입원중인 정신분열병 환자에서 비전형 및 전형 항정신병약물에 대한 주관적인 반응

Abstract

Objectives: Drug Attitude Inventory (DAI) was used to compare the subjective response to antipsychotics between schizophrenic inpatients receiving atypical and typical antipsychotic medications.Methods: Seventy three patients meeting selection criteria and receiving atypical (N=31) and typical antipsychotics (N=42) were examined. All of them were in the stabilized stage of their illnesses. Subjective response to neuroleptics was evaluated using 10-items of Drug Attitude Inventory (DAI-10). Demographic and clinical data were also analyzed between two groups.Results: Patients receiving typical antipsychotics had more adjuvant medications such as anticholinergics and more complained of the neuroleptic-induced side effects. They showed more dysphoric responses to the subjective responses to neuroleptics. Patients taking atypical antipsychotics showed significantly non-dysphoric responses on the items asking the negative aspects of medications and more subjective positive responses on the final scores. Conclusion: These results suggest that atypical antipsychotics influenced on the subjective positive responses to neuroleptics and neuroleptic-induced side effect affected the subjective negative feelings and attitude to antipsychotics.