The Screening of Herbal Medicines for Relieving COVID-19 Symptoms and Sequelae Based on Network Pharmacology and Data-driven Analysis
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초록
The herbal medicine is actively applied to the treatment of corona virus infectious diseases and pharmacological network is one of suitable tool for screening candidate drugs. We established a herb-compound-protein-disease pharmacological network for herbal medicines in the Korean, Chinese, and Japanese pharmacopeias. To analyze the built network in backward direction, we designed weight models of the main symptoms and sequelae of COVID-19 from previous studies. Then we explored the general efficacy of the identified herbs through compositional compounds, target proteins and literature reviews. Through backward analysis, Cichorii intybi radix, Glycine semen nigra, and Granati fructus are expected to have the greatest therapeutic efficacy for COVID-19 symptoms. Cnidii rhizoma, Foeniculi amari fructus, and Thymi herba showed potential therapeutic efficacy for COVID-19 sequelae. From literature reviews, we found that they have efficacy such as anti-inflammatory, anti-oxidant, anti-bacterial, anti-thrombotic, and immunomodulatory effects and contain some of the leading substances for COVID-19 treatments. We showed that pharmacological networks and backward network analysis could recommend herbal medicines expected to have efficacy for COVID-19 symptom and sequelae relief. The data-driven approach adopted in this work has shown the potential to function as a tool for selecting candidate herbal medicines and screening natural product-based leading substances.
Abstract
The herbal medicine is actively applied to the treatment of corona virus infectious diseases and pharmacological network is one of suitable tool for screening candidate drugs. We established a herb-compound-protein-disease pharmacological network for herbal medicines in the Korean, Chinese, and Japanese pharmacopeias. To analyze the built network in backward direction, we designed weight models of the main symptoms and sequelae of COVID-19 from previous studies. Then we explored the general efficacy of the identified herbs through compositional compounds, target proteins and literature reviews. Through backward analysis, Cichorii intybi radix, Glycine semen nigra, and Granati fructus are expected to have the greatest therapeutic efficacy for COVID-19 symptoms. Cnidii rhizoma, Foeniculi amari fructus, and Thymi herba showed potential therapeutic efficacy for COVID-19 sequelae. From literature reviews, we found that they have efficacy such as anti-inflammatory, anti-oxidant, anti-bacterial, anti-thrombotic, and immunomodulatory effects and contain some of the leading substances for COVID-19 treatments. We showed that pharmacological networks and backward network analysis could recommend herbal medicines expected to have efficacy for COVID-19 symptom and sequelae relief. The data-driven approach adopted in this work has shown the potential to function as a tool for selecting candidate herbal medicines and screening natural product-based leading substances.
참고문헌 (19)
- J. L. Ren, "Traditional Chinese medicine for COVID-19treatment", Pharmacological research, 155, pp.104~743 (2020)
- H. Luo, "Can Chinese medicine be used for prevention of corona virus disease 2019(COVID-19)? A review of historical classics, research evidence and current prevention programs", Chinese journal of integrative medicine, 26(4), pp.243~250 (2019)
- X. Ren, "Identifying potential treatments of COVID-19from Traditional Chinese Medicine (TCM) by using a data-driven approach", Journal of Ethnopharmacoloy, 258, pp.112932~ (2020)
- J. Fang, "Network pharmacology-based study on the mechanism of action for herbal medicines in Alzheimer treatment", Journal of ethnopharmacology, 196, pp.281~292 (2017)
- A. Y. Lee, "Network pharmacology-based prediction of active compounds and molecular targets in Yijin-Tang acting on hyperlipidaemia and atherosclerosis", Journal of Ethnopharmacology, 221, pp.151~159 (2018)
- S. J. Yea, "A framework for the targeted selection of herbs with similar efficacy by exploiting drug repositioning technique and curated biomedical knowledge", Journal of ethnopharmacology, 208, pp.117~128 (2017)
- J. R. Larsen, "Modeling the Onset of Symptoms of COVID-19", Frontiers in public health, 8, pp.473~ (2020)
- Y. Wu, "SymMap: an integrative database of traditional Chinese medicine enhanced by symptom mapping", Nucleic acids research, 47(D1), pp.1110~1117 (2019)
- Q. Xiong, "Clinical sequelae of COVID-19 survivors in Wuhan, China: a single-centre longitudinal study", Clinical Microbiology and Infection, 27(1), pp.89~95 (2021)
- J. Lépine, "Specificity and regioselectivity of the conjugation of estradiol, estrone, and their catecholestrogen and methoxyestrogen metabolites by human uridine diphospho-glucuronosyltransferases expressed in endometrium", The journal of clinical endocrinology & metabolism, 89(10), pp.5222~5232 (2004)
- M. M. Youssef, "Ferulic Acid in Foods:An Overview", Alexandira J of Food Science & Technology, 9(2), pp.47~52 (2012)
- L. M. Forstbauer, "Genome-wide pooling approach identifies SPATA5 as a new susceptibility locus for alopecia areata", European journal of human genetics, 20(3), pp.326~332 (2012)
- A. Riaz, "Astragalin: a bioactive phytochemical with potential therapeutic activities", Advances in pharmacological sciences, pp.9794625~ (2018)
- "Defining Dictionary for Medicinal Herbs" (2021)[URL]
- "Oriental Medicine Advanced Searching Integrated System" (2021)[URL]
- K. Chandra, "Therapeutic potential of Cichorium intybus in lifestyle disorders: A review", Asian J Pharm Clin Res, 9(3), pp.20~25 (2016)
- R. Islam, "A molecular modeling approach to identify effective antiviral phytochemicals against the main protease of SARS-CoV-2", Journal of Biomolecular Structure and Dynamics, pp.1~12 (2020)
- Z. Chen, "A systematic review on the rhizome of Ligusticum chuanxiong Hort. (Chuanxiong)", Food and chemical toxicology, 119, pp.309~325 (2018)
- S. Hiremath, "In silico docking analysis revealed the potential of phytochemicals present in Phyllanthus amarus and Andrographis paniculata, used in Ayurveda medicine in inhibiting SARS-CoV-2", 3 Biotech, 11(2), pp.1~18 (2021)