성문하에 발생한 미분화성 다형성 육종 1예
A Case of Subglottic Undifferentiated Pleomorphic Sarcoma
0
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Undifferentiated pleomorphic sarcoma (UPS) is rare type of soft tissue sarcomas that occur in all parts of body but mostly in the extremities. Sixty -year-old woman presented dyspnea and stridor with benign looking subglottic mass on laryngoscope. Endoscopic laser surgery was performed and histopathology showed diffuse proliferation of pleomorphic plump and spindle cells with no particular orientation to vessels. In immunochemistry, the tumor cells were positive for vimentin, CD68, Ki-67 and negative for Melan A, leukocyte common antigen, CK, S-100, smooth muscle actin, CD1a, CD21, CD23, CD34, D2-40. The patient was finally diagnosed with UPS and underwent postoperative radiotherapy. She was followed for 1 year without recurrence and metastasis. We stress that if a benign looking subglottic mass is accompanied by dyspnea, the possibility of malignancy should be considered and UPS could be included in the differential diagnosis.
Abstract
Undifferentiated pleomorphic sarcoma (UPS) is rare type of soft tissue sarcomas that occur in all parts of body but mostly in the extremities. Sixty -year-old woman presented dyspnea and stridor with benign looking subglottic mass on laryngoscope. Endoscopic laser surgery was performed and histopathology showed diffuse proliferation of pleomorphic plump and spindle cells with no particular orientation to vessels. In immunochemistry, the tumor cells were positive for vimentin, CD68, Ki-67 and negative for Melan A, leukocyte common antigen, CK, S-100, smooth muscle actin, CD1a, CD21, CD23, CD34, D2-40. The patient was finally diagnosed with UPS and underwent postoperative radiotherapy. She was followed for 1 year without recurrence and metastasis. We stress that if a benign looking subglottic mass is accompanied by dyspnea, the possibility of malignancy should be considered and UPS could be included in the differential diagnosis.
참고문헌 (15)
- Ozzello L, "Cultural characteristics of malignant histiocytomas and fibrous xanthomas", Cancer, 16(3), pp.331~344 (1963)
- Aljabab A, "Head and neck soft tissue sarcoma", Indian J Surg Oncol, 2(4), pp.286~290 (2011)
- Scott KM, "Malignant fibrous histiocytoma of the larynx : case report and literature review", J Otolaryngol, 24(3), pp.198~200 (1995)
- Keenan JP, "Malignant fibrous histiocytoma of the larynx", Otolaryngol Head Neck Surg, 87(5), pp.599~603 (1979)
- Johnson JT, "Fibrous histiocytoma of the subglottic larynx", Ann Otol Rhinol Laryngol, 86(2), pp.243~246 (1977)
- Godoy J, "Malignant fibrous histiocytoma of the larynx", J Surg Oncol, 31(1), pp.62~65 (1986)
- Weiss SW, "Malignant fibrous histiocytoma : an analysis of 200 cases", Cancer, 41(6), pp.2250~2266 (1978)
- Bai Y, "Management of low-grade myofibroblastic sarcoma of the larynx", Ear Nose Throat J, 99(7), pp.NP82~NP83 (2020)
- Patel RR, "Undifferentiated pleomorphic sarcoma in a child with type 1 neurofibromatosis", Br J Dermatol, 163(2), pp.431~433 (2010)
- Landry JP, "Comparison of cancer prevalence in patients with neurofibromatosis type 1 at an academic cancer center vs in the general population from 1985 to 2020", JAMA Netw Open, 4(3), pp.e210945~ (2021)
- 한예은, "A Rare Case of Small Bowel Undifferentiated Pleomorphic Sarcoma: Imaging Findings on CT and Magnetic Resonance Enterography", 대한영상의학회지, 80(1), pp.122~128 (2019), 대한영상의학회[DOI]
- Nishio J, "Establishment of a new human pleomorphic malignant fibrous histiocytoma cell line, FUMFH-2 : molecular cytogenetic characterization by multicolor fluorescence in situ hybridization and comparative genomic hybridization", J Exp Clin Cancer Res, 29, pp.153~ (2010)
- Soh KB, "Malignant fibrous histiocytomas of the larynx--report of two cases", Ann Acad Med Singap, 25(6), pp.878~881 (1996)
- Kim JP, "A rare case of malignant fibrous histiocytoma(pleomorphic undifferentiated sarcoma NOS)of the vocal fold", Ear Nose Throat J, 94(7), pp.270~272 (2015)
- Vodanovich DA, "Predicting the prognosis of undifferentiated pleomorphic soft tissue sarcoma : a 20-year experience of 266 cases", ANZ J Surg, 89(9), pp.1045~1050 (2019)