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Factors Affecting Recurrence in Patients with Schizophrenia Received More Than Factors Affecting Recurrence in Patients with Schizophrenia Received More Than 10 Years of Treatment
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Objectives : The purpose of this study is to investigate the factors affecting recurrence in patients with schizophrenia received more than 10 years of long-term treatment. Methods : The medical records of long-term follow-up patients with the diagnosis of schizophrenia from department of psychiatry, Inha university hospital for more than 10 years were reviewed. The recurrence was defined as the re-emergence or aggravation of psychotic symptoms after maintenance treatment during 6 months. Results : Of the 110 patients who were included in the study, 78 patients were recurred. Half of the patients were experiencing at least 1 recurrence within six years. After adjustment of sociodemographic variables, female, poor drug compliance, younger baseline age, shorter duration of illness and longer duration of hospitalization at first admission were significantly related to an increased likelihood of recurrence. The most common stressor of recurrence was irregular drug taking (61.73%). Conclusion : The results show the importance of gender, drug compliance, baseline age, duration of illness, and duration of hospitalization at first admission in predicting recurrence of long-term follow-up patients with schizophrenia.
Abstract
Objectives : The purpose of this study is to investigate the factors affecting recurrence in patients with schizophrenia received more than 10 years of long-term treatment. Methods : The medical records of long-term follow-up patients with the diagnosis of schizophrenia from department of psychiatry, Inha university hospital for more than 10 years were reviewed. The recurrence was defined as the re-emergence or aggravation of psychotic symptoms after maintenance treatment during 6 months. Results : Of the 110 patients who were included in the study, 78 patients were recurred. Half of the patients were experiencing at least 1 recurrence within six years. After adjustment of sociodemographic variables, female, poor drug compliance, younger baseline age, shorter duration of illness and longer duration of hospitalization at first admission were significantly related to an increased likelihood of recurrence. The most common stressor of recurrence was irregular drug taking (61.73%). Conclusion : The results show the importance of gender, drug compliance, baseline age, duration of illness, and duration of hospitalization at first admission in predicting recurrence of long-term follow-up patients with schizophrenia.
참고문헌 (29)
- Gelder M, "New Oxford Textbook of Psychiatry" (2000), Oxford University Press
- Pigott TA, "Aripiprazole for the prevention of relapse in stabilized patients with chronic schizophrenia: a placebo-controlled 26-week study", J Clin Psychiatry, 64, pp.1048~1056 (2003)
- Almond S, "Relapse in schizophrenia: cost, clinical outcomes and quality of life", BJP, 184, pp.346~351 (2004)
- Knapp M, "The global cost of schizophrenia", Schizophr Bull, 30, pp.279~293 (2004)
- Doering S, "Predictors of relapse and rehospitalization in schizophrenia and schizoaffective disorder", Schizophr Bull, 24(1), pp.87~98 (1998)
- Goodpastor WA, "Factors associated with multiple readmissions to an urban public psychiatric hospital", Hosp Community Psychiatry, 42, pp.85~87 (1991)
- Lin CH, "Predictors of psychiatric readmissions in the short- and long-term: a populationbased study in taiwan", Clinics (Sao Paulo), 65, pp.481~489 (2010)
- Kane JM, "Pharmacologic treatment of schizophrenia", Biol Psychiatry, 46, pp.1396~1408 (1999)
- Gilbert PL, "Neuroleptic withdrawal in schizophrenic patients: a review of the literature", Arch Gen Psychiatry, 52, pp.173~188 (1995)
- Gitlin M, "Clinical outcome following neuroleptic discontinuation in patients with remitted recent-onset schizophrenia", Am J Psychiatry, 158, pp.1835~1842 (2001)
- Ayuso-Gutiérrez JL, "Factors influencing relapse in the long-term course of schizophrenia", Schizophr Res, 28, pp.199~206 (1997)
- Gaebel W, "Towards the improvement of compliance: the significance of psycho-education and new antipsychotic drugs", Int Clin Psychopharmacol, 12(Suppl 1), pp.S37~S42 (1997)
- Hudson TJ, "A pilot study of barriers to medication adherence in schizophrenia", J Clin Psychiatry, 65, pp.211~216 (2004)
- Valenstein M, "Poor antipsychotic adherence among patients with schizophrenia: medication and patient factors", Schizophr Bull, 30, pp.255~264 (2004)
- Lacro JP, "Prevalence of and risk factors for medication nonadherence in patients with schizophrenia: a comprehensive review of recent literature", J Clin Psychiatry, 63, pp.892~909 (2002)
- Fenton WS, "Determinants of medication compliance in schizophrenia: empirical and clinical findings", Schizphr Bull, 23, pp.637~651 (1997)
- Suzuki T, "Simplifying psychotropic medication regimen into a single night dosage and reducing the dose for patients with chronic schizophrenia", Psychopharmacology (Berl), 181, pp.566~575 (2005)
- Perkins DO, "Predictors of noncompliance in patients with schizophrenia", J Clin Psychiatry, 63, pp.1121~1128 (2002)
- World Health Organization, "The ICD-10 Classification of Mental and Behavioural Disorders: Clinical Descriptions and Diagnostic Guidelines", World Health Organization, ~ (1992)
- American Psychiatric Association, "Diagnostic and Statistical Manual of Mental Disorders", American Psychiatric Association, ~ (2000)
- Velligan DI, "The expert consensus guideline series: adherence problems in patients with serious and persistent mental illness", J Clin Psychiatry, 70(suppl 4) (2009)
- Zhang M, "Randomised-control trial of family intervention for 78 first-episode male schizophrenic patients. An 18-month study in Suzhou, Jiangsu", Br J Psychiatry Suppl, 24, pp.96~102 (1994)
- Scottish Schizophrenia Research Group, "The Scottish first epidose schizophrenia study. VIII. Five-year follow-up: clinical and psychosocial findings", Br J Psychiatry, 161, pp.496~500 (1992)
- Robinson DG, "Predictors of relapse following response from a first episode of schizophrenia or schizoaffective disorder", Arch Gen Psychiarty, 56, pp.241~247 (1999)
- Lee JI, "The comparison of haloperidol, risperidone, and olanzapine in the prevention of relapse in schizophrenic patients", J Korean Assoc Soc Psychiatry, 11, pp.23~29 (2006)
- Zin ST, "A study on relapse factors in schizophrenia", Inje Medical Journal, 11, pp.481~491 (1999)
- Kazadi NJ, "Factors associated with relapse in schizophrenia", S Afr J Psychiatr, 14, pp.52~62 (2008)
- Jeon KS, "Effects of psychoeducation on relapse of schizophrenic patients", J Korean Assoc Soc Psychiatry, 38, pp.1421~1431 (1999)
- Kampman O, "Compliance in psychoses", Acta Psychiatr Scand, 100, pp.167~175 (1999)
