본문 바로가기
KERD
논문KCI 등재

Impacts of Fluid Dynamics Simulation in Study of Nasal Airflow Physiology and Pathophysiology in Realistic Human Three-Dimensional Nose Models

De Yun Wang, MD, PhD|Heow Peuh Lee|Bruce R. Gordon
대한이비인후과학회 (Korean Society of Otorhinolaryngology-Head and Neck Surgery)|2012.12|Clinical and Experimental Otorhinolaryngology|제5권 제4호|pp. 181-187

2

조회

0

다운로드

0

인용

0

참고문헌

키워드

Computational fluid dynamicsNose modelsNasal airflow dynamicsAirflow physiology and pathophysiology

초록

During the past decades, numerous computational fluid dynamics (CFD) studies, constructed from CT or MRI images, have simulated human nasal models. As compared to rhinomanometry and acoustic rhinometry, which provide quantitative information only of nasal airflow, resistance, and cross sectional areas, CFD enables additional measurements of airflow passing through the nasal cavity that help visualize the physiologic impact of alterations in intranasal structures. Therefore, it becomes possible to quantitatively measure, and visually appreciate, the airflow pattern (laminar or turbulent), velocity, pressure,wall shear stress, particle deposition, and temperature changes at different flow rates, in different parts of the nasal cavity. The effects of both existing anatomical factors, as well as post-operative changes, can be assessed. With recent improvements in CFD technology and computing power, there is a promising future for CFD to become a useful tool in planning, predicting, and evaluating outcomes of nasal surgery. This review discusses the possibilities and potential impacts, as well as technical limitations, of using CFD simulation to better understand nasal airflow physiology.

Abstract

During the past decades, numerous computational fluid dynamics (CFD) studies, constructed from CT or MRI images, have simulated human nasal models. As compared to rhinomanometry and acoustic rhinometry, which provide quantitative information only of nasal airflow, resistance, and cross sectional areas, CFD enables additional measurements of airflow passing through the nasal cavity that help visualize the physiologic impact of alterations in intranasal structures. Therefore, it becomes possible to quantitatively measure, and visually appreciate, the airflow pattern (laminar or turbulent), velocity, pressure,wall shear stress, particle deposition, and temperature changes at different flow rates, in different parts of the nasal cavity. The effects of both existing anatomical factors, as well as post-operative changes, can be assessed. With recent improvements in CFD technology and computing power, there is a promising future for CFD to become a useful tool in planning, predicting, and evaluating outcomes of nasal surgery. This review discusses the possibilities and potential impacts, as well as technical limitations, of using CFD simulation to better understand nasal airflow physiology.

참고문헌 (54)

  1. Keyhani K, "Numerical simulation of airflow in the human nasal cavity", J Biomech Eng, 117(4), pp.429~441 (1995)
  2. Castro Ruiz P, "Computational fluid dynamics simulations of the airflow in the human nasal cavity", Acta Otorrinolaringol Esp, 56(9), pp.403~410 (2005)
  3. Martonen TB, "Flow simulation in the human upper respiratory tract", Cell Biochem Biophys, 37(1), pp.27~36 (2002)
  4. Weinhold I, "Numerical simulation of airflow in the human nose", Eur Arch Otorhinolaryngol, 261(8), pp.452~455 (2004)
  5. Horschler I, "On the assumption of steadiness of nasal cavity flow", J Biomech, 43(6), pp.1081~1085 (2010)
  6. Leong SC, "A review of the implications of computational fluid dynamic studies on nasal airflow and physiology", Rhinology, 48(2), pp.139~145 (2010)
  7. Pless D, "Numerical simulation of air temperature and airflow patterns in the human nose during expiration", Clin Otolaryngol Allied Sci, 29(6), pp.642~647 (2004)
  8. Chen XB, "Numerical simulation of the effects of inferior turbinate surgery on nasal airway heating capacity", Am J Rhinol Allergy, 24(5), pp.118~122 (2010)
  9. Keyhani K, "A numerical model of nasal odorant transport for the analysis of human olfaction", J Theor Biol, 186(3), pp.279~301 (1997)
  10. Zhao K, "Effect of anatomy on human nasal air flow and odorant transport patterns: implications for olfaction", Chem Senses, 29(5), pp.365~379 (2004)
  11. Zhao K, "Numerical modeling of nasal obstruction and endoscopic surgical intervention: outcome to airflow and olfaction", Am J Rhinol, 20(3), pp.308~316 (2006)
  12. Kimbell JS, "Use of computational fluid dynamics models for dosimetry of inhaled gases in the nasal passages", Inhal Toxicol, 13(5), pp.325~334 (2001)
  13. Chen XB, "Assessment of septal deviation effects on nasal air flow: a computational fluid dynamics model", Laryngoscope, 119(9), pp.1730~1736 (2009)
  14. Grant O, "Numerical model of a nasal septal perforation", Stud Health Technol Inform, 107(2), pp.1352~1356 (2004)
  15. Pless D, "Numerical simulation of airflow patterns and air temperature distribution during inspiration in a nose model with septal perforation", Am J Rhinol, 18(6), pp.357~362 (2004)
  16. Lee HP, "Effects of septal perforation on nasal airflow: computer simulation study", J Laryngol Otol, 124(1), pp.48~54 (2010)
  17. Chen XB, "Assessments of nasal bone fracture effects on nasal airflow: a computational fluid dynamics study", Am J Rhinol Allergy, 25(1), pp.39~43 (2011)
  18. Lee HP, "Changes of airflow pattern in inferior turbinate hypertrophy: a computational fluid dynamics model", Am J Rhinol Allergy, 23(2), pp.153~158 (2009)
  19. Chen XB, "Impact of inferior turbinate hypertrophy on the aerodynamic pattern and physiological functions of the turbulent airflow: a CFD simulation model", Rhinology, 48(2), pp.163~168 (2010)
  20. Wexler D, "Aerodynamic effects of inferior turbinate reduction: computational fluid dynamics simulation", Arch Otolaryngol Head Neck Surg, 131(12), pp.1102~1107 (2005)
  21. Chen XB, "Aerodynamic effects of inferior turbinate surgery on nasal airflow: a computational fluid dynamics model", Rhinology, 48(4), pp.394~400 (2010)
  22. "Comparison between effects of various partial inferior turbinectomy options on nasal airflow: a computer simulation study"[URL]
  23. Lindemann J, "Numerical simulation of intranasal airflow after radical sinus surgery", Am J Otolaryngol, 26(3), pp.175~180 (2005)
  24. Chen XB, "Aerodynamic characteristics inside the rhino-sinonasal cavity after functional endoscopic sinus surgery", Am J Rhinol Allergy, 25(6), pp.388~392 (2011)
  25. Garlapati RR, "Indicators for the correct usage of intranasal medications: a computational fluid dynamics study", Laryngoscope, 119(10), pp.1975~1982 (2009)
  26. Chen XB, "A computational fluid dynamics model for drug delivery in a nasal cavity with inferior turbinate hypertrophy", J Aerosol Med Pulm Drug Deliv, 23(5), pp.329~338 (2010)
  27. Chen XB, "Drug delivery in the nasal cavity after functional endoscopic sinus surgery: a computational fluid dynamics study", J Laryngol Otol, 126(5), pp.487~494 (2012)
  28. Hooper RG, "Forced inspiratory nasal flow-volume curves: a simple test of nasal airflow", Mayo Clin Proc, 76(10), pp.990~994 (2001)
  29. Lin CL, "Characteristics of the turbulent laryngeal jet and its effect on airflow in the human intra-thoracic airways", Respir Physiol Neurobiol, 157(1), pp.295~309 (2007)
  30. Suh MW, "Computed tomography versus nasal endoscopy for the measurement of the internal nasal valve angle in Asians", Acta Otolaryngol, 128(6), pp.675~679 (2008)
  31. Terheyden H, "Acoustic rhinometry: validation by three-dimensionally reconstructed computer tomographic scans", J Appl Physiol, 89(3), pp.1013~1021 (2000)
  32. Cole P, "Acoustic rhinometry and rhinomanometry", Rhinol Suppl, 16, pp.29~34 (2000)
  33. Eccles R, "Nasal airflow in health and disease", Acta Otolaryngol, 120(5), pp.580~595 (2000)
  34. Cole P, "The four components of the nasal valve", Am J Rhinol, 17(2), pp.107~110 (2003)
  35. Farmer SE, "Chronic inferior turbinate enlargement and the implications for surgical intervention", Rhinology, 44(4), pp.234~238 (2006)
  36. Wang DY, "Acoustic rhinometry in nasal allergen challenge study: which dimensional measures are meaningful?", Clin Exp Allergy, 34(7), pp.1093~1098 (2004)
  37. Garcia GJ, "Atrophic rhinitis: a CFD study of air conditioning in the nasal cavity", J Appl Physiol, 10(3), pp.1082~1092 (2007)
  38. Wen J, "Numerical simulations for detailed airflow dynamics in a human nasal cavity", Respir Physiol Neurobiol, 161(2), pp.125~135 (2008)
  39. Lee JH, "Unsteady flow characteristics through a human nasal airway", Respir Physiol Neurobiol, 172(3), pp.136~146 (2010)
  40. Cole P, "Physiology of the nose and paranasal sinuses", Clin Rev Allergy Immunol, 16(1), pp.25~54 (1998)
  41. Hood CM, "Computational modeling of flow and gas exchange in models of the human maxillary sinus", J Appl Physiol, 107(4), pp.1195~1203 (2009)
  42. Naraghi M, "Nitric oxide: a new concept in chronic sinusitis pathogenesis", Am J Otolaryngol, 28(5), pp.334~337 (2007)
  43. Moncada S, "The L-arginine-nitric oxide pathway", N Engl J Med, 329(27), pp.2002~2012 (1993)
  44. Xiong G, "Numerical flow simulation in the post-endoscopic sinus surgery nasal cavity", Med Biol Eng Comput, 46(11), pp.1161~1167 (2008)
  45. Bhattacharyya N, "Bacterial infection after endoscopic sinus surgery: a controlled prospective study", Laryngoscope, 114(4), pp.765~767 (2004)
  46. Nayak DR, "De novo bacterial reinfections after endoscopic sinus surgery: can uncinate process preservation surgeries prevent it?", Laryngoscope, 115(5), pp.928~ (2005)
  47. Bousquet J, "Allergic rhinitis and its impact on asthma", J Allergy Clin Immunol, 108(5 Suppl), pp.S147~S334 (2001)
  48. Fokkens W, "European Position Paper on Rhinosinusitis and Nasal Polyps Group. European position paper on rhinosinusitis and nasal polyps 2007", Rhinol Suppl, 20, pp.1~136 (2007)
  49. Senocak D, "Sinonasal distribution of topically applied particles: computerized tomographic detection and the effects of topical decongestion", Otolaryngol Head Neck Surg, 133(6), pp.944~948 (2005)
  50. Homer JJ, "A quantitative analysis of the intranasal delivery of topical nasal drugs to the middle meatus: spray versus drop administration", J Laryngol Otol, 116(1), pp.10~13 (2002)
  51. Wenzel A, "Nasal respiratory resistance and head posture: effect of intranasal corticosteroid (Budesonide) in children with asthma and perennial rhinitis", Am J Orthod, 84(5), pp.422~426 (1983)
  52. Zhu JH, "Evaluation and comparison of nasal airway flow patterns among three subjects from Caucasian, Chinese and Indian ethnic groups using computational fluid dynamics simulation", Respir Physiol Neurobiol, 175(1), pp.62~69 (2011)
  53. Rhee JS, "Toward personalized nasal surgery using computational fluid dynamics", Arch Facial Plast Surg, 13(5), pp.305~310 (2011)
  54. Pawar SS, "Objective measures in aesthetic and functional nasal surgery: perspectives on nasal form and function", Facial Plast Surg, 26(4), pp.320~327 (2010)

관련 논문AI추천

Intersession Repeatability of Acoustic Rhinometry Measurements in Healthy VolunteersJadwiga Anna Wedzicha, John Robert Hurst, Mohammed Dhafer Al Ahmari대한이비인후과학회 · Clinical and Experimental Otorhinolaryngology2012 · 제5권 제3호수치해석 기법을 이용한 호흡 유량에 따른 사람의 기도 내 유동 특성 연구성건혁, 유홍선대한의용생체공학회 · 의공학회지2012 · 제33권 제4호A Prospective Population-based Study of Total Nasal Resistance in Korean Subjects신철, 김세중, 김은중, 김제형, 이승구, 이승훈, 전영준, 최지호, Soichiro Miyazaki대한이비인후과학회 · Clinical and Experimental Otorhinolaryngology2012 · 제5권 제1호Effectiveness of Septal Swell Body Reduction for Patients With Nasal Airway Obstruction: A Systematic Review and Meta-Analysis김지선, 황세환, Gulnaz Stybayeva대한이비인후과학회 · Clinical and Experimental Otorhinolaryngology2025 · 제18권 제2호전산유체역학을 이용한 소아 청소년 환자에서 상악 확장에 따른 상기도 내 공기 유동 변화 분석김재곤, 김태현, 양연미, 이경호, 이대우, 정진무대한치과의사협회 · 대한치과의사협회지2024 · 제62권 제12호Objective Parameters for Evaluating Internal Nasal Valve Compromise: Beyond the Angle Perspective김수진, 방제호, 이건희대한이비인후과학회 · Clinical and Experimental Otorhinolaryngology2024 · 제17권 제3호

이 간행물의 다른 논문 (11건)

The Efficiency of Simultaneous Binaural Ocular Vestibular Evoked Myogenic Potentials: A Comparative Study with Monaural Acoustic Stimulation in Healthy Subjects반재호, 김민범pp. 188-193Long-Term Evolution of the Electrical Stimulation Levels for Cochlear Implant PatientsIsaac Alvarez, Angel de la Torre, Jose Luis Vargas, Manuel Sainz, Cristina Roldanpp. 194-200Pseudo-Spontaneous Nystagmus in Lateral Semicircular Canal Benign Paroxysmal Positional Vertigo이효정, 홍성광, 김형종, 김용현pp. 201-206The Prognostic Role of p16 Expression in Tonsil Cancer Treated by Either Surgery or Radiation김태욱, 최성용, 고영혜, 손영익, 백정환pp. 207-212What is the Relationship between the Localization of Maxillary Fungal Balls and Intranasal Anatomic Variations?강준명, 황세환, 김병국, 조진희pp. 213-217
원문 보기