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대표적인 구강 및 비강 세정제의 Coronavirus Disease 2019 (COVID-19) 적용 연구의 현황

Current Status of the Use of Oral and Nasal Antiseptics during the Coronavirus Disease 2019 (COVID-19) Pandemic

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초록

This report provides the available evidence of the use of mouthwash and nasal irrigation with antiseptics to in- activate or eradicate severe, acute respiratory syndrome coronavirus-2 (SARS-CoV-2). The oral cavity and nasal cavity are essential part of the upper airway tract, and are considered to play an important role in the pathoge- nicity and transmission of SARS-CoV-2. Angiotensin converting enzyme 2, cellular receptor for SARS-CoV-2, is found to highly expressed in the oral cavity and nasal cavity. Because there have been no approved treatment for coronavirus disease 2019 (COVID-19), considering mouthwash and nasal irrigation with the agents that can alleviate the viral load is an extremely simple and feasible strategy to prevent progression and transmission of COVID-19. Although sufficient in-vitro studies identified the efficacy of mouthwash and nasal irrigation, in-vivo evidence is still limited. Currently, there are many clinical trials to elucidate the efficacy of mouthwash and na- sal irrigation with variable agents. This effort will reduce the pathogenicity and the transmission of COVID-19 through the simple mouthwash and nasal irrigation.

Abstract

This report provides the available evidence of the use of mouthwash and nasal irrigation with antiseptics to in- activate or eradicate severe, acute respiratory syndrome coronavirus-2 (SARS-CoV-2). The oral cavity and nasal cavity are essential part of the upper airway tract, and are considered to play an important role in the pathoge- nicity and transmission of SARS-CoV-2. Angiotensin converting enzyme 2, cellular receptor for SARS-CoV-2, is found to highly expressed in the oral cavity and nasal cavity. Because there have been no approved treatment for coronavirus disease 2019 (COVID-19), considering mouthwash and nasal irrigation with the agents that can alleviate the viral load is an extremely simple and feasible strategy to prevent progression and transmission of COVID-19. Although sufficient in-vitro studies identified the efficacy of mouthwash and nasal irrigation, in-vivo evidence is still limited. Currently, there are many clinical trials to elucidate the efficacy of mouthwash and na- sal irrigation with variable agents. This effort will reduce the pathogenicity and the transmission of COVID-19 through the simple mouthwash and nasal irrigation.

참고문헌 (66)

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