Crosstalk Between Mucosal Inflammation and Bone Metabolism in Chronic Rhinosinusitis
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초록
Chronic rhinosinusitis (CRS) is a multifactorial and highly heterogeneous upper airway disease that affects approximately 12% of the general population. There is increasing evidence supporting the impact of osteitis on the pathophysiology of CRS. Osteitis is frequently observed in patients with CRS, and is associated with severe sinonasal inflammation and recalcitrant cases. The overlying inflammatory sinonasal mucosa plays a critical role in the initiation of osteitis; however, the underlying molecular mechanisms and functional significance remain unclear. Increasingly many studies have suggested that immune cells play a crucial role in the bone remodeling process in CRS. The purpose of this review is to summarize the current state of knowledge regarding the specific role of sinonasal inflammation in bone remodeling in CRS patients.
Abstract
Chronic rhinosinusitis (CRS) is a multifactorial and highly heterogeneous upper airway disease that affects approximately 12% of the general population. There is increasing evidence supporting the impact of osteitis on the pathophysiology of CRS. Osteitis is frequently observed in patients with CRS, and is associated with severe sinonasal inflammation and recalcitrant cases. The overlying inflammatory sinonasal mucosa plays a critical role in the initiation of osteitis; however, the underlying molecular mechanisms and functional significance remain unclear. Increasingly many studies have suggested that immune cells play a crucial role in the bone remodeling process in CRS. The purpose of this review is to summarize the current state of knowledge regarding the specific role of sinonasal inflammation in bone remodeling in CRS patients.
참고문헌 (79)
- Fokkens WJ, "EPOS 2012: European position paper on rhinosinusitis and nasal polyps 2012. A summary for otorhinolaryngologists", Rhinology, 50(1), pp.1~12 (2012)
- Hamilos DL, "Chronic rhinosinusitis: epidemiology and medical management", J Allergy Clin Immunol, 128(4), pp.693~707 (2011)
- Schleimer RP, "Immunopathogenesis of chronic rhinosinusitis and nasal polyposis", Annu Rev Pathol, 12, pp.331~357 (2017)
- Roza Khalmuratova, "Immune Cell Responses and Mucosal Barrier Disruptions in Chronic Rhinosinusitis", Immune Network, 17(1), pp.60~67 (2017), 대한면역학회[DOI]
- Akdis CA, "Endotypes and phenotypes of chronic rhinosinusitis: a PRACTALL document of the European Academy of Allergy and Clinical Immunology and the American Academy of Allergy, Asthma & Immunology", J Allergy Clin Immunol, 131(6), pp.1479~1490 (2013)
- Van Zele T, "Differentiation of chronic sinus diseases by measurement of inflammatory mediators", Allergy, 61(11), pp.1280~1289 (2006)
- Brescia G, "Nasal polyposis pathophysiology: endotype and phenotype open issues", Am J Otolaryngol, 39(4), pp.441~444 (2018)
- Cao PP, "Distinct immunopathologic characteristics of various types of chronic rhinosinusitis in adult Chinese", J Allergy Clin Immunol, 124(3), pp.478~484 (2009)
- Kim SJ, "Changes in histological features of nasal polyps in a Korean population over a 17-year period", Otolaryngol Head Neck Surg, 149(3), pp.431~437 (2013)
- Tikaram A, "Asian nasal polyps: a separate entity?", Med J Malaysia, 68(6), pp.445~447 (2013)
- Cho SW, "Classification of chronic rhinosinusitis according to a nasal polyp and tissue eosinophilia:limitation of current classification system for Asian population", Asia Pac Allergy, 7(3), pp.121~130 (2017)
- Snidvongs K, "Osteitis in chronic rhinosinusitis", Curr Allergy Asthma Rep, 19(5), pp.24~ (2019)
- Bhandarkar ND, "Osteitis in chronic rhinosinusitis: a review of the literature", Int Forum Allergy Rhinol, 3(5), pp.355~363 (2019)
- Snidvongs K, "Osteitis is a misnomer: a histopathology study in primary chronic rhinosinusitis", Int Forum Allergy Rhinol, 4(5), pp.390~396 (2014)
- Lee JT, "The incidence of concurrent osteitis in patients with chronic rhinosinusitis: a clinicopathological study", Am J Rhinol, 20(3), pp.278~282 (2006)
- Sacks PL, "The impact of neo-osteogenesis on disease control in chronic rhinosinusitis after primary surgery", Int Forum Allergy Rhinol, 3(10), pp.823~827 (2013)
- Snidvongs K, "Osteitic bone: a surrogate marker of eosinophilia in chronic rhinosinusitis", Rhinology, 50(3), pp.299~305 (2012)
- Georgalas C, "Global Osteitis Scoring Scale and chronic rhinosinusitis: a marker of revision surgery", Clin Otolaryngol, 35(6), pp.455~461 (2010)
- Cho SH, "CT analysis and histopathology of bone remodeling in patients with chronic rhinosinusitis", Otolaryngol Head Neck Surg, 135(3), pp.404~408 (2006)
- Biedlingmaier JF, "Histopathology and CT analysis of partially resected middle turbinates", Laryngoscope, 106(1 Pt 1), pp.102~104 (1996)
- Giacchi RJ, "Histopathologic evaluation of the ethmoid bone in chronic sinusitis", Am J Rhinol, 15(3), pp.193~197 (2001)
- Bhandarkar ND, "The impact of osteitis on disease severity measures and quality of life outcomes in chronic rhinosinusitis", Int Forum Allergy Rhinol, 1(5), pp.372~378 (2011)
- Snidvongs K, "Correlation of the Kennedy Osteitis Score to clinico-histologic features of chronic rhinosinusitis", Int Forum Allergy Rhinol, 3(5), pp.369~375 (2013)
- Meng Y, "Predictive significance of computed tomography in eosinophilic chronic rhinosinusitis with nasal polyps", Int Forum Allergy Rhinol, 6(8), pp.812~819 (2016)
- Kong IG, "Receptor activator of nuclear factor κB ligand is a biomarker for osteitis of chronic rhinosinusitis", Int Forum Allergy Rhinol, 10(3), pp.364~373 (2020)
- Florencio-Silva R, "Biology of bone tissue: structure, function, and factors that influence bone cells", Biomed Res Int, 2015, pp.421746~ (2015)
- Caetano-Lopes J, "Osteoblasts and bone formation", Acta Reumatol Port, 32(2), pp.103~110 (2007)
- Metzger CE, "The role of osteocytes in inflammatory bone loss", Front Endocrinol (Lausanne), 10, pp.285~ (2019)
- Ishino T, "Establishment of osteoblast culture from human ethmoidal sinus", Auris Nasus Larynx, 30(1), pp.45~51 (2003)
- Stevens PR, "Chronic rhinosinusitis osteoblasts differ in cellular properties from normal bone", Int Forum Allergy Rhinol, 5(2), pp.124~131 (2015)
- Mehta V, "Blood and sputum eosinophil levels in asthma and their relationship to sinus computed tomographic findings", Mayo Clin Proc, 83(6), pp.671~678 (2008)
- Gunel C, "Osteitis is associated with P-glycoprotein overexpression in patients with chronic sinusitis without nasal polyps", Am J Rhinol Allergy, 28(2), pp.99~102 (2014)
- Miyake MM, "P-glycoprotein and chronic rhinosinusitis", World J Otorhinolaryngol Head Neck Surg, 4(3), pp.169~174 (2018)
- Cheng YS, "Influence of P-glycoprotein function on chronic rhinosinusitis", nasal polyps pathophysiology, 2016, pp.79, 38~47
- Feldman RE, "P-glycoprotein is a marker of tissue eosinophilia and radiographic inflammation in chronic rhinosinusitis without nasal polyps", Int Forum Allergy Rhinol, 3(8), pp.684~687 (2013)
- Bleier BS, "P-glycoprotein promotes epithelial T helper 2-associated cytokine secretion in chronic sinusitis with nasal polyps", Int Forum Allergy Rhinol, 4(6), pp.488~494 (2014)
- Bleier BS, "P-glycoprotein regulates Staphylococcus aureus enterotoxin B-stimulated interleukin-5 and thymic stromal lymphopoietin secretion in organotypic mucosal explants", Int Forum Allergy Rhinol, 6(2), pp.169~177 (2016)
- Onoe Y, "IL-13 and IL-4 inhibit bone resorption by suppressing cyclooxygenase-2-dependent prostaglandin synthesis in osteoblasts", J Immunol, 156(2), pp.758~764 (1996)
- Silfversward CJ, "Reduced cortical bone mass in mice with inactivation of interleukin-4 and interleukin-13", J Orthop Res, 25(6), pp.725~731 (2007)
- Silfversward CJ, "Expression of markers of activity in cultured human osteoblasts: effects of interleukin-4 and interleukin-13", Scand J Clin Lab Invest, 70(5), pp.338~342 (2010)
- Tuszynska A, "Inflammatory cytokines gene expression in bone tissue from patients with chronic rhinosinusitis: a preliminary study", Rhinology, 48(4), pp.415~419 (2010)
- Wang M, "Differing roles for TGF-β", Smad signaling in osteitis in chronic rhinosinusitis with and without nasal polyps, 2015, pp.29(5), e152~e159
- Gunel C, "Microarray analysis of the genes associated with osteitis in chronic rhinosinusitis", Laryngoscope, 127(3), pp.E85~E90 (2017)
- Jin L, "Growth differentiation factor 5 regulation in bone regeneration", Curr Pharm Des, 19(19), pp.3364~3373 (2013)
- Sautter NB, "Tissue remodeling gene expression in a murine model of chronic rhinosinusitis", Laryngoscope, 122(4), pp.711~717 (2012)
- Wu D, "Osteitis is associated with dysregulated pro-osteoblastic activity in patients with nasal polyps", Laryngoscope, 129(3), pp.E102~E109 (2019)
- Oue S, "Increased IL-13 expression is independently associated with neo-osteogenesis in patients with chronic rhinosinusitis", J Allergy Clin Immunol, 140(5), pp.1444~1448 (2017)
- Roza Khalmuratova, "Evaluation of Neo-Osteogenesis in Eosinophilic Chronic Rhinosinusitis Using a Nasal Polyp Murine Model", Allergy, Asthma & Immunology Research, 12(2), pp.306~321 (2020), 대한천식알레르기학회
- Shi N, "Runx2, a novel regulator for goblet cell differentiation and asthma development", FASEB J, 31(1), pp.412~420 (2017)
- Khalmuratova R, "Interleukin (IL)-13and IL-17A contribute to neo-osteogenesis in chronic rhinosinusitis by inducing RUNX2", EBioMedicine, 46, pp.330~341 (2019)
- Komori T, "Regulation of bone development and maintenance by Runx2", Front Biosci, 13, pp.898~903 (2008)
- Jensen ED, "Regulation of gene expression in osteoblasts", Biofactors, 36(1), pp.25~32 (2010)
- Komori T, "Regulation of bone development and extracellular matrix protein genes by RUNX2", Cell Tissue Res, 339(1), pp.189~195 (2010)
- Boyce BF, "Functions of RANKL", RANK, Arch Biochem Biophys, pp.2008, 473(2)[DOI]
- Walsh MC, "Biology of the RANKL-RANK-OPG system in immunity, bone, and beyond", Front Immunol, 5, pp.511~ (2014)
- Yeo L, "Cytokine mRNA profiling identifies B cells as a major source of RANKL in rheumatoid arthritis", Ann Rheum Dis, 70(11), pp.2022~2028 (2011)
- Ogasawara N, "Role of RANK-L as a potential inducer of ILC2-mediated type 2 inflammation in chronic rhinosinusitis with nasal polyps", Mucosal Immunol, 13(1), pp.86~95 (2020)
- Huber C, "In human basophils, IL-3 selectively induces RANKL expression that is modulated by IgER-dependent and IgER-independent stimuli", Allergy, 69(11), pp.1498~1505 (2014)
- Huang Z, "Clinical predictors of neo-osteogenesis in patients with chronic rhinosinusitis", Int Forum Allergy Rhinol, 5(4), pp.303~309 (2015)
- Karempelis P, "Risk factors for neo-osteogenesis in cystic fibrosis and non-cystic fibrosis chronic rhinosinusitis", Int Forum Allergy Rhinol, 10(4), pp.505~510 (2020)
- Dong D, "Correlation between bacterial biofilms and osteitis in patients with chronic rhinosinusitis", Laryngoscope, 124(5), pp.1071~1077 (2014)
- Zhao YC, "Biofilm and osteitis in refractory chronic rhinosinusitis", Otolaryngol Clin North Am, 50(1), pp.49~60 (2017)
- Braga AA, "An experimental model of eosinophilic chronic rhinosinusitis induced by bacterial toxins in rabbits", Am J Rhinol Allergy, 33(6), pp.737~750 (2019)
- Cho DY, "Sinus microanatomy and microbiota in a rabbit model of rhinosinusitis", Front Cell Infect Microbiol, 7, pp.540~ (2018)
- Shin HW, "Animal models in CRS and pathophysiologic insights gained: a systematic review", Laryngoscope Investig Otolaryngol, 1(5), pp.116~123 (2016)
- Perloff JR, "Bone involvement in sinusitis: an apparent pathway for the spread of disease", Laryngoscope, 110(12), pp.2095~2099 (2000)
- Khalid AN, "The role of bone in chronic rhinosinusitis", Laryngoscope, 112(11), pp.1951~1957 (2002)
- Dong Y, "Computed tomography and histopathological evaluation of osteitis in rabbit models with rhinosinusitis", Acta Otolaryngol, 137(5), pp.534~540 (2017)
- Khalmuratova R, "Induction of nasal polyps using house dust mite and Staphylococcal enterotoxin B in C57BL", 6 mice, 2016, pp.44(1), 66~75
- Kim DW, "Staphylococcus aureus enterotoxin B contributes to induction of nasal polypoid lesions in an allergic rhinosinusitis murine model", Am J Rhinol Allergy, 25(6), pp.e255~e261 (2011)
- Wang S, "Establishment of a mouse model of lipopolysaccharide-induced neutrophilic nasal polyps", Exp Ther Med, 14(6), pp.5275~5282 (2017)
- Lee M, "Sirtuin 1 attenuates nasal polypogenesis by suppressing epithelial-tomesenchymal transition", J Allergy Clin Immunol, 137(1), pp.87~98 (2016)
- Lee M, "Sinonasal delivery of resveratrol via mucoadhesive nanostructured microparticles in a nasal polyp mouse model", Sci Rep, 7, pp.40249~ (2017)
- Kim SW, "Periostin may play a protective role in the development of eosinophilic chronic rhinosinusitis with nasal polyps in a mouse model", Laryngoscope, 123(5), pp.1075~1081 (2013)
- Khalmuratova R, "Wogonin attenuates nasal polyp formation by inducing eosinophil apoptosis through HIF-1α and survivin suppression", Sci Rep, 8(1), pp.6201~ (2018)
- Vandamme TF, "Rodent models for human diseases", Eur J Pharmacol, 759, pp.84~89 (2015)
- Wang Z, "Histological and computed tomographic characteristics of the sinonasal structure of BALB", c mice, 2020, pp.49(2), 222~226
- Kim SW, "Resveratrol prevents development of eosinophilic rhinosinusitis with nasal polyps in a mouse model", Allergy, 68(7), pp.862~869 (2013)
- Kim Y, "α-Helical cell-penetrating peptide-mediated nasal delivery of resveratrol for inhibition of epithelial-to-mesenchymal transition", J Control Release, 317, pp.181~194 (2020)
