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Sinonasal Glomangiopericytoma Causing Oncogenic Osteomalacia

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초록

A 60-year-old woman suffered from recurrent femur neck fracture. Laboratory data showed serum hypophosphatemia, ele- vated alkaline phosphatase, normal serum calcium levels, and normal parathyroid hormone levels. Radiological examina- tions revealed a tumor in the right maxillary alveolar bone. The nasal cavity mass was removed, and the histological fea- tures were those of glomangiopericytoma. After removal of the tumor, some of the laboratory data normalized. Based on the clinical features, histopathological diagnosis and postoperative course of events, a diagnosis of glomangiopericytoma causing oncogenic osteomalacia was confirmed. We report a case of oncogenic osteomalacia caused by sinonasal gloman- giopericytoma.

Abstract

A 60-year-old woman suffered from recurrent femur neck fracture. Laboratory data showed serum hypophosphatemia, ele- vated alkaline phosphatase, normal serum calcium levels, and normal parathyroid hormone levels. Radiological examina- tions revealed a tumor in the right maxillary alveolar bone. The nasal cavity mass was removed, and the histological fea- tures were those of glomangiopericytoma. After removal of the tumor, some of the laboratory data normalized. Based on the clinical features, histopathological diagnosis and postoperative course of events, a diagnosis of glomangiopericytoma causing oncogenic osteomalacia was confirmed. We report a case of oncogenic osteomalacia caused by sinonasal gloman- giopericytoma.

참고문헌 (9)

  1. Dandekar M, "Sinonasal glomangiopericytoma: case re port with emphasis on the differential diagnosis", Arch Pathol Lab Med, 134(10), pp.1444~1449 (2010)
  2. Higashi K, "Glomangiopericytoma of the nasal cavity", Auris Nasus Larynx, 38(3), pp.415~417 (2011)
  3. Sakamoto A, "Glomangiopericytoma causing oncogenic osteomalacia: a case report with immunohistochemical analysis", Arch Orthop Trauma Surg, 121, pp.104~108 (2001)
  4. Jiang Y, "Tumor-induced osteomalacia: an important cause of adult-onset hypophosphatemic osteomalacia in China. Report of 39 cases and review of the literature", J Bone Miner Res, 27(9), pp.1967~1975 (2012)
  5. Gonzalez-Compta X, "Oncogenic osteomalacia: case report and review of head and neck associated tumours", J Laryngol Otol, 112(4), pp.389~392 (1998)
  6. Beech TJ, "A haemangiopericytoma of the ethmoid sinus causing oncogenic osteomalacia: a case report and review of the literature", Int J Oral Maxillofac Surg, 36(10), pp.956~958 (2007)
  7. Brandwein-Gensler M, "Striking pathology gold: a singular experience with daily reverberations: sinonasal hemangiopericytoma (glomangiopericytoma) and oncogenic osteomalacia", Head Neck Pathol, 6(1), pp.64~74 (2012)
  8. Jonsson KB, "Fibroblast growth factor 23 in oncogenic osteomalacia and X-linked hypophosphatemia", N Engl J Med, 348(17), pp.1656~1663 (2003)
  9. Wilkins GE, "Oncogenic osteomalacia: evidence for a humoral phosphaturic factor", J Clin Endocrinol Metab, 80(5), pp.1628~1634 (1995)

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