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조현병 환자에서 아미설프라이드에 의한 체중증가와 도파민 D2 수용체 유전자다형성의(rs1800497) 연관성

The Relationship between the Amisulpride-Induced Weight Gain and the Dopamine D2 Receptor Genes Polymorphisms(rs1800497) in Schizophrenia Patients

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주제분류정신과학

초록

Objectives: The aim of this study is to evaluate the association between antipsychotics-induced weight gain and the polymorphisms in the dopamine receptor D2(DRD2) genes. Methods: We measured the weight and height of 125 schizophrenia patients before and after treatment. The genotyping for rs1800497 was performed using TaqMan single nucleotide polymorphism(SNP) genotyping assay. Results: There was a significant difference in the amisulpride-induced change of body mass index(BMI) according to the frequency of rs1800497 genotype. Conclusion: This is the first positive association study between DRD2 gene and the amisulpride induced weight gain in Korean schizophrenia patients. A larger scale research on more SNP of the DRD2 gene will make a progress in the study of amisulpride induced weight gain.

Abstract

Objectives: The aim of this study is to evaluate the association between antipsychotics-induced weight gain and the polymorphisms in the dopamine receptor D2(DRD2) genes. Methods: We measured the weight and height of 125 schizophrenia patients before and after treatment. The genotyping for rs1800497 was performed using TaqMan single nucleotide polymorphism(SNP) genotyping assay. Results: There was a significant difference in the amisulpride-induced change of body mass index(BMI) according to the frequency of rs1800497 genotype. Conclusion: This is the first positive association study between DRD2 gene and the amisulpride induced weight gain in Korean schizophrenia patients. A larger scale research on more SNP of the DRD2 gene will make a progress in the study of amisulpride induced weight gain.

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