갑상선장애 환자에서 불면증에 연관되는 인자
Factors Associated with Insomnia in Patient with Thyroid Disorder
0
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Objectives:The aims of this study were to know the frequency and clinical characteristics of insomnia, and related various factors to insomnia in patients diagnosed with thyroid disorders. Methods:For 90 patients with thyroid disorders, interviews were performed. The data were obtained from interviews from about history and assessment of insomnia and depression. Insomnia was evaluated using the Korean Version of the Insomnia Severity Index(ISI-K). According to the cutoff score of 15.5 on the ISI-K, subjects were divided into the group of thyroid patients with insomnia(n=21) and those without insomnia(n=69) at first, and then statistically analyzed. Results:1) Insomnia is found in 23.33% of patients with thyroid disorder. 2) Insomnia in patients with thyroid disorder had significantly more comorbidities of physical and psychiatric illnesses(p<0.005, respectively), more hyperthyroidism (p<0.01), higher T3(p<0.05), and longer than 60 minutes of sleep latency(p<0.001). 3) Among scores of the ISI-K,total scores(p<0.001), and scores for initial sleep(p<0.05), sleep satisfaction(p<0.005) and distress(p<0.05) were significantly higher in insomnia in patient with thyroid disorder. Conclusion:Insomnia is not rare among patients with thyroid disorder. According to the presence of insomnia, clinical characteristics including sleep quality as well as quantity seemed to be different.
Abstract
Objectives:The aims of this study were to know the frequency and clinical characteristics of insomnia, and related various factors to insomnia in patients diagnosed with thyroid disorders. Methods:For 90 patients with thyroid disorders, interviews were performed. The data were obtained from interviews from about history and assessment of insomnia and depression. Insomnia was evaluated using the Korean Version of the Insomnia Severity Index(ISI-K). According to the cutoff score of 15.5 on the ISI-K, subjects were divided into the group of thyroid patients with insomnia(n=21) and those without insomnia(n=69) at first, and then statistically analyzed. Results:1) Insomnia is found in 23.33% of patients with thyroid disorder. 2) Insomnia in patients with thyroid disorder had significantly more comorbidities of physical and psychiatric illnesses(p<0.005, respectively), more hyperthyroidism (p<0.01), higher T3(p<0.05), and longer than 60 minutes of sleep latency(p<0.001). 3) Among scores of the ISI-K,total scores(p<0.001), and scores for initial sleep(p<0.05), sleep satisfaction(p<0.005) and distress(p<0.05) were significantly higher in insomnia in patient with thyroid disorder. Conclusion:Insomnia is not rare among patients with thyroid disorder. According to the presence of insomnia, clinical characteristics including sleep quality as well as quantity seemed to be different.
참고문헌 (38)
- Walsh JK, "Clinical and socioeconomic correlates of insomnia", J Clin Psychiatry, 65(Suppl 8), pp.13~19 (2004)
- IsHak WW, "Quality of life in patients suffering from insomnia", Innov Clin Neurosci, 9, pp.13~26 (2012)
- Lo CM, "Prevalence and impacts of poor sleep on quality of life and associated factors of good sleepers in a sample of older Chinese adults", Health Qual Life Outcomes, 10, pp.72~ (2012)
- Ohayon MM, "Epidemiology of insomnia : what we know and what we still need to learn", Sleep Med Rev, 6, pp.97~111 (2002)
- Eastman CI, "Effect of thyroxine on sleep in the rat", Sleep, 2, pp.215~232 (1979)
- Gronfier C, "Ultradian rhythms in pituitary and adrenal hormones : their relations to sleep", Sleep Med Rev, 2, pp.17~29 (1998)
- Pereira JC Jr, "The role of thyroid hormone in sleep deprivation", Med Hypotheses, 82, pp.350~355 (2014)
- Xia L, "Alterations in hypothalamus-pituitary-adrenal", thyroid axes and gonadotropin-releasing hormone in the patients with primary insomnia: a clinical research, 2013, pp.8, e71065~
- Moffett SX, "Effects of acute microinjections of thyroid hormone to the preoptic region of hypothyroid adult male rats on sleep, motor activity and body temperature", Brain Res, 1516, pp.55~65 (2013)
- 조용원, "Validation of a Korean Version of the Insomnia Severity Index", Journal of Clinical Neurology, 10(3), pp.210~215 (2014), 대한신경과학회[DOI]
- Morin CM, "Insomnia: Psychological Assessment and Management", pp.61~79 (1993), Gilford Press
- Bastien CH, "Validation of the Insomnia Severity Index as an outcome measure for insomnia research", Sleep Med, 2, pp.297~307 (2001)
- 박광민, "코골이 및 수면무호흡증 환자에서 설문조사 간의 비교분석", 대한이비인후과학회지 두경부외과학, 50(10), pp.888~895 (2007), 대한이비인후과학회
- 이중서, "한국판 Hamilton 우울증 평가 척도의 신뢰도, 타당도 연구", 신경정신의학, 44(4), pp.456~465 (2005), 대한신경정신의학회
- Walsh JK, "Nighttime insomnia symptoms and perceived health in the America Insomnia Survey", Sleep, 34, pp.997~1011 (2011)
- Ohayon MM, "Prevalence of insomnia and associated factors in South Korea", J Psychosom Res, 53, pp.593~600 (2002)
- Buysse DJ, "Chronic insomnia", Am J Psychiatr, 165, pp.678~686 (2008)
- Kim BS, "DSM-IV psychiatric comorbidity according to symptoms of insomnia : a nationwide sample of Korean adults", Soc Psychiatry Psychiatr Epidemiol, 47, pp.2019~2033 (2012)
- Singareddy R, "Risk factors for incident chronic insomnia : a general population prospective study", Sleep Med, 13, pp.346~353 (2012)
- Ohayon MM, "What are the contributing factors for insomnia in the general population?", J Psychosom Res, 51, pp.745~755 (2001)
- Staner L., "Comorbidity of insomnia and depression", Sleep Med Rev, 14, pp.35~46 (2010)
- Stone KC, "Nonrestorative sleep", Sleep Med Rev, 12, pp.275~288 (2008)
- Zhang J, "Differentiating nonrestorative sleep from nocturnal insomnia symptoms: demographic, clinical, inflammatory, and functional correlates", Sleep, 36, pp.671~679 (2013)
- Budhiraja R, "Prevalence and polysomnographic correlates of insomnia comorbid with medical disorders", Sleep, 34, pp.859~867 (2011)
- Luo J, "Sleep disturbance and incidence of thyroid cancer in postmenopausal women : the Women’s Health Initiative", Am J Epidemiol, 177, pp.42~49 (2013)
- Bauer M, "The thyroidbrain interaction in thyroid disorders and mood disorders", J Neuroendocrinol, 20, pp.1101~1114 (2008)
- Shinno H, "Effect of levothyroxine on prolonged nocturnal sleep time and excessive daytime somnolence in patients with idiopathic hypersomnia", Sleep Med, 12, pp.578~583 (2011)
- Paramasivan V., "Prevalence of sleep abnormalities and their association among hypothyroid patients in Indian population", Sleep Med, 12(Suppl 1), pp.S74~ (2011)
- Krishnan PV, "Prevalence of sleep abnormalities and their association among hypothyroid patients in an Indian population", Sleep Med, 13, pp.1232~1237 (2012)
- Andersen ML, "Is thyroid screening of sleep clinic patients essential?", Sleep Med, 13, pp.1215~1216 (2012)
- Koehler C, "Short-term severe thyroid hormone deficiency does not influence sleep parameters", Sleep Breath, 17, pp.253~258 (2013)
- Akatsu H, "For The Osteoporotic Fractures in Men Mros Research Group. Association between thyroid function and objective and subjective sleep quality in older men: the Osteoporotic Fractures in Men(MrOs)", Endocr Pract, 20, pp.576~586 (2014)
- Schmid SM, "Partial sleep restriction modulates secretory activity of thyrotropic axis in healthy men", J Sleep Res, 22, pp.166~169 (2013)
- Kessler L, "Changes in serum TSH and free T4 during human sleep restriction", Sleep, 33, pp.1115~1118 (2010)
- Salin-Pascual RJ, "Differences in sleep variables, blood adenosine, and body temperature between hypothyroid and euthyroid rats before and after REM sleep deprivation", Sleep, 20, pp.957~962 (1997)
- Bergmann BM, "Rechtschaffen A. Sleep deprivation in the rat: XIX. effects of thyroxine administration", Sleep, 18, pp.317~324 (1995)
- James TD, "Effects of acute microinjections of the thyroid hormone derivative 3-iodothyronamine to the preoptic region of adult male rats on sleep, thermoregulation and motor activity", Horm Behav, 64, pp.81~88 (2013)
- Li J, "The prevalence of impaired glucose regulation in psychiatric patients with sleep disorders and its relationship with altered hypothalamopituitaryadrenal and hypothalamopituitary-thyroid axis activity", Sleep Med, 14, pp.662~667 (2013)
