Clinical Efficacy of Primary Tumor Volume Measurements: Comparison of Different Primary Sites
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Objectives. The purpose of study was to determine the clinical efficacy of primary tumor volume measurements of different primary sites in the oropharynx compared to the oral cavity. Methods. A retrospective analysis of 85 patients with oral cavity or oropharynx cancer. The tumor area was manually outlined from axial magnetic resonance (MR) series. The software calculated the tumor volumes, automatically. The values of the primary tumor volumes were then subdivided into separate groups (≤3,500 ㎣, >3,500 ㎣). Results. The prognostic indicators were the cT and cN (oral cavity); age, primary site, cT, cN, and primary tumor volume (oropharynx) on the univariate analysis. There was no significant prognostic factor for oral cavity cancer on the multivariate analysis. Primary site, cN, and primary tumor volume were independent prognostic indicators for oropharynx cancer by multivariate analysis. Conclusion. Primary tumor volume measurement is a reliable way to stratify outcome, and make up for the weak points in the American Joint Committee on Cancer staging system with oropharynx cancer.
Abstract
Objectives. The purpose of study was to determine the clinical efficacy of primary tumor volume measurements of different primary sites in the oropharynx compared to the oral cavity. Methods. A retrospective analysis of 85 patients with oral cavity or oropharynx cancer. The tumor area was manually outlined from axial magnetic resonance (MR) series. The software calculated the tumor volumes, automatically. The values of the primary tumor volumes were then subdivided into separate groups (≤3,500 ㎣, >3,500 ㎣). Results. The prognostic indicators were the cT and cN (oral cavity); age, primary site, cT, cN, and primary tumor volume (oropharynx) on the univariate analysis. There was no significant prognostic factor for oral cavity cancer on the multivariate analysis. Primary site, cN, and primary tumor volume were independent prognostic indicators for oropharynx cancer by multivariate analysis. Conclusion. Primary tumor volume measurement is a reliable way to stratify outcome, and make up for the weak points in the American Joint Committee on Cancer staging system with oropharynx cancer.
참고문헌 (13)
- Kimura Y, "Volumetric MR imaging of oral, maxillary sinus, oropharyngeal, and hypopharyngeal cancers: correlation between tumor volume and lymph node metastasis", AJNR Am J Neuroradiol, 26(9), pp.2384~2389 (2005)
- Le Tourneau C, "Prognostic indicators for survival in head and neck squamous cell carcinomas:analysis of a series of 621 cases", Head Neck, 27(9), pp.801~808 (2005)
- Mancuso AA, "Preradiotherapy computed tomography as a predictor of local control in supraglottic carcinoma", J Clin Oncol, 17(2), pp.631~637 (1999)
- Lo SM, "Tumour volume: implications in T2", T3 glottic, J Otolaryngol, pp.1998, 27(5)[DOI]
- Chao KS, "Intensity-modulated radiation therapy for oropharyngeal carcinoma:impact of tumor volume", Int J Radiat Oncol Biol Phys, 59(1), pp.43~50 (2004)
- Doweck I, "Tumor volume predicts outcome for advanced head and neck cancer treated with targeted chemoradiotherapy", Laryngoscope, 112(10), pp.1742~1749 (2002)
- Johnson CR, "The tumor volume and clonogen number relationship: tumor control predictions based upon tumor volume estimates derived from computed tomogra-phy", Int J Radiat Oncol Biol Phys, 33(2), pp.281~287 (1995)
- Johnson CR, "The influence of quantitative tumor volume measurements on local control in advanced head and neck cancer using concomitant boost accelerated superfractionated irradiation", Int J Radiat Oncol Biol Phys, 32(3), pp.635~641 (1995)
- Chang CC, "The effect of primary tumor volumes in advanced T-staged nasopharyngeal tumors", Head Neck, 24(10), pp.940~946 (2002)
- Weiss E, "The impact of gross tumor volume (GTV) and clinical target volume (CTV) definition on the total accuracy in radiotherapy theoretical aspects and practical experiences", Strahlenther Onkol, 179(1), pp.21~30 (2003)
- Gordon AR, "Intraobserver variability in the MR determination of tumor volume in squamous cell carcinoma of the pharynx", AJNR Am J Neuroradiol, 25(6), pp.1092~1098 (2004)
- Lenz M, "Oropharynx, oral cavity, floor of the mouth: CT and MRI", Eur J Radiol, 33(3), pp.203~215 (2000)
- Daisne JF, "Tumor volume in pharyngolaryngeal squamous cell carcinoma:comparison at CT, MR imaging, and FDG PET and validation with surgical specimen", Radiology, 233(1), pp.93~100 (2004)