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경도인지장애와 알츠하이머병 환자에서 뇌량 크기의 비교

Comparison of Size of Corpus Callosum in Patients with Mild Cognitive Impairment and Alzheimer’ Disease

김재민|윤진상|신희영|김성완|양수진|신일선|송영헌
대한생물치료정신의학회 (Korean Society Of Biological Therapies In Psychiatry)|2010.12|생물치료정신의학 (Journal of the Korean Society of Biological Therapies in Psychiatry)|제16권 제2호|pp. 122-129

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참고문헌

키워드

뇌량·경도인지장애·알츠하이머병·자기공명영상Corpus callosum · Mild cognitive impairment · Alzheimer’s disease · Magnetic resonance imaging
주제분류정신과학

초록

목 적 : 뇌량(corpus callosum, 이하 CC)은 뇌의 양쪽 좌우반구를 연결하는 주요 연결부이다. 경도인지장애(mildcognitive impairment, 이하 MCI)와 알츠하이머병(Alzheimer’sdisease, 이하 AD) 환자에서 CC의 위축에대한 연구는 비교적 드물다. 본 연구는 AD와 MCI 환자에서 CC의 위축을 비교하고자 하였다. 방 법 : 41명의 MCI 환자와 34명의 AD 환자를 대상으로뇌자기공명영상을 이용하여 정중시상면에서 CC를 수기로 그려졌다. 반자동 소프트웨어인 Scion을 이용하여 측정하였다. CC의 원래 측정값을 뇌의 정중시상면에서구한 두개 내(intracranial) 면적으로 나누어 100을 곱하여 보정하였다. 결 과 : CC 전체면적이 AD 환자군이 MCI 환자군에 비해서유의하게 더 적었고, CC1, CC2, CC5 하부영역의 면적에서도 AD 환자군이 MCI 환자군에 비해서 유의하게더 적었다. 결 론 : AD 환자가 MCI 환자에 비해서 CC의 부리(rostrum)와 팽대부(splenium)에서 유의하게 위축되었다.

Abstract

Objectives：The corpus callosum(CC) is the major commissure connecting both cerebral hemispheres. Relatively few studies have explored atrophy of the CC in mild cognitive impairment(MCI) and Alzheimer’s disease(AD). This study aimed to compare the atrophy of MCI with that of AD. Methods：Fourty one subjects with MCI, 34 with AD were investigated using magnetic resonance imaging. In the midsagittal slice the CC was traced manually. Anatomical measurements were conducted on a PC workstation using the semi-automated software Scion Image for Windows Scion Corporation, INC. We used adjusted callosal measures(raw measures divided by midsagittal intracranial area, multiplied by 100) in all analyses. Results：Total callosal area was significantly reduced in patients with AD when compared with subjects with MCI. Comparison of the subregion of the CC showed significant smaller CC1, CC2 and CC5 in patients with AD relative to subjects with MCI. Conclusion：We found significant regional atrophy of the CC predominantly in the callosal rostrum and splenium in AD when compared with MCI.

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