본문 바로가기
KERD
논문KCI 등재

사료 내 Hot Melt Extrusion 가공된 황산아연의 첨가가 이유자돈의 사양성적, 영양소 소화율, 소장의 형태학적 변화 및 분중 아연 배출에 미치는 영향

Effects of Supplementation of Hot Melt Extrusion Processed Zinc Sulfate on Growth Performance, Nutrients Digestibility, Small Intestinal Morphologyand Excretion of Zinc in Weanling Pigs

김광열|조현종|최요한|이송이|남수영|구자성|심영호|강위수|채병조|Abdolreza Hosseindoust|김민주
동물생명과학연구소 (Institute of Animal Life Science)|2017.12|동물자원연구 (ANNALS OF ANIMAL RESOURCE SCIENCES)|제28권 제4호|pp. 169-179|DOI https://doi.org/10.12718/AARS.2017.28.4.169

1

조회

0

다운로드

3

인용

0

참고문헌

키워드

ZincNanoparticleWeanling pigsZinc sourcesHME process
주제분류축산학

초록

The objective of this experiment was to determine the effect of supplementation of hot melt extrusion (HME) processed Zn sulfate on growth performance, nutrients digestibility, small intestinal morphology and excretion of Zn in weanling pigs. A total of 200 piglets of mixed sex randomly allotted to four treatments on the basis of initial BW (7.15±0.81 kg). There were five replicates in each treatment with 10 pigs per replicate. The experimental treatments consisted of: 1) basal diet containing ZnSO4; 2) basal diet containing Zn-Methionine (ZnMet); 3) basal diet containing low level of nano-Zn as HME (ZnHME50); 4) basal diet containing medium level of nano-Zn as HME ZnSO4 (Zn-HME75). The average daily gain was improved by the ZnMet and ZnHME75 compared with the pigs fed ZnSO4 supplemented diets (p=0.009). Moreover, ZnHME75 and ZnMet affected on the ATTD of CP during phase 2 (p=0.014). The villus height (VH) was affected by increasing when pigs fed diets supplemented the ZnHME75 (P=0.044). The pigs fed diets supplemented ZnHME50 had significantly the lowest (p=0.037) Zn content in liver compared with other treatments. The Zn content in the feces was significantly higher (p<0.001) in ZnSO4 and ZnMet compared with ZnHME50 or ZnHME75. In conclusion, it could be concluded that dietary Zn can be reduced by 25% with ZnHME without any detrimental effect on performance of weanling pigs.

Abstract

The objective of this experiment was to determine the effect of supplementation of hot melt extrusion (HME) processed Zn sulfate on growth performance, nutrients digestibility, small intestinal morphology and excretion of Zn in weanling pigs. A total of 200 piglets of mixed sex randomly allotted to four treatments on the basis of initial BW (7.15±0.81 kg). There were five replicates in each treatment with 10 pigs per replicate. The experimental treatments consisted of: 1) basal diet containing ZnSO4; 2) basal diet containing Zn-Methionine (ZnMet); 3) basal diet containing low level of nano-Zn as HME (ZnHME50); 4) basal diet containing medium level of nano-Zn as HME ZnSO4 (Zn-HME75). The average daily gain was improved by the ZnMet and ZnHME75 compared with the pigs fed ZnSO4 supplemented diets (p=0.009). Moreover, ZnHME75 and ZnMet affected on the ATTD of CP during phase 2 (p=0.014). The villus height (VH) was affected by increasing when pigs fed diets supplemented the ZnHME75 (P=0.044). The pigs fed diets supplemented ZnHME50 had significantly the lowest (p=0.037) Zn content in liver compared with other treatments. The Zn content in the feces was significantly higher (p<0.001) in ZnSO4 and ZnMet compared with ZnHME50 or ZnHME75. In conclusion, it could be concluded that dietary Zn can be reduced by 25% with ZnHME without any detrimental effect on performance of weanling pigs.

참고문헌 (51)

  1. Albanese, A., "The effect of nanoparticle size, shape, and surface chemistry on biological systems", Annu. Rev. Biomed. Eng, 14, pp.1~6 (2012)
  2. Ali, S., "Supplementation of Zinc Oxide nanoparticles has beneficial effects on intestinal morphology in broiler chicken", Pak. Vet. J, pp.2074~7764 (2017)
  3. AOAC., "Official Methods of Analysis of the Association of Official Analytical Chemists International" (2007)
  4. Awad, W., "Intestinal structure and function of broiler chickens on diets supplemented with a synbiotic containing Enterococcus faecium and oligosaccharides", Int. J. Mol. Sci, 9(11), pp.2205~2216 (2008)
  5. Baiarzhal, M., "Comparative evaluation of zinc organic and inorganic form bioavailability in vivo. Vopr", Pitan, 77(1), pp.34~37 (2008)
  6. Cao, J., "Relative bioavailability of organic zinc sources based on tissue zinc and metallothionein in chicks fed conventional dietary zinc concentrations", Anim. Feed Sci. Technol, 101(1), pp.161~170 (2002)
  7. Carlson, D., "The physiological role of dietary zinc and copper in weaned piglets, with emphasis on zinc and intestinal mucosal function", Ph.D., pp.2003
  8. Carlson, D., "Influence of weaning and effect of post weaning dietary zinc and copper on electrophysiological response to glucose, theophyllineand 5-HT in piglet small intestinal mucosa", Comp. Biochem. Physiol., Part A Mol. Integr. Physiol, 137(4), pp.757~765 (2004)
  9. Carlson, M. S., "Evaluation of various inclusion rates of organic zinc either as polysaccharide or proteinate complex on the growth performance, plasma, and excretion of nursery pigs", J. Anim. Sci, 82(5), pp.1359~1366 (2004)
  10. Case, C. L., "Effect of feeding organic and inorganic sources of additional zinc on growth performance and zinc balance in nursery pigs", J. Anim. Sci, 80(7), pp.1917~1924 (2002)
  11. Chaudhry, Q., "Food applications of nanotechnologies: an overview of opportunities and challenges for developing countries", Trends Food Sci. Technol, 22, pp.595~603 (2011)
  12. Cheng, J., "Influence of dietary lysine on the utilization of zinc from zinc sulfate and a zinc-lysine complex by young pigs", J. Anim. Sci, 76(4), pp.1064~1074 (1998)
  13. Crowley, M. M., "Pharmaceutical applications of hot-melt extrusion: part I", Drug Dev. Ind. Pharm, 33(9), pp.909~926 (2007)
  14. Davda, J., "Characterization of nanoparticle uptake by endothelial cells", Int. J. Pharm, 233, pp.51~59 (2002)
  15. Dibner, J. J., "Metabolic challenges and early bone development", J. Appl. Poult. Res, 16, pp.167~174 (2007)
  16. Ezzati, M. S., "Effects of different levels of zinc supplementation on broilers performance and immunity response to Newcastle disease vaccine", Eur. J. Exp. Biol, 3(5), pp.497~501 (2013)
  17. Fenton, T. W., "An improved procedure for the determination of chromic oxide in feed and feces", Can. J. Anim. Sci, 59(3), pp.631~634 (1979)
  18. Hampson, D. J., "Alterations in piglet small intestinal structure at weaning", Res. Vet. Sci, 40(1), pp.32~40 (1986)
  19. Hedemann, M. S., "Small intestinal morphology and activity of intestinal peptidases in piglets around weaning", J. Anim. Physiol. Anim. Nutr, 87(1-2), pp.32~41 (2003)
  20. Hedemann, M. S., "Influence of dietary zinc and copper on digestive enzyme activity and intestinal morphology in weaned pigs", J. Anim. Sci, 84(12), pp.3310~3320 (2006)
  21. Hill, G. M., "Comparison of organic and inorganic zinc sources to maximize growth and meet the zinc needs of the nursery pig", J. Anim. Sci, 92(4), pp.1582~1594 (2014)
  22. Jones, D. S., "Engineering drug delivery using polymer extrusion", injection moulding technologies, 2008, pp.4, 9~
  23. Kendrick, M. J., "Metals in Biological Systems", pp.142~149 (1992), MidsomerNorton
  24. Kickinger, T., "Survey on zinc and copper contents in dung from Austrian livestock production", Die Bodenkultur, 101(59), pp.1~4 (2008)
  25. Kickinger, T., "Zinc and copper in feeds, slurry and soils from Austrian pig fattening farms feeding commercial complete feedor feed mixtures produced on-farm", Die Bodenkultur, 60, pp.47~58 (2010)
  26. Lee, S. Y., "Fabrication and characterizations of hot-melt extruded nanocomposites based on zinc sulfate monohydrate and soluplus", Appl Sci, 7(9), pp.902~ (2017)
  27. Li, M. Z., "Nanosize of zinc oxide and the effects on zinc digestibility, growth performances, immune response and serum parameters of weanling piglets", Anim. Sci. J, 87, pp.1379~1385 (2016)
  28. Maniruzzaman, M., "A review of hot-melt extrusion: process technology to pharmaceutical products", ISRN Pharm, ~ (2012)
  29. Martinez, M. M, "Dietary pharmacological or excess zinc and phytase effects on tissue mineral concentrations, metallothionein, and apparent mineral retention in the newly weaned pig", Biol. Trace Elem. Res, 105(1), pp.97~115 (2005)
  30. Mcginity, J. W., "Preparation and evaluation of rapid-release granules using a novel hot-melt extrusion technique", Pharmaceutical Technology Conference, 2, pp.153~154 (1997)
  31. NRC., "Nutrient Requirements of Swine" (2012), Academic. Press
  32. Pluske, J. R., "Factors influencing the structure and function of the small intestine in the weaned pig: a review", Livest. Prod. Sci, 51(1), pp.215~236 (1997)
  33. Prasad, A. S., "Discovery and importance of zinc in human nutrition", Fed. Proc, 43, pp.13~ (1984)
  34. Rajendran, D., "Nutrition and Reproductive Physiology (Recent Concepts)", pp.517~530 (2013), Satish Serial Publishing House
  35. Revy, P. S., "Effect of zinc supplemented as either an organic or an inorganic source and of microbial phytase on zinc and other minerals utilisation by weanling pigs", Anim. Feed Sci. Technol, 116(1), pp.93~112 (2004)
  36. Rincker, M. J., "Effects of dietary zinc and iron supplementation on mineral excretion, body composition, and mineral status of nursery pigs", J. Anim. Sci, 83(12), pp.2762~2774 (2005)
  37. SAS., "SAS Software for PC. Release 9.3", SAS Institute. Ins, ~ (2012)
  38. Schell, T. C., "Zinc concentration in tissues and performance of weanling pigs fed pharmacological levels of zinc from ZnO, Zn-methionine, Zn-lysine, or ZnSO4", J. Anim. Sci, 74(7), pp.1584~1593 (1996)
  39. Schlegel, P., "Bioavailability of zinc sources and their interaction with phytates in broilers and piglets", Animal, 7(1), pp.47~59 (2013)
  40. Sheikh, A. A., "Effect of in vitro zinc supplementation on HSPs expression and Interleukin 10 production in heat treated peripheral blood mononuclear cells of transition Sahiwal and Karan Fries cows", J. Therm. Biol, 56, pp.68~76 (2016)
  41. Singhal, S., "Hot melt extrusion technique", ~ (2011)
  42. Southon, S., "Intestinal microflora, morphology and enzyme activity in zinc-deficient and Zn-supplemented rats", Br. J. Nutr, 55(3), pp.603~611 (1986)
  43. Spreeuwenberg, M. A. M., "Small intestine epithelial barrier function is compromised in pigs with low feed intake at weaning", J. Nutr, 131(5), pp.1520~1527 (2001)
  44. Swain, P. S., "Nano zinc, an alternative to conventional zinc as animal feed supplement: a review", Anim. Nutr, 2, pp.134~141 (2016)
  45. Swiatkiewicz, S., "The bioavailability of zinc from inorganic and organic sources in broiler chickens as affected by addition of phytase", J. Anim. Feed Sci, 10, pp.317~328 (2001)
  46. Uni, Z., "Posthatch development of mucosal function in the broiler small intestine", Poult. Sci, 77, pp.75~82 (1998)
  47. Walk, C. L., "Influence of a microbial phytase and zinc oxide on young pig growth performance and serum minerals", J. Anim. Sci, 91(1), pp.286~291 (2013)
  48. Wang, Y., "Dietary zinc glycine chelate on growth performance, tissue mineral concentrations, and serum enzyme activity in weanling piglets", Biol. Trace Elem. Res, 133(3), pp.325~334 (2010)
  49. Wedekind, K. J., "Methodology for assessing zinc bioavailability:Efficacy estimates for zinc-methionine, zinc sulfate, and zinc oxide", J. Anim. Sci, 70(1), pp.178~187 (1992)
  50. Xia, T., "Dietary ZnO nanoparticles alters intestinal microbiota and inflammation response in weaned piglets", Oncotarget, ~ (2017)
  51. Zhao, C. Y., "Effects of dietary zinc oxide nanoparticles on growth performance and antioxidative status in broilers", Biol. Trace Elem. Res, 160(3), pp.361~367 (2014)

이 간행물의 다른 논문 (5건)

소 분화세포에서 삽입된 AID, TDG 유전자와 전능성 유전자의 탈메틸화 증가이준희, 진상진, 문송이, 백상기, 김태숙, 조영수pp. 143-160DNA Degradation이 Genotyping-by-Sequencing(GBS) 자료 기반 한우 유전적 표지 발굴에 미치는 영향유동안, 조서애, 김덕경, 김권도pp. 161-168동물의 혈액으로부터 정제된 아미노산 사료첨가제가 이유자돈의 성장과 면역 반응에 미치는 효과나주마 조쉬, 테레시아 갈루 완디타, 박해성, 남인식, 황성구pp. 180-186재래흑염소 주요 4개 근육의 아미노산 조성과 미네랄 함량이정규, 주성현, 주선태, 정우철pp. 187-193한우의 말초혈액 단핵세포 염증성 사이토카인에 대한 브로피리민의 효과 확인김의형, 조용민, 정기용, 박종은, 이승환, 채한화, 김승창, 최봉환, 임다정pp. 194-203
원문 보기