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인간배아줄기세포를 이용한 췌장세포의 유도 분화 및 당뇨병의 세포치료

Directed Differentiation of Pancreatic Islets From Human Embryonic Stem Cells and Cell Therapy of Diabetes Mellitus

김종훈|심중현|김슬기|우동훈
한국발생생물학회 (The Korea Society Of Developmental Biology)|2007.09|발생과 생식 (DEVELOPMENT & REPRODUCTION)|제11권 제2호|pp. 67-78

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참고문헌

주제분류생물학

초록

최근 제 1형 당뇨병을 치료하기 위하여 인슐린-분비성 세포를 이식하는 세포대체요법이 새로운 치료법으로서 주목받고 있다. 그럼에도 불구하고 췌장세포 이식술은 이식원의 절대적인 부족으로 인해 광범위한 시행이 이루어지지 못하고 있는 실정이다. 무한증식과 전분화능을 보유하는 배아줄기세포는 이식할 β-세포의 부족을 해결할 수 있는 잠재적 세포공급원이 될 수 있을 것으로 기대된다. 본 종설에서는 인간배아줄기세포로부터 췌장 β-세포로의 유도분화방법에 관한 최근 동향을 살펴보고, 당뇨병 치료에 세포 이식술을 적용함에 있어 고려해야할 문제점 및 극복방안들을 소개하고자 한다.

Abstract

Replacement of insulin-producing cells represents an almost ideal treatment for patients with diabetes mellitus type 1. Transplantation of pancreatic islets of Langerhans is limited by the lack of donor organs. Therefore, generation of insulin-producing cells from human embryonic stem cells represents an attractive alternative. The present review summarizes the current knowledge on the differentiation of insulin-producing cells from human embryonic stem cells and their application to the cell therapy for treating diabetes mellitus.

참고문헌 (62)

  1. "Insulinotropic hormone glucagon-like peptide-1 differentiation of human pancreatic islet-derived progenitor cells into insulin-producing cells", 143, pp.3152~3161 (2002)
  2. "Insulin production by human embryonic stem cells", 50, pp.1691~1697 (2001)
  3. "Glucagon-like peptide-1 enhances production of insulin in insulin-producing cells derived from mouse embryonic stem cells", 186, pp.343~352 (2005)
  4. "Radiopaque alginate microcapsules for X-ray visualization and immunoprotection of cellular therapeutics", 5, pp.531~538 (2006)
  5. "Magnetic resonanace-guided, real-time targeted delivery and imaging of magnetocapsules immunoprotecting pancreatic islet cells", 13, pp.986~991 (2007)
  6. "Signals from the embryonic mouse pancreas induce differentiation of human embryonic stem cells into insulin-producing beta-cell-like cells", 54, pp.2867~2874 (2005)
  7. "Enrichment of neurons and neural precursors from human embryonic stem cells", 172, pp.383~397 (2001)
  8. "Engineering and material considerations in islet cell transplantation", 1, pp.103~127 (1999)
  9. "Efficient differentiation of human embryonic stem cells to definitive endoderm", 23, pp.1534~1541 (2005)
  10. "Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells", 24, pp.1392~1401 (2006)
  11. "Autonomous endodermal determination in Xenopus : regulation of expression of the pancreatic gene XIHbox8", 171, pp.240~251 (1995)
  12. "Artificial insulin release from differentiated embryonic stem cells", 53, pp.2603~2609 (2004)
  13. "Proinsulin in development : new roles for an ancient prohormone", 49, pp.1142~1150 (2006)
  14. "Growth inhibitors promote differentiation of insulin-producing tissue from embryonic stem cells", 99, pp.16105~16110 (2002)
  15. "Differentiation of human embryonic stem cells into embryoid bodies compromising the three embryonic germ layers", 6, pp.88~95 (2000)
  16. "Hematopoietic colony-forming cells derived from human embryonic stem cells", 98, pp.10716~10721 (2001)
  17. "Bone morphogenetic proteins induce germ cell differentiation from human embryonic stem cells", 15, pp.831~837 (2006)
  18. "The Wnt co-receptors Lrp5 and Lrp6 are essential for gastrulation in mice", 131, pp.2803~2815 (2004)
  19. "Committing embryonic stem cells to early endocrine pancreas in vitro", 22, pp.1205~1217 (2004)
  20. "Development of definitive endoderm from embryonic stem cells in culture", 131, pp.1651~1662 (2004)
  21. "Differentiation and isolation of hepatic-like cells from human embryonic stem cells", 72, pp.230~238 (2004)
  22. "Regulation of the pancreatic pro-endocrine gene neurogenin3. Diabetes 50 928-936", 50, pp.928~936 (2001)
  23. "Directed differentiation of rhesus monkey ES cells into pancreatic cell phenotypes", 16, pp.42~ (2004)
  24. "Endothelial cells derived from human embryonic stem cells", 99, pp.4391~4396 (2002)
  25. "Selective agenesis of the dorsal pancreas in mice lacking homeobox gene Hlxb9. Nat Genet 23", pp.67~70 (1999)
  26. "Genetic dissection of nodal function in patterning the mouse embryo", 128, pp.1831~1843 (2001)
  27. "From fertilization to gastrulation : axis formation in the mouse embryo", 11, pp.384~392 (2001)
  28. "Ultrastructural evidence for blood microvessels devoid of an endothelial cell lining in transplanted pancreatic islets", 146, pp.429~435 (1995)
  29. "Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets", 292, pp.1389~1394 (2001)
  30. "Regulated expression of pdx-1 promotes in vitro differentiation of insulin-producing cells from embryonic stem cells", 53, pp.1030~1037 (2004)
  31. "Analysis of insulin-producing cells during in vitro differentiation from feeder-free embryonic stem cells", 52, pp.1163~1168 (2003)
  32. "Vascular endothelial growth factor gene delivery for revascularization in transplanted human islets", 21, pp.15~25 (2004)
  33. "PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum", 122, pp.983~995 (1996)
  34. "Transplantation for type 1 diabetes whole organ pancreas and islet cells", 6, pp.473~478 (2006)
  35. "Requirement for LIM homeoboxgene Isl1 in motor neuron generation reveals a motor neuron-dependent step in interneuron differentiation", 84, pp.309~320 (1996)
  36. "Current challenges in human embryonic stem cell research directed differentiation and transplantation tolerance", 18, pp.347~351 (2004)
  37. "Insulin staining of ES cell progeny from insulin uptake", 299, pp.363~ (2003)
  38. "Neural progenitors from human embryonic stem cells", 19, pp.1134~1140 (2001)
  39. "Gastrula organiser and embryonic patterning in the mouse", 15, pp.543~554 (2004)
  40. "Bio-engineering inslulin-secreting cells from embryonic stem cells: a review of progress", 41, pp.384~391 (2003)
  41. "Differentiation of human embryonic stem cells into insulin-producing clusters", 22, pp.265~274 (2004)
  42. "Islet and stem cell transplantation for treating diabetes", 322, pp.29~32 (2001)
  43. "Directed differentiation of human embryonic stem cells towards a pancreatic cell fate", 50, pp.1228~1238 (2007)
  44. "Identification of insulin-producing cells derived from embryonic stem cells by zinc-chelating dithizone", 20, pp.284~292 (2002)
  45. "Mechanisms, mechanics and function of epithelial-mesenchymal transitions in early development", 120, pp.1351~1383 (2003)
  46. "Influence of VEGF on the viability of encapsulated pancreatic rat islets after transplantation in diabetic mice", 12, pp.627~635 (2003)
  47. "In-vitro differentiation of pancreatic beta-cells", 68, pp.205~219 (2001)
  48. "From stem cells to beta cells new strategies in cell therapy of diabetes mellitus", 44, pp.407~415 (2001)
  49. "The gene Pax4 is an essential regulator of pancreatic beta-cell development.", 18, pp.289~294 (2004)
  50. "Pax6 is required for differentiation of glucagon-producing alpha-cells in mouse pancreas", 387, pp.406~409 (1997)
  51. "Retinoic acid signaling is required for a critical early step in zebrafish pancreatic development", 12, pp.1215~1220 (2002)
  52. "Embryonic stem cell lines derived from human blastocysts", 282, pp.1145~1147 (1998)
  53. "Formation of the definitive endoderm in mouse is a smad2-dependent process", 127, pp.3079~3090 (2000)
  54. "The production and directed differentiation of human embryonic stem cells", pp.208~219 (2006)
  55. "Gene expression of VEGF and its receptors Flk-1", KDR and Flt-1 in cultured and transplanted rat islets, 2001, pp.71, 924~935
  56. "Cell fate decisions within the mouse organizer are governed by graded Nodal signals", 17, pp.1646~1662 (2003)
  57. "Early mouse endoderm is patterned by soluble factors from adjacent germ layers", 127, pp.1563~1572 (2000)
  58. "Characterization and enrichment of cardiomyocytes derived from human embryonic stem cells", 20, pp.501~508 (2002)
  59. "In vitro differentiation of transplantable neural precursors from human embryonic stem cells", 19, pp.1129~1133 (2001)
  60. "Multipotential nestin-positive stem cells isolated from adult pancreatic islets differentiate ex vivo into pancreatic endocrine, exocrine and hepatic phenotypes", 50, pp.521~533 (2001)
  61. "Differentiation of human embryonic stem cells to cardiomyocytes: role of coculture with visceral endoderm-like cells", 107, pp.2733~2740 (2003)
  62. "Mesendoderm. an ancient germ layer?", 105, pp.169~172 (2001)

관련 논문AI추천

Stem Cell Therapy for Type 1 Diabetes Mellitus유은경대한소아내분비학회 · Annals of Pediatric Endocrinology & Metabolism2012 · 제17권 제2호Recent advances in organoid culture for insulin production and diabetes therapy: methods and challenges김경석, 이수빈, 임경민, 전탁일, 조쌍구, 아브달아메드생화학분자생물학회 · BMB Reports2019 · 제52권 제5호줄기세포 치료의 연구 현황 및 최신 지견장성규, 최욱환대한산부인과학회 · Obstetrics & Gynecology Science2007 · 제50권 제4호SIRT1 Knockdown Enhances the Differentiation of Human Embryonic Stem Cells into Pancreatic β Cells서난희, 송화령, 한명관한국발생생물학회 · 발생과 생식2019 · 제23권 제4호췌도이식의 과거, 현재 및 미래김광원, 김재현대한내과학회 · 대한내과학회지2008 · 제75권 제3호Pancreas transplant in type 1 diabetes mellitus: the emerging role of islet cell transplantJain Rakhi, Kochar Inderpal Singh대한소아내분비학회 · Annals of Pediatric Endocrinology & Metabolism2021 · 제26권 제2호

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