혈장 염증 시토카인과 치매, 경도인지장애 진단의 연관성
The Association of Plasma Inflammatory Cytokines with Dementia and Mild Cognitive Impairment
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Objectives：The aim of this study was to investigate the association of plasma levels of inflammatory cytokines with dementia and mild cognitive impairment. Methods：We compared serum levels of tumor necrosis factor-alpha(TNF-alpha), interleukin-6(IL-6), and insulinlike growth factor-1(IGF-I) in patients with dementia(n=8), mild cognitive impairment(MCI, n=15) and normal elderly (n=14). The diagnosis of dementia was made by the Diagnostic Statistical Manual of Mental Disorders-4th edition (DSM-IV). MCI was diagnosed based on the criteria of the National Institute of Aging and Alzheimer Association(NIAAA) working group. Results：When compared with normal controls, the levels of TNF-alpha and IL-6 were increased and level of IGF-I was decreased in MCI and dementia. Higher levels of TNF-alpha and IL-6 and lower level of IGF-I were also associated with increased age. However, when adjusted for age, the association between diagnosis and TNF-alpha, Il-6 and IGF-I was not significant. Conclusion：The difference in plasma levels of inflammatory cytokines in dementia and MCI may be associated with aging.
Abstract
Objectives：The aim of this study was to investigate the association of plasma levels of inflammatory cytokines with dementia and mild cognitive impairment. Methods：We compared serum levels of tumor necrosis factor-alpha(TNF-alpha), interleukin-6(IL-6), and insulinlike growth factor-1(IGF-I) in patients with dementia(n=8), mild cognitive impairment(MCI, n=15) and normal elderly (n=14). The diagnosis of dementia was made by the Diagnostic Statistical Manual of Mental Disorders-4th edition (DSM-IV). MCI was diagnosed based on the criteria of the National Institute of Aging and Alzheimer Association(NIAAA) working group. Results：When compared with normal controls, the levels of TNF-alpha and IL-6 were increased and level of IGF-I was decreased in MCI and dementia. Higher levels of TNF-alpha and IL-6 and lower level of IGF-I were also associated with increased age. However, when adjusted for age, the association between diagnosis and TNF-alpha, Il-6 and IGF-I was not significant. Conclusion：The difference in plasma levels of inflammatory cytokines in dementia and MCI may be associated with aging.
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