원발성 이하선암종의 예후인자에 관한 고찰
Analysis of Prognostic Risk Factors of Parotid Cancer
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Background and Objectives：Cancer developing in the parotid gland tends to be large variety of histologic types. The relative rarity of parotid cancer makes epidemiologic study more difficult. To develop a rational therapeutic plan for parotid cancer, the surgeon must be fully cognizant of the factors that may affect survival. The objective of this study was to identify the clinical feature and prognostic factors of parotid cancer. Materials and Methods：The authors retrospectively studied 72 patients with histologically confirmed parotid cancer at Pusan National University Hospital between 1995 and 2011. We analyzed 5-year survival rate according to the some prognostic factors. Results：The overall 5-year survival rate was 82.5%. We observed statistically significant differences for patients of different clinical stages (p=0.009), regional lymph node metastasis (p＜0.001), preoperative facial nerve involvement (p=0.001), distant metastasis (p＜0.001). There was no statistically significant difference in the tumor size, surgical margin, histologic grade. Superficial parotidectomy may be a safe procedure without po-tential morbidity, such as postoperative facial palsy. Conclusions：Clinical stages, regional lymph node metasta-sis, preoperative facial nerve involvement and distant metastasis are the significant prognostic factors, and these factors need to be considered in the treatment of parotid cancer.
Abstract
Background and Objectives：Cancer developing in the parotid gland tends to be large variety of histologic types. The relative rarity of parotid cancer makes epidemiologic study more difficult. To develop a rational therapeutic plan for parotid cancer, the surgeon must be fully cognizant of the factors that may affect survival. The objective of this study was to identify the clinical feature and prognostic factors of parotid cancer. Materials and Methods：The authors retrospectively studied 72 patients with histologically confirmed parotid cancer at Pusan National University Hospital between 1995 and 2011. We analyzed 5-year survival rate according to the some prognostic factors. Results：The overall 5-year survival rate was 82.5%. We observed statistically significant differences for patients of different clinical stages (p=0.009), regional lymph node metastasis (p＜0.001), preoperative facial nerve involvement (p=0.001), distant metastasis (p＜0.001). There was no statistically significant difference in the tumor size, surgical margin, histologic grade. Superficial parotidectomy may be a safe procedure without po-tential morbidity, such as postoperative facial palsy. Conclusions：Clinical stages, regional lymph node metasta-sis, preoperative facial nerve involvement and distant metastasis are the significant prognostic factors, and these factors need to be considered in the treatment of parotid cancer.
참고문헌 (19)
- Spiro RH, "Salivary neoplasm: overview of a 35-year experience with 2,807 patients", Head Neck Surg, 8(3), pp.177~184 (1986)
- Gallia LJ, "The incidence of neoplastic versus inflammatory disease in major salivary gland masses diagnosed by surgery", Laryngoscope, 91(4), pp.512~516 (1981)
- Million RR, "Major salivary gland tumors, In Management of head and neck cancer", pp.711~735 (1994), Lippincott Co
- Myers EN, "Cancer of the head and neck, In Malignant tumors of the salivary glands", pp.525~561 (1996), Saunders
- Matsuba HM, "High-grade malignancies of the parotid gland: effective use of planned combined surgery and irradiation", Laryngoscope, 95(9 Pt 1), pp.1059~1063 (1985)
- Park SJ, "The study of prognostic factor of the parotid tumor", Korean J Otolaryngol-Head Neck Surg, 41(6), pp.773~777 (1998)
- 임영창, "이하선암종에서 경부 림프절 전이가 예후에 미치는 영향 및 전이의 위험인자에 관한 고찰", 대한이비인후과학회지 두경부외과학, 46(10), pp.856~861 (2003), 대한이비인후과학회
- 김현직, "이하선 천엽에 국한된 이하선암종 치료로서의 이하선 천엽절제술과 전 이하선절제술과의 비교", 대한이비인후과학회지 두경부외과학, 47(2), pp.161~167 (2004), 대한이비인후과학회
- Renehan AG, "Clinico-pathological and treatment-related factors influencing survival in parotid cancer", Br J Can, 80(8), pp.1296~1300 (1999)
- Spiro IJ, "Carcinoma of the parotid gland: ananlysis of treatment results and pattern of failure after combined surgery and radiation therapy", Cancer, 71(9), pp.2699~2705 (1993)
- Zbaren P, "Carcinoma of the parotid gland", Am J Surg, 186(1), pp.57~62 (2003)
- Seifert G, "The World Health Organization’s histologically classification of salivary gland tumors", Cancer, 70(2), pp.379~385 (1992)
- Bardwill JM, "Tumors of the parotid gland", Am J Surg, 114(4), pp.498~502 (1967)
- Eneroth CM, "Histological and clinical aspects of parotid tumor", Acta Otolaryngol Suppl, 188(suppl), pp.1~99 (1964)
- Lambert JA, "Parotid gland tumors", Milit Med, 136(5), pp.484~492 (1971)
- Spitz MR, "Major salivary gland carcinoma-descriptive epidemiology and survival of 498 patients", Arch Otolaryngol, 110(1), pp.45~49 (1984)
- Malata CM, "Malignant tumours of the parotid gland: a 12-year review", Br J Plast Surg, 50(8), pp.600~608 (1997)
- Kirkbride P, "Outcome of curative management of malignant tumours of the parotid gland", J Otolarynogol, 30(5), pp.71~79 (2001)
- Levitt SH, "Clinical staging system for cancer of the salivary gland: a retrospective study", Cancer, 47(11), pp.2712~2724 (1981)