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두경부암에서 인간유두종바이러스 : 치료

HPV in Head and Neck Cancer : Treatment

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참고문헌

키워드

주제분류이비인후과학

초록

HPV DNA(+) 두경부암(특히, 구인두암)은 HPV DNA (-) 두경부암에 비해 예후가 우수한 것으로 명백하게 밝혀져 있으며, 이에 따라 HPV DNA(+) 두경부암은 치료의 강도를 낮추고(de-intensification), HPV DNA(-) 두경부암은 치료의 강도를 높이는(intensification) 방향으로 이 두 군에 대한 치료 법이 달라져야 할 것이다. 이는 두경부암 치료 방법의 결정에 전통적으로 사용해 온 병기 이외에 새로운 지표인 HPV DNA 유무가 추가되는 것으로 종양의 생물학적 지표를 이용한 개인별 맞춤 치료(individual-ized treatment)가 도입되는 것이다. 아직까지는 이러한 접근 법에 대한 정당성을 부여할 만큼의 충분한 연구가 시행되지는 않은 상태이지만, 현재 진행중인 또는 앞으로 진행될 여러 연구들을 통해 조만간 충분히 정당성을 확보할 수 있으리라고 예상된다.

참고문헌 (23)

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