Physiology of Cellular Prion Proteins in Reproduction
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Cellular prion protein (PrPC ) encoded at Prnp gene is well-known to form a misfolded isoform, termed scrapie PrP (PrPSC) that cause transmissible degenerative diseases in central nervous system. The physiological role of PrPC has been proposed by many studies, showing that PrPC interacts with various intracellular, membrane, and extracellular molecules including mitochondrial inner membrane as a scaffold. PrPC is expressed in most cell types including reproductive organs. Numerous studies using PrPC knockout rodent models found no obvious phenotypic changes, in particular the clear phenotypes in development and reproduction have not demonstrated in these knockout models. However, various roles of PrPC have been evaluated at the cellular levels. In this review, we summarized the known roles of PrPC in various cell types and tissues with a special emphasis on those involved in reproduction.
Abstract
Cellular prion protein (PrPC ) encoded at Prnp gene is well-known to form a misfolded isoform, termed scrapie PrP (PrPSC) that cause transmissible degenerative diseases in central nervous system. The physiological role of PrPC has been proposed by many studies, showing that PrPC interacts with various intracellular, membrane, and extracellular molecules including mitochondrial inner membrane as a scaffold. PrPC is expressed in most cell types including reproductive organs. Numerous studies using PrPC knockout rodent models found no obvious phenotypic changes, in particular the clear phenotypes in development and reproduction have not demonstrated in these knockout models. However, various roles of PrPC have been evaluated at the cellular levels. In this review, we summarized the known roles of PrPC in various cell types and tissues with a special emphasis on those involved in reproduction.
참고문헌 (64)
- Abi Nahed R, "The multifaceted functions of prion protein(PrPC)in cancer", Cancers(Basel), 15, pp.4982~ (2023)
- Aguzzi A, "The prion’s elusive reason for being", Annu Rev Neurosci, 31, pp.439~477 (2008)
- Allais-Bonnet A, "Role of the prion protein family in the gonads", Front Cell Dev Biol, 2, pp.56~ (2014)
- Alves RN, "A new take on prion protein dynamics in cellular trafficking", Int J Mol Sci, 21, pp.7763~ (2020)
- Bakkebø MK, "The cellular prion protein : A player in immunological quiescence", Front Immunol, 6, pp.450~ (2015)
- Behrens A, "Absence of the prion protein homologue Doppel causes male sterility", EMBO J, 21, pp.3652~3658 (2002)
- Béland M, "The prion protein unstructured N-terminal region is a broad-spectrum molecular sensor with diverse and contrasting potential functions", J Neurochem, 120, pp.853~868 (2012)
- Bendheim PE, "Nearly ubiquitous tissue distribution of the scrapie agent precursor protein", Neurology, 42, pp.149~156 (1992)
- Besnier LS, "The cellular prion protein PrPC is a partner of the Wnt pathway in intestinal epithelial cells", Mol Biol Cell, 26, pp.3313~3328 (2015)
- Bravard A, "The prion protein is critical for DNA repair and cell survival after genotoxic stress", Nucleic Acids Res, 43, pp.904~916 (2015)
- Budnik V, "Extracellular vesicles round off communication in the nervous system", Nat Rev Neurosci, 17, pp.160~172 (2016)
- Caetano FA, "Endocytosis of prion protein is required for ERK1", 2 signaling induced by stress-inducible protein 1, 2008, pp.28, 6691~6702
- Castle AR, "Physiological functions of the cellular prion protein", Front Mol Biosci, 4, pp.19~ (2017)
- Chakrabortee S, "Luminidependens(LD)is an Arabidopsis protein with prion behavior", Proc Natl Acad Sci USA, 113, pp.6065~6070 (2016)
- De Mario A, "The link of the prion protein with Ca2+ metabolism and ROS production, and the possible implication in Aβ toxicity", Int J Mol Sci, 20, pp.4640~ (2019)
- Ding NZ, "Cellular prion protein is involved in decidualization of mouse uterus", Biol Reprod, 99, pp.319~325 (2018)
- Dohler F, "High molecular mass assemblies of amyloid-β oligomers bind prion protein in patients with Alzheimer’s disease", Brain, 137, pp.873~886 (2014)
- Ecroyd H, "Compartmentalization of prion isoforms within the reproductive tract of the ram", Biol Reprod, 71, pp.993~1001 (2004)
- Faris R, "Cellular prion protein is present in mitochondria of healthy mice", Sci Rep, 7, pp.41556~ (2017)
- Forde N, "Association of the prion protein and its expression with ovarian follicle development in cattle", Mol Reprod Dev, 75, pp.243~249 (2008)
- Fujisawa M, "Expression of Prnp mRNA(prion protein gene)in mouse spermatogenic cells", J Reprod Dev, 50, pp.565~570 (2004)
- Gatti JL, "Prion protein is secreted in soluble forms in the epididymal fluid and proteolytically processed and transported in seminal plasma", Biol Reprod, 67, pp.393~400 (2002)
- Gibbings D, "Human prion protein binds Argonaute and promotes accumulation of microRNA effector complexes", Nat Struct Mol Biol, 19, pp.517~524 (2012)
- Gilch S, "New developments in prion disease research", Cell Tissue Res, 392, pp.1~5 (2023)
- Gruszecki TM, "Effect of PRNP gene polymorphism on reproductive performance of mother sheep and their ofspring growth", Bull Vet Inst Pulawy, 56, pp.279~282 (2012)
- Hajj GN, "Cellular prion protein interaction with vitronectin supports axonal growth and is compensated by integrins", J Cell Sci, 120, pp.1915~1926 (2007)
- Heisler FF, "Muskelin coordinates PrPC lysosome versus exosome targeting and impacts prion disease progression", Neuron, 99, pp.1155~1169 (2018)
- Iglesia RP, "Engagement of cellular prion protein with the co-chaperone Hsp70", 90 organizing protein regulates the proliferation of glioblastoma stem-like cells, 2017, pp.8, 76~
- Isaacs JD, "The role of the cellular prion protein in the immune system", Clin Exp Immunol, 146, pp.1~8 (2006)
- Johnston DS, "Stage-specific gene expression is a fundamental characteristic of rat spermatogenic cells and Sertoli cells", Proc Natl Acad Sci USA, 105, pp.8315~8320 (2008)
- Johnson ML, "Prion(PrPC)expression in ovine uteroplacental tissues increases after estrogen treatment of ovariectomized ewes and during early pregnancy", Reproduction, 148, pp.1~10 (2014)
- Klamt F, "Imbalance of antioxidant defense in mice lacking cellular prion protein", Free Radic Biol Med, 30, pp.1137~1144 (2001)
- Kovač V, "Prion protein : The molecule of many forms and faces", Int J Mol Sci, 23, pp.1232~ (2022)
- Li C, "Binding of pro-prion to filamin a disrupts cytoskeleton and correlates with poor prognosis in pancreatic cancer", J Clin Invest, 119, pp.2725~2736 (2009)
- Li QQ, "Cellular prion protein promotes glucose uptake through the Fyn-HIF-2α-Glut1 pathway to support colorectal cancer cell survival", Cancer Sci, 102, pp.400~406 (2011)
- Liang J, "Cellular prion protein promotes proliferation and G1", S transition of human gastric cancer cells SGC7901 and AGS, 2007, pp.21, 2247~2256
- Limone A, "Emerging roles of the cellular prion protein(PrPC)and 37", 67 kDa laminin receptor(RPSA)interaction in cancer biology, 2023, pp.80, 207~
- Linden R, "The biological function of the prion protein : A cell surface scaffold of signaling modules", Front Mol Neurosci, 10, pp.77~ (2017)
- Liu J, "Prion protein participates in the protection of mice from lipopolysaccharide infection by regulating the inflammatory process", J Mol Neurosci, 55, pp.279~287 (2015)
- Makrinou E, "Genomic characterization of the human prion protein(PrP)gene locus", Mamm Genome, 13, pp.696~703 (2002)
- Málaga-Trillo E, "Regulation of embryonic cell adhesion by the prion protein", PLOS Biol, 7, pp.e55~ (2009)
- Martellucci S, "Prion protein in stem cells : A lipid raft component involved in the cellular differentiation process", Int J Mol Sci, 21, pp.4168~ (2020)
- Mattei V, "Role of lipid rafts in neuronal differentiation of dental pulpderived stem cells", Exp Cell Res, 339, pp.231~240 (2015)
- Megra BW, "Inflammatory mediators reduce surface PrPC on human BMVEC resulting in decreased barrier integrity", Lab Invest, 98, pp.1347~1359 (2018)
- Miranda A, "The role of prion protein in stem cell regulation", Reproduction, 146, pp.R91~R99 (2013)
- Nandi PK, "Interaction of prion peptide HuPrP106-126 with nucleic acid", Arch Virol, 142, pp.2537~2545 (1997)
- Pantera B, "PrPC activation induces neurite outgrowth and differentiation in PC12 cells : Role for caveolin-1 in the signal transduction pathway", J Neurochem, 110, pp.194~207 (2009)
- Peng HY, "PrPC promotes endometriosis progression by reprogramming cholesterol metabolism and estrogen biosynthesis of endometrial stromal cells through PPARα pathway", Int J Biol Sci, 18, pp.1755~1772 (2022)
- Pereira RM, "Prion protein testis specific(PRNT)gene polymorphisms and transcript level in ovine spermatozoa : Implications in freezability, fertilization and embryo production", Theriogenology, 115, pp.124~132 (2018)
- Petit CS, "Requirement of cellular prion protein for intestinal barrier function and mislocalization in patients with inflammatory bowel disease", Gastroenterology, 143, pp.122~132 (2012)
- Prusiner SB, "Molecular biology of prion diseases", Science, 252, pp.1515~1522 (1991)
- Roucou X, "Regulation of PrP(C)signaling and processing by dimerization", Front Cell Dev Biol, 2, pp.57~ (2014)
- Sarnataro D, "The 37", 67 kDa laminin receptor (LR) inhibitor, NSC47924, affects 37, Sci Rep, pp.2016, 6[DOI]
- Schmitz M, "Behavioral abnormalities in prion protein knockout mice and the potential relevance of PrP(C) for the cytoskeleton", Prion, 8, pp.381~386 (2014)
- Shaked Y, "A C-terminal-truncated PrP isoform is present in mature sperm", J Biol Chem, 274, pp.32153~32158 (1999)
- Sigurdson CJ, "Cellular and molecular mechanisms of prion disease", Annu Rev Pathol, 14, pp.497~516 (2019)
- Sorice M, "Trafficking of PrPC to mitochondrial raft-like microdomains during cell apoptosis", Prion, 6, pp.354~358 (2012)
- Strom A, "Identification of prion protein binding proteins by combined use of far-Western immunoblotting, two dimensional gel electrophoresis and mass spectrometry", Proteomics, 6, pp.26~34 (2006)
- Tanji K, "Analysis of PrPc mRNA by in situ hybridization in brain, placenta, uterus and testis of rats", Intervirology, 38, pp.309~315 (1995)
- Thumdee P, "Expression of the prion protein gene(PRNP)and cellular prion protein(PrPC)in cattle and sheep fetuses and maternal tissues during pregnancy", Gene Expr, 13, pp.283~297 (2007)
- Tuo W, "Prp-c and Prp-Sc at the fetal-maternal interface", J Biol Chem, 276, pp.18229~18234 (2001)
- Vanderperre B, "An overlapping reading frame in the PRNP gene encodes a novel polypeptide distinct from the prion protein", FASEB J, 25, pp.2373~2386 (2011)
- Walmsley AR, "Membrane topology influences N-glycosylation of the prion protein", EMBO J, 20, pp.703~712 (2001)
- Walsh KP, "Cellular prion protein : A co-receptor mediating neuronal cofilin-actin rod formation induced by β-amyloid and proinflammatory cytokines", Prion, 8, pp.375~380 (2014)
