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리스페리돈이나 올란자핀에서 지프라시돈으로 약물 교체한 정신분열병 환자의 주관적 삶의 질

Subjective Quality of Life in Patients with Schizophrenia Switched from Risperidone or Olanzapine to Ziprasidone

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주제분류정신과학

초록

Objectives:The purpose of this study is to assess the subjective quality of life in stable but symptomatic patients with schizophrenia switched from risperidone or olanzapine to ziprasidone. And we investigated how the subjective quality of life is related with depression, drug attitude, drug satisfaction and psychopathology of schizophrenia. Methods:Twenty-three schizophrenic patients in 3 hospitals were switched to an 8-week, open label, flexible dose(80-160mg/day) of ziprasidone. Psychiatric status was evaluated by Korean version of 4th Revision of Schizophrenia Quality of Life Scale(SQLS-R4K), Korean version of Calgary Depression Scale for Schizophrenia(KCDSS), Korean version of Drug Attitude Inventory(KDAI-10), Drug Satisfaction Questionaire (DSQ), Positive and Negative Syndrome Scale (PANSS), and Clinical Global Impression scale (CGI) at baseline, day 1, week 4 and week 8. Results:Subjective quality of life and depressive symptom were not improved significantly after switching to ziprasidone. Subjective quality of life was related significantly with depressive symptoms and drug attitude, but not drug satisfaction. Subjective quality of life correlated significantly with total scores and positive symptom scores in PANSS and CGI-S. Conclusion:This study suggests that the subjective quality of life of schizophrenia, who had treated by prior atypical antipsychotics, is not influenced significantly by switching to ziprasidone. Active management for depressive and positive symptoms, and drug side effect is recommended to improve patients' quality of life.

Abstract

Objectives:The purpose of this study is to assess the subjective quality of life in stable but symptomatic patients with schizophrenia switched from risperidone or olanzapine to ziprasidone. And we investigated how the subjective quality of life is related with depression, drug attitude, drug satisfaction and psychopathology of schizophrenia. Methods:Twenty-three schizophrenic patients in 3 hospitals were switched to an 8-week, open label, flexible dose(80-160mg/day) of ziprasidone. Psychiatric status was evaluated by Korean version of 4th Revision of Schizophrenia Quality of Life Scale(SQLS-R4K), Korean version of Calgary Depression Scale for Schizophrenia(KCDSS), Korean version of Drug Attitude Inventory(KDAI-10), Drug Satisfaction Questionaire (DSQ), Positive and Negative Syndrome Scale (PANSS), and Clinical Global Impression scale (CGI) at baseline, day 1, week 4 and week 8. Results:Subjective quality of life and depressive symptom were not improved significantly after switching to ziprasidone. Subjective quality of life was related significantly with depressive symptoms and drug attitude, but not drug satisfaction. Subjective quality of life correlated significantly with total scores and positive symptom scores in PANSS and CGI-S. Conclusion:This study suggests that the subjective quality of life of schizophrenia, who had treated by prior atypical antipsychotics, is not influenced significantly by switching to ziprasidone. Active management for depressive and positive symptoms, and drug side effect is recommended to improve patients' quality of life.

참고문헌 (35)

  1. Awad AG, "Subjective response to neuroleptics and the quality of life: implications for treatment outcome", Acta Psychiatr Scand Suppl, 380, pp.27~32 (1994)
  2. Norman RM, "The relationship of symptoms and level of functioning in schizophrenia to general wellbeing and the Quality of Life Scale", Acta Psychiatr Scand, 102, pp.303~309 (2000)
  3. Meyer JM, "Antipsychotic safety and efficacy concerns", J Clin Psychiatry, 68(14), pp.20~26 (2007)
  4. eier A, "Olanzapine versus ziprasidone: results of a 28-week double-blind study in patients with schizophrenia", Am J Psychiatry, 162, pp.1879~1887 (2005)
  5. Ballas C, "Ziprasidone: a novel psychotropic with unique properties", Expert Rev Neurother, 4, pp.179~186 (2004)
  6. Addington DE, "Efficacy and tolerability of ziprasidone versus risperidone in patients with acute exacerbation of schizophrenia or schizoaffective disorder: an 8-week, double-blind, multicenter trial", J Clin Psychiatry, 65, pp.1624~1633 (2004)
  7. Simpson GM, "Randomized, controlled, double-blind multicenter comparison of the efficacy and tolerability of ziprasidone and olanzapine in acutely ill inpatients with schizophrenia or schizoaffective disorder", Am J Psychiatry, 161, pp.1837~1847
  8. Weiden PJ, "Effectiveness of switching to ziprasidone for stable but symptomatic outpatients with schizophrenia", J Clin Psychiatry, 64, pp.580~588 (2003)
  9. Daniel DG, "Ziprasidone 80mg", day and 160mg, Neuropsychopharmacology, pp.1999, 20[DOI]
  10. Simpson GM, "Six-month, blinded, multicenter continuation study of ziprasidone versus olanzapine in schizophrenia", Am J Psychiatry, 162, pp.1535~1538 (2005)
  11. Rossi A, "Assessment of clinical and metabolic status, and subjective well-being, in schizophrenic patients switched from typical and atypical antipsychotics to ziprasidone", Int Clin Psychopharmacol, 23, pp.216~222 (2008)
  12. 이승재, "Ziprasidone의 자연적 임상경험에 대한 후향적 조사 연구 : 3개 대학병원의 경험", 신경정신의학, 46(3), pp.214~222 (2007), 대한신경정신의학회
  13. 이종훈, "리스페리돈(Risperidone)을 투약 중인 정신분열병 환자에서 지프라시돈(Ziprasidone)으로 교체 투약 시 보이는 임상적 및 대사적 이득에 대한 전향적 개방 연구", 생물치료정신의학, 15(1), pp.88~95 (2009), 대한생물치료정신의학회
  14. American Psychiatric A, American Psychiatric Association, "Task Force on D-I. Diagnostic and statistical manual of mental disorders: DSM-IV" (1994), American Psychiatric Association
  15. 김용구, "한국어판 정신분열병의 캘거리 우울증 척도의 신뢰도 및 타당도 연구", 신경정신의학, 44(4), pp.446~455 (2005), 대한신경정신의학회
  16. Kay SR, "The positive and negative syndrome scale(PANSS) for schizophrenia", Schizophr Bull, 13, pp.261~276 (1987)
  17. Guy W, "ECDEU Assessment Manual for psychopharmacology, revised" (1976), National Institute of Mental Health
  18. 김진훈, "한국어판 정신분열병 삶의 질 척도의 개발과 PANSS와의 관련성", 신경정신의학, 45(5), pp.401~410 (2006), 대한신경정신의학회
  19. 윤보현, "한국판 약물태도 척도의 심리측정적 특성", 대한정신약물학회지, 16(6), pp.480~487 (2005), 대한정신약물학회
  20. Baker F, "Quality of life in the evaluation of community support systems", Eval Program Plann, 5, pp.69~79 (1982)
  21. Kudla D, "Effectiveness, tolerability, and safety of ziprasidone in patients with schizophrenia or schizoaffective disorder: results of a multi-centre observational trial", Eur Psychiatry, 22, pp.195~202 (2007)
  22. Yen CF, "Quality of life and its association with insight, adverse effects of medication and use of atypical antipsychotics in patients with bipolar disorder and schizophrenia in remission", Bipolar Disord, 10, pp.617~624 (2008)
  23. 민성길, "안정화된 만성 정신분열병 환자에서 주관적 삶의 질에 미치는 Haloperidol과 Risperidone의 영향", 신경정신의학, 41(1), pp.76~83 (2002), 대한신경정신의학회
  24. Dickerson FB, "Subjective quality of life in out-patients with schizophrenia: clinical and utilization correlates", Acta Psychiatr Scand, 98, pp.124~127 (1998)
  25. Huppert JD, "Quality of life in schizophrenia: contributions of anxiety and depression", Schizophr Res, 51, pp.171~180 (2001)
  26. Yamauchi K, "Predictors of subjective and objective quality of life in outpatients with schizophrenia", Psychiatry Clin Neurosci, 62, pp.404~411 (2008)
  27. Tomotake M, "Subjective and objective measures of quality of life have different predictors for people with schizophrenia", Psychol Rep, 99, pp.477~487 (2006)
  28. Aki H, "Subjective and objective quality of life, levels of life skills, and their clinical determinants in outpatients with schizophrenia", Psychiatry Res, 158, pp.19~25 (2008)
  29. Awad AG, "A conceptual model of quality of life in schizophrenia: description and preliminary clinical validation", Qual Life Res, 6, pp.21~26 (1997)
  30. Silva de Lima M, "Quality of life in schizophrenia: a multicenter, randomized, naturalistic, controlled trial comparing olanzapine to first-generation antipsychotics", J Clin Psychiatry, 66, pp.831~838 (2005)
  31. Weiden P, "Atypical antipsychotic drugs and long-term outcome in schizophrenia", J Clin Psychiatry, 57(11), pp.53~60 (1996)
  32. Awad AG, "Intervention research in psychosis: issues related to the assessment of quality of life", Schizophr Bull, 26, pp.557~564 (2000)
  33. Brissos S, "Quality of life in bipolar type I disorder and schizophrenia in remission: clinical and neurocognitive correlates", Psychiatry Res, 160, pp.55~62 (2008)
  34. Fitzgerald PB, "Subject and observer-rated quality of life in schizophrenia", Acta Psychiatr Scand, 103, pp.387~392 (2001)
  35. Moller HJ, "Efficacy and safety of direct transition to risperidone long-acting injectable in patients treated with various antipsychotic therapies", Int Clin Psychopharmacol, 20, pp.121~130 (2005)

관련 논문AI추천

리스페리돈(Risperidone)을 투약 중인 정신분열병 환자에서 지프라시돈(Ziprasidone)으로 교체 투약 시 보이는 임상적 및 대사적 이득에 대한 전향적 개방 연구구본훈, 송진옥, 이광헌, 이승재, 이종훈, 정성원대한생물치료정신의학회 · 생물치료정신의학2009 · 제15권 제1호Amisulpride를 투여한 급성기 정신분열병 환자에서 주관적 삶의 질소교옥, 이종훈, 최태영대한생물치료정신의학회 · 생물치료정신의학2010 · 제16권 제1호체중증가 발생 가능성에 따른 항정신병약물 네 군 간의 정신분열병 환자의 주관적 삶의 질 비교 연구강권영, 강시현, 김경훈, 김권곤, 소민아, 안길준, 이가회, 이종일대한신경정신의학회 · 신경정신의학2011 · 제50권 제5호안정화된 만성 정신분열병 환자에서 주관적 삶의 질에 미치는 Haloperidol과 Risperidone의 영향김동기, 민성길, 박진균, 서신영대한신경정신의학회 · 신경정신의학2002 · 제41권 제1호비정형 항정신병약물을 투여 중인 정신분열병 환자의 주관적 삶의 질 : 정신병리, 약물 부작용 및 약물에 대한 주관적 반응과의 관련성강웅구, 김용식, 김종훈, 노경희, 윤세창, 윤정희, 이자영, 홍성극대한신경정신의학회 · 신경정신의학2003 · 제42권 제2호항정신병약물 사용 중인 정신분열병 환자에서 올란자핀으로의 교체 방법에 관한 연구(I)권용실, 권준수, 김용식, 민성호, 박두병, 소형석, 송종호, 신윤식, 안용민, 양문정, 우행원, 유범희, 이홍석, 정한용, 한창환대한신경정신의학회 · 신경정신의학2002 · 제41권 제5호

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