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Current Treatment Options for Bilateral Vocal Fold Paralysis: A State-of-the-Art Review

Yike Li|Gaelyn Garrett|David Zealear
대한이비인후과학회 (Korean Society of Otorhinolaryngology-Head and Neck Surgery)|2017.09|Clinical and Experimental Otorhinolaryngology|제10권 제3호|pp. 203-212|DOI https://doi.org/10.21053/ceo.2017.00199

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참고문헌

키워드

SynkinesisBotulinum ToxinsVocal Cord ParalysisRecurrent Laryngeal Nerve InjuriesElectric Stimulation Therapy

초록

Vocal fold paralysis (VFP) refers to neurological causes of reduced or absent movement of one or both vocal folds. Bilateral VFP (BVFP) is characterized by inspiratory dyspnea due to narrowing of the airway at the glottic level with both vocal folds assuming a paramedian position. The primary objective of intervention for BVFP is to relieve patients’ dyspnea. Common clinical options for management include tracheostomy, arytenoidectomy and cordotomy. Other options that have been used with varying success include reinnervation techniques and botulinum toxin (Botox) injections into the vocal fold adductors. More recently, research has focused on neuromodulation, laryngeal pacing, gene therapy, and stem cell therapy. These newer approaches have the potential advantage of avoiding damage to the voicing mechanism of the larynx with an added goal of restoring some physiologic movement of the affected vocal folds. However, clinical data are scarce for these new treatment options (i.e., reinnervation and pacing), so more investigative work is needed. These areas of research are expected to provide dramatic improvements in the treatment of BVFP.

Abstract

Vocal fold paralysis (VFP) refers to neurological causes of reduced or absent movement of one or both vocal folds. Bilateral VFP (BVFP) is characterized by inspiratory dyspnea due to narrowing of the airway at the glottic level with both vocal folds assuming a paramedian position. The primary objective of intervention for BVFP is to relieve patients’ dyspnea. Common clinical options for management include tracheostomy, arytenoidectomy and cordotomy. Other options that have been used with varying success include reinnervation techniques and botulinum toxin (Botox) injections into the vocal fold adductors. More recently, research has focused on neuromodulation, laryngeal pacing, gene therapy, and stem cell therapy. These newer approaches have the potential advantage of avoiding damage to the voicing mechanism of the larynx with an added goal of restoring some physiologic movement of the affected vocal folds. However, clinical data are scarce for these new treatment options (i.e., reinnervation and pacing), so more investigative work is needed. These areas of research are expected to provide dramatic improvements in the treatment of BVFP.

참고문헌 (100)

  1. Mueller AH, "Laryngeal pacing for bilateral vocal fold immobility", Curr Opin Otolaryngol Head Neck Surg, 19(6), pp.439~443 (2011)
  2. Zealear DL, "Neurophysiology of vocal fold paralysis", Otolaryngol Clin North Am, 37(1), pp.1~23 (2004)
  3. Hillel AD, "Evaluation and management of bilateral vocal cord immobility", Otolaryngol Head Neck Surg, 121(6), pp.760~765 (1999)
  4. Benninger MS, "Changing etiology of vocal fold immobility", Laryngoscope, 108(9), pp.1346~1350 (1998)
  5. Misono S, "Evidence-based practice: evaluation and management of unilateral vocal fold paralysis", Otolaryngol Clin North Am, 45(5), pp.1083~1108 (2012)
  6. Myssiorek D., "Recurrent laryngeal nerve paralysis: anatomy and etiology", Otolaryngol Clin North Am, 37(1), pp.25~44 (2004)
  7. Li Y, "An implantable system for in vivo chronic electromyographic study in the larynx", Muscle Nerve, 55(5), pp.706~714 (2017)
  8. Sapundzhiev N, "Surgery of adult bilateral vocal fold paralysis in adduction: history and trends", Eur Arch Otorhinolaryngol, 265(12), pp.1501~1514 (2008)
  9. Young VN, "Arytenoid and posterior vocal fold surgery for bilateral vocal fold immobility", Curr Opin Otolaryngol Head Neck Surg, 19(6), pp.422~427 (2011)
  10. Gilony D, "Effects of tracheostomy on well-being and body-image perceptions", Otolaryngol Head Neck Surg, 133(3), pp.366~371 (2005)
  11. DeSanto LW, "Quality of life after surgical treatment of cancer of the larynx", Ann Otol Rhinol Laryngol, 104(10 Pt 1), pp.763~769 (1995)
  12. Naunheim MR, "Surgical management of bilateral vocal fold paralysis: a cost-effectiveness comparison of two treatments", Laryngoscope, 127(3), pp.691~697 (2017)
  13. Cheung NH, "Tracheostomy: epidemiology, indications, timing, technique, and outcomes", Respir Care, 59(6), pp.895~915 (2014)
  14. Newman MH, "Arytenoidectomy revisited", Laryngoscope, 86(6), pp.840~849 (1976)
  15. Woodman D., "A modification of the extralaryngeal approach to arytenoidectomy for bilateral abductor paralysis", Arch Otolaryngol, 43, pp.63~65 (1946)
  16. Helmus C., "Microsurgical thyrotomy and arytenoidectomy for bilateral recurrent laryngeal nerve paralysis", Laryngoscope, 82(3), pp.491~503 (1972)
  17. Downey WL, "Laryngofissure approach for bilateral abductor paralysis", Arch Otolaryngol, 88(5), pp.513~517 (1968)
  18. Pearlman SJ, "Thyrotomy approach for arytenoidectomy in bilateral abductor paralysis of the vocal cords", Ann Otol Rhinol Laryngol, 62(1), pp.207~212 (1953)
  19. Thornell WC., "A new intralaryngeal approach in arytenoidectomy in bilateral abductor paralysis of the vocal cords; report of three cases", Arch Otolaryngol, 50(5), pp.634~639 (1949)
  20. Whicker JH, "Long-term results of Thornell arytenoidectomy in the surgical treatment of bilateral vocal cord paralysis", Laryngoscope, 82(7), pp.1331~1336 (1972)
  21. de Campora E, "Thornell’s approach for arytenoidectomy in the surgical treatment of bilateral abductor paralysis; personal experience and results", J Laryngol Otol, 99(4), pp.379~382 (1985)
  22. Maurizi M, "CO2 laser subtotal arytenoidectomy and posterior true and false cordotomy in the treatment of post-thyroidectomy bilateral laryngeal fixation in adduction", Eur Arch Otorhinolaryngol, 256(6), pp.291~295 (1999)
  23. Ossoff RH, "Endoscopic laser arytenoidectomy for the treatment of bilateral vocal cord paralysis", Laryngoscope, 94(10), pp.1293~1297 (1984)
  24. Ossoff RH, "Endoscopic laser arytenoidectomy", Lasers Surg Med, 2(4), pp.293~299 (1983)
  25. Remacle M, "Subtotal carbon dioxide laser arytenoidectomy by endoscopic approach for treatment of bilateral cord immobility in adduction", Ann Otol Rhinol Laryngol, 105(6), pp.438~445 (1996)
  26. Sato K, "Laser arytenoidectomy for bilateral median vocal fold fixation", Laryngoscope, 111(1), pp.168~171 (2001)
  27. Crumley RL., "Endoscopic laser medial arytenoidectomy for airway management in bilateral laryngeal paralysis", Ann Otol Rhinol Laryngol, 102(2), pp.81~84 (1993)
  28. Hillel AT, "Voice outcomes following posterior cordotomy with medial arytenoidectomy in patients with bilateral vocal fold immobility", JAMA Otolaryngol Head Neck Surg, 141(8), pp.728~732 (2015)
  29. Yilmaz T, "Comparison of voice and swallowing parameters after endoscopic total and partial arytenoidectomy for bilateral abductor vocal fold paralysis:a randomized trial", JAMA Otolaryngol Head Neck Surg, 139(7), pp.712~718 (2013)
  30. Yilmaz T, "Total and partial laser arytenoidectomy for bilateral vocal fold paralysis", Biomed Res Int, 2016, pp.3601612~ (2016)
  31. Googe B, "Coblator arytenoidectomy in the treatment of bilateral vocal cord paralysis", Case Rep Otolaryngol, 2015, pp.487280~ (2015)
  32. Dennis DP, "Carbon dioxide laser posterior cordectomy for treatment of bilateral vocal cord paralysis", Ann Otol Rhinol Laryngol, 98(12 Pt 1), pp.930~934 (1989)
  33. Wassermann K, "Concurrent glottic and tracheal stenoses: restoration of airway continuity in end-stage malignant disease", Ann Otol Rhinol Laryngol, 110(4), pp.349~355 (2001)
  34. Pia F, "CO(2) laser posterior ventriculocordectomy for the treatment of bilateral vocal cord paralysis", Eur Arch Otorhinolaryngol, 256(8), pp.403~406 (1999)
  35. Eckel HE, "Cordectomy versus arytenoidectomy in the management of bilateral vocal cord paralysis", Ann Otol Rhinol Laryngol, 103(11), pp.852~857 (1994)
  36. Szakacs L, "A comparison between transoral glottis-widening techniques for bilateral vocal fold immobility", Laryngoscope, 125(11), pp.2522~2529 (2015)
  37. Li Y, "Comparison of ventilation and voice outcomes between unilateral laryngeal pacing and unilateral cordotomy for the treatment of bilateral vocal fold paralysis", ORL J Otorhinolaryngol Relat Spec, 75(2), pp.68~73 (2013)
  38. Sessions DG, "Surgical management of bilateral vocal cord paralysis", Laryngoscope, 86(4), pp.559~566 (1976)
  39. Damrose EJ., "Suture laterofixation of the vocal fold for bilateral vocal fold immobility", Curr Opin Otolaryngol Head Neck Surg, 19(6), pp.416~421 (2011)
  40. Lichtenberger G., "Comparison of endoscopic glottis-dilating operations", Eur Arch Otorhinolaryngol, 260(2), pp.57~61 (2003)
  41. Jatzko GR, "Recurrent nerve palsy after thyroid operations: principal nerve identification and a literature review", Surgery, 115(2), pp.139~144 (1994)
  42. Ejnell H, "A new simple method of laterofixation and its effects on orolaryngeal airway resistance and fonation", Acta Otolaryngol, 93(suppl 386), pp.196~197 (1982)
  43. Ejnell H, "A simple operation for bilateral vocal cord paralysis", Laryngoscope, 94(7), pp.954~958 (1984)
  44. Gandhi S, "Suture lateralization for bilateral vocal fold immobility: a review of various techniques", J Laryngol Voice, 6(1), pp.1~6 (2016)
  45. Lichtenberger G., "Endo-extralaryngeal needle carrier instrument", Laryngoscope, 93(10), pp.1348~1350 (1983)
  46. Remsen K, "Laser lateralization for bilateral vocal cord abductor paralysis", Otolaryngol Head Neck Surg, 93(5), pp.645~649 (1985)
  47. Lichtenberger G., "Reversible immediate and definitive lateralization of paralyzed vocal cords", Eur Arch Otorhinolaryngol, 256(8), pp.407~411 (1999)
  48. Rovo L, "“Early” vocal cord laterofixation for the treatment of bilateral vocal cord immobility", Eur Arch Otorhinolaryngol, 258(10), pp.509~513 (2001)
  49. Mathur NN, "Simple method of vocal cord lateralization in bilateral abductor cord paralysis in paediatric patients", Int J Pediatr Otorhinolaryngol, 68(1), pp.15~20 (2004)
  50. Ejnell H, "Acute temporary laterofixation for treatment of bilateral vocal cord paralyses after surgery for advanced thyroid carcinoma", World J Surg, 17(2), pp.277~281 (1993)
  51. Jori J, "Vocal cord laterofixation as early treatment for acute bilateral abductor paralysis after thyroid surgery", Eur Arch Otorhinolaryngol, 255(7), pp.375~378 (1998)
  52. Lichtenberger G., "Reversible lateralization of the paralyzed vocal cord without tracheostomy", Ann Otol Rhinol Laryngol, 111(1), pp.21~26 (2002)
  53. Woodson G, "Arytenoid abduction for dynamic rehabilitation of bilateral laryngeal paralysis", Ann Otol Rhinol Laryngol, 116(7), pp.483~490 (2007)
  54. Woodson G., "Arytenoid abduction for bilateral vocal fold immobility", Curr Opin Otolaryngol Head Neck Surg, 19(6), pp.428~433 (2011)
  55. Kirchner FR., "Endoscopic lateralization of the vocal cord in abductor paralysis of the larynx", Laryngoscope, 89(11), pp.1779~1783 (1979)
  56. Nawka T, "Permanent transoral surgery of bilateral vocal fold paralysis: a prospective multi-center trial", Laryngoscope, 125(6), pp.1401~1408 (2015)
  57. Ezzat WF, "Adjustable laterofixation of the vocal fold in bilateral vocal fold paralysis", Laryngoscope, 120(4), pp.731~733 (2010)
  58. Crumley RL., "Phrenic nerve graft for bilateral vocal cord paralysis", Laryngoscope, 93(4), pp.425~428 (1983)
  59. Marina MB, "Laryngeal reinnervation for bilateral vocal fold paralysis", Curr Opin Otolaryngol Head Neck Surg, 19(6), pp.434~438 (2011)
  60. Miehlike A., "Rehabilitation of vocal cord paralysis: studies using the vagus recurrent bypass anastomosis, type ramus posterior shunt", Arch Otolaryngol, 100(6), pp.431~441 (1974)
  61. Li M, "Reinnervation of bilateral posterior cricoarytenoid muscles using the left phrenic nerve in patients with bilateral vocal fold paralysis", PLoS One, 8(10), pp.e77233~ (2013)
  62. Tucker HM, "Human laryngeal reinnervation: long-term experience with the nerve-muscle pedicle technique", Laryngoscope, 88(4), pp.598~604 (1978)
  63. Tucker HM, "Human laryngeal reinnervation", Laryngoscope, 86(6), pp.769~779 (1976)
  64. Zealear DL, "Control of paralyzed axial muscles by electrical stimulation", Trans Sect Otolaryngol Am Acad Ophthalmol Otolaryngol, 84(2), pp.310~ (1977)
  65. Obert PM, "Use of direct posterior cricoarytenoid stimulation in laryngeal paralysis", Arch Otolaryngol, 110(2), pp.88~92 (1984)
  66. Zealear DL, "Electrical pacing of the paralyzed human larynx", Ann Otol Rhinol Laryngol, 105(9), pp.689~693 (1996)
  67. Broniatowski M, "Laryngeal pacemaker: II. electronic pacing of reinnervated posterior cricoarytenoid muscles in the canine", Laryngoscope, 95(10), pp.1194~1198 (1985)
  68. Herzon GD, "Use of an electronic laryngeal implant to restore glottic function in patients with bilateral vocal cord paralysis", Cancer Focus, 8(1-2), pp.45~48 (1986)
  69. Nomura K, "Bilateral motion restored to the paralyzed canine larynx with implantable stimulator", Laryngoscope, 120(12), pp.2399~2409 (2010)
  70. Zealear DL, "Rehabilitation of bilaterally paralyzed canine larynx with implantable stimulator", Laryngoscope, 119(9), pp.1737~1744 (2009)
  71. Zealear DL, "Reanimation of the paralyzed human larynx with an implantable electrical stimulation device", Laryngoscope, 113(7), pp.1149~1156 (2003)
  72. Andreas H. Mueller, "Laryngeal pacing for bilateral vocal fold paralysis: Voice and respiratory aspects", The Laryngoscope, 127(8), pp.1838~1844 (2017), Wiley-Blackwell[DOI]
  73. Mueller AH, "Laryngeal pacing via an implantable stimulator for the rehabilitation of subjects suffering from bilateral vocal fold paralysis:a prospective first-in-human study", Laryngoscope, 126(8), pp.1810~1816 (2016)
  74. Ongkasuwan J, "The role of botulinum toxin in the management of airway compromise due to bilateral vocal fold paralysis", Curr Opin Otolaryngol Head Neck Surg, 19(6), pp.444~448 (2011)
  75. Scott AB., "Botulinum toxin injection into extraocular muscles as an alternative to strabismus surgery", Ophthalmology, 87(10), pp.1044~1049 (1980)
  76. Zealear DL, "Electrically stimulated glottal opening combined with adductor muscle botox blockade restores both ventilation and voice in a patient with bilateral laryngeal paralysis", Ann Otol Rhinol Laryngol, 111(6), pp.500~506 (2002)
  77. Marie JP, "Bilateral laryngeal movement disorder and synkinesia:value of botulism toxin: apropos of a case", Rev Laryngol Otol Rhinol (Bord), 119(4), pp.261~264 (1998)
  78. Ekbom DC, "Botulinum toxin injections for new onset bilateral vocal fold motion impairment in adults", Laryngoscope, 120(4), pp.758~763 (2010)
  79. Tamaki H, "Effect of electrical stimulation-induced muscle force and streptomycin treatment on muscle and trabecular bone mass in earlystage disuse musculoskeletal atrophy", J Musculoskelet Neuronal Interact, 15(3), pp.270~278 (2015)
  80. Hu L, "Low-frequency electrical stimulation attenuates muscle atrophy in CKD: a potential treatment strategy", J Am Soc Nephrol, 26(3), pp.626~635 (2015)
  81. Willand MP, "Sensory nerve cross-anastomosis and electrical muscle stimulation synergistically enhance functional recovery of chronically denervated muscle", Plast Reconstr Surg, 134(5), pp.736e~745e (2014)
  82. Williams HB., "The value of continuous electrical muscle stimulation using a completely implantable system in the preservation of muscle function following motor nerve injury and repair: an experimental study", Microsurgery, 17(11), pp.589~596 (1996)
  83. Cheetham J, "Effects of functional electrical stimulation on denervated laryngeal muscle in a large animal model", Artif Organs, 39(10), pp.876~885 (2015)
  84. Zealear DL, "The effects of chronic electrical stimulation on laryngeal muscle physiology and histochemistry", ORL J Otorhinolaryngol Relat Spec, 62(2), pp.81~86 (2000)
  85. Gharib NM, "Efficacy of electrical stimulation as an adjunct to repetitive task practice therapy on skilled hand performance in hemiparetic stroke patients: a randomized controlled trial", Clin Rehabil, 29(4), pp.355~364 (2015)
  86. Zealear DL, "The effects of chronic electrical stimulation on laryngeal muscle reinnervation", ORL J Otorhinolaryngol Relat Spec, 62(2), pp.87~95 (2000)
  87. Zealear DL, "Electrical stimulation of a denervated muscle promotes selective reinnervation by native over foreign motoneurons", J Neurophysiol, 87(4), pp.2195~2199 (2002)
  88. Zealear DL, "Stimulation of denervated muscle promotes selective reinnervation, prevents synkinesis, and restores function", Laryngoscope, 124(5), pp.E180~E187 (2014)
  89. Bijangi-Vishehsaraei K, "Microarray analysis gene expression profiles in laryngeal muscle after recurrent laryngeal nerve injury", Ann Otol Rhinol Laryngol, 125(3), pp.247~256 (2016)
  90. Heavner SB, "Dysfunction of the recurrent laryngeal nerve and the potential of gene therapy", Ann Otol Rhinol Laryngol, 116(6), pp.441~448 (2007)
  91. Rubin A, "Delivery of an adenoviral vector to the crushed recurrent laryngeal nerve", Laryngoscope, 113(6), pp.985~989 (2003)
  92. Rubin AD, "Remote delivery of rAAV-GFP to the rat brainstem through the recurrent laryngeal nerve", Laryngoscope, 111(11 Pt 1), pp.2041~2045 (2001)
  93. Flint PW, "IGF-1 gene transfer into denervated rat laryngeal muscle", Arch Otolaryngol Head Neck Surg, 125(3), pp.274~279 (1999)
  94. Shiotani A, "Reinnervation of motor endplates and increased muscle fiber size after human insulin-like growth factor I gene transfer into the paralyzed larynx", Hum Gene Ther, 9(14), pp.2039~2047 (1998)
  95. Shiotani A, "Gene therapy for laryngeal paralysis", Ann Otol Rhinol Laryngol, 116(2), pp.115~122 (2007)
  96. Saito K, "Adenoviral GDNF gene transfer prevents motoneuron loss in the nucleus ambiguus", Brain Res, 962(1-2), pp.61~67 (2003)
  97. Araki K, "Adenoviral GDNF gene transfer enhances neurofunctional recovery after recurrent laryngeal nerve injury", Gene Ther, 13(4), pp.296~303 (2006)
  98. Halum SL, "Injection of autologous muscle stem cells (myoblasts) for the treatment of vocal fold paralysis: a pilot study", Laryngoscope, 117(5), pp.917~922 (2007)
  99. Dirja BT, "Potential of laryngeal muscle regeneration using induced pluripotent stem cell-derived skeletal muscle cells", Acta Otolaryngol, 136(4), pp.391~396 (2016)
  100. Nishio N, "Autologous fat injection therapy including a high concentration of adipose-derived regenerative cells in a vocal fold paralysis model:animal pilot study", J Laryngol Otol, 130(10), pp.914~922 (2016)

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