이종 장기이식 위기 극복을 위한 돼지의 형질전환(총설)
Transgenesis of Pigs for Xenotransplantation Crisis - an Update
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Transgenic pigs are promising donor organisms for xenotransplantation as they share many anatomical and physiological characteristics with humans. Recently, a step has been moved closer to xenotransplantation by producing genetically modified pigs that has no α-1,3-Gal epitope, the major xenoantigens triggering HAR of pig to primate xenografts. Further genetic modifications such as expression of human complementary regulatory proteins, CD39, endothelial protein C receptor, heme-oxygenase 1, thrombomodulin, tissue factor pathway inhibitoras well as modulators of the HLA-E/β-2-microglobulin, and CTLA-4Ig are due to address for further rejection mechanisms and incompatibilities between porcine and primate blood coagulation systems. Although the pig is the favored species for use as a xenograft donor, a detailed description of the transgenic pig development and surgical technique is lacking which seems mandatory to address for broader understanding of this issue.
Abstract
Transgenic pigs are promising donor organisms for xenotransplantation as they share many anatomical and physiological characteristics with humans. Recently, a step has been moved closer to xenotransplantation by producing genetically modified pigs that has no α-1,3-Gal epitope, the major xenoantigens triggering HAR of pig to primate xenografts. Further genetic modifications such as expression of human complementary regulatory proteins, CD39, endothelial protein C receptor, heme-oxygenase 1, thrombomodulin, tissue factor pathway inhibitoras well as modulators of the HLA-E/β-2-microglobulin, and CTLA-4Ig are due to address for further rejection mechanisms and incompatibilities between porcine and primate blood coagulation systems. Although the pig is the favored species for use as a xenograft donor, a detailed description of the transgenic pig development and surgical technique is lacking which seems mandatory to address for broader understanding of this issue.
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