신경퇴행성 질환이 암 발병에 미치는 영향: 국민건강보험공단 빅데이터를 이용한 코호트 연구
Impact of Neurodegenerative Disease on the Development of Cancer in Elderly Koreans: A 10-Year Cohort Study Using National Health Insurance Database
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Objective: We evaluated the association between cancer and various neurodegenerative diseases (NDs), including Alzheimer’sdisease (AD), Parkinson’s disease (PD), and circumscribed brain atrophy (CBA) and to evaluate the impact of ND on the development of cancer. Methods: A population-based longitudinal study was conducted using the National Health Information Database for 2002-2015. A total of 9,365 ND patients (3,157 AD, 5,866 PD, 342 CBA) were included in the study, as were 46,818 matched controls. Results: Various NDs were newly developed in control and ND groups during the 10-year follow-up periods. Newly developed ND cases were as follows: 33.0% in control, 35.3% in AD, 19.9% in PD, and 45.3% in CBA. Cancer developed in 22.6% of ND groups (20.5% AD, 23.6% PD, 24.3% CBA) and in 18.5% of control group. Cancer development was significantly higher in AD patients with new ND cases (especially PD cases), compared to patients without new ND cases (22.8% vs. 19.3%, p=0.019). There were no differences in the frequencies of cancer development between patients with and without new ND cases in PD, CBA, and control groups. The adjusted hazard ratios for cancer in AD, PD, and CBA groups were 1.43, 1.55, and 1.58, respectively. Conclusion: This study showed that various NDs are positively associated with development of cancer and suggests that newly developed PD in AD group during the follow-up period may influence the development of cancer that follows.
Abstract
Objective: We evaluated the association between cancer and various neurodegenerative diseases (NDs), including Alzheimer’sdisease (AD), Parkinson’s disease (PD), and circumscribed brain atrophy (CBA) and to evaluate the impact of ND on the development of cancer. Methods: A population-based longitudinal study was conducted using the National Health Information Database for 2002-2015. A total of 9,365 ND patients (3,157 AD, 5,866 PD, 342 CBA) were included in the study, as were 46,818 matched controls. Results: Various NDs were newly developed in control and ND groups during the 10-year follow-up periods. Newly developed ND cases were as follows: 33.0% in control, 35.3% in AD, 19.9% in PD, and 45.3% in CBA. Cancer developed in 22.6% of ND groups (20.5% AD, 23.6% PD, 24.3% CBA) and in 18.5% of control group. Cancer development was significantly higher in AD patients with new ND cases (especially PD cases), compared to patients without new ND cases (22.8% vs. 19.3%, p=0.019). There were no differences in the frequencies of cancer development between patients with and without new ND cases in PD, CBA, and control groups. The adjusted hazard ratios for cancer in AD, PD, and CBA groups were 1.43, 1.55, and 1.58, respectively. Conclusion: This study showed that various NDs are positively associated with development of cancer and suggests that newly developed PD in AD group during the follow-up period may influence the development of cancer that follows.
참고문헌 (36)
- "2020 Statistics for the elderly"[URL]
- "Life Tables for Korea" (2019)[URL]
- McHugh D, "Senescence and aging: causes, consequences, and therapeutic avenues", J Cell Biol, 217, pp.65~77 (2018)
- Migliore L, "Genetic and environmental factors in cancer and neurodegenerative diseases", Mutat Res, 512, pp.135~153 (2002)
- Park JH, "Etiological classification and epidemiology of dementia", J Korean Geriatr Psychiatry, 1, pp.16~22 (1997)
- Lowe SW, "Apoptosis in cancer", Carcinogenesis, 21, pp.485~495 (2000)
- Tabarés-Seisdedos R, "Inverse cancer comorbidity : a serendipitous opportunity to gain insight into CNS disorders", Nat Rev Neurosci, 14, pp.293~304 (2013)
- Musicco M, "Inverse occurrence of cancer and Alzheimer disease : a population-based incidence study", Neurology, 81, pp.322~328 (2013)
- Driver JA, "Inverse association between cancer and neurodegenerative disease : review of the epidemiologic and biological evidence", Biogerontology, 15, pp.547~557 (2014)
- Morris LG, "Genetic determinants at the interface of cancer and neurodegenerative disease", Oncogene, 29, pp.3453~3464 (2010)
- Candelario KM, "The role of extracellular vesicles in the progression of neurodegenerative disease and cancer", Trends Mol Med, 20, pp.368~374 (2014)
- Thanan R, "Oxidative stress and its significant roles in neurodegenerative diseases and cancer", Int J Mol Sci, 16, pp.193~217 (2014)
- Seo J, "Molecular crosstalk between cancer and neurodegenerative diseases", Cell Mol Life Sci, 77, pp.2659~2680 (2020)
- Mölsä PK, "Survival and cause of death in Alzheimer's disease and multi-infarct dementia", Acta Neurol Scand, 74, pp.103~107 (1986)
- Hwang Y, "Dementia mortality and related clinical factors at a nursing home", J Korean Geriatr Psychiatry, 6, pp.110~116 (2002)
- Park J, "Etiological classification and epidemiology of dementia", J Korean Geriatr Psychiatry, 1, pp.16~22 (1997)
- Erkkinen MG, "Clinical neurology and epidemiology of the major neurodegenerative diseases", Cold Spring Harb Perspect Biol, 10, pp.a033118~ (2018)
- Zhang Q, "Inverse relationship between cancer and Alzheimer’s disease : a systemic review meta-analysis", Neurol Sci, 36, pp.1987~1994 (2015)
- Shafi O, "Inverse relationship between Alzheimer’s disease and cancer, and other factors contributing to Alzheimer’s disease: a systematic review", BMC Neurol, 16, pp.236~ (2016)
- Shi HB, "Alzheimer disease and cancer risk : a meta-analysis", J Cancer Res Clin Oncol, 141, pp.485~494 (2015)
- Bajaj A, "Parkinson’s disease and cancer risk : a systematic review and meta-analysis", Cancer Causes Control, 21, pp.697~707 (2010)
- Katisko K, "Low prevalence of cancer in patients with frontotemporal lobar degeneration", J Alzheimers Dis, 62, pp.789~794 (2018)
- Moskalev AA, "The role of DNA damage and repair in aging through the prism of Koch-like criteria", Ageing Res Rev, 12, pp.661~684 (2013)
- López-Otín C, "The hallmarks of aging", Cell, 153, pp.1194~1217 (2013)
- Hooper C, "p53 is upregulated in Alzheimer’s disease and induces tau phosphorylation in HEK293a cells", Neurosci Lett, 418, pp.34~37 (2007)
- Bretaud S, "p53-dependent neuronal cell death in a DJ-1-deficient zebrafish model of Parkinson’s disease", J Neurochem, 100, pp.1626~1635 (2007)
- Meek DW, "Regulation of the p53 response and its relationship to cancer", Biochem J, 469, pp.325~346 (2015)
- Ording AG, "Alzheimer’s and Parkinson’s diseases and the risk of cancer : a cohort study", J Alzheimers Dis, 72, pp.1269~1277 (2019)
- Houck AL, "At the crossroads between neurodegeneration and cancer : a review of overlapping biology and its implications", Curr Aging Sci, 11, pp.77~89 (2018)
- Fan X, "14-3-3 Proteins are on the crossroads of cancer, aging, and age-related neurodegenerative disease", Int J Mol Sci, 20, pp.3518~ (2019)
- Ji Eun Lee, "Association between Alzheimer’s Disease and Cancer Risk in South Korea: an 11-year Nationwide Population-Based Study", Dementia and Neurocognitive Disorders(대한치매학회지), 17(4), pp.137~147 (2018), 대한치매학회[DOI]
- Park JH, "Cancer risk in patients with Parkinson’s disease in South Korea: a nationwide, population-based cohort study", Eur J Cancer, 117, pp.5~13 (2019)
- van der Willik KD, "Cancer and dementia : two sides of the same coin", Eur J Clin Invest, 48, pp.e13019~ (2018)
- Filippou PS, "Cancer and Parkinson’s disease: common targets, emerging hopes", Mov Disord, 36, pp.340~346 (2021)
- 주새한, "만성 정신병원의 노인환자 변화추이와 수반된 내과 질환", 노인정신의학, 22(1), pp.25~32 (2018), 대한노인정신의학회[DOI]
- Pendlebury ST, "Prevalence, incidence, and factors associated with pre-stroke and post-stroke dementia: a systematic review and meta-analysis", Lancet Neurol, 8, pp.1006~1018 (2009)