신경성 식욕부진증의 특징적인 신경인지기능 결함；예비연구
Neurocognitive Deficits of Anorexia Nervosa
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목적 : 최근 신경성 식욕부진증의 병태생리를이해하고, 치료에 대한 반응이나 예후를 예측하기 위해이 질환의 특징적 사고양상의 근간이 되는 인지적 특성에 대한 관심이 증대되고 있다. 본 연구에서는 신경성 식욕부진증에서 저하가 보고된 인지적 기능영역들이 여타 정신질환 들과 비교해서도 구별되는 독특한 인지적 결함인지를 찾고자 한다. 방법 : 전산화 신경인지검사를 통해 신경성 식욕부진증군에서 일반신경증 환자군에 비해 기호잇기검사 A 및 기호잇기검사 B의 수행 정도에 유의한 저하를 확인하였다. 결론 : 신경성 식욕부진증 환자들에서 여타 일반 신경증 환자들에 비해 주의력 및 인지적 도식변화 영역에서 기능이 저하되어 있는 것으로 나타났다
Abstract
Objectives：As the known neurocognitive impairments in anorexia nervosa(AN) are also reported to be found in other psychiatric disorders, it has been difficult to understand the pathognomonic neurocognitive features of AN. This study aims to find the distinguishing neurocognitive impairments of AN compared with other neurotic disorders. Methods：Based on our former study, a neuropsychological battery of tests composed of the trail making test (TMT) part A and part B, the visual span test(VST), and the finger tapping test(FTT) were administered to 32 women with AN and 13 patients with neurotic disorders or depressive disorders of comparable age, intelligence and education. Results：The AN group showed poor performance on the TMT part A and part B compared to the control group. There were no significant differences in the performance level of the VST reflecting the ability of visual/working memory and the FTT reflecting the ability of motor skills between groups. Conclusion：Our results suggest that dysfunction in attention and set-shifting ability may be the distinguishing features of AN compared with neurotic disorders or depressive disorders. The deficit in set-shifting ability is suggested to be proper in AN, which could apply to a customized treatment for AN. The results of the study are informative but require confirmation in a larger control group with specific diagnostic entities.
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