A New Calculation Model for Calcium Requirements After Parathyroidectomy in Patients With Secondary Hyperparathyroidism
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Objectives. We aimed to develop a new calculation model for calcium requirements in dialysis patients following parathy-roidectomy. Methods. A total of 98 patients with secondary hyperparathyroidism receiving parathyroidectomy from January 2014 toJanuary 2022 were enrolled in this study. Among these patients, 78 were randomly selected for construction of thecalcium requirement calculation model, and the remaining 20 patients were selected for model validation. The calci-um requirement model estimated the total calcium supplementation for 1 week after surgery using variables withsignificant relationships in the derivation group by stepwise multiple linear regression analysis. Bias, precision, andaccuracy were measured in the validation group to determine the performance of the model. Results. The model was as follows: calcium requirement for 1 week after surgery =33.798–8.929×immediate postoperativecalcium+0.190×C-reactive protein–0.125×age+0.002×preoperative intact parathyroid hormone+0.003×preopera-tive alkaline phosphatase (R2 =0.8). The model was successfully validated. Conclusion. We generated a novel model to guide calcium supplementation. This model can assist in stabilizing the serumcalcium levels of patients during the early postoperative period. Furthermore, it contributes to the individualized andprecise treatment of hypocalcemia in patients following parathyroidectomy.
Abstract
Objectives. We aimed to develop a new calculation model for calcium requirements in dialysis patients following parathy-roidectomy. Methods. A total of 98 patients with secondary hyperparathyroidism receiving parathyroidectomy from January 2014 toJanuary 2022 were enrolled in this study. Among these patients, 78 were randomly selected for construction of thecalcium requirement calculation model, and the remaining 20 patients were selected for model validation. The calci-um requirement model estimated the total calcium supplementation for 1 week after surgery using variables withsignificant relationships in the derivation group by stepwise multiple linear regression analysis. Bias, precision, andaccuracy were measured in the validation group to determine the performance of the model. Results. The model was as follows: calcium requirement for 1 week after surgery =33.798–8.929×immediate postoperativecalcium+0.190×C-reactive protein–0.125×age+0.002×preoperative intact parathyroid hormone+0.003×preopera-tive alkaline phosphatase (R2 =0.8). The model was successfully validated. Conclusion. We generated a novel model to guide calcium supplementation. This model can assist in stabilizing the serumcalcium levels of patients during the early postoperative period. Furthermore, it contributes to the individualized andprecise treatment of hypocalcemia in patients following parathyroidectomy.
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