change of antipsychotics to aripiprazole (hyperprolactinemia and prolonged QTc) or clozapine (tardive dyskinesia) could be used. Conclusion: Updated pharmacotherapy strategies for co-existing symptoms and antipsychotics-related side effects in schizophrenia patients as presented in KMAP-SCZ 2019 could help effective clinical decision making of psychiatrists as a preferable option.
Abstract
Objectives: The current study covers a secondary revision of the guidelines for the pharmacotherapy of schizophrenia issued by the Korean Medication Algorithm for Schizophrenia (KMAP-SCZ) 2001, specifically for co-existing symptoms and antipsychotics-related side-effects in schizophrenia patients. Methods: An expert consensus regarding the strategies of pharmacotherapy for positive symptoms of schizophrenia, co-existing symptoms of schizophrenia, and side-effect of antipsychotics in patients with schizophrenia was retrieved by responses obtained using a 30-item questionnaire. Results: For the co-existing symptoms, agitation could be treated with oral or intramuscular injection of benzodiazepine or antipsychotics; depressive symptoms with atypical antipsychotics and adjunctive use of antidepressant; obsessive-compulsive symptoms with selective serotonin reuptake inhibitors and antipsychotics other than clozapine and olanzapine; negative symptoms with atypical antipsychotics or antidepressants; higher risk of suicide with clozapine; comorbid substance abuse with use of naltrexone or bupropion/varenicline, respectively. For the antipsychotics-related side effects, anticholinergics (extrapyramidal symptom), propranolol and benzodiazepine (akathisia), topiramate or metformin (weight gain), change of antipsychotics to aripiprazole (hyperprolactinemia and prolonged QTc) or clozapine (tardive dyskinesia) could be used. Conclusion: Updated pharmacotherapy strategies for co-existing symptoms and antipsychotics-related side effects in schizophrenia patients as presented in KMAP-SCZ 2019 could help effective clinical decision making of psychiatrists as a preferable option.
참고문헌 (146)
- 안용민, "주요 정신질환의 약물치료에 대한 한국형 알고리듬 개발 (1) - 알고리듬과 임상지침서의 장·단점 및 개발과 관련된 일반사항 -", 대한정신약물학회지, 13(1), pp.18~29 (2002), 대한정신약물학회
- 김대진, "주요 정신질환의 약물치료에 대한 한국형 알고리듬 개발 (2)- 한국형 알고리듬 개발 사업내용과 기본계획, 조직구성, 알고리듬 개발의 기본원칙, 개발방법, 제한점 및 사용 시 주의점 -", 대한정신약물학회지, 13(1), pp.30~36 (2002), 대한정신약물학회
- 배승오, "한국형 정신분열병 약물치료 알고리듬의 임상 적용 가능성 (I): 치료효과 측면에서의 분석", 대한정신약물학회지, 17(1), pp.24~34 (2006), 대한정신약물학회
- 안용민, "한국형 정신분열병 약물치료 알고리듬의 임상 적용 가능성(II): 적용상의 문제점 및 향후 개정 방향", 대한정신약물학회지, 17(1), pp.35~49 (2006), 대한정신약물학회
- 김승현, "한국형 정신분열병 약물치료 알고리듬의 임상 적용 가능성(III):정신분열병 약물치료에 대한 한국형 알고리듬의 적용에 치료환경이 미치는 영향", 대한정신약물학회지, 17(2), pp.149~161 (2006), 대한정신약물학회
- Manschreck TC, "The CATIE schizophrenia trial: results, impact, controversy", Harv Rev Psychiatry, 15, pp.245~258 (2007)
- Swartz MS, "What CATIE found: results from the schizophrenia trial", Psychiatr Serv, 59, pp.500~506 (2008)
- Naber D, "The CATIE and CUtLASS studies in schizophrenia: results and implications for clinicians", CNS Drugs, 23, pp.649~659 (2009)
- Fleischhacker WW, "The European First Episode Schizophrenia Trial (EUFEST): rationale and design of the trial", Schizophr Res, 78, pp.147~156 (2005)
- Kahn RS, "Effectiveness of antipsychotic drugs in first-episode schizophrenia and schizophreniform disorder: an open randomised clinical trial", Lancet, 371, pp.1085~1097 (2008)
- Pijnenborg GH, "Differential effects of antipsychotic drugs on insight in first episode schizophrenia: data from the European First-Episode Schizophrenia Trial (EUFEST)", Eur Neuropsychopharmacol, 25, pp.808~816 (2015)
- Citrome L, "Long-acting injectable antipsychotics update: lengthening the dosing interval and expanding the diagnostic indications", Expert Rev Neurother, 17, pp.1029~1043 (2017)
- Correll CU, "The use of long-acting injectable antipsychotics in schizophrenia: evaluating the evidence", J Clin Psychiatry, 77, pp.1~24 (2016)
- Miyamoto S, "The use of long-acting injectable antipsychotics in schizophrenia", Curr Treat Options Psychiatry, 4, pp.117~126 (2017)
- Taipale H, "Comparative effectiveness of antipsychotic drugs for rehospitalization in schizophrenia-a nationwide study with 20-year follow-up", Schizophr Bull, 44, pp.1381~1387 (2018)
- Moore TA, "The Texas Medication Algorithm Project antipsychotic algorithm for schizophrenia: 2006 update", J Clin Psychiatry, 68, pp.1751~1762 (2007)
- Buchanan RW, "The 2009 schizophrenia PORT psychopharmacological treatment recommendations and summary statements", Schizophr Bull, 36, pp.71~93 (2010)
- National Collaborating Centre for Mental Health, "National Institute for Health and Clinical Excellence: Guidance. Psychosis and Schizophrenia in Adults: Treatment and Management: Updated Edition 2014", National Institute for Health and Care Excellence, ~ (2014)
- Barnes TR., "Evidence-based guidelines for the pharmacological treatment of schizophrenia: recommendations from the British Association for Psychopharmacology", J Psychopharmacol, 25, pp.567~620 (2011)
- Hasan A, "World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for Biological Treatment of Schizophrenia, part 1: update 2012 on the acute treatment of schizophrenia and the management of treatment resistance", World J Biol Psychiatry, 13, pp.318~378 (2012)
- Hasan A, "World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for biological treatment of schizophrenia, part 2: update 2012 on the long-term treatment of schizophrenia and management of antipsychotic-induced side effects", World J Biol Psychiatry, 14, pp.2~44 (2013)
- Galletly C, "Royal Australian and New Zealand College of Psychiatrists clinical practice guidelines for the management of schizophrenia and related disorders", Aust N Z J Psychiatry, 50, pp.410~472 (2016)
- Amodeo G, "Older and newer strategies for the pharmacological management of agitation in patients with bipolar disorder or schizophrenia", CNS Neurol Disord Drug Targets, 16, pp.885~890 (2017)
- Ostinelli EG, "Risperidone for psychosis-induced aggression or agitation (rapid tranquillisation)", Cochrane Database Syst Rev, 4, pp.Cd009412~ (2018)
- Ostinelli EG, "Haloperidol for psychosis-induced aggression or agitation (rapid tranquillisation)", Cochrane Database Syst Rev, 7, pp.Cd009377~ (2017)
- Upthegrove R, "Depression and schizophrenia:cause, consequence, or trans-diagnostic Issue?", Schizophr Bull, 43, pp.240~244 (2017)
- Helfer B, "Efficacy and safety of antidepressants added to antipsychotics for schizophrenia: a systematic review and meta-analysis", Am J Psychiatry, 173, pp.876~886 (2016)
- Galletly C, "Royal Australian and New Zealand College of Psychiatrists clinical practice guidelines for the management of schizophrenia and related disorders", Aust N Z J Psychiatry, 50, pp.410~472 (2016)
- Kasper S, "Treatment of depressive symptoms in patients with schizophrenia: a randomized, open-label, parallel-group, flexible-dose subgroup analysis of patients treated with extended-release quetiapine fumarate or risperidone", Int Clin Psychopharmacol, 30, pp.14~22 (2015)
- Lamy FX, "The use of adjunctive antipsychotics to treat depression in UK primary care", Curr Med Res Opin, 33, pp.891~898 (2017)
- Bosanac P, "Schizophrenia and depression", Med J Aust, 199, pp.S36~S39 (2013)
- Altshuler LL, "The expert consensus guideline series. Treatment of depression in women", Postgrad Med, pp.1~107 (2001)
- Alexopoulos GS, "The expert consensus guideline series. Pharmacotherapy of depressive disorders in older patients", Postgrad Med, pp.1~86 (2001)
- Naslund J, "Incidence of early anxiety aggravation in trials of selective serotonin reuptake inhibitors in depression", Acta Psychiatr Scand, 136, pp.343~351 (2017)
- Malki K, "Highly polygenic architecture of antidepressant treatment response: comparative analysis of SSRI and NRI treatment in an animal model of depression", Am J Med Genet B Neuropsychiatr Genet, 174, pp.235~250 (2017)
- Vahid-Ansari F, "Overcoming resistance to selective serotonin reuptake inhibitors: targeting serotonin, serotonin-1A receptors and adult neuroplasticity", Front Neurosci, 13, pp.404~ (2019)
- Paulzen M, "Reduced clearance of venlafaxine in a combined treatment with quetiapine", Prog Neuropsychopharmacol Biol Psychiatry, 85, pp.116~121 (2018)
- Hendset M, "The effect of coadministration of duloxetine on steady-state serum concentration of risperidone and aripiprazole: a study based on therapeutic drug monitoring data", Ther Drug Monit, 32, pp.787~790 (2010)
- Polcwiartek C, "The clinical potentials of adjunctive fluvoxamine to clozapine treatment: a systematic review", Psychopharmacology (Berl), 233, pp.741~750 (2016)
- Murray M, "Variation in the response of clozapine biotransformation pathways in human hepatic microsomes to CYP1A2- and CYP3A4-selective inhibitors", Basic Clin Pharmacol Toxicol, 122, pp.388~395 (2018)
- Williams AM, "Seizure associated with clozapine: incidence, etiology, and management", CNS Drugs, 29, pp.101~111 (2015)
- Grover S, "Obsessive compulsive symptoms", disorder in patients with schizophrenia: prevalence, relationship with other symptom dimensions and impact on functioning, 2017, pp.250, 277~284
- Doyle M, "Obsessive compulsive symptoms in patients with schizophrenia on clozapine and with obsessive compulsive disorder: a comparison study", Compr Psychiatry, 55, pp.130~136 (2014)
- Szmulewicz AG, "Suicidality in clozapinetreated patients with schizophrenia: role of obsessive-compulsive symptoms", Psychiatry Res, 230, pp.50~55 (2015)
- Wu TH, "Obsessive-compulsive symptoms in patients with schizophrenia:relationships with olanzapine pharmacological parameters, psychopathology, and quality of life", Psychiatry Res, 276, pp.1~5 (2019)
- Fonseka TM, "Second generation antipsychotic-induced obsessive-compulsive symptoms in schizophrenia:a review of the experimental literature", Curr Psychiatry Rep, 16, pp.510~ (2014)
- Schirmbeck F, "Increased orbitofrontal cortex activation associated with “pro-obsessive” antipsychotic treatment in patients with schizophrenia", J Psychiatry Neurosci, 40, pp.89~99 (2015)
- Schirmbeck F, "Antiserotonergic antipsychotics are associated with obsessive-compulsive symptoms in schizophrenia", Psychol Med, 41, pp.2361~2373 (2011)
- Stryjer R, "Escitalopram in the treatment of patients with schizophrenia and obsessive-compulsive disorder: an open-label, prospective study", Int Clin Psychopharmacol, 28, pp.96~98 (2013)
- Grover S, "Obsessive-compulsive symptoms in schizophrenia: a review", Acta Neuropsychiatr, pp.1~11 (2018)
- Eryilmaz G, "Aripirazole augmentation in clozapine-associated obsessive-compulsive symptoms in schizophrenia", Ann Gen Psychiatry, 12, pp.40~ (2013)
- Temmingh H, "Anxiety in patients with schizophrenia:epidemiology and management", CNS Drugs, 29, pp.819~832 (2015)
- Grillault Laroche D, "Induced obsessive compulsive symptoms (OCS) in schizophrenia patients under atypical 2 antipsychotics (AAPs): review and hypotheses", Psychiatry Res, 246, pp.119~128 (2016)
- Schirmbeck F, "Differential effects of antipsychotic agents on obsessive-compulsive symptoms in schizophrenia: a longitudinal study", J Psychopharmacol, 27, pp.349~357 (2013)
- Kim SW, "Amisulpride improves obsessive-compulsive symptoms in schizophrenia patients taking atypical antipsychotics: an open-label switch study", J Clin Psychopharmacol, 28, pp.349~352 (2008)
- Kim SW, "The 5-HT2 receptor profiles of antipsychotics in the pathogenesis of obsessive-compulsive symptoms in schizophrenia", Clin Neuropharmacol, 32, pp.224~226 (2009)
- Juven-Wetzler A, "Treatment with ziprasidone for schizophrenia patients with OCD", Eur Neuropsychopharmacol, 24, pp.1454~1462 (2014)
- Krause DL, "Ziprasidone for obsessive compulsive disorder in schizophrenia", Ther Adv Psychopharmacol, 3, pp.115~116 (2013)
- Davis MC, "Psychopharmacology of the negative symptoms: current status and prospects for progress", Eur Neuropsychopharmacol, 24, pp.788~799 (2014)
- Moller HJ, "Pharmacological treatment of negative symptoms in schizophrenia", Eur Arch Psychiatry Clin Neurosci, 265, pp.567~578 (2015)
- Liang Y, "Effectiveness of amisulpride in Chinese patients with predominantly negative symptoms of schizophrenia: a subanalysis of the ESCAPE study", Neuropsychiatr Dis Treat, 13, pp.1703~1712 (2017)
- Barnes TR, "Amisulpride augmentation in clozapine-unresponsive schizophrenia (AMICUS): a double-blind, placebo-controlled, randomised trial of clinical effectiveness and cost-effectiveness", Health Technol Assess, 21, pp.1~56 (2017)
- Novick D, "Realworld effectiveness of antipsychotics for the treatment of negative symptoms in patients with schizophrenia with predominantly negative symptoms", Pharmacopsychiatry, 50, pp.56~63 (2017)
- Harvey RC, "A systematic review and network meta-analysis to assess the relative efficacy of antipsychotics for the treatment of positive and negative symptoms in early-onset schizophrenia", CNS Drugs, 30, pp.27~39 (2016)
- Zhang JP, "Efficacy and safety of individual second-generation vs. first-generation antipsychotics in first-episode psychosis: a systematic review and meta-analysis", Int J Neuropsychopharmacol, 16, pp.1205~1218 (2013)
- Stip E, "A neuroimaging study of emotion-cognition interaction in schizophrenia:the effect of ziprasidone treatment", Psychopharmacology (Berl), 234, pp.1045~1058 (2017)
- Kishi T, "Meta-analysis of noradrenergic and specific serotonergic antidepressant use in schizophrenia", Int J Neuropsychopharmacol, 17, pp.343~354 (2014)
- Bodkin JA, "Treatment of negative symptoms in schizophrenia and schizoaffective disorder by selegiline augmentation of antipsychotic medication. A pilot study examining the role of dopamine", J Nerv Ment Dis, 184, pp.295~301 (1996)
- Wagner E, "Clozapine augmentation strategies-a systematic meta-review of available evidence. Treatment options for clozapine resistance", J Psychopharmacol, 33, pp.423~435 (2019)
- Goff DC, "Citalopram in first episode schizophrenia: the DECIFER trial", Schizophr Res, 208, pp.331~337 (2019)
- Lu ML, "Effects of adjunctive fluvoxamine on metabolic parameters and psychopathology in clozapine-treated patients with schizophrenia: a 12-week, randomized, double-blind, placebo-controlled study", Schizophr Res, 193, pp.126~133 (2018)
- Rahim T, "Comparison of depression symptoms between primary depression and secondary-to-schizophrenia depression", Int J Psychiatry Clin Pract, 21, pp.314~317 (2017)
- Jakhar K, "Self-harm and suicide attempts in schizophrenia", Asian J Psychiatr, 30, pp.102~106 (2017)
- Jones PB, "Randomized controlled trial of the effect on Quality of Life of second- vs first-generation antipsychotic drugs in schizophrenia:Cost Utility of the Latest Antipsychotic Drugs in Schizophrenia Study (CUtLASS 1)", Arch Gen Psychiatry, 63, pp.1079~1087 (2006)
- Mayerova M, "Influence of dose, gender, and cigarette smoking on clozapine plasma concentrations", Neuropsychiatr Dis Treat, 14, pp.1535~1543 (2018)
- Bennett ME, "Treatment of substance use disorders in schizophrenia", Am J Drug Alcohol Abuse, 43, pp.377~390 (2017)
- Petrakis IL, "Naltrexone augmentation of neuroleptic treatment in alcohol abusing patients with schizophrenia", Psychopharmacology (Berl), 172, pp.291~297 (2004)
- Cather C, "Achieving smoking cessation in individuals with schizophrenia: special considerations", CNS Drugs, 31, pp.471~481 (2017)
- Lyu X, "Naltrexone and bupropion combination treatment for smoking cessation and weight loss in patients with schizophrenia", Front Pharmacol, 9, pp.181~ (2018)
- Brunette MF, "Benzodiazepine use and abuse among patients with severe mental illness and cooccurring substance use disorders", Psychiatr Serv, 54, pp.1395~1401 (2003)
- Hufner K, "Neurology issues in schizophrenia", Curr Psychiatry Rep, 17, pp.32~ (2015)
- Yuen JWY, "Clozapine-induced cardiovascular side effects and autonomic dysfunction: a systematic review", Front Neurosci, 12, pp.203~ (2018)
- Leucht S, "Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia: a multiple-treatments meta-analysis", Lancet, 382, pp.951~962 (2013)
- Caroff SN, "Movement disorders induced by antipsychotic drugs: implications of the CATIE schizophrenia trial", Neurol Clin, 29, pp.127~148 (2011)
- Divac N, "Second-generation antipsychotics and extrapyramidal adverse effects", Biomed Res Int, 2014, pp.656370~ (2014)
- Mitchell AJ, "Prevalence of metabolic syndrome and metabolic abnormalities in schizophrenia and related disorders--a systematic review and meta-analysis", Schizophr Bull, 39, pp.306~318 (2013)
- Young SL, "“First do no harm.” A systematic review of the prevalence and management of antipsychotic adverse effects", J Psychopharmacol, 29, pp.353~362 (2015)
- MacKenzie NE, "Antipsychotics, metabolic adverse effects, and cognitive function in schizophrenia", Front Psychiatry, 9, pp.622~ (2018)
- Ward KM, "Antipsychotic-related movement disorders:drug-induced parkinsonism vs. tardive dyskinesia-key differences in pathophysiology and clinical management", Neurol Ther, 7, pp.233~248 (2018)
- May R, "Acute laryngeal dystonia: a persisting psychiatric emergency", Australas Psychiatry, 24, pp.497~498 (2016)
- Goga JK, "Acute laryngeal dystonia associated with aripiprazole", J Clin Psychopharmacol, 32, pp.837~839 (2012)
- Ogino S, "Benefits and limits of anticholinergic use in schizophrenia: focusing on its effect on cognitive function", Psychiatry Clin Neurosci, 68, pp.37~49 (2014)
- Bogers J, "Dose reduction of high-dose first-generation antipsychotics or switch to ziprasidone in long-stay patients with schizophrenia: a 1-year double-blind randomized clinical trial", Eur Neuropsychopharmacol, 28, pp.1024~1034 (2018)
- Loonen A, "The mechanism of drug-induced akathisia", CNS Spectr, 15, pp.491~494 (2011)
- Salem H, "Revisiting antipsychotic-induced akathisia: current issues and prospective challenges", Curr Neuropharmacol, 15, pp.789~798 (2017)
- Juncal-Ruiz M, "Incidence and risk factors of acute akathisia in 493 individuals with first episode non-affective psychosis: a 6-week randomised study of antipsychotic treatment", Psychopharmacology (Berl), 234, pp.2563~2570 (2017)
- Grattan DR, "60 years of neuroendocrinology: the hypothalamoprolactin axis", J Endocrinol, 226, pp.T101~T122 (2015)
- Capozzi A, "Hyperprolactinemia:pathophysiology and therapeutic approach", Gynecol Endocrinol, 31, pp.506~510 (2015)
- Montejo AL, "Spanish consensus on the risks and detection of antipsychotic drug-related hyperprolactinaemia", Rev Psiquiatr Salud Ment, 9, pp.158~173 (2016)
- De Hert M, "Relationship between antipsychotic medication, serum prolactin levels and osteoporosis", osteoporotic fractures in patients with schizophrenia: a critical literature review, 2016, pp.15, 809~823
- Chen JX, "Adjunctive aripiprazole in the treatment of risperidone-induced hyperprolactinemia: a randomized, double-blind, placebo-controlled, dose-response study", Psychoneuroendocrinology, 58, pp.130~140 (2015)
- Montejo AL, "Multidisciplinary consensus on the therapeutic recommendations for iatrogenic hyperprolactinemia secondary to antipsychotics", Front Neuroendocrinol, 45, pp.25~34 (2017)
- Yoon HW, "Comparing the effectiveness and safety of the addition of and switching to aripiprazole for resolving antipsychotic-induced hyperprolactinemia:a multicenter, open-label, prospective study", Clin Neuropharmacol, 39, pp.288~294 (2016)
- Krysiak R, "The effect of bromocriptine treatment on sexual functioning and depressive symptoms in women with mild hyperprolactinemia", Pharmacol Rep, 70, pp.227~232 (2018)
- Belvederi Murri M, "Second-generation antipsychotics and neuroleptic malignant syndrome: systematic review and case report analysis", Drugs R D, 15, pp.45~62 (2015)
- Berman BD, "Neuroleptic malignant syndrome: a review for neurohospitalists", Neurohospitalist, 1, pp.41~47 (2011)
- Ware MR, "Neuroleptic malignant syndrome:diagnosis and management", Prim Care Companion CNS Disord, 20 (2018)
- Oruch R, "Neuroleptic malignant syndrome: an easily overlooked neurologic emergency", Neuropsychiatr Dis Treat, 13, pp.161~175 (2017)
- Velamoor R, "Neuroleptic malignant syndrome: a neuro-psychiatric emergency: recognition, prevention, and management", Asian J Psychiatr, 29, pp.106~109 (2017)
- Pileggi DJ, "Neuroleptic malignant syndrome", Ann Pharmacother, 50, pp.973~981 (2016)
- Macaluso M, "Tardive dyskinesia: a historical perspective", J Psychiatr Pract, 23, pp.121~129 (2017)
- Correll CU, "Epidemiology, prevention, and assessment of tardive dyskinesia and advances in treatment", J Clin Psychiatry, 78, pp.1136~1147 (2017)
- Mentzel TQ, "Clozapine monotherapy as a treatment for antipsychotic-induced tardive dyskinesia: a meta-analysis", J Clin Psychiatry, 79 (2018)
- Aguilar L, "Tardive dyskinesia after aripiprazole treatment that improved with tetrabenazine, clozapine, and botulinum toxin", Front Pharmacol, 10, pp.281~ (2019)
- Hauser RA, "KINECT 3: a phase 3 randomized, double-blind, placebo-controlled trial of valbenazine for tardive dyskinesia", Am J Psychiatry, 174, pp.476~484 (2017)
- Fernandez HH, "Randomized controlled trial of deutetrabenazine for tardive dyskinesia: the ARM-TD study", Neurology, 88, pp.2003~2010 (2017)
- Soares-Weiser K, "Vitamin E for antipsychotic-induced tardive dyskinesia", Cochrane Database Syst Rev, 1, pp.Cd000209~ (2018)
- Manu P, "Weight gain and obesity in schizophrenia: epidemiology, pathobiology, and management", Acta Psychiatr Scand, 132, pp.97~108 (2015)
- Gao K, "Subjective versus objective weight gain during acute treatment with second-generation antipsychotics in schizophrenia and bipolar disorder", J Clin Psychopharmacol, 36, pp.637~642 (2016)
- Magni LR, "Superwellness Program: a cognitive-behavioral therapy-based group intervention to reduce weight gain in patients treated with antipsychotic drugs", Braz J Psychiatry, 39, pp.244~251 (2017)
- Ribeiro ELA, "Efficacy and safety of aripiprazole for the treatment of schizophrenia: an overview of systematic reviews", Eur J Clin Pharmacol, 74, pp.1215~1233 (2018)
- Lau SL, "Predicting weight gain in patients treated with clozapine: the role of sex, body mass index, and smoking", J Clin Psychopharmacol, 36, pp.120~124 (2016)
- Gressier F, "Pharmacogenetics of clozapine response and induced weight gain: a comprehensive review and meta-analysis", Eur Neuropsychopharmacol, 26, pp.163~185 (2016)
- Lord CC, "The atypical antipsychotic olanzapine causes weight gain by targeting serotonin receptor 2C", J Clin Invest, 127, pp.3402~3406 (2017)
- Zhuo C, "Topiramate and metformin are effective add-on treatments in controlling antipsychotic-induced weight gain: a systematic review and network meta-analysis", Front Pharmacol, 9, pp.1393~ (2018)
- Zheng W, "Amantadine for antipsychotic-related weight gain: meta-analysis of randomized placebo-controlled trials", J Clin Psychopharmacol, 37, pp.341~346 (2017)
- Hoffmann VP, "Assessment of treatment algorithms including amantadine, metformin, and zonisamide for the prevention of weight gain with olanzapine: a randomized controlled open-label study", J Clin Psychiatry, 73, pp.216~223 (2012)
- Hoffman RP, "The complex inter-relationship between diabetes and schizophrenia", Curr Diabetes Rev, 13, pp.528~532 (2017)
- Mamakou V, "Schizophrenia and type 2 diabetes mellitus", Psychiatriki, 29, pp.64~73 (2018)
- Agarwal SM, "Brain insulin action in schizophrenia: something borrowed and something new", Neuropharmacology, pp.107633~ (2019)
- Agarwal SM, "Brain insulin action: implications for the treatment of schizophrenia", Neuropharmacology (2019)
- Marder SR, "Physical health monitoring of patients with schizophrenia", Am J Psychiatry, 161, pp.1334~1349 (2004)
- Larsen JR, "Effect of liraglutide treatment on prediabetes and overweight or obesity in clozapine- or olanzapine-treated patients with schizophrenia spectrum disorder: a randomized clinical trial", JAMA Psychiatry, 74, pp.719~728 (2017)
- Guina J, "Oral glucose tolerance test performance in olanzapine-treated schizophreniaspectrum patients is predicted by BMI and triglycerides but not olanzapine dose or duration", Hum Psychopharmacol, 32 (2017)
- Takeuchi Y, "Atypical antipsychotics and the risk of hyperlipidemia: a sequence symmetry analysis", Drug Saf, 38, pp.641~650 (2015)
- Himmerich H, "Weight gain and metabolic changes during treatment with antipsychotics and antidepressants", Endocr Metab Immune Disord Drug Targets, 15, pp.252~260 (2015)
- Coughlin M, "Enhancing metabolic monitoring for children and adolescents using second-generation antipsychotics", Int J Ment Health Nurs, 27, pp.1188~1198 (2018)
- Woo YS, "Effects of switching to aripiprazole from current atypical antipsychotics on subsyndromal symptoms and tolerability in patients with bipolar disorder", Int Clin Psychopharmacol, 31, pp.275~286 (2016)
- Mandrioli R, "Evaluation of the pharmacokinetics, safety and clinical efficacy of ziprasidone for the treatment of schizophrenia and bipolar disorder", Expert Opin Drug Metab Toxicol, 11, pp.149~174 (2015)
- Nilsson BM, "Tachycardia in patients treated with clozapine versus antipsychotic long-acting injections", Int Clin Psychopharmacol, 32, pp.219~224 (2017)
- Czekalla J, "Cardiac safety parameters of olanzapine: comparison with other atypical and typical antipsychotics", J Clin Psychiatry, 62(Suppl 2), pp.35~40 (2001)
- Beach SR, "QTc prolongation, torsades de pointes, and psychotropic medications", Psychosomatics, 54, pp.1~13 (2013)
- Hasnain M, "QTc interval prolongation and torsade de pointes associated with second-generation antipsychotics and antidepressants: a comprehensive review", CNS Drugs, 28, pp.887~920 (2014)
- Takeuchi H, "Antipsychotic polypharmacy and corrected QT interval: a systematic review", Can J Psychiatry, 60, pp.215~222 (2015)
- Polcwiartek C, "The cardiac safety of aripiprazole treatment in patients at high risk for torsade: a systematic review with a meta-analytic approach", Psychopharmacology (Berl), 232, pp.3297~3308 (2015)
- Hwang TJ, "Fast versus slow strategy of switching patients with schizophrenia to aripiprazole from other antipsychotics", J Clin Psychopharmacol, 35, pp.635~644 (2015)
