본문 바로가기
KERD
논문KCI 등재

Potency of Melatonin in Living Beings

2

조회

0

다운로드

7

인용

0

참고문헌

키워드

주제분류생물학

초록

Living beings are surrounded by various changes exhibiting periodical rhythms in environment. The environmental changes are imprinted in organisms in various pattern. The phenomena are believed to match the external signal with organisms in order to increase their survival rate. The signals are categorized into circadian, seasonal, and annual cycles. Among the cycles, the circadian rhythm is regarded as the most important factor because its periodicity is in harmony with the levels of melatonin secreted from pineal gland. Melatonin is produced by the absence of light and its presence displays darkness. Melatonin plays various roles in creatures. Therefore, this review is to introduce the diverse potential ability of melatonin in manifold aspects in living organism.

Abstract

Living beings are surrounded by various changes exhibiting periodical rhythms in environment. The environmental changes are imprinted in organisms in various pattern. The phenomena are believed to match the external signal with organisms in order to increase their survival rate. The signals are categorized into circadian, seasonal, and annual cycles. Among the cycles, the circadian rhythm is regarded as the most important factor because its periodicity is in harmony with the levels of melatonin secreted from pineal gland. Melatonin is produced by the absence of light and its presence displays darkness. Melatonin plays various roles in creatures. Therefore, this review is to introduce the diverse potential ability of melatonin in manifold aspects in living organism.

참고문헌 (236)

  1. Abecia JA, "Effect of exogenous melatonin on the ovary, the embryo and the establishment of pregnancy in sheep", Dom Animal Reprod, 2, pp.399~404 (2008)
  2. Abecia JA, "The effect of melatonin on the secretion of progesterone in sheep and on the development of ovine embryos in vitro", Vet Res Commun, 26, pp.151~158 (2002)
  3. Acuña-Castroviejo D, "Interaction between calcium ionophore A-23187 and melatonin in the rat striatum", J Physiol Biochem, 53, pp.119~ (1997)
  4. Aldhous M, "Plasma concentrations of melatonin in man following oral absorption of different preparations", Br J Clin Pharmacol, 19, pp.517~521 (1985)
  5. Alesci S, "Major depression is associated with significant diurnal elevations in plasma interleukin-6 levels, a shift of its circadian rhythm, and loss of physiological complexity in its secretion: clinical implications", J Clin Endocrinol Metab, 90, pp.2522~2530 (2005)
  6. Anisimov VN, "Melatonin increases both life span and tumor incidence in female CBA mice", J Gerontol, 56, pp.B311~B323 (2001)
  7. Antoniadis EA, "Circadian rhythms, aging and memory", Behav Brain Res, 111, pp.25~37 (2000)
  8. Arangino S, "Effects of melatonin on vascular reactivity, catecholamine levels and blood pressure in healthy men", Am J Cardiol, 83, pp.1417~1419 (1999)
  9. Arendt J, "Melatonin: characteristics, concerns and prospects", J Biol Rhythms, 20, pp.291~303 (2005)
  10. Arendt J, "Melatonin and human rhythms", Chronobiol Int, 23, pp.21~37 (2006)
  11. Arendt J, "Light and melatonin as Zeitgebers in man", Chronobiol Int, 4, pp.273~282 (1987)
  12. Bangha E, "Suppression of UV-induced erythema by topical treatment with melatonin (N-acetyl-5-methoxytryptamine). Influence of the application time point", Dermatology, 195, pp.248~252 (1997)
  13. Barrett P, "Sensitization: a mechanism for melatonin action in the pars tuberalis", J Neuroendocrinol, 15, pp.415~421 (2003)
  14. Baskett JJ, "Melatonin in older people with agerelated sleep maintenance problems: a comparison with age matched normal sleepers", Sleep, 24, pp.418~424 (2001)
  15. Bazil CW, "Patients with intractable epilepsy have low melatonin, which increases following seizures", Neurology, 55, pp.1746~1748 (2000)
  16. Beck-Friis J, "Serum melatonin in relation to clinical variables in patients with major depressive disorder and a hypothesis of a low melatonin syndrome", Acta Psychiatr Scand, 71, pp.319~330 (1985)
  17. Bertuglia S, "Melatonin reduces ventricular arrhythmias and preserves capillary perfusion during ischemia-reperfusion events in cardiomyopathetic hamsters", J Pineal Res, 42, pp.55~63 (2007)
  18. Beversdorf DQ, "Increased discrimination of “false memories” in autism spectrum disorder", Proc Natl Acad Sci USA, 97, pp.8734~8737 (2000)
  19. Bob P, "Melatonin, consciousness, and traumatic stress", J Pineal Res, 44, pp.341~347 (2008)
  20. Boivin DB, "Circadian adaptation to night-shift work by judicious light and darkness exposure", J Biol Rhythms, 17, pp.556~567 (2002)
  21. Bomman MS, "Melatonin and sperm motility", Andrologia, 21, pp.483~485 (1989)
  22. Bouhuys AL, "Potential psychosocial mechanisms linking depression to immune function in elderly subjects", Psychiatry Res, 127, pp.237~245 (2004)
  23. Brown R, "Differences in nocturnal melatonin secretion between melancholic depressed patients and control subjects", Am J Psychiatry, 142, pp.811~816 (1985)
  24. Brunner P, "Pineal and cortical melatonin receptors MT1 and MT2 are decreased in Alzheimer’s disease", Eur J Histochem, 50, pp.311~316 (2006)
  25. Brusco LI, "Monozygotic twins with Alzheimer's disease treated with melatonin: case report", J Pineal Res, 25, pp.260~263 (1998)
  26. Brzezinski A, "Melatonin in humans", N Engl J Med, 336, pp.186~195 (1997)
  27. Brzezinski A, "Melatonin in human preovulatory follicular fluid", J Clin Endocrinol Metab, 64, pp.865~867 (1987)
  28. Bubenik GA, "Gastrointestinal melatonin: localization, function, and clinical relevance", Dig Dis Sci, 47, pp.2336~2348 (2002)
  29. Bubenik GA, "Melatonin and aging: prospects for human treatment", J Physiol Pharmacol, 62, pp.13~19 (2011)
  30. Burgess HJ, "Bright light, dark and melatonin can promote circadian adaptation in night shift workers", Sleep Med Rev, 6, pp.407~420 (2002)
  31. Cagnacci A, "Influences of melatonin administration on the circulation of women", Am J Physiol, 274(2 Pt 2), pp.R335~R338 (1998)
  32. Cahill GM, "Circadian regulation of melatonin production in cultured zebra fish pineal and retina", Brain Res, 708, pp.177~181 (1996)
  33. Cardinali DP, "Clinical aspects of melatonin intervention in Alzheimer's disease progression", Curr Neuropharmacol, 8, pp.218~227 (2010)
  34. Carrillo-Vico A, "Evidence of melatonin synthesis by human lymphocytes and its physiological significance: possible role as intracrine, autocrine, and", or paracrine substance, 2004, pp.18, 537~539
  35. Carter DS, "Antigonadal effects of timed melatonin infusion in pinealectomized male Djungarian hamsters (Phodopus sungorus sungorus): duration is the critical parameter", Endocrinology, 113, pp.1268~1273 (1983)
  36. Castillo MR, "Circadian rhythm of core body temperature in two laboratory mouse lines", Physiol Behav, 86, pp.538~545 (2005)
  37. Chaudhury D, "Circadian modulation of learning and memory in fear-conditioned mice", Behav Brain Res, 133, pp.95~108 (2002)
  38. Chemineau P, "Seasonality of reproduction in mammals: intimate mechanisms and practical applications", Reprod Domest Anim, 43(suppl 2), pp.40~47 (2008)
  39. Choi D, "Reproductive physiology of pineal hormone melatonin", Korean J Zool, 39, pp.337~351 (1996)
  40. 최돈찬, "Continuous Melatonin Attenuates the Regressing Activities of Short Photoperiod in Male Golden Hamsters", 발생과 생식, 17(2), pp.111~119 (2013), 한국발생생물학회
  41. Choi D, "A study for the expression of melatonin receptor in golden hamsters exposed to photoperiod", Dev Reprod, 6, pp.45~54 (2002)
  42. 최돈찬, "Neuroendocrine System in Seasonal Breeder: Focusing on the Reproductive Activity of Male Golden Hamster", 발생과 생식, 16(1), pp.1~8 (2012), 한국발생생물학회[DOI]
  43. Choi J, "Anti-apoptotic effect of melatonin on porcine parthenogenic embryos", Mol Reprod Dev, 75, pp.1127~1135 (2008)
  44. Claustrat B, "Melatonin and jet lag: confirmatory result using a simplified protocol", Biol Psychiatry, 32, pp.705~711 (1992)
  45. Coelho LA, "Annual pattern of plasma melatonin and progesterone concentrations in hair and wool ewe lambs kept under natural photoperiod at lower latitudes in the southern hemisphere", J Pineal Res, 41, pp.101~107 (2006)
  46. Collins DR, "Melatonin blocks the induction of long-term potentiation in an N-methyl-Daspartate independent manner", Brain Res, 767, pp.162~165 (1997)
  47. Conti A, "Evidence for melatonin synthesis in mouse and human bone marrow cells", J Pineal Res, 28, pp.193~202 (2000)
  48. Cowen PJ, "Plasma melatonin during desmethylimipramine treatment: evidence for changes in noradrenergic transmission", Br J Clin Pharmacol, 19, pp.799~805 (1985)
  49. Cuspidi C, "Cardiovascular target organ damage in essential hypertensives with or without reproducible nocturnal fall in blood pressure", J Hypertens, 22, pp.273~280 (2004)
  50. Czeisler CA, "Stability, precision, and near-24-hour period of the human circadian pacemaker", Science, 284, pp.2177~2181 (1999)
  51. Daan S, "Scheduled exposure to daylight: a potential strategy to reduce “jet lag” following transmeridian flight", Psychopharmacol Bull, 20, pp.566~568 (1984)
  52. Danner M, "Association between depression and elevated C-reactive protein", Psychosom Med, 65, pp.347~356 (2003)
  53. Dardente H, "RF amide-related peptide and its cognate receptor in the sheep: cDNA cloning, mRNA distribution in the hypothalamus and the effect of photoperiod", J Neuroendocrinol, 20, pp.1252~1259 (2008)
  54. Detanico BC, "Antidepressantlike effects of melatonin in the mouse chronic mild stress model", Eur J Pharmacol, 607, pp.121~125 (2009)
  55. Devan BD, "Circadian phase-shifted rats shown or malacquisition but impaired long-term retention of place information in the water task", Neurobiol Learn Mem, 75, pp.51~62 (2001)
  56. Dominguez-Rodriguez A, "Elevated levels of oxidized low-density lipoprotein and impaired nocturnal synthesis of melatonin in patients with myocardial infarction", Atherosclerosis, 180, pp.101~105 (2005)
  57. Dominguez-Rodriguez A, "A unicenter, randomized, double-blind, parallel group, placebo-controlled study of melatonin as an adjunct in patients with acute myocardial infarction undergoing primary angioplasty -The Melatonin Adjunct in the acute myocaRdial Infarction treated with Angioplasty (MARIA) trial: study design and rationale", Contemp Clin Trials, 28, pp.532~539 (2007)
  58. Dominguez-Rodriguez A, "Usefulness of intraplatelet melatonin levels to predict angiographic no-reflow after primary percutaneous coronary intervention in patients with ST-segment elevation myocardial infarction", Am J Cardiol, 106, pp.1540~1544 (2010)
  59. Dominguez-Rodriguez A, "Melatonin and cardiovascular disease: Myth or reality?", Rev Esp Cardiol, 65, pp.215~218 (2012)
  60. Dominguez-Rodriguez A, "Melatonin and circadian biology in human cardiovascular disease", J Pineal Res, 49, pp.14~22 (2010)
  61. Dupre SM, "Identification of melatonin regulated genes in the ovine pars tuberalis, a target site for seasonal hormonal control", Endocrinology, 149, pp.5527~5539 (2008)
  62. Eastman CI, "Advancing circadian rhythms before eastward flight: a strategy to prevent or reduce jet lag", Sleep, 28, pp.33~44 (2005)
  63. Elliott JA, "Circadian rhythms and photoperiodic time measurement in mammals", Fed Proc, 35, pp.2339~2346 (1976)
  64. Finocchiaro LM, "Melatonin biosynthesis and metabolism in peripheral blood mononuclear leukocytes", Biochem J, 280, pp.727~731 (1991)
  65. Fischer TW, "Melatonin increases anagen hair rate in women with androgenetic alopecia or diffuse alopecia: results of a pilot randomized controlled trial", Br J Dermatol, 150, pp.341~345 (2004)
  66. Fischer TW, "Melatonin and the hair follicle", J Pineal Res, 44, pp.1~15 (2008)
  67. Fischer TW, "Melatonin as a major skin protectant: from free radical scavenging to DNA damage", Exp Dermatol, 17, pp.713~730 (2008)
  68. Forcada F, "The effect of melatonin implants during the seasonal anestrous on embryo production after superovulation in aged highprolificacy Rasa Aragonesa ewes", Theriogenology, 65, pp.356~365 (2006)
  69. Fujinoki M, "Melatonin-enhanced hyperactivation of hamster sperm", Reproduction, 136, pp.533~541 (2008)
  70. Fulia F, "Increased levels of malondialdehyde and nitrite", nitrate in the blood of asphyxiated newborns: reduction by melatonin, 2001, pp.31, 343~349
  71. Galecki P, "Single-nucleotide polymorphisms and mRNA expression for melatonin synthesis rate-limiting enzyme in recurrent depressive disorder", J Pineal Res, 48, pp.311~317 (2010)
  72. Gaston S, "Pineal function: the biological clock in the sparrow?", Science, 160, pp.1125~1127 (1968)
  73. Gaudet SJ, "Identification and characterization of two isozymic forms of arylamine N-acetyltransferase in Syrian hamster skin", J Invest Dermatol, 101, pp.660~665 (1993)
  74. Germain A, "Circadian rhythm disturbances in depression", Hum Psychopharmacol, 23, pp.571~585 (2008)
  75. Gerstner JR, "Cycling behavior and memory formation", J Neurosci, 29, pp.12824~12830 (2009)
  76. Golden RN, "The efficacy of light therapy in the treatment of mood disorders: a review and meta-analysis of the evidence", Am J Psychiatry, 162, pp.656~662 (2011)
  77. Grossman E, "Effect of melatonin on nocturnal blood pressure: meta-analysis of randomized controlled trials", Vascular Health and Risk Management, 7, pp.577~584 (2011)
  78. Guerrero M, "Physiological levels of melatonin contribute to the antioxidant capacity of human serum", J Pineal Res, 27, pp.59~64 (1999)
  79. Guillaume JL, "The PDZ protein MUPP1 promotes Gi coupling and signaling of the MT1 melatonin receptor", J Biol Chem, 283, pp.16762~16771 (2008)
  80. Gupta M, "Add-on melatonin improves quality of life in epileptic children on valproate monotherapy: a randomized, double-blind, placebocontrolled trial", Epilepsy Behav, 5, pp.316~321 (2004)
  81. Hardeland R, "Antioxidative protection by melatonin: multiplicity of mechanisms from radical detoxification to radical avoidance", Endocrine, 27, pp.119~130 (2005)
  82. Harding CF, "Hormonal specificity and activation of sexual behaviors in male zebra finches", Horm Behav, 17, pp.111~133 (1983)
  83. Haresign W, "Manipulation of reproduction in sheep", J Reprod Fertil (Suppl), 45, pp.127~139 (1992)
  84. Haresign W, "The effect of melatonin implants on breeding activity and litter size in commercial sheep flocks in the UK", Anim Product, 50, pp.111~121 (1990)
  85. Hartley RC, "Are carotenoids a red herring in sexual display?", Trends Ecol Evol, 19, pp.353~354 (2004)
  86. Hatter S, "Melanopsin containing ganglion cells: architecture, projections, and intrinsic photosensitivity", Science, 295, pp.1065~1070 (2002)
  87. Hoffman RA, "Influence of compensatory mechanisms and the pineal upon light-induced gonadal atrophy in hamsters", Nature, 207, pp.658~659 (1965)
  88. Hoffman RA, "Pineal gland: influence on gonads of male hamsters", Science, 148, pp.1609~1611 (1965)
  89. Hogan MV, "The modulation of neuronal activity by melatonin: in vitro studies on mouse hippocampal slices", J Pineal Res, 30, pp.87~96 (2001)
  90. Hojo Y, "Autonomic nervous system activity in essential hypertension: A comparison between dippers and non-dippers", J Hum Hypertens, 11, pp.665~671 (1997)
  91. Huether G, "The contribution of extrapineal sites of circulating melatonin levels in higher vertebrates", Experientia, 49, pp.665~670 (1994)
  92. Hughes RJ, "The role of melatonin and circadian phase in age- related sleepmaintenance insomnia: assessment in a clinical trial of melatonin replacement", Sleep, 21, pp.52~68 (1998)
  93. Hurd MW, "Circadian rhythms of locomotor activity in zebra fish", Physiol Behav, 65, pp.465~472 (1998)
  94. Ibraheem M, "Growth of secondary hair follicle of the Cashmere goat in vitro and their response to prolactin and melatonin", J Anat, 185, pp.135~142 (1994)
  95. Illnerova H, "Melatonin rhythm in human milk", J Clin Endocrinol Metab, 77, pp.838~841 (1993)
  96. Itoh MT, "Melatonin, its precursors, and synthesizing enzyme activities in the human ovary", Mol Hum Reprod, 5, pp.402~408 (1999)
  97. Itoh MT, "Detection of melatonin and serotonin N-acetyltransferase and hydroxyindole-O-methyltransferase activities in rat ovary", Mol Cell Endocrinol, 136, pp.7~13 (1997)
  98. Iyengar B, "Melatonin and melanocyte functions", Biol Signals Recept, 9, pp.260~266 (2000)
  99. James M, "Can melatonin improve adaptation to night shift?", Am J Emerg Med, 16, pp.367~370 (1998)
  100. Jansen R, "Melatonin affects the temporal organization of the song of the zebra finch", FASEB J, 19, pp.848~850 (2005)
  101. Johnston B, "Role of prolactin in regulating the onset of winter fur growth in mink (Mustela vison): A reconsideration", J Exp Zool, 284, pp.437~444 (1999)
  102. Johnston JD, "Gonadotrophin-releasing hormone drives melatonin down-regulation in the developing pituitary gland", Proc Natl Acad Sci USA, 100, pp.2831~2835 (2003)
  103. Kabuto H, "Melatonin inhibits iron induced epileptic discharges in rats by suppressing preoxidation", Epilepsia, 39, pp.237~243 (1998)
  104. Kang JT, "Effects of melatonin on in vitro maturation of porcine oocyte and expression of melatonin receptor RNA in cumulus and granulosa cells", Journal of Pineal Research, 46(1), pp.22~28 (2009), Blackwell Publishing Inc.
  105. Kim SH, "Cytoprotective effects of melatonin against necrosis and apoptosis induced by ischemiareperfusion injury in rat liver", J Pineal Res, 44, pp.165~171 (2008)
  106. Kobayashi H, "A role of melatonin in neuroectodermal-mesodermal interactions: the hair follicle synthesized melatonin and expresses functional melatonin receptors", The FASEB J, 19, pp.1710~1712 (2005)
  107. Kolla BP, "Jet lag and shift work sleep disorders: How to help reset the internal clock", Cleveland Clinic J Med, 78, pp.675~684 (2011)
  108. Korkmaz A, "Hyperglycemia-related pathophysiologic mechanisms and potential beneficial actions of melatonin", Mini Rev Med Chem, 8, pp.1144~1153 (2008)
  109. Kostovski E, "Melatonin stimulates release of tissue factor pathway inhibitor from the vascular endothelium", Blood Coagul Fibrinolysis, 22, pp.254~259 (2011)
  110. Kurcer Z, "Melatonin protects from ischemia", reperfusion-induced renal injury in rats: this effect is not mediated by proinflammatory cytokines, 2007, pp.43, 172~178
  111. Kvetnoy IM, "Extrapineal melatonin: location and role within diffuse neuroendocrine system", Histochem J, 31, pp.1~12 (1999)
  112. Lam RW, "Pathophysiology of seasonal affective disorder: a review", J Psychiatry Neurosci, 25, pp.469~480 (2000)
  113. Larson J, "Impaired hippocampal long-term potentiation in melatonin MT2 receptordeficient mice", Neurosci Lett, 393, pp.23~26 (2006)
  114. Lehman MN, "Neural plasticity and seasonal reproduction in sheep", Eur J Neurosci, 32, pp.2152~2164 (2010)
  115. Lerner AB, "Isolation of melatonin, the pineal gland factor that lightens melanocytes", J Am Chem Soc, 80, pp.2587~ (1958)
  116. Linkowski P, "ACTH, cortisol and growth hormone 24-hour profiles in major depressive illness", Acta Psychiatr Belg, 85, pp.615~623 (1985)
  117. Logan A, "Post-tyrosinase inhibition of melanogenesis by melatonin in hair follicles in vitro", J Invest Dermatol, 74, pp.47~50 (1980)
  118. Lusardi P, "Cardiovascular effects of melatonin in hypertensive patients well controlled by nifedipine: A 24-hour study", Clin Pharmacol, 49, pp.423~427 (2000)
  119. Lusardi P, "Effect of bedtime melatonin ingestion on blood pressure of normotensive subjects", Blood Press Monit, 2, pp.99~103 (1997)
  120. Lyons LC, "Circadian modulation of complex learning in diurnal and nocturnal Aplysia", Proc Natl Acad Sci USA, 102, pp.12589~12594 (2005)
  121. Maestroni GJ, "Role of the pineal gland in immunity. Circadian synthesis andrelease of melatonin modulates the antibody response and antagonizes the immunosuppressive effect of corticosterone", J Neuroimmunol, 13, pp.19~30 (1986)
  122. Manjunatha B, "Effect of taurine and melatonin in the culture medium on buffalo in vitro embryo development", Reprod Domest Anim, 44, pp.12~16 (2009)
  123. Martin XD, "The ciliary body-the third organ found to synthesize indoleamines in humans", Eur J Ophthalmol, 2, pp.67~72 (1992)
  124. Masoro ED, "Retardation of aging processes by nutritional means. Physiopathological processes of aging", Ann NY Acad Sci, 673, pp.29~35 (1992)
  125. Mayo JC, "Anti-inflammatory action of melatonin and its metabolites, N-acetyl-Nformyl- 5-methoxykynuramine (AFMK) and N-acetyl- 5-methoxykynuramine (AMK) in macrophages", J Neuroimmunol, 165, pp.139~149 (2005)
  126. Melke J, "Abnormal melatonin synthesis in autism spectrum disorders", Mol Psychiatry, 13, pp.90~98 (2008)
  127. Menendez-Pelaez A, "Nuclear localization of melatonin in different mammalian tissues: immunocytochemical and radioimmunoassay evidence", J Cell Biochem, 53, pp.373~382 (1993)
  128. Molina-Carballo A, "Utility of high doses of melatonin as adjunctive anticonvulsant therapy in a child with severe myoclonic epilepsy: two years experience", J Pineal Res, 23, pp.97~105 (1997)
  129. Moline ML, "Age-related differences in recovery from simulated jet lag", Sleep, 15, pp.28~40 (1992)
  130. Moore RY, "Neural control of pineal function in mammals and birds", J Neural Transm (Suppl), 13, pp.47~58 (1978)
  131. Moore RY, "The retinohypothalamic tract originates from a distinct subset of retinal ganglion cells", J Comp Neurol, 352, pp.351~366 (1995)
  132. Muhm JM, "Effect of aircraft-cabin altitude on passenger discomfort", N Engl J Med, 357, pp.18~27 (2007)
  133. Muñoz-Hoyos A, "Comparison between tryptophan methoxyindole and kynurenine metabolic pathways in normal and preterm neonates and in neonates with acute fetal distress", Eur J Endocrinol, 139, pp.89~95 (1998)
  134. Musselman DL, "Paroxetine for the prevention of depression induced by high-dose interferon alfa", N Engl J Med, 344, pp.961~966 (2001)
  135. Naji L, "Expression of membrane and nuclear melatonin receptors in mouse peripheral organs", Life Sci, 74, pp.2227~2236 (2004)
  136. Nakamura Y, "Increased endogenous level of melatonin in preovulatory human follicles does not directly influence progesterone production", Fertil Steril, 80, pp.1012~1016 (2003)
  137. Nickel A, "Melatonin protects human keratinocytes from UVB irradiation by light absorption", Arch Dermatol Res, 292, pp.366~368 (2000)
  138. Nixon AJ, "Seasonal fiber growth cycles of ferrets (Mustela putorius furo) and long-term effects of melatonin treatment", J Exp Zool, 272, pp.435~445 (1995)
  139. Nixon AJ, "Fiber growth initiation in hair follicles of goats treated with melatonin", J Exp Zool, 267, pp.47~56 (1993)
  140. Owen BM, "Raised levels of plasma interleukin-1 beta in major and postviral depression", Acta Psychiatr Scand, 103, pp.226~228 (2001)
  141. Palazidou E, "Noradrenaline uptake inhibition increases melatonin secretion, a measure of noradrenergic neurotransmission, in depressed patients", Psychol Med, 22, pp.309~315 (1992)
  142. Pandi-Perumal SR, "Melatonin. Nature’s most versatile biological signal?", FEBS J, 273, pp.2813~2836 (2006)
  143. Pandi-Perumal SR, "Melatonin and sleep in aging population", Exp Gerontol, 40, pp.911~925 (2005)
  144. Paparrigopoulos T, "Melatonin response to atenolol administration in depression: indication of betaadrenoceptor dysfunction in a subtype of depression", Acta Psychiatr Scand, 106, pp.440~445 (2002)
  145. Pappola MA, "Melatonin prevents death of neuroblastoma cells exposed to the Alzheimer amyloid peptide", J Neurosci, 17, pp.1683~1690 (1997)
  146. Pariante CM, "The proinflammatory cytokine, interleukin-1 alpha, reduces glucocorticoid receptor translocation and function", Endocrinology, 140, pp.4359~4366 (1999)
  147. Parry BL, "Plasma melatonin circadian rhythm disturbances during pregnancy and postpartum in depressed women and women with personal or family histories of depression", Am J Psychiatry, 165, pp.1551~1558 (2008)
  148. Peled N, "Melatonin effect on seizures in children with severe neurologic deficit disorders", Epilepsia, 42, pp.1208~1210 (2001)
  149. Petrie K, "A double-blind trial of melatonin as a treatment for jet lag in international cabin crew", Biol Psychiatry, 33, pp.526~530 (1993)
  150. Peyrot F, "Potential role of tryptophan derivatives in stress responses characterized by the generation of reactive oxygen and nitrogen species", J Pineal Res, 45, pp.235~246 (2008)
  151. Pickering TG, "The clinical significance of diurnal blood pressure variations. Dippers and nondippers", Circulation, 81, pp.700~702 (1990)
  152. Pieri C, "Melatonin: a peroxyl radical scavenger more effective than vitamin E", Life Sciences, 55, pp.271~276 (1994)
  153. Pierpaoli W, "The pineal aging and death program. I. Grafting of old age pineals in young mice accelerates their aging", J Antiaging Med, 4, pp.31~37 (2001)
  154. Pierpaoli W, "Melatonin: a principal neuroimmunoregulatory and anti-stress hormone: its antiaging effects", Immunol Lett, 16, pp.355~362 (1987)
  155. Pierpaoli W, "Pineal control of aging: effect of melatonin and pineal grafting on aging mice", Proc Nat Acad Sci USA, 94, pp.787~791 (1994)
  156. Pilorz V, "Age and oestrus cycle-related changes in glucocorticoid excretion and wheel-running activity in female mice carrying mutations in the circadian clock genes Per1 and Per2", Physiol Behav, 96, pp.57~63 (2009)
  157. Poeggeler B, "Melatonin, aging, and age-related diseases. Perspectives for prevention, intervention and therapy", Endocrine, 27, pp.201~212 (2005)
  158. Poirel VJ, "MT1 melatonin receptor mRNA tissular localization by PCR amplification", Neuroendocrinol Lett, 24, pp.33~38 (2003)
  159. Qiu X, "Induction of photosensitivity by heterologous expression of melanopsin", Nature, 433, pp.745~749 (2005)
  160. Raikhlin NT, "Melatonin and enterochromaffin cells", Acta Histochem, 55, pp.19~24 (1976)
  161. Rasmussen DD, "Daily melatonin administration at middle age suppresses male visceral fat, plasma leptin, and plasma insulin to youthful levels", Endocrinology, 140, pp.1009~1012 (1999)
  162. Ray CA, "Melatonin attenuates sympathetic nerve responses to orthostatic stress in humans", J Physiol, 555(Pt 3), pp.1043~1048 (2003)
  163. Rechcinski T, "Melatonin for nondippers with coronary artery disease: Assessment of blood pressure profile and heart rate variability", Hypertens Res, 33, pp.56~61 (2010)
  164. Reiter RJ, "The pineal and its hormones in the control of reproduction in mammals", Endocr Rev, 1, pp.109~131 (1980)
  165. Reiter RJ, "Interactions of the pineal hormone melatonin with oxygen-centered free radicals: a brief review", Br J Med Biol Res, 26, pp.1141~1155 (1993)
  166. Reiter RJ, "The pineal gland and melatonin in relation to aging: a summary of the theories and of the data", Exp Gerontol, 30, pp.199~212 (1995)
  167. Reiter RJ, "Cytoprotective properties of melatonin: presumed association with oxidative damage and aging", Nutrition, 14, pp.691~696 (1998)
  168. Reiter RJ, "Interrelationships of the pineal gland, the superior cervical ganglia and the photoperiod in the regulation of the endocrine systems of hamsters", Endocrinology, 79, pp.1168~1170 (1966)
  169. Reiter RJ, "What constitutes a physiological concentration of melatonin?", J Pineal Res, 34, pp.79~80 (2003)
  170. Reiter RJ, "Melatonin: a novel protective agent against oxidative injury of the ischemic", reperfused heart, 2003, pp.58, 10~19
  171. Reiter RJ, "Melatonin: a multitasking molecule", Prog Brain Res, 181, pp.127~151 (2010)
  172. Reiter RJ, "Melatonin and reproduction revisited", Biol Reprod, 81, pp.445~456 (2009)
  173. Reiter RJ, "Actions of melatonin in the reduction of oxidative stress: a review", J Biomed Sci, 7, pp.444~458 (2000)
  174. Reppert SM, "Melatonin receptors: molecular biology of a new family of G protein-coupled receptors", J Biol Rhythms, 12, pp.528~531 (1997)
  175. Reppert SM, "Molecular characterization of a second melatonin receptor expressed in human retina and brain: the Mel1b melatonin receptor", Proc Natl Acad Sci USA, 92, pp.8734~8738 (1995)
  176. Roberson ED, "Transient activation of cyclic AMP-dependent protein kinase during hippocampal long-term potentiation", J Biol Chem, 271, pp.30436~30441 (1996)
  177. Roky R, "Food restriction alters the diurnal distribution of sleep in rats", Physiol Behav, 67, pp.697~703 (1999)
  178. Rose J, "Apparent role of melatonin and prolactin in initiating winter fur growth in mink", Gen Comp Endocrinol, 65, pp.212~215 (1987)
  179. Rosenwasser AM, "Functional neuroanatomy of sleep and circadian rhythms", Brain Res Rev, 61, pp.281~306 (2009)
  180. Roy D, "Cyclical regulation of GnRH gene expression in GTI-7 GnRH-secreting neurons by melatonin", Endocrinology, 142, pp.4711~4720 (2001)
  181. Sarabia L, "Melatonin prevents damage elicited by the organophosphorous pesticide diazinon on mouse sperm DNA", Ecotoxicol Environ Saf, 72, pp.938~942 (2009)
  182. Savaskan E, "Melatonin in aging and neurodegeneration", Drug Develop Res, 56, pp.482~490 (2002)
  183. Savaskan E, "Reduced hippocampal MT2 melatonin receptor expression in Alzheimer’s disease", J Pineal Res, 38, pp.10~16 (2005)
  184. Schapel GJ, "Melatonin response in active epilepsy", Epilepsia, 36, pp.75~78 (1995)
  185. Scheer FA, "Daily nighttime melatonin reduces blood pressure in male patients with essential hypertension", Hypertension, 43, pp.192~197 (2004)
  186. Schenker S, "Antioxidant transport by the human placenta", Clin Nutr, 17, pp.159~167 (1998)
  187. Schlabritz-Loutsevitch N, "The human myometrium as a target for melatonin", J Clin Endocrinol Metab, 8, pp.908~913 (2003)
  188. Sharkey JT, "Melatonin synergizes with oxytocin to enhance contractility of human myometrial smooth muscle cells", J Clin Endocrinol Metab, 94, pp.421~427 (2009)
  189. Sies H, "Strategies of antioxidant defense", Eur J Biochem, 215, pp.213~219 (1993)
  190. Simko F, "Melatonin as a potential antihypertensive treatment", J Pineal Res, 42, pp.319~322 (2007)
  191. Skwarlo-Sonta K, "Bidirectional communication between the pineal gland and the immune system", Can J Physiol Pharmacol, 81, pp.342~349 (2003)
  192. Slominski A, "Murine skin as a target for melatonin bioregulation", Exp Dermatol, 3, pp.45~50 (1994)
  193. Slominski A, "Characterization of the serotoninergic system in the C57BL", 6 mouse skin, 2003, pp.270, 3335~3344
  194. Slominski A, "Melatonin inhibits proliferation and melanogenesis in rodent melanoma cells", Exp Cell Res, 206, pp.189~194 (1993)
  195. Souêtre E, "Circadian rhythms in depression and recovery: evidence for blunted amplitude as the main chronobiological abnormality", Psychiatry Res, 28, pp.263~278 (1989)
  196. Srinivasan V, "Melatonin in Alzheimer's disease and other neurodegenerative disorders", Behav Brain Func, 2, pp.15~37 (2006)
  197. Stetson MH, "Photoperiodic regulation of hamster testis: circadian sensitivity to the effect of light", Biol Reprod, 13, pp.329~339 (1975)
  198. Stewart LS, "Endogenous melatonin and epileptogenesis: facts and hypothesis", Intern J Neurosci, 107, pp.77~85 (2001)
  199. Stewart LS, "Hippocampal melatonin receptors modulate seizure threshold", Epilepsia, 46, pp.473~480 (2005)
  200. Stokkan KA, "Entrainment of the circadian clock in the liver by feeding", Science, 291, pp.490~493 (2001)
  201. Suhner A, "Comparative study to determine the optimal melatonin dosage form for the alleviation of jet lag", Chronobiol Int, 15, pp.655~666 (1998)
  202. Syrseloudis D, "Association of nighttime hypertension with central arterial stiffness and urinary albumin excretion in dipper hypertensive subjects", Hypertens Res, 34, pp.120~125 (2011)
  203. Takahashi JS, "Regulation of circadian rhythmicity", Science, 217, pp.1104~1111 (1982)
  204. Tamura H, "Melatonin and the ovary: physiological and pathophysiological implications", Fertil Steril, 92, pp.328~343 (2009)
  205. Tamura H, "Melatonin and pregnancy in the human", Reprod Toxicol, 25, pp.291~303 (2008)
  206. Tamura H, "Oxidative stress impairs oocyte quality and melatonin protects oocytes from free radical damage and improves fertilization rates", J Pineal Res, 44, pp.280~287 (2008)
  207. Tan DX, "Melatonin: a potent, endogenous hydroxyl radical scavenger", Endocrine J, 1, pp.57~60 (1993)
  208. Tan DX, "High physiological levels of melatonin in the bile of mammals", Life Sci, 65, pp.2523~2529 (1999)
  209. Tan DX, "One molecule, many derivatives: a neverending interaction of melatonin with reactive oxygen and nitrogen species?", J Pineal Res, 42, pp.28~42 (2007)
  210. Tapp WN, "Phase shifting circadian rhythms produces retrograde amnesia", Science, 211, pp.1056~1058 (1981)
  211. Tengattini S, "Cardiovascular diseases: protective effects of melatonin", J Pineal Res, 44, pp.16~25 (2008)
  212. Thomas AJ, "Increase in interleukin-1beta in late-life depression", Am J Psychiatry, 162, pp.175~177 (2005)
  213. Tiemeier H, "Inflammatory proteins and depression in the elderly", Epidemiology, 14, pp.103~107 (2003)
  214. Tomas-Zapio C, "A proposed mechanism to explain the stimulatory effect of melatonin on antioxidative enzymes", J Pineal Res, 39, pp.99~104 (2005)
  215. Tosini G, "The clock in the mouse retina: melatonin synthesis and photoreceptor degeneration", Brain Res, 789, pp.221~228 (1998)
  216. Touitou Y, "Human aging and melatonin. Clinical relevance", Exp Gerontol, 36, pp.1083~1100 (2001)
  217. Touitou Y, "Alteration with aging of the endocrine and neuroendocrine circadian system in humans", Chronobiol Int, 17, pp.369~390 (2000)
  218. van der Zwan LP, "Reduction of myeloperoxidase activity by melatonin and pycnogenol may contribute to their blood pressure lowering effect", Hypertension, 56, pp.e34~ (2010)
  219. Vasquez MI, "Effects of melatonin and undernutrition on the viability of ovine embryos during anestrus and the breeding season", Anim Reprod Sci, 112, pp.83~94 (2009)
  220. Verdecchia P, "Blunted nocturnal fall in blood pressure in hypertensive women with future cardiovascular morbid events", Circulation, 88, pp.986~992 (1993)
  221. Voznesenskaya T, "Melatonin protects against experimental immune ovarian failure in mice", Biol Reprod, 7, pp.207~220 (2007)
  222. Wagner GC, "Redefining the limits of daylength responsiveness in a seasonal mammal", Endocrinology, 149, pp.32~39 (2008)
  223. Wakatsuki A, "Melatonin protects against ischemia", reperfusioninduced oxidative damage to mitochondria in fetal rat brain, 2001, pp.31, 167~172
  224. Waldhauser F, "Age related changes in melatonin levels in humans and its potential consequences for sleep disorders", Exp Gerontol, 33, pp.759~772 (1998)
  225. Waldhauser F, "Bioavailability of oral melatonin in humans", Neuroendocrinology, 39, pp.307~313 (1984)
  226. Wan Q, "Differential modulation of GABA receptor function by Mel and Mel receptors", Nat Neurosci, 2, pp.401~403 (1999)
  227. Wang LM, "Melatonin inhibits hippocampal long-term potentiation", Eur J Neurosci, 22, pp.2231~2237 (2005)
  228. Waterhouse J, "Identifying some determinants of “jet lag” and its symptoms: a study of athletes and other travellers", Br J Sports Med, 36, pp.54~60 (2002)
  229. Weil ZM, "Melatonin receptor (MT1) knockout mice display depression-like behaviors and deficits in sensorimotor gating", Brain Res Bull, 68, pp.425~429 (2006)
  230. Witt-Enderby PA, "Melatonin receptors and their regulation: biochemical and structural mechanisms", Life Sci, 72, pp.2183~2198 (2003)
  231. Wu YH, "Distribution of MT1 melatonin receptor immunoreactivity in the human hypothalamus and pituitary gland: colocalization of MT1 with vasopressin, oxytocin, and corticotropin-releasing hormone", J Comp Neurol, 499, pp.897~910 (2006)
  232. Yoon IY, "Role of morning melatonin administration and attenuation of sunlight exposure in improving adaptation of nightshift workers", Chronobiol Int, 19, pp.903~913 (2002)
  233. Yu YW, "Association study of the interleukin-1 beta (C-511T) genetic polymorphism with major depressive disorder, associated symptomatology, and antidepressant response", Neuropsychopharmacology, 28, pp.1182~1185 (2003)
  234. Zeitzer JM, "Do plasma melatonin concentrations decline with age?", Am J Med, 108, pp.432~436 (1999)
  235. Zimmerman NH, "Neural connections of sparrow pineal: role in circadian control of activity", Science, 190, pp.477~479 (1975)
  236. Zuniga O, "The effect of melatonin implants on the response to the male effect and on the subsequent cyclicity of Rasa Aragonesa ewes implanted in April", Anim Reprod Sci, 72, pp.165~174 (2002)

관련 논문AI추천

이 간행물의 다른 논문 (13건)