갑상선 유두상 암의 경부 림프절 전이에서 발생한 갑상선 역형성 암
Anaplastic Thyroid Carcinoma Arising from Latent Cervical Metastasis of Papillary Thyroid Carcinoma
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Anaplastic thyroid carcinoma (ATC) has the most aggressive progression among thyroid malignancies and its prognosis is almost invariably fatal. ATC may arise de novo, but in most cases it develops from a pre-existing well-differentiated thyroid cancer. We present the case of a 77-year-old woman complained of neck mass and pain. She had a history of papillary thyroid carcinoma (PTC) and underwent total thyroidectomy in 14 years ago. 6 years ago, follow-up ultrasonography revealed cervical lymph node enlargement in left level III and fine needle aspiration cytology showed PTC. Because of the reluctance for surgery, the metastatic node was closely observed without re-operation. Ultrasonography guided core needle biopsy for cervical mass was performed and histopathology was consistent with ATC. Rapid deterioration of the patient’s general condition finalized with death within in six months from the initial presentation. Despite its rare occurrence, the possibility of anaplastic transformation from latent cervical metastasis of PTC and aggressive management should be considered.
Abstract
Anaplastic thyroid carcinoma (ATC) has the most aggressive progression among thyroid malignancies and its prognosis is almost invariably fatal. ATC may arise de novo, but in most cases it develops from a pre-existing well-differentiated thyroid cancer. We present the case of a 77-year-old woman complained of neck mass and pain. She had a history of papillary thyroid carcinoma (PTC) and underwent total thyroidectomy in 14 years ago. 6 years ago, follow-up ultrasonography revealed cervical lymph node enlargement in left level III and fine needle aspiration cytology showed PTC. Because of the reluctance for surgery, the metastatic node was closely observed without re-operation. Ultrasonography guided core needle biopsy for cervical mass was performed and histopathology was consistent with ATC. Rapid deterioration of the patient’s general condition finalized with death within in six months from the initial presentation. Despite its rare occurrence, the possibility of anaplastic transformation from latent cervical metastasis of PTC and aggressive management should be considered.
참고문헌 (12)
- Patel KN, "Poorly differentiated and anaplastic thyroid cancer", Cancer Control, 13(2), pp.119~128 (2006)[DOI]
- Wein RO, "Anaplastic thyroid carcinoma: palliation or treatment?", Curr Opin Otolaryngol Head Neck Surg, 19(2), pp.113~118 (2011)[DOI]
- Wiseman SM, "Anaplastic transformation of thyroid cancer: review of clinical, pathologic, and molecular evidence provides new insights into disease biology and future therapy", Head Neck, 25(8), pp.662~670 (2003)[DOI]
- O'Neill JP, "Anaplastic thyroid cancer", Oral Oncol, 49(7), pp.702~706 (2013)[DOI]
- Ito Y, "Prognosis of patients with papillary carcinoma showing anaplastic transformation in regional lymph nodes that were curatively resected", Endocr J, 55(6), pp.985~989 (2008)[DOI]
- Park KC, "Synergistic Activity of N-hydroxy-7-(2-naphthylthio) Heptanomide and Sorafenib Against Cancer Stem Cells, Anaplastic Thyroid Cancer", Neoplasia, 19(3), pp.145~153 (2017)[DOI]
- Tahara M, "Lenvatinib for Anaplastic Thyroid Cancer", Front Oncol, 1(7), pp.25~ (2017)
- Baek SK, "Role of surgery in the management of anaplastic thyroid carcinoma: Korean nationwide multicenter study of 329 patients with anaplastic thyroid carcinoma, 2000 to 2012", Head Neck, 39(1), pp.133~139 (2017)[DOI]
- Smallridge RC, "Anaplastic thyroid cancer: molecular pathogenesis and emerging therapies", Endocr Relat Cancer, 16(1), pp.17~44 (2009)
- Ito Y, "Prognosis of patients with papillary thyroid carcinoma showing postoperative recurrence to the central neck", World J Surg, 35(4), pp.767~772 (2011)[DOI]
- Grant CS, "Local recurrence in papillary thyroid carcinoma: is extent of surgical resection important?", Surgery, 104(6), pp.954~962 (1988)
- Wang SG, "A Case of Papillary Thyroid Carcinoma with Anaplastic Transformation of Cervical Lymph Node Metastasis", J Clinical Otolaryngol, 15, pp.146~149 (2004)