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Transforming Stimulated Clone 22 (TSC-22) Interacts Directly with Bromodomain-Containing Protein 7 (BRD7) to Enhance the Inhibition of Extracellular Signal-Regulate Kinase (ERK) Pathway in Ovarian Cancer

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초록

Bromodomain-containing protein 7 (BRD7) participates in many cellular processes and embryo development. BRD7 is down-regulated in various cancers and evidence of its tumor suppressor function has been accumulating. Here, we identified transforming stimulated clone 22 (TSC-22) as a novel BRD7 interacting protein and show its novel function as a positive regulator of BRD7. We found that TSC-22 expression potentiated the inactivation of the extracellular signal-regulate kinase (ERK) pathway by BRD7. Our data establishes TSC- 22 as a modulator of BRD7 and unravels the molecular mechanisms that drive the synergistic tumor-suppressing effects of TSC-22 and BRD7. Our findings may open new avenues for developing novel molecular therapies for tumors exhibiting down-regulated BRD7 and/or TSC-22.

Abstract

Bromodomain-containing protein 7 (BRD7) participates in many cellular processes and embryo development. BRD7 is down-regulated in various cancers and evidence of its tumor suppressor function has been accumulating. Here, we identified transforming stimulated clone 22 (TSC-22) as a novel BRD7 interacting protein and show its novel function as a positive regulator of BRD7. We found that TSC-22 expression potentiated the inactivation of the extracellular signal-regulate kinase (ERK) pathway by BRD7. Our data establishes TSC- 22 as a modulator of BRD7 and unravels the molecular mechanisms that drive the synergistic tumor-suppressing effects of TSC-22 and BRD7. Our findings may open new avenues for developing novel molecular therapies for tumors exhibiting down-regulated BRD7 and/or TSC-22.

참고문헌 (30)

  1. Anastas JN, "WNT signalling pathways as therapeutic targets in cancer", Nat Rev Cancer, 13, pp.11~26 (2013)
  2. Beroukhim R, "The landscape of somatic copy-number alteration across human cancers", Nature, 463, pp.899~905 (2010)
  3. Chen CL, "Bromodomain-containing protein 7(BRD7)as a potential tumor suppressor in hepatocellular carcinoma", Oncotarget, 7, pp.16248~16261 (2016)
  4. Cho MJ, "TSC-22inhibits CSF-1R function and induces apoptosis in cervical cancer", Oncotarget, 8, pp.97990~98003 (2017)
  5. Drost J, "BRD7 is a candidate tumour suppressor gene required for p53 function", Nat Cell Biol, 12, pp.380~389 (2010)
  6. Gao Y, "BRD7 acts as a tumor suppressor gene in lung adenocarcinoma", PLOS ONE, 11, pp.e0156701~ (2016)
  7. Harte MT, "BRD7, a subunit of SWI", SNF complexes, binds directly to BRCA1 and regulates BRCA1-dependent transcription, 2010, pp.70, 2538~2547
  8. Hino S, "Nuclear translocation of TSC-22(TGF-β-stimulated clone-22)concomitant with apoptosis : TSC-22 as a putative transcriptional regulator", Biochem Biophys Res Commun, 278, pp.659~664 (2000)
  9. Kester HA, "Transforming growth factor-β-stimulated clone-22 is a member of a family of leucine zipper proteins that can homo-and heterodimerize and has transcriptional repressor activity", J Biol Chem, 274, pp.27439~27447 (1999)
  10. Kikuchi M, "TRIM24 mediates ligand-dependent activation of androgen receptor and is repressed by a bromodomain-containing protein, BRD7, in prostate cancer cells", Biochim Biophys Acta, 1793, pp.1828~1836 (2009)
  11. Lee JH, "Interaction between fortilin and transforming growth factor-beta stimulated clone-22(TSC-22)prevents apoptosis via the destabilization of TSC-22", FEBS Lett, 582, pp.1210~1218 (2008)
  12. Liu T, "Tumor suppressor bromodomain-containing protein 7 cooperates with Smads to promote transforming growth factor-β responses", Oncogene, 36, pp.362~372 (2017)
  13. Mantovani F, "Gene regulation and tumor suppression by the bromodomain-containing protein BRD7", Cell Cycle, 9, pp.2777~2781 (2010)
  14. Meek DW, "Regulation of the p53 response and its relationship to cancer", Biochem J, 469, pp.325~346 (2015)
  15. Nakamura M, "Transforming growth factor-β-stimulated clone-22 is a negative-feedback regulator of Ras", Raf signaling : Implications for tumorigenesis, 2012, pp.103, 26~33
  16. Nakashiro K, "Down-regulation of TSC-22(transforming growth factor β-stimulated clone 22)markedly enhances the growth of a human salivary gland cancer cell line in vitro and in vivo", Cancer Res, 58, pp.549~555 (1998)
  17. Park SW, "Emerging roles of BRD7 in pathophysiology", Int J Mol Sci, 21, pp.7127~ (2020)
  18. Park YA, "The interactions between MicroRNA-200c and BRD7 in endometrial carcinoma", Gynecol Oncol, 124, pp.125~133 (2012)
  19. Park YA, "Tumor suppressive effects of bromodomain-containing protein 7(BRD7)in epithelial ovarian carcinoma", Clin Cancer Res, 20, pp.565~575 (2014)
  20. Rentsch CA, "Differential expression of TGFβ-stimulated clone 22 in normal prostate and prostate cancer", Int J Cancer, 118, pp.899~906 (2006)
  21. Shang S, "The regulation of β-catenin activity and function in cancer : Therapeutic opportunities", Oncotarget, 8, pp.33972~33989 (2017)
  22. Shibanuma M, "Isolation of a gene encoding a putative leucine zipper structure that is induced by transforming growth factor β1 and other growth factors", J Biol Chem, 267, pp.10219~10224 (1992)
  23. Shostak KO, "Patterns of expression of TSC-22protein in astrocytic gliomas", Exp Oncol, 27, pp.314~318 (2005)
  24. Taketo MM, "Shutting down Wnt signal–activated cancer", Nat Genet, 36, pp.320~322 (2004)
  25. Wu M, "Signaling transduction network mediated by tumor suppressor", susceptibility genes in NPC, 2009, pp.10, 216~222
  26. Wu WJ, "Prognostic relevance of BRD7 expression in colorectal carcinoma", Eur J Clin Invest, 43, pp.131~140 (2013)
  27. Yang JY, "ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation", Nat Cell Biol, 10, pp.138~148 (2008)
  28. Yoon CH, "Crucial role of TSC-22 in preventing the proteasomal degradation of p53 in cervical cancer", PLOS ONE, 7, pp.e42006~ (2012)
  29. Yu X, "BRD7 : A novel tumor suppressor gene in different cancers", Am J Transl Res, 8, pp.742~748 (2016)
  30. Zhou M, "Identification of nuclear localization signal that governs nuclear import of BRD7 and its essential roles in inhibiting cell cycle progression", J Cell Biochem, 98, pp.920~930 (2006)

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