경도인지장애와 알츠하이머병에서 삶의 질
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Background and Aims：Relatively few studies have explored the quality of life(QOL) in mild cognitive impairment (MCI) and Alzheimer’s disease(AD). This study aimed to compare the QOL in MCI with that in AD. Methods：24 normal controls, 29 mild MCI patients, 20 AD patients, and their caregivers participated. QOL was assessed using the Korean version of QOL-AD(KQOL-AD). Korean version-Mini Mental State Examination(K-MMSE), Activities of Daily Living(ADL), Clinical Dementia Rating(CDR), and Neuropsychiatric Inventory(NPI) were also used to assess the participants. Results：Both patient and caregiver-reported QOL scores of AD group were lower than those of MCI and control groups. However, there were no significant differences among the three groups in QOL(p=0.069, p=0.058). Patient-reported QOL scores of all participants showed were significant negative correlations with ADL scores and NPI scores, but not with K-MMSE scores(r=-0.316, p=0.009 ; r=-0.349, p=0.010 ; and r=0.094, p=0.430). Caregiver-reported QOL scores of all participants showed significant negative correlations with ADL scores and NPI scores, but not with K-MMSE scores(r=-0.369, p=0.015 ; r=-0.413, p=0.007 ; and r=0.147, p=0.341). Conclusion：Both patient-reported and caregiver-reported QOL scores of AD patients were not significantly different from those of MCI patients and normal controls. NPI and ADL scores were negatively associated with QOL, while K-MMSE scores were not. Thus, therapeutic strategies for behavioral and psychological symptoms of MCI and AD will be need to improve patient QOL.
Abstract
Background and Aims：Relatively few studies have explored the quality of life(QOL) in mild cognitive impairment (MCI) and Alzheimer’s disease(AD). This study aimed to compare the QOL in MCI with that in AD. Methods：24 normal controls, 29 mild MCI patients, 20 AD patients, and their caregivers participated. QOL was assessed using the Korean version of QOL-AD(KQOL-AD). Korean version-Mini Mental State Examination(K-MMSE), Activities of Daily Living(ADL), Clinical Dementia Rating(CDR), and Neuropsychiatric Inventory(NPI) were also used to assess the participants. Results：Both patient and caregiver-reported QOL scores of AD group were lower than those of MCI and control groups. However, there were no significant differences among the three groups in QOL(p=0.069, p=0.058). Patient-reported QOL scores of all participants showed were significant negative correlations with ADL scores and NPI scores, but not with K-MMSE scores(r=-0.316, p=0.009 ; r=-0.349, p=0.010 ; and r=0.094, p=0.430). Caregiver-reported QOL scores of all participants showed significant negative correlations with ADL scores and NPI scores, but not with K-MMSE scores(r=-0.369, p=0.015 ; r=-0.413, p=0.007 ; and r=0.147, p=0.341). Conclusion：Both patient-reported and caregiver-reported QOL scores of AD patients were not significantly different from those of MCI patients and normal controls. NPI and ADL scores were negatively associated with QOL, while K-MMSE scores were not. Thus, therapeutic strategies for behavioral and psychological symptoms of MCI and AD will be need to improve patient QOL.
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